[HN Gopher] Controversial experiments that could make bird flu m...
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       Controversial experiments that could make bird flu more risky to
       resume (2019)
        
       Author : shermablanca
       Score  : 53 points
       Date   : 2023-02-16 18:37 UTC (4 hours ago)
        
 (HTM) web link (www.science.org)
 (TXT) w3m dump (www.science.org)
        
       | octonion wrote:
       | [dead]
        
       | doodlebugging wrote:
       | With all this smoke, (H5N1 bird flu and Covid-19 GoF research
       | funded for various researchers in the US and abroad) there has to
       | be a fire somewhere.
       | 
       | I can't wait for the accountability parade.
        
         | [deleted]
        
       | Y_Y wrote:
       | Better not resume bird flu then
        
         | stickfigure wrote:
         | I was trying to figure out how bird flu would damage my CV.
        
           | stonemetal12 wrote:
           | Bird flu is down around Cobol in popularity. Sure they have
           | their niches, but is that someplace you want to work?
        
       | snshn wrote:
       | Weird title, needs a comma after "risky", but I guess HN removes
       | them while sanitizing
        
       | gensym wrote:
       | In other news: https://www.nature.com/articles/d41586-023-00283-y
       | 
       | How many times would you be comfortable rolling a million-sided
       | die for humanity's extinction?
        
         | [deleted]
        
       | candiddevmike wrote:
       | I truthfully do not see the value (vs risk) in this kind of
       | research. Humanity is too careless to do this kind of thing
       | safely. Figure out better ways to model this in software instead,
       | IM (uninformed) O.
        
         | LatteLazy wrote:
         | As long as china and other countries refuse to operate sanitary
         | food chains, the risk they represent will be 1000s of times
         | higher than a high security lab. That is why so many zoonotic
         | diseases come from such places and so few from the rest of the
         | world.
         | 
         | Don't "strain out a fly and swallow a camel"...
        
           | geysersam wrote:
           | That, or because a fifth of the worlds population live there.
        
         | mikeyouse wrote:
         | A general defense is that nature is a far better incubator and
         | gain-of-function laboratory that we could ever hope to be. A
         | few billion birds have caught bird flu in the past decade, so
         | we're talking about trillions and trillions of viruses
         | constantly undergoing mutation in close proximity with farm
         | mammals and humans all over the world... If we know the
         | genetics of what turns a bird flu into one transmissible to
         | humans, it's probably better to "get in front of it" rather
         | than just awaiting that mutation to happen somewhere in nature
         | for the first time.
        
           | adrianb wrote:
           | Trillions and trillions of mutations and still the most
           | dangerous H5N1 viruses were created a decade ago by Fouchier
           | and Kawaoka. And how did that help us prepare for the
           | inevitable natural evolution of the same virus?
        
             | mikeyouse wrote:
             | Sure, but that's only if you restrict it to H5N1 instead of
             | looking at the history of Influenza A and things like the
             | Spanish Flu, which was the most deadly disease in human
             | history and derived from a mutated bird flu.
             | 
             | https://www.nejm.org/doi/full/10.1056/nejmp058281
             | 
             | Even still, H5N1 has repeatedly infected humans in the
             | wild... the most famous case in Hong Kong infecting 18
             | people and killing 6 of those. So you can make the case
             | that GoF is irresponsible given the stakes, but it seems
             | important to acknowledge that you're basically just hoping
             | these horrific viruses don't mutate as we predict them to.
             | 
             | https://pubmed.ncbi.nlm.nih.gov/11938498/
        
           | programmarchy wrote:
           | hand-waving
        
         | bboygravity wrote:
         | There's a chance that being more informed might help form a
         | different opinion more aligned with most informed people.
        
       | rhelz wrote:
       | Back in 2019, I was just working as hard as I could to keep my
       | little world together. I'd already despaired of trying to do
       | anything like get ahead.
       | 
       | And then there are these guys taking billion dollar sledgehammers
       | to the foundations of civil society.
        
         | [deleted]
        
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       (page generated 2023-02-16 23:01 UTC)