[HN Gopher] Study finds new pathway for clearing misfolded proteins
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Study finds new pathway for clearing misfolded proteins
Author : geox
Score : 58 points
Date : 2023-04-20 19:31 UTC (3 hours ago)
(HTM) web link (news.stanford.edu)
(TXT) w3m dump (news.stanford.edu)
| zamalek wrote:
| I assume this wouldn't hold any value for prions (as the entropic
| anti-life tarpit that they are), and more value for "benign" and
| merely useless misfolds?
| m3kw9 wrote:
| This can solve mad cow diseases?
| LinuxBender wrote:
| Or hopefully CWD. I feed about 40 deer a day, twice a day and
| they are at high risk of getting chronic wasting disease
| _misfolded prions_. I don 't consume the deer but CWD can be
| passed from urine and feces so I wear dedicated shoes
| specifically for the purpose of feeding them and sterilize them
| with chemicals and UV light.
| echelon wrote:
| I'm not sure what the risk of spontaneous CWD development in
| deer is (extremely low?), but I'm also not sure that your
| sterilization protocol is sufficient either.
|
| > Prions cannot be destroyed by boiling, alcohol, acid,
| standard autoclaving methods, or radiation. In fact, infected
| brains that have been sitting in formaldehyde for decades can
| still transmit spongiform disease [1]
|
| How do you spot a diseased animal, and what's your protocol
| for dealing with it?
|
| [1] https://learn.genetics.utah.edu/content/basics/prions
| LinuxBender wrote:
| _How do you spot a diseased animal, and what 's your
| protocol for dealing with it?_
|
| It's tricky because the symptoms may not manifest for up to
| a year and sometimes even longer. This time of year is
| extra tricky because I get deer that show up late in winter
| and are emaciated from a lack of food, but it could also be
| disease. If I suspect a deer is infected I call the game
| warden and they would come out to put it down and get the
| lymph nodes tested. There is no other way. Thus far I have
| not had to do this. The only deer I have lost thus far was
| one that for sure was starving for too long in the hills
| and took too long to find his way to me and several last
| year that played chicken in the highway but that has
| stopped since I started feeding them twice a day.
|
| I could actually see formaldehyde preserving the prions. I
| would be surprised if the bleach I use does not decompose
| the prions but maybe I have been going through the wrong
| process all this time. If you can suggest a better
| procedure I will look into it.
| robwwilliams wrote:
| Back on topic:
|
| Nuclear waste (the kind we eukaryotes all make) get lumped into a
| garbage can that then gets fused to a cytoplasmic trash
| truck/digester called a vacuole or lysosome.
|
| There is a lot of excitement in lysosomal processing if protein
| and polyglucosan aggregates in aging brain (work of Ralph Nixon).
| But still a very long haul for this work in yeast to
| applications, if any, in humans. Bravo anyway--after all, yeast
| are family.
|
| "Tying that particular family of proteins and this aspect of
| vesicle traffic biology to protein clearance gives us a new way
| to look at Alzheimer's, Parkinson's, Huntington's - all these
| neurodegenerative diseases," said Sontag.
| [deleted]
| foolfoolz wrote:
| if i don't eat collagen because i'm afraid of prions is that
| overkil?
| slashdev wrote:
| Statistically, yes. There's thousands of risks you don't even
| consider that are more dangerous. So probably not rational to
| worry about collagen.
|
| There is no definite proof that gelatin can contain infectious
| prions, as long as it is manufactured according to industry
| standards. It's theoretically possible. But your odds of
| getting struck by lightning are far higher in any given year. I
| wouldn't worry about it.
| tandr wrote:
| Great comment, but... Now they will be afraid to go outside.
| ;)
| deegles wrote:
| Just buy glycine, it's cheaper and has the same effect. Up to
| 20g/day is safe.
| clumsysmurf wrote:
| Do you have a link for the 20g/safe claim?
| LinuxBender wrote:
| Examine.com has some data on this. [1]
|
| _No toxicity with glycine supplementation has been
| observed with doses up to 0.8 g /kg body weight (64 grams
| per day for a 176 lb adult)_
|
| [1] - https://examine.com/supplements/glycine/research/#KQe
| k8l9-ba...
| m3kw9 wrote:
| Eating steak can also get you that
| clumsysmurf wrote:
| If this concerns you, look into hydrolyzed collagen (aka
| collagen peptides). I assume since they are broken down its a
| bit different, but can't back up my assumption.
| jcims wrote:
| This seems like one of those things that I don't want to
| google.
| el_benhameen wrote:
| From someone who's been down the rabbit hole: don't.
| candiddevmike wrote:
| Best not to walk barefoot outside or touch something barehanded
| either. You'd also need to sterilize everything you eat and
| drink.
| mromanuk wrote:
| We need to use a bubble, right?
| akiselev wrote:
| You'll need to sterilize everything with a 50% solution of
| bleach. Not by spraying it like a domestic cleaning agent,
| mind you, but by submersing or covering it for five minutes.
| That should be enough to denature prions on the surfaces of
| everyday objects - but not tissue like food!
| nemo44x wrote:
| A friend of mine got infected with prions. Well, it's what the
| doctors believe since all other tests came up negative. They
| aren't 100% sure but have documented it as that.
|
| It's amazing how quickly he degenerated. He was feeling weird
| physically and mentally and went to a doctor. Within a few
| months he was a different person but could recognize friends.
| He needed assistance for living. Within a year he was
| completely mentally gone. Just a different person with no means
| of communicating or doing anything for himself. Just completely
| sad.
| bread90 wrote:
| How'd he get it you think?
| 7speter wrote:
| I imagine you'd okay if you ate gelatin (whether in stock, or
| jello are the knox stuff added to whatever)?
| [deleted]
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