[HN Gopher] Study links 'stuck' stem cells to hair turning gray
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Study links 'stuck' stem cells to hair turning gray
Author : gmays
Score : 106 points
Date : 2023-04-20 13:50 UTC (9 hours ago)
(HTM) web link (phys.org)
(TXT) w3m dump (phys.org)
| rvbissell wrote:
| This 'stuck' notion tracks with my anecdata, as I once noticed
| one of my own hairs switch back from gray to colored. ... Alas,
| its comrades did not follow its lead.
| MichaelZuo wrote:
| Same. I've noticed a few times where a solid strand of my hair
| suddenly turned into a curious grey/white colour, with perhaps
| a bit of a reddish interval inbetween, then after some length
| turns back into the original colour...
|
| And once it didn't turn all the way, but it got stuck on a
| curious reddish-yellow colour, then reverted.
| hair wrote:
| This article gives me an opportunity to share a story that I've
| shared with my kids though I don't think they believe me.
|
| When I was a teen I heard my dad say that my uncle (his older
| brother) would make a habit of advice that he liked, and then
| keep the habit forever. For example, a long time ago someone had
| advised him to massage his scalp daily for healthy hair. He was
| in his 70s at that point and had far less grey than my much
| younger dad.
|
| So, around that time I started to vigorously massage my scalp
| every day while taking a shower. I spend about 15-20 seconds
| doing so.
|
| My uncle passed away in his mid eighties with far less grey than
| is normal at that age.
|
| I'm now approaching my mid fifties with only a handful of grey
| and keep on getting "you don't look your age" comments.
|
| It may be genes or it may be this practice.
| VeninVidiaVicii wrote:
| Hard to refute -- I use a pretty vigorous spin-brush-dryer on
| my hair every day for ~5 minutes, which only does the top and
| front. I just noticed recently that the sides have grown out
| beyond a few mm, and they are much grayer than the top.
| zeroclick wrote:
| Doesn't everyone grey on the sides first?
| jnsie wrote:
| Uncle didn't have any tips for a receding hairline by any
| chance?
| tyre wrote:
| Finasteride.
| dennis_jeeves1 wrote:
| Transplant hair from nose to head, perhaps?
| jnsie wrote:
| I don't want _that much_ hair, jeez :-)
| moralestapia wrote:
| Hit the gym? Lol.
| copperx wrote:
| To increase testosterone and speed up the onset of
| baldness?
| kevviiinn wrote:
| I don't think working out increases testosterone
| fsckboy wrote:
| if we included testosterone supplements I think we'll
| find a correlation
| pengaru wrote:
| > I don't think working out increases testosterone
|
| You think wrongly, they're definitely linked:
|
| "Exercise: Resistance training increases testosterone
| levels acutely, however, in older men, that increase can
| be avoided by protein ingestion. Endurance training in
| men may lead to lower testosterone levels." [0]
|
| [0] https://en.wikipedia.org/wiki/Testosterone#Regulation
| agumonkey wrote:
| maybe microvascular stimulation helps hair follicles lifecycle
| LazyMans wrote:
| There is a subreddit dedicated to hair loss and techniques. I
| think one of the highly rated posts discusses use of weekly
| dermarolling, massaging the scalp, in combination with the
| regular things like finasteride, minoxidil, and ketoconazole
| shampoo. Anyways, this isn't exactly science. I think one mode
| of action to explore is increased blood flow helping with hair
| growth.
|
| We know massaging an area increases blood flow to that area, in
| turn promoting better cellular metabolic processes.
| Dermarolling seems to do this through inflicted
| trauma/irritation to said area. I know one of the actions of
| minoxidil is a vasodilator.
|
| Checks out. Worst case you just have really clean hair and
| developed a new daily mindfulness technique.
| esotericsean wrote:
| The What I've Learned YouTube channel recently did a video on
| this! https://youtu.be/Yehk_h_Uj6k
| HopenHeyHi wrote:
| It works even better if you rub your belly at the same time.
| Not a lot of people have that kind of coordination tho.
| Freire_Herval wrote:
| Science:
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740347/
| hair wrote:
| Wow! Thank you
| HopenHeyHi wrote:
| Ahem. https://pubmed.ncbi.nlm.nih.gov/19965058/
| Freire_Herval wrote:
| Doesn't help hair.
| whitemary wrote:
| [flagged]
| proc0 wrote:
| Name one other system that has produced even a fraction of the
| progress.
| hatsunearu wrote:
| clearly many people care about grey hair, despite how frivolous
| you think it is. do their opinions not matter?
| kofejnik wrote:
| You can always move to North Korea to avoid capitalist
| healthcare
| melling wrote:
| Can you believe the budget for Fast and Furious 10 is $340
| million?
|
| Here comes the classic ..."Oh wait", ... someone is once again
| complaining because we are spending money on "superficial"
| healthcare (e.g. hair loss, grey hair, aging etc)
|
| Spending money to better understand the human body is valuable.
| Sure, I wish people would wake up and demand that we cure
| cancer(s), Alzheimer's, Parkinson's, etc. In lieu of that, we
| should be happy that money is funneled into "healthcare" to
| solve any problems.
|
| Btw, interest on the US debt will soon be over $1 trillion a
| year.
| feoren wrote:
| > interest on the US debt will soon be over $1 trillion a
| year
|
| And that trillion dollars gets, what, flushed down the
| toilet? No, it goes into the hands of bond-holders, who spend
| it the same way they spend the rest of their money, including
| on plucking hairs out of mice to study aging. (Obviously I
| mostly agree with you here, just nitpicking the idea that
| that trillion dollars is "wasted" somehow.)
| melling wrote:
| Well, we either have to raise taxes or keep increasing the
| debt, paying even more interest. That doesn't sound like an
| efficient use of capital.
| foxyv wrote:
| To be honest, I'm happy any money is going towards actual
| healthcare research instead of lining the pockets of vultures.
| outworlder wrote:
| Studying the processes that are related to aging is important
| even when they are just cosmetic.
| meepmorp wrote:
| In fact, the 'cosmetic' (or, better, 'easily visible') nature
| of this process probably makes it easier to study in vivo.
| Tagbert wrote:
| Yes, why aren't they working on a new video game, instead!? /s
|
| There are a lot of different medical issuers that affect people
| in various way. some are more impactful than others, but it
| makes no sense to put all resources on a single, most impactful
| problem. Better to put some resources on a variety of problems.
| Cancer research is still going to get a lot more resources than
| this.
| LinuxBender wrote:
| I think this is an appropriate use of resources. Fixing
| motility of stem cells in this case may reverse grey hair but
| improving the motility of other stem cells may have other
| health, immune and age related benefits. It is entirely
| possible this is just the tip of the iceberg so to speak. I
| just wish we could find non-RX methods to do these things.
| throw1234651234 wrote:
| Did any of the hyped anti-aging things pan out / show
| reproducible effect? Specifically the telomere research, blood
| transfusions, and extensive fasting?
|
| Was low-calorie diet -> lower mortality ever proven when
| accounting for likely resulting lower muscle mass/fitness?
| tashoecraft wrote:
| Typically in mice. Testing in humans takes a very long time and
| has ethical concerns so if you wait until it gets "proven" to
| trust anything you'll be long dead already.
| xwdv wrote:
| low calorie stuff is very difficult to get right. You are more
| likely to mess up and actually reduce your lifespan while also
| living worse quality of life (weaker, low energy, low
| endurance). No way around it, the body needs fuel to build
| cells and produce energy.
|
| Eating normal and exercising regularly to maintain muscle mass
| will reduce chances of all cause mortality and delay morbidity
| for as long as possible, however you must also maintain
| creatine supplementation well into old age to support the
| muscles and brain. The effects of creatine on the brain are
| often understated but they are significant.
| pengaru wrote:
| > Eating normal
|
| Considering "normal" these days is metabolic syndrome, this
| doesn't even pass the smell test.
| xwdv wrote:
| Depends on what country you're from.
| aranchelk wrote:
| "Ito says the team has plans to investigate means of restoring
| motility of McSCs or of physically moving them back to their germ
| compartment, where they can produce pigment."
|
| Sharpen your machetes, tape up your baseball bat handles, time
| for the zombies.
| meepmorp wrote:
| Yes, but their hair will fantastically luxurious.
| novia wrote:
| > In the latest experiments in mice whose hair was physically
| aged by plucking and forced regrowth
|
| ...
|
| edit:
|
| The researchers in this case decided to pluck hairs from young
| mice repeatedly until it started growing in grey instead of just
| looking at grey hairs on older lab mice.
|
| I think with animal research there needs to be a careful balance
| struck between the amount of pain/harm caused to the animal and
| the potential good that can come from the research. Like, in
| animal studies that are done to try to prevent future cancer
| deaths, purposefully inducing cancer in lab rats is defensible.
|
| In this case, without looking at the research paper to get more
| details, it sounds like they basically tortured live lab mice
| without a defensible reason, due to the fact that alternative
| methods were available.
|
| Their methodology also makes the results less useful for the
| thing they were trying to research. Instead of knowing that stem
| cells exist but get stuck in older mammals who go grey, we
| instead know that if you repeatedly pluck out your own hair while
| you're young and then you go grey where you plucked out your
| hair, it's likely due to stem cells getting stuck.
| feoren wrote:
| Say what you mean. "..." is not a useful comment.
| slater wrote:
| I'm guessing it's the old "in mice" thing that needs to be
| added to the title, which has become somewhat of a trope here
| ;)
| [deleted]
| [deleted]
| agumonkey wrote:
| Anybody knows a link between stem cell maturation and emotional
| shock ? a good 10% of my hair became white after some event. I'm
| very surprised about the overnight change and the fact that
| they're not replaced.
| gorkish wrote:
| Once there was this kid who got into an accident and couldn't
| come to school, but when he finally came back his hair had
| turned from black into bright white. He said that it was from
| when the cars had smashed so hard.
| agumonkey wrote:
| hmm hmm hmm
|
| ps: timeless intro
| coldtea wrote:
| Yes, it has been studied too, e.g.:
|
| https://www.nih.gov/news-events/nih-research-matters/how-str...
| agumonkey wrote:
| thanks a lot
| el_don_almighty wrote:
| Once there was this kid who
|
| Got into an accident and couldn't come to school
|
| But when he finally came back
|
| His hair had turned from black into bright white
|
| He said that it was from when
|
| The cars had smashed so hard
| FollowingTheDao wrote:
| Might want to look into zinc for these stuck stem cells:
|
| Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation
| and Differentiation towards a Neuronal Fate
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932442/
|
| Quercetin/Zinc complex and stem cells: A new drug therapy to
| ameliorate glycometabolic control and pulmonary dysfunction in
| diabetes mellitus: Structural characterization and genetic
| studies
| https://journals.plos.org/plosone/article?id=10.1371/journal...
| Khelavaster wrote:
| This is according to Alan Turing's 1952 thesis, The Chemical
| Basis of Morphogensis: https://embryo.asu.edu/pages/chemical-
| basis-morphogenesis-19...
| kordlessagain wrote:
| When I was a kid our poodle got heartworms. They shaved the side
| of her and applied some type of salve there in addition to shots
| and/or pills. That spot on her stayed pretty much jet black while
| the rest of her turned grey until she died at 18.
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