[HN Gopher] Jet Automatic Hypodermic Injection Apparatus - Vacci...
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Jet Automatic Hypodermic Injection Apparatus - Vaccine Gun (2021)
Author : areoform
Score : 25 points
Date : 2022-12-11 04:37 UTC (18 hours ago)
(HTM) web link (americanhistory.si.edu)
(TXT) w3m dump (americanhistory.si.edu)
| areoform wrote:
| I learned today that these are real-life hyposprays. In fact, the
| Star Trek hyposprays are named after the brand name for one of
| these. Here's a photo of what these look like in action,
|
| https://pbs.twimg.com/media/Fjooo0jXEAEri7D?format=jpg&name=...
|
| They work with pressure to deliver a dose of the vaccine
| subcutaneously without needles. (I had always thought that they
| were some kind of needle-based injector instead)
|
| I just think it's so cool that we already have hyposprays and
| it's a thing that we can improve! And deploy everywhere,
| including dense jungles. These worked on _literal pedal power_.
| _And_ were painless. > Hingson's device used a
| piston to propel the vaccine at a rapid speed into and under the
| skin--the vaccine moved so quickly and under such pressure that
| no needles were needed. Public health practitioners gleefully
| noted that this method of vaccination was so painless that it
| could be used on a sleeping baby. But best of all, the jet
| injector could hold 500 or more doses of vaccine, meaning that
| hundreds of doses could be delivered within an hour.
|
| Alas, they were phased out due to backwash and contamination from
| the injection process. But that's a fixable problem. I think.
| tgsovlerkhgsel wrote:
| > phased out due to backwash and contamination from the
| injection process. But that's a fixable problem. I think.
|
| I'm kinda glad that they don't keep trying to fix it in
| production when a good enough alternative exists.
|
| (Backwash = spreading disease from one patient to the next, and
| nasty stuff too like Hepatitis)
| klyrs wrote:
| > Alas, they were phased out due to backwash and contamination
| from the injection process.
|
| That's how the army gave my aunt Hep C. Numerous attempts have
| been made to solve this "backwash" issue, but fluid dynamics is
| a harsh mistress. When you shoot a droplet at a fluid
| interface, the interface shoots back.
| ratsnake wrote:
| I only received one injection with this device, but I can tell
| you it wasn't painless. In fact, it was by far the most painful
| injection I've ever had.
| areoform wrote:
| I'm sorry that you experienced that! Would you happen to know
| what kind of injection you had? Was it subcutaneous,
| intradermal, or intramuscular? And what kind of vaccine was
| it?
|
| I found a study addressing the pain and the authors theorized
| that the depth of the injection determined the pain
| experienced by the patients,
| https://www.pnas.org/doi/full/10.1073/pnas.0700182104
| > Motivated by the limitations of injections, needle-free
| liquid jet injectors were invented more than 50 years ago (4)
| and have been used for delivering several vaccines and
| protein drugs. More recently, a number of other technologies
| have also been proposed to deliver proteins across the skin
| without using needles (5-13). These technologies are at
| varying degrees of development. As of today, however, liquid
| jet injectors comprise the only needle-free tool in the hands
| of clinicians for delivery of proteins and other
| macromolecules. Commercially available liquid jet injectors
| use compressed gas or a spring to create high-pressure jets
| of drug solutions that deliver drugs in the s.c. or i.m.
| region (14, 15). Despite their long history, needle-free
| liquid jet injectors have been met with disappointing
| acceptance as a result of frequent bruising and pain (4),
| which immediately offset their advantages against needles. We
| hypothesized that pain and bruising originate from deep
| penetration of jets into skin leading to their interactions
| with nerves and blood capillaries. This issue could
| potentially be addressed by minimizing the penetration depth
| of jets into the skin; however, attempts to reduce the
| penetration depth have led to a concurrent loss of delivery
| efficiency (16). Decoupling penetration depth and delivery
| efficiency has been difficult as a result of the very design
| of conventional jet injectors. We overcame this issue by
| adopting a new strategy of jet injection, pulsed microjets.
| We propose the use of high-velocity microjets (v >100 m/s) to
| ensure skin penetration but small jet diameters (50-100 mm)
| and extremely small volumes (a few nanoliters) to limit the
| penetration depth. We describe a microjet device that meets
| these criteria and demonstrate its capabilities by using
| insulin as a model drug.
| cptskippy wrote:
| In my limited experience, high pressure pneumatic wounds are
| accute blunt force trauma and the pain is intense and long
| lasting.
|
| It doesn't surprise me that this would hurt a lot.
| [deleted]
| o_1 wrote:
| does this produce the polio vaccine scar we most commonly see on
| people born 1950-70
| digitalblade wrote:
| No... https://www.healthline.com/health/smallpox-vaccine-scar
| zoom6628 wrote:
| Looks like gear that vets and farmers still use.
| jokowueu wrote:
| They keep saying it's painless but I've heard more than once
| that's it's very painful.
| GuB-42 wrote:
| Side note, high pressure injection was and still is a common
| workplace accident[1].
|
| It happens when you work with highly pressurized fluids, like
| with a grease gun, and there is a leak. The high pressure jet can
| penetrate your body without too much visible damage, but you just
| injected yourself with nasty chemicals, and the consequence can
| be serious, or even fatal.
|
| The jet injector idea was that if high pressure jets can inject
| people with poison, why not use the same principle to inject
| medicine.
|
| [1] https://en.wikipedia.org/wiki/High_pressure_injection_injury
| daniel_reetz wrote:
| Also a hazard when operating a waterjet cutter. Mine came with
| cards that advise the doc to treat the wound like a gunshot
| wound.
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(page generated 2022-12-11 23:01 UTC)