[HN Gopher] Intranasal vaccine confers broad mucosal and systemi...
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       Intranasal vaccine confers broad mucosal and systemic immunity
       against SARS-CoV2
        
       Author : luu
       Score  : 31 points
       Date   : 2023-04-19 20:48 UTC (2 hours ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | TheRealPomax wrote:
       | This should really have "in mice" added at the end of the title,
       | even if the publication itself omits this because it's in the
       | abstract. As published, this has effectively nothing to do with
       | what people think it has anything to do with yet.
        
       | version_five wrote:
       | All author affiliations are Chinese institutions. For Americans
       | it's probably not coming to a pharmacy near you. I don't have a
       | sense of the global vaccine R&D landscape but I don't belive
       | western countries ever got any chinese covid vaccines
        
         | maw wrote:
         | I don't know about other countries but in Mexico they gave out
         | Cansino and Sinovac among many others.
         | 
         | I count myself fortunate to live in an area where they were
         | administering A-Z.
        
           | HillRat wrote:
           | Yeah, Sinovac was useless; everyone I know in Mexico who got
           | it came down repeatedly with COVID after vaccination, only
           | improving after they were able to get AZ or the mRNA vaccines
           | in the US. Hopefully this signals better vaccines on the
           | horizon for China, given what they went through once lockdown
           | collapsed there.
        
             | VagueMag wrote:
             | > _everyone I know in Mexico who got it came down
             | repeatedly with COVID after vaccination_
             | 
             | This is a pretty common story with the mRNA and DNA/AAV
             | vaccines as well. Did any of them wind up in the hospital?
        
         | davidw wrote:
         | Our mRNA vaccines were 'better' from what I understand.
        
       | BigCryo wrote:
       | Time it's for real
        
       | medvezhenok wrote:
       | RadVac in the Boston area had an intranasal vaccine out by June
       | of 2020. Not FDA approved/authorized, but quite a few people took
       | it early on with little adverse consequences. About 6 months
       | earlier than the first FDA authorized vaccines became available.
       | 
       | https://radvac.org/vaccine/
        
         | fsh wrote:
         | There is no reason to believe that this actually worked. There
         | were lots of vaccine candidates in early 2020, and many of them
         | failed to produce a strong enough immune responce. This even
         | happened to big corporations like Sanofi-GSK. The hard part is
         | not to produce some vaccine candidates, but to test the safety
         | and efficacy.
        
         | ethanbond wrote:
         | Ha! I actually had a vaccine delivered by lightbulb directly
         | onto your skin 4 months before COVID ever infected a human.
         | 
         | I know this because I changed my lightbulb 4 months prior to
         | COVID and didn't end up catching it until I moved apartments
         | and forgot to move my vaccinating lightbulb with me.
         | 
         | FDA doesn't want you to know this one weird trick!
         | 
         | P.S. it's super, super easy to make a drug that maybe-works.
        
       | yborg wrote:
       | ...in mice.
        
         | dsjoerg wrote:
         | Great point and it's a step in the right direction.
        
         | hughw wrote:
         | There's a Twitter account https://twitter.com/justsaysinmice
         | who simply links to articles whose titles could use a good "IN
         | MICE"
        
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       (page generated 2023-04-19 23:00 UTC)