[HN Gopher] Bovine meat and milk protein in tumor-free mucosa of...
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Bovine meat and milk protein in tumor-free mucosa of colorectal
cancer patients
Author : deneb84
Score : 57 points
Date : 2023-02-26 14:39 UTC (8 hours ago)
(HTM) web link (febs.onlinelibrary.wiley.com)
(TXT) w3m dump (febs.onlinelibrary.wiley.com)
| californiadreem wrote:
| I think a meaningful question to ask is what other foods are also
| packaged in plastic or plasticized-paper that require anoxic
| environments for food safety purposes? These will be raw animal
| products like seafood, poultry, cheese, or ready-to-eat cooked-
| in-plastic meals.
|
| We already have at least one study that points towards
| ultraprocessed food consumption as increasing the risk of
| specifically ovarian cancer by 30%. I wouldn't be surprised to
| find colorectal cancer rates similarly increased with their
| consumption.
|
| It'd be interesting to see a metastudy on whether dietary-
| associated cancers, endocrine disruption, and lower testosterone
| are correlated with industrial single-plastic packaging for
| majority-consumed foodstuffs.
| azinman2 wrote:
| My guess is, assuming to genetic predisposition, colorectal
| cancer is far more tied to diet than plastic (which is likely
| non-region specific). Things like complex fiber, the right
| micro biome, etc.
| californiadreem wrote:
| "What makes the increase particularly mysterious is the fact
| that the overall incidence of colorectal cancer has dropped
| by 45% since the mid-1980s. While the cancer is still most
| frequently diagnosed in people over 55, the study found that
| patients younger than 55 were 58% more likely to be diagnosed
| with advanced disease."
|
| If the cause were beef and milk consumption _as such_ , it
| seems unlikely that a severe shift like this would occur. To
| me, it's far more likely to be something like crop
| dessication for grains--they started soaking cereal crops in
| glyphosate prior to harvest and suddenly this category of
| food that sustained the planet for millennia suddenly starts
| causing broad spectrum inflammation that people blame on the
| crop and not the processes and adjuncts.
|
| I smell a Bayer, Nestle, DuPont, J&J, Pfizer, Monsanto, etc-
| style hidden externality at work rather than animal
| husbandry. Like, what are the colorectal cancer rates for
| those people that actively practice transhumance? Do they
| differ significantly despite predominantly animal-product and
| dairy-based diets?
| azinman2 wrote:
| Many things have happened since the 80s; obesity as also
| shot up. In general people eat out more, eat fast food, and
| more simple carbohydrates. I think it would be hard to pin
| this one on any particular one thing. I
|
| It's also possible it isn't one thing, but a confluence of
| factors.
| tptacek wrote:
| Does this square epidemiologically with beef consumption? The
| countries with the highest beef consumption are in South America
| (and it's _sharply_ more beef consumption); the countries with
| the highest colon cancer rates are in central and northern
| Europe.
|
| It doesn't follow from a correlation that beef is by itself
| causative; it can be, for instance, beef plus some other
| X-factor. Somebody is going to point out that South American
| cattle are grass fed, but European cattle are also more grass fed
| than American cattle, and yet they still top the leaderboard.
| bitL wrote:
| Could there be a significant difference in soil composition
| between South America and Europe, leading to different health
| outcomes? If you travel through Europe and South America at
| similar +/- latitudes, the countryside is completely different.
| Similarly US vs Europe at the same latitude.
| Stealthisbook wrote:
| It would be helpful to look at import/export flows. I suspect
| that quite a large percentage of European beef consumption
| isn't locally sourced, with likely quite a bit coming from S.
| America.
| pkaye wrote:
| If you know specific countries or trade blocs, you can look
| it up here.
|
| https://oec.world/en/profile/international_organization/eur
| o...
| davrosthedalek wrote:
| Are these numbers corrected for testing bias?
| toomuchtodo wrote:
| Heavy use of antibiotics?
|
| Edit: perhaps not
|
| > It is estimated that livestock alone uses 50-80% of the total
| antibiotics produced in most of the developed countries. China,
| Brazil, and the United States are the largest consumers of
| antimicrobials in livestock production.
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896880/
| (Antimicrobial uses for livestock production in developing
| countries)
|
| An alternative approach would be to sequence the DNA of those
| who have had this cancer to see if they have a predisposition
| to this cancer on certain diets due to a specific set of genes.
| cma wrote:
| Less other causes of death might mean more colorectal cancer as
| you age. Also age distribution is different (skews way younger
| in South America for not just longevity reasons) so you need to
| adjust for that.
| [deleted]
| curiousgal wrote:
| Beef without fibre?
| code_duck wrote:
| Lack of fiber is already a known factor in colorectal cancer,
| isn't it?
| largbae wrote:
| So if I understand right, we know that those with colorectal
| cancer have suspiciously correlated proteins, which could be used
| for a better screen for this cancer.
|
| But do we know that consuming cow always causes this cancer?
|
| If not, what's next?
| CodeWriter23 wrote:
| Yes, we know at this time that consuming cow does not always
| cause colorectal cancer.
| pengaru wrote:
| Weird not to see HPV even mentioned anywhere as one of the CRC
| risks they accounted for.
| pphysch wrote:
| From an uninformed intuitive perspective, it would make sense
| that a substance developed to provide nutrients to rapidly
| growing babies could cause abnormal growth (tumors) in mature
| individuals. Same logic applies to artificial growth hormones,
| which are applied to livestock.
| CommanderData wrote:
| > BMMFs have been proposed as zoonotic infectious agents and
| drivers of indirect carcinogenesis of CRC, inducing chronic
| tissue inflammation, radical formation and increased levels of
| DNA damage.
|
| There's also a strong relationship between BMMFs and
| Osteoporosis, which also is linked with hearing loss.
| xwdv wrote:
| TL;DR: Eat cows or drink their milk = get cancer.
| mjfl wrote:
| > Albeit not reaching statistical significance
| viksit wrote:
| could someone please ELI5? lots of conflicting terms here and i'm
| not sure what to take away.
| paulpauper wrote:
| wow...this can def. explain the uptick in colon cancer,
| especially in young people.
| raverbashing wrote:
| Well it looks a bit weird to me. Maybe due to increased
| consumption of beef, surely, but not sure if milk consumption
| has gone up
|
| Though I'm very surprised at the mechanism, that was totally
| news to me
| yeeetz wrote:
| While late diagnosis of Stage III/IV CRC in young adults is
| tragic, both incidence and death rate of colon cancer has
| fallen in recent years in the U.S. as early detection (more
| colonoscopies) and proactive removal of pre-cancerous polyps
| has increased.
| Madmallard wrote:
| It's fiber. High red meat no fiber bad news. Brazil eats tons of
| steak but also tons of beans and plantains.
| stefantalpalaru wrote:
| [dead]
| zoklet-enjoyer wrote:
| [flagged]
| dawatchusay wrote:
| This is the WORST summary title of a post I've ever seen. The
| wording implies actually the opposite of the article; it implies
| to those without deep knowledge of the topic that bovine and milk
| proteins are associated with remission. The full title of the
| research states that those things interfere with patient
| survival. Instead, reading only the title first, I think "oh,
| tumor-free! Great!"
| tsol wrote:
| "Bovine meat and milk factors (BMMFs) are episomal, plasmid-like
| DNA molecules isolated from bovine sera and milk products and
| from the peritumor of colorectal cancer CRC patients [[1-6]].
| BMMFs were proposed as zoonotic infectious agents and risk
| factors involved in indirect cancerogenesis of several types of
| cancer including CRC [[7-10]]. Our studies specifically focus on
| a link between BMMF and colorectal cancer and are supported by an
| epidemiological association between global consumption of bovine
| (red) meat and dairy products and colorectal cancer incidence"
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(page generated 2023-02-26 23:02 UTC)