[HN Gopher] Aging is associated with a systemic length-associate...
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Aging is associated with a systemic length-associated transcriptome
imbalance
Author : Anon84
Score : 42 points
Date : 2022-12-22 19:29 UTC (3 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| epicureanideal wrote:
| Amazing! Another step forward in defeating aging!
| seydor wrote:
| So we just intersperse random bases?
| mromanuk wrote:
| Over 20 years ago, I watched a video by Aubrey De Grey that
| really impressed me. In the video, he presented a short list of
| "problems" associated with aging and described aging as a
| disease. I haven't received any updates on this topic in a long
| time. Is it still science fiction to think about living to be
| over 120 years old?
| Tade0 wrote:
| Imagine job listings with 50 years minimum experience.
|
| Lending and investing also become interesting at these
| timespans.
| xwdv wrote:
| Not science fiction, but the first people to start topping out
| at those ages consistently will likely have the right
| combination of wealth, lifestyle and good genetics.
| jonahbenton wrote:
| Not science fiction. 150 might be possible for some people
| alive now.
|
| Andrew Huberman's interview with researcher David Sinclair
| mid-2022 well worth a listen for high level but technical
| coverage of state of play.
|
| Yes, these people are avid promoters of their work, but they
| are doing the work.
| mromanuk wrote:
| Thanks! I don't mind the marketing, in fact, if there is good
| science behind it I totally support it.
| idonotknowwhy wrote:
| It's a shame his company is gate keeping NMN now that he's
| created demand for it
| nradov wrote:
| There's no scientific reason to expect that anyone alive
| today will live to 150. It's purely based on conjecture and
| hope. If that was likely to happen then we would be seeing
| some incremental progress towards the goal already. But still
| we haven't seen anyone verified to live past 122. And she
| died in 1997.
|
| Maximum lifespan is unimportant anyway. What actually matters
| is _healthspan_. If anything we 're going backwards on that
| metric.
| epicureanideal wrote:
| Change can happen gradually then suddenly. For example,
| massive human death due to disease, and then in the space
| of one human lifetime in the rich world the death rate from
| disease dropped incredibly fast.
| mromanuk wrote:
| Healthspan is super important, will be really cool to have
| a youngish person living to 130/140/150, but yes a healthy
| centenarian is really cool, too.
| voyager1 wrote:
| What do you think about his promotion of NMN? I was very
| excited at first, but looking at his past, it all seems very
| shady.
|
| In 2004, Sinclair, along with serial entrepreneur Andrew
| Perlman, Christoph Westphal, Richard Aldrich, Richard Pops,
| and Paul Schimmel, founded Sirtris Pharmaceuticals. Sirtris
| was focused on developing Sinclair's research into activators
| of sirtuins, work that began in the Guarente lab. The company
| was specifically focused on resveratrol formulations and
| derivatives as activators of the SIRT1 enzyme; Sinclair
| became known for making statements about resveratrol like:
| "(It's) as close to a miraculous molecule as you can find.
| ... One hundred years from now, people may be taking these
| molecules on a daily basis to prevent heart disease, stroke,
| and cancer." Most of the anti-aging field was more cautious,
| especially with regard to what else resveratrol might do in
| the body and its lack of bioavailability. The company's
| initial product was called SRT501, and was a formulation of
| resveratrol. Five years later, GSK shuttered the Sirtris
| program without successful drug development.
|
| Sinclair broadly discusses his longevity practices on social
| media and includes them in his book. They include daily doses
| of NMN and resveratrol, which Sinclair says are activators of
| SIRT1.
|
| Studies published in 2009 and early 2010 by scientists from
| Amgen and Pfizer cast doubt on whether SIRT1 was directly
| activated by resveratrol and showed that the apparent
| activity was actually due to a fluorescent reagent used in
| the experiments.
|
| https://en.wikipedia.org/wiki/David_A._Sinclair
| https://en.wikipedia.org/wiki/Sirtris_Pharmaceuticals
| nradov wrote:
| We just don't know about NMN. It appears to be generally
| safe, but no study has ever shown it to extend lifespan in
| primates. More research is needed.
|
| https://peterattiamd.com/ama35/
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