[HN Gopher] A tiny genetic change inflicts old age on young kids
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A tiny genetic change inflicts old age on young kids
Author : bookofjoe
Score : 35 points
Date : 2023-02-12 18:44 UTC (4 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| danbmil99 wrote:
| This horrible disease touched my extended family. Unfortunately,
| rare 'orphan' diseases are under-funded because there aren't
| enough patients to make them profitable. More Pharma shareholder
| value with yet another drug that appears to have a slight
| statistical effect on Alzheimer's than with a full cure for
| progeria.
| nscalf wrote:
| I'm curious how much of the research going into Nature if funded
| by the US government.
| tgv wrote:
| Open a journal, sample a bunch of articles. Usually, there's an
| acknowledgement (sometimes in the first footnote) with the
| program that funded the research. If there is none, it's
| possibly a regular, university funded project, in which case
| you'd have to look up the uni's funding.
|
| E.g., for this article:
| https://www.nature.com/articles/s43587-023-00361-w#Ack1
| A_D_E_P_T wrote:
| This particular paper was funded by the National Natural
| Science Foundation of China, along with various other Chinese
| organizations. China's biology/biotech research is top-tier,
| these days, and the Chinese government actively funds quite a
| lot of basic research in the life sciences. Interestingly, very
| little of it seems to translate to in-country pharmaceutical
| development.
| [deleted]
| klyrs wrote:
| ... in humans. Wake me up when it's found to work on cheese.
| chartpath wrote:
| Haha, much better response than the usual "wake me up when it's
| replicated in humans" any time there is a mouse study shared.
| [deleted]
| interlock wrote:
| I'd kickstart this, I want older cheese faster.
| lisper wrote:
| Time dilation is what you need.
| contravariant wrote:
| Though that does have the slight side effect of ageing the
| rest of the world as well.
| lisper wrote:
| Sometimes you have to make some sacrifices for good
| cheese.
| A_D_E_P_T wrote:
| That summary is paywalled, but the paper it supposedly summarizes
| is open access. Available here:
| https://www.nature.com/articles/s43587-023-00361-w
|
| Basically, the authors were able to treat progeria (to some
| extent) by designing a peptide which prevented progerin (the
| characteristic progeria protein) from binding with the ubiquitous
| cellular regulator protein BUBR1.
|
| It has been known for about 20 years that BUBR1 irregularities
| can be associated with early-onset aging phenotypes:
| https://www.nature.com/articles/ng1382
| yieldcrv wrote:
| are there any learnings to delay the other indicators of old age?
| ben_w wrote:
| Loads, but it's still hard to tell which of them are (1) more
| than just statistical anomalies, (2) aren't limited to in
| vitro/in muribus, and (3) don't have "cause cancer" as a side
| effect.
| m3kw9 wrote:
| Is this aging or damage that looks like aging?
| colechristensen wrote:
| Aging is a set of effects, in one sense of course it's not
| aging if the time hasn't actually passed but it seems that some
| of the same effects are happening.
| EGreg wrote:
| Are you saying regular aging is due to damage rather than the
| genetic plan? Like prostate getting bigger etc.
| MacsHeadroom wrote:
| Aging is failure to follow the genetic plan faithfully due
| to breakdown of various epigenetic processes.
| moralestapia wrote:
| Nope.
|
| Diseases that have to do with "failure to follow the
| genetic plan [...]" are much more worse than aging, you
| don't even get to age!
| 988747 wrote:
| Don't see how that contradicts anything GP said. "Aging
| bad, genetic diseases worse" - that's the gist of the
| disscussion here.
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