[HN Gopher] Link between Alzheimer's disease and gut microbiota ...
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       Link between Alzheimer's disease and gut microbiota is confirmed
        
       Author : gardenfelder
       Score  : 21 points
       Date   : 2023-03-17 20:28 UTC (2 hours ago)
        
 (HTM) web link (www.sciencedaily.com)
 (TXT) w3m dump (www.sciencedaily.com)
        
       | LorenPechtel wrote:
       | I'm not at all surprised. Bacteria can produce quite a variety of
       | compounds, the idea that some gut bacteria could produce harmful
       | compounds seems pretty obvious.
        
       | Jerry2 wrote:
       | This article is very short on details.
       | 
       | > _" Indeed, high blood levels of lipopolysaccharides and certain
       | short-chain fatty acids (acetate and valerate) were associated
       | with both large amyloid deposits in the brain._
       | 
       | Any indications which bacteria produces these amyloids?
        
         | tomohelix wrote:
         | I doubt there is a concrete answer. Many bacteria produce
         | amyloids as a normal part of their body. Amyloids are just one
         | specific type of protein fold stacking on each other, and it is
         | so, so common.
         | 
         | Same thing with SCFAs, they are normally part of the metabolic
         | cycle of many bacteria. Tracking down one of them is nearly
         | impossible from something as complex as the gut microbiome.
        
         | blakesterz wrote:
         | That was my question to...                 This discovery paves
         | the way for potentially highly innovative protective strategies
         | -- through the administration of a bacterial cocktail, for
         | example, or of pre-biotics to feed the "good" bacteria in our
         | intestine.
         | 
         | Do we know what GOOD bacteria are or what diet to follow to get
         | them where we want them? Do those same GOOD bacteria help with
         | other things like heart disease?
        
           | CommanderData wrote:
           | I did some reading on 'good bacteria' for bone health and my
           | take away was it can depend person to person.
           | 
           | I wouldn't be surprised if there isn't a one sized fits all
           | here. Probably having a big diverse population is better than
           | shooting yourself with a few strains, as we get older we have
           | less diversity of gut bacteria and interesting the younger
           | have the opposite.
           | 
           | I'm unsure how? we're generally consuming the same foods, if
           | not better quality comparatively to younger people?
        
             | srcreigh wrote:
             | Antibiotics, poor diet over time. I wonder if alcohol has
             | any effect too.
        
       | chemmail wrote:
       | What they don't tell you is that you cannot just ingest
       | prebiotics and expect it to do anything. You need to do fecal
       | transplant to really have an effect.
        
       | gainofunc wrote:
       | And next, autism.
        
         | LorenPechtel wrote:
         | They're already a suspect.
        
         | Kukumber wrote:
         | I always thought of autism as a remnant of our past as primates
         | 
         | An example with orangutans
         | 
         | https://intertheory.org/postmodern-autism.htm
        
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       (page generated 2023-03-17 23:02 UTC)