[HN Gopher] Hypothalamic Menin regulates systemic aging and cogn...
       ___________________________________________________________________
        
       Hypothalamic Menin regulates systemic aging and cognitive decline
        
       Author : bookofjoe
       Score  : 52 points
       Date   : 2023-03-17 16:48 UTC (6 hours ago)
        
 (HTM) web link (journals.plos.org)
 (TXT) w3m dump (journals.plos.org)
        
       | pfdietz wrote:
       | This is a bit alarming, in that menin inhibitors are promising
       | anticancer drugs.
       | 
       | https://www.targetedonc.com/view/menin-inhibitors-may-shape-...
        
         | smolder wrote:
         | Since the effects the study sees are related to menin levels in
         | the hypothalamus specifically, I wonder, could targeted
         | treatments of some kind still work? Maybe menin can be
         | inhibited at tumor-related sites specifically or raised in the
         | hypothalamus specifically, to separate the opposing effects?
        
           | pfdietz wrote:
           | Perhaps look for an inhibitor that doesn't cross the blood-
           | brain barrier?
           | 
           | Anyway, this may give some human data on the question here,
           | independent of the anticancer effects.
           | 
           | I'm sure this will come up in the approval process.
        
       | fnordpiglet wrote:
       | (In mice)
        
         | hinkley wrote:
         | > Menin signaling diminished in aged mice, which correlates
         | with systemic aging and cognitive deficits.
         | 
         | Goddamnit.
        
           | fnordpiglet wrote:
           | Some day we will have ensured super genius mice will live
           | forever. Douglas Adams is proven right once again.
        
       | LinuxBender wrote:
       | Archive [1]
       | 
       | How do we test this in humans? Supplement D-serine [2] and have a
       | control group?
       | 
       | [1] - https://archive.ph/GZjKL
       | 
       | [2] - https://examine.com/supplements/d-serine/
        
         | smolder wrote:
         | It seems that simply increasing D-serine has some of the
         | benefits of increased menin levels in the hypothalamus, but not
         | all of them. It's downstream, metabolically.
        
           | ianai wrote:
           | From the Wikipedia page, its formation in neurons can be
           | blocked. So maybe the preventative is to prevent and look for
           | signs of blockage. I am totally out of my field here.
        
       | layer8 wrote:
       | With these constant advancements in mice, they should have
       | virtually immortal rodents by now. ;)
        
         | fathyb wrote:
         | That's an interesting question! How long can modern science
         | make a mice live? The oldest known mice lives in a zoo and had
         | its 9th birthday last February. [0] I would have hoped for a
         | mice in an aging research laboratory, but my quick search
         | couldn't find cases with more than 5 years.
         | 
         | [0]: https://www.theguardian.com/us-news/2023/feb/09/pat-
         | pocket-m...
        
       ___________________________________________________________________
       (page generated 2023-03-17 23:02 UTC)