[HN Gopher] Polio cases in Africa linked to new oral vaccine
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       Polio cases in Africa linked to new oral vaccine
        
       Author : gmays
       Score  : 40 points
       Date   : 2023-03-21 21:11 UTC (1 hours ago)
        
 (HTM) web link (www.science.org)
 (TXT) w3m dump (www.science.org)
        
       | ggm wrote:
       | Some amount of vaccine caused polio has for a long time been a
       | problem. The point being made here is that this was a newer polio
       | vaccine which attempted to avoid the risk.
       | 
       | It's "vaccine designed to minimise vaccine-caused polio still
       | causes a small number of cases"
       | 
       | The second take away is, it's still better than earlier versions
       | of the vaccine.
       | 
       | So it could have been "reduced breakout vaccine-caused polio
       | cases in new vaccine deployed in Africa"
        
         | makomk wrote:
         | "A problem" is a bit of an understatement... at this point it's
         | basically caused the global polio eradication effort to fail.
         | Wild type 2 poliovirus no longer exists anywhere in the world,
         | and all infections with it over the last couple of decades are
         | vaccine-derived. The original plan was that everywhere would
         | switch to a bivalent oral vaccine without the type 2 virus, any
         | remaining vaccine-derived outbreaks could be mopped up with
         | monovalent vaccine, and then it would finally be eradicated for
         | real. This failed - there were widespread outbreaks and
         | targetted vaccination just caused the number of outbreaks to
         | increase. The new oral vaccine was the fallback plan and the
         | fact that this is already happening with it is not a great
         | sign.
        
           | bbarnett wrote:
           | Hmm.
           | 
           | If I were evil, and owned a pharma company, I'd want
           | eradication to fail.
        
             | NoZebra120vClip wrote:
             | I personally believe that those qualities are orthogonal.
        
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       (page generated 2023-03-21 23:01 UTC)