[HN Gopher] America's syringe exchanges kill drug users
       ___________________________________________________________________
        
       America's syringe exchanges kill drug users
        
       Author : ryzvonusef
       Score  : 30 points
       Date   : 2022-12-03 17:18 UTC (5 hours ago)
        
 (HTM) web link (www.economist.com)
 (TXT) w3m dump (www.economist.com)
        
       | gusgus01 wrote:
       | For those interested, the study from Ms. Packham:
       | https://apackham.github.io/mywebsite/opioidpaper_webcopy.pdf
        
         | rhaway84773 wrote:
         | That's interesting. I read the approach details. Nothing in
         | there indicates why the results should reflect causation versus
         | correlation.
         | 
         | Before reading that I thought that maybe the SEP groups were
         | wrong to call the publishing of the paper a mistake, but now
         | having read it and seeing that it presents correlational data
         | as causational data I understand why those groups were
         | criticizing the research itself.
         | 
         | I'm not an expert in this field so I would appreciate if others
         | can also read the actual paper and explain to me why the author
         | is correct to claim causation instead of correlation.
        
       | wwarner wrote:
       | Cigarettes are taxed at $4.35/pack to discourage smoking. But you
       | can get syringes for free.
        
         | tonyarkles wrote:
         | I get the point you're trying to make, but there's a bit of
         | nuance here and there. Long-term I agree with you:
         | 
         | - smoking has long-term negative health outcomes
         | 
         | - drug abuse also has long-term negative health outcomes
         | 
         | Short term:
         | 
         | - I can't even really think of a dirty-needle equivalent for
         | smoking
         | 
         | - using a dirty needle has a large number of short-
         | term/acute/immediate outcomes: infection, incurable disease
         | (Hepatitis, HIV, etc) and spreads between users
         | 
         | It's not as if we're taxing cigarettes and giving away fentanyl
         | for free to everyone. Yes, we even do give some drugs out for
         | free (e.g., methadone and suboxone), but only to people who
         | have already ruined their reward systems and become addicted. I
         | couldn't go to a doctor or a clinic and say "the last time I
         | consumed an opiate was 12 years ago after my knee surgery but
         | please sign me up for free methadone!"
        
       | its-obvious wrote:
       | Legalize opium and the number of overdoses would plummet, as well
       | as blood-transmissible diseases like these.
       | 
       | It's at the point that if you're not aware of and advocating for
       | obvious solutions like this, the blood is on your hands.
        
         | edgyquant wrote:
         | This is a lie that is continuously propagated. Portugal has not
         | seen a reeducation in overdoses: quite the opposite
         | 
         | https://www.statista.com/statistics/911927/drug-overdose-dea...
        
           | jeffbee wrote:
           | I assumed that Zurich's failed experiment decades ago would
           | have ended the possibility of further debate.
        
         | TylerE wrote:
         | Part of the problem, ironically is the war on opioids. I've
         | read many accounts of people with legit chronic pain being cut
         | off by the doctor... which simply results in them getting
         | relief wherever they can find it.
        
           | ROTMetro wrote:
           | Many dudes I knew in prison on drug charges were ex-military
           | recent vets who picked up a pill habit from their service
           | related injuries/chronic pain. That pill habit needed to be
           | fed and pills got harder to find leading to dealing/importing
           | fentanyl analogs from China.
        
         | vorpalhex wrote:
         | Would opium deaths be then on your hands?
        
           | its-obvious wrote:
           | Sure, because there would be a fraction as many. It's very
           | unlikely to OD smoking opium, sublingual is slightly more
           | dangerous but still nothing compared to fentanyl, dipshit.
        
             | edgyquant wrote:
             | Smoked opium is not gonna cut it for heroin junkies. Save
             | your condescension for after you have actual points.
        
         | standardUser wrote:
         | Why downvote this? It's plainly true. Most drug-related deaths
         | are from disease, contamination (fentanyl), improper dosing and
         | black market violence. Those issues all virtually vanish with
         | legal access to drugs. So we can choose to a) change our
         | obviously failed policies and start saving lives or b) keep
         | doing what we're doing and keep paying the cost in taxes,
         | personal liberty and lost human lives.
         | 
         | If you need data, look at Portugal.
        
           | edgyquant wrote:
           | 1. Because it isn't plainly true. The number of drug
           | overdoses has risen in Portugal over the last decade
           | https://www.statista.com/statistics/911927/drug-overdose-
           | dea...
           | 
           | 2. Even if it were true, nations get to dictate their
           | policies and it is perfectly understandable for them to not
           | want to subsidize drug abuse.
        
             | standardUser wrote:
             | Portugal has had massive success across the board with
             | decriminalization, but they have not gone far enough to
             | prevent overdose deaths because they still ban
             | manufacturing and distribution. As long as a government
             | protects a black market, there will be preventable deaths.
        
               | vorpalhex wrote:
               | Legalizing has resulted in more ODs so you want to..
               | legalize more?
               | 
               | How does legalizing manufacturing of a killer substance
               | stop ODs?
        
               | tonyarkles wrote:
               | > How does legalizing manufacturing of a killer substance
               | stop ODs?
               | 
               | It's not legalizing it that could potentially help with
               | ODs but regulating it. It's the difference between
               | injecting a random-assumed-to-be-heroin substance
               | dissolved in tap water on a heated spoon and injecting a
               | known 10mg/mL vial of heroin.
        
       | [deleted]
        
       | ryzvonusef wrote:
       | > Decades of research prove that these programmes curtail
       | disease. Junkies are in fact less prone to sharing needles when
       | they get free ones. That sharply decreases rates of blood-borne
       | illnesses. In 2014 an analysis found that every dollar spent on
       | syringe exchanges spares the government around $7 in HIV-related
       | health-care costs. Needle exchanges opened across America and
       | Europe. For years no one detected the feared rise in substance
       | abuse.              > That was before the opioid crisis plagued
       | America and economists started looking into the trade-offs. A new
       | study by Analisa Packham published in the Journal of Public
       | Economics uncovers an uncomfortable truth: this particular harm-
       | reduction tool does lots of harm. Ms Packham compares how drug
       | users fared in counties that opened syringe exchanges between
       | 2008 and 2016 with those in counties that did not. Before the
       | clinics opened, upticks in HIV diagnoses or overdoses in one set
       | of counties were mirrored in the other. Once a syringe exchange
       | came to town, outcomes diverged. Rates of HIV fell by 15% in
       | counties with the new programme. But deaths soared. On average
       | syringe-exchange programmes led to a 22% spike in opioid-related
       | mortality.               > Simply lowering the risks of getting
       | sick--and the costs of paraphernalia, as Flaco from the Bronx
       | articulated--could also incentivise drug use. Distributing PrEP,
       | an HIV-prevention medication, has been shown to make gay men less
       | inclined to use condoms during sex. So too could harm-reduction
       | tools make addicts use drugs more incautiously. In a study
       | published in 2018 Jennifer Doleac and Anita Mukherjee found that
       | when states legalised naloxone, a medication that reverses
       | overdoses, opioid abuse increased. Though lauded by public-health
       | advocates, naloxone did not save lives as intended. In some
       | regions, fewer addicts died; in others, more did.
        
         | croes wrote:
         | And how many are these 15% and 22%?
        
         | f38zf5vdt wrote:
         | In terms of burdening the already dysfunctional healthcare and
         | criminal justice systems of the US, it sounds like it works
         | great. If the junkies no longer exist and less frequently get
         | HIV, their cost to society is less than if they were alive,
         | disease spreading, and committing crime.
        
           | giraffe_lady wrote:
           | This comment is an excellent example of how you can openly
           | call for violence against the vulnerable on HN without
           | censure or consequence as long as you do it in a certain
           | tone.
        
             | throwayyy479087 wrote:
             | Saying that we shouldn't enable certain behavior is not
             | violence. Violence is violence, stop messing with the
             | meaning of words.
        
               | ROTMetro wrote:
               | I am sure you currently work with or have family members
               | who secretly are addicts. Labeling them as a cost to
               | society, disease spreading, and committing crime and
               | justifying their death instead of talking about them as
               | people in pain is definitely disgusting and not the type
               | of discourse I would have expected from this site. But
               | hey, keep on with your reductionism as justification for
               | complicity in peoples deaths. Also remember, they can't
               | get needles not because they don't want to buy them but
               | because it is illegal to sell them.
        
               | giraffe_lady wrote:
               | What is the meaningful difference between killing someone
               | yourself and letting them die when it's in your power to
               | prevent it?
               | 
               | Saying that a certain population should die because of
               | their criminal nature and high "cost to society" is
               | straight up nazi shit. What's the policy implementation
               | of that opinion just curious? It really doesn't get more
               | clear than this.
        
           | nkrisc wrote:
           | Why not extend this to everyone? When your projected costs to
           | society exceed your projected benefit to society you get
           | ground into food for the rest?
        
             | the_only_law wrote:
             | > Why not extend this to everyone?
             | 
             | They already implicitly did. Turns out the dysfunctional
             | criminal justice and medical system the praise affect more
             | than just addicts. Who would have thought.
        
             | f38zf5vdt wrote:
             | There is a reason economics is called "the dismal science".
             | Most resources on the planet are finite and their
             | consumption is a zero-sum game. If one less drug addict
             | means having the public resources to supply one more
             | diabetic child with life-saving insulin, which would you
             | choose?
        
               | [deleted]
        
               | mcguire wrote:
               | Essentially all choices real people make are not
               | economically optimal.
        
         | ryzvonusef wrote:
         | seems like people would rather suppress the truth rather than
         | let research be allowed to stand scrutiny on it's own merit
         | > These works have been met with anger. Their findings upset
         | harm-reduction defenders who consider their efforts already
         | besieged by critics. The experience was so miserable that Ms
         | Doleac, who studies crime, has decided never to write another
         | health paper.              > Leo Beletsky, a former drug
         | dealer, now at Northeastern University, deems Ms Packham's
         | findings "nonsensical" and thinks her paper should not have
         | been published. Don Des Jarlais, at New York University, argues
         | that addicts do not respond to incentives like others do,
         | making the moral-hazard effect inconceivable. Susan Sherman of
         | Johns Hopkins University says she doubts that new evidence that
         | harm reduction does more bad than good would convince her to
         | disregard previous research demonstrating otherwise.
         | > A barrage of complaints led the editors of the International
         | Journal of Drug Policy to retract a meta-analysis that found
         | that safe-injection sites, where users do drugs in supervised
         | settings, did not decrease rates of deadly overdose.
         | "Retractions used to be reserved for fraud," says Keith
         | Humphreys of Stanford University, a former drug-policy adviser
         | for the Obama administration. No longer, it seems.
        
           | version_five wrote:
           | People are really bad at accepting information that
           | superficially contradicts something they want, and react by
           | disputing the information instead of taking it into
           | consideration while still pushing for the ends they want to
           | achieve.
           | 
           | In this case, I'd speculate that harm reduction advocates aim
           | is to (tautologically) reduce the (physical/health) harm of
           | drug use so that it's one less problem users face. One aspect
           | of this may be safe consumption, which this article says
           | doesn't work on it's own. Another aspect is overdoses form
           | Fentanyl et al, (which I would argue is largely a byproduct
           | of a drug war that has made heroin too hard to import, and no
           | safe medical supply options for treatment). So the focus
           | could shift to addressing this (which in tandem with safe
           | injection sites could still produce better overall outcomes).
           | 
           | My point is that it's not productive to dispute the studies,
           | better to accept on balance of probabilities and look at how
           | it fits with your overall aim.
           | 
           | (Climate change is very similar. People dispute the studies
           | because they don't like the political rhetoric about how we
           | should react, not because deep down they think all the
           | research is flawed)
        
             | hooverd wrote:
             | I think some drug warriors become harm advocates. If drug
             | users can't overcome their moral failures, before they
             | suffocate on their vomit than be resuscitated with
             | naloxone.
        
               | the_only_law wrote:
               | What? This isn't even a sentence. It's a collection of
               | sentence fragments and I can't tell what the hell it's
               | trying to say.
        
               | hooverd wrote:
               | It should read "better they" not "before they". Anyways,
               | I was thinking of a specific incident where a fire chief
               | came out and said they would prefer that junkies just die
               | vs adding naxolone to their kit.
        
           | cma wrote:
           | The meta-analysis largely relied on studies that used cities
           | or states as a control on deaths to the small (usually
           | hardest hit) regions where the programs were offered. Like
           | doing an intervention in Skid Row, then using LA as the
           | control for the non-intervention.
           | 
           | Many of the problems are detailed in "Supervised consumption
           | sites: a nuanced assessment of the causal evidence."
           | 
           | It mentions the reason for retraction, something about
           | "pooling diverse outcomes into a composite measure," anyone
           | have a link to the actual details of the retraction other
           | than that it wasn't for fraud?
        
           | slowmovintarget wrote:
           | > "Retractions used to be reserved for fraud," says Keith
           | Humphreys of Stanford University...
           | 
           | Science denial has many forms. This appears to be one of the
           | older ones.
        
           | joe5150 wrote:
           | > The experience was so miserable that Ms Doleac, who studies
           | crime, has decided never to write another health paper.
           | 
           | Good move on Doleac's part; her naloxone paper was atrocious.
        
             | Mistletoe wrote:
             | What was bad about it?
        
         | aqme28 wrote:
         | The article is paywalled, but this suggests to me we go further
         | in harm-reduction. The problem is specifically opioid
         | overdoses, so we should have more supervised-injection sites.
        
           | dmix wrote:
           | Yeah there's still plenty of solutions here within the
           | current system.
        
           | the-printer wrote:
           | Helping the drug users get off the drugs could reduce plenty
           | of harm, I reckon, but when that fails why is the alternative
           | helping them stay on?
        
             | aqme28 wrote:
             | Why are those mutually exclusive? We should help drug users
             | get off drugs, but we shouldn't make it deadlier for them
             | if we fail.
        
               | the-printer wrote:
               | Because making it "less deadly" somehow equates to
               | enabling them.
               | 
               | I think that people are more concerned with opioid death
               | statistics than opioid addiction itself. And there is a
               | shattering sense of defeat, which is normal, that is
               | associated with realizing that you cannot help anyone who
               | doesn't want to help themselves. And if they don't want
               | to help themselves, then they may go down a collision
               | course that will be their undoing. In this case that
               | often means death.
        
               | aqme28 wrote:
               | > people are more concerned with opioid death statistics
               | than opioid addiction itself.
               | 
               | I feel strongly this way, or maybe I'm missing your
               | point. Addiction is terrible, but _death_ is clearly
               | worse than addiction. Addiction is survivable.
        
               | the-printer wrote:
               | Would you choose addiction over death? I'm talking hard
               | drugs. Bottoms out on the same street that you grew up
               | on, or raised your children on, or worked on.
               | 
               | My point is that the "preventive maintenance" approach to
               | opioid addiction is more about death _statistics_ than it
               | is about death itself. It's a numbers game. A nation's
               | response to situations such as this will largely be
               | determined by how many people don't die, because people
               | have a distaste toward death and the general public is
               | subservient to what data suggests irrespective of its
               | practical and tangible representations.
        
             | cwmma wrote:
             | Easy because if you fail to get them to quit, then the goal
             | is to keep them alive so you can help them quit latter.
        
             | mcguire wrote:
             | What alternative do you propose?
             | 
             | "Helping them stay on drugs" is very much the wrong way to
             | look at it. How about "reducing the harm they do to
             | others"?
        
               | the-printer wrote:
               | Who designed the standard for harm in this instance? How
               | is the self-inflicted harm of addiction that is the
               | actual foundation of the secondary harm caused, for
               | example, by dirty needles and overdose weighed? Is the
               | harm dealt to one's family considered?
               | 
               | "Helping them stay on drugs" is the practical way of
               | looking at it, because in practice that's what's
               | happening. "Reducing harm" in this context sounds like
               | some sort of neo-Hippocratic Orwellian spin on the fact
               | that the alternative is to address the greater issues
               | that lead to and foster drug addiction that are beyond
               | the scope of this tiny box that I'm typing into and do
               | not involve more needles.
        
       | puppycodes wrote:
       | Calling drug users "junkies" made me feel like this was written
       | in the 80's
        
       | throwawayoaky wrote:
       | Horrifying pull quote:
       | 
       | "Simply lowering the risks of getting sick--and the costs of
       | paraphernalia, as Flaco from the Bronx articulated--could also
       | incentivise drug use."
        
       | rhaway84773 wrote:
       | The study mentioned makes no effort to show causation.
       | 
       | And the correlation can very easily be backwards. In fact, its
       | more likely backwards.
       | 
       | Counties which are facing an increasing barrage of opioids and
       | all the issues related to it, especially spread of disease and an
       | increase in deaths due to unsafe use are almost certainly more
       | likely to create safe needle exchanges.
       | 
       | For the economist to write this article as if causation is
       | established, and further to moralize is insane.
       | 
       | Especially since the Economist famously doesn't provide bylines
       | so this becomes the official view of the magazine as opposed to a
       | specific editor's.
       | 
       | And finally, even if the causation is correct, all it indicates
       | is that needle exchange programs need to also provide drug
       | testing capabilities so the presence of fentanyl can easily be
       | identified.
        
         | theptip wrote:
         | The paper opens with a discussion of causation.
         | 
         | > the data from the studies included in the aforementioned
         | literature reviews (i.e. General Accounting Office (1993);
         | World Health Organization (2004)) rely on small sample sizes
         | and self-reported data regarding individ- uals' drug use, and
         | do not typically consider attrition nor spillover effects on
         | those not directly treated. Additionally, many studies use data
         | from Canada, Sweden, or New Zealand to serve as a comparison
         | group for drug rates in the US. Such methods are problematic
         | for addressing causality, given that other developed countries
         | have differing policies on the operations of SEPs and greater
         | access to substance abuse treatment.1 I overcome these existing
         | limitations by cre- ating a novel dataset that combines
         | information on SEP opening dates with restricted administrative
         | county-level data on HIV diagnoses. These data proxy for drug
         | use without relying on self-reporting behavior, and are
         | representative of counties across the US.
         | 
         | It's using newly-opened SEPs for a discontinuity analysis,
         | which does provide evidence of causation (and furthermore notes
         | that previous studies were correlational).
        
         | vorpalhex wrote:
         | You're assuming the fentanyl is accidental, not intended.
        
         | htag wrote:
         | I agree with most of what you said, but I think one line is out
         | of touch.
         | 
         | > And finally, even if the causation is correct, all it
         | indicates is that needle exchange programs need to also provide
         | drug testing capabilities so the presence of fentanyl can
         | easily be identified.
         | 
         | This assumes that there are no individuals that are knowingly
         | injecting fentanyl or that a drug user would not take drugs in
         | their possession if they knew it contained fentanyl. Yes, there
         | are individuals that unknowingly take a fentanyl containing
         | substance but I am doubtful that those deepest in opioid
         | addiction avoid it.
        
           | ThrowawayTestr wrote:
           | Fentanyl is not a pleasurable drug. Someone buying heroin
           | wants heroin, not a drug that will just knock them out or
           | kill them.
        
             | hotpotamus wrote:
             | The only opioid I've ever taken was fentanyl when I had my
             | wisdom teeth taken out. I highly recommend it if it's an
             | option, and frankly there are many calls I've been on where
             | I wish that sedation was available.
        
               | newaccount74 wrote:
               | I got a local anesthetic and Ibuprofen when my wisdom
               | teeth were taken out. Worked fine.
               | 
               | I don't understand why doctors are still so quick to
               | prescribe opioids.
        
               | saltcured wrote:
               | Having wisdom teeth removed can range from a simple tooth
               | extraction to invasive oral surgery.
               | 
               | In the heavier cases, a flap of gum tissue and covering
               | jaw bone are cut away to expose a submerged tooth that is
               | oriented the wrong way. The tooth is then demolished in
               | place so that the chunks can be lifted out. The patient
               | would be sedated during this procedure, and the wound and
               | recovery period is significantly different.
        
               | effingwewt wrote:
               | I had impacted (the aforementioned submerged and inward-
               | facing) wisdom teeth- one of which had fractured from the
               | pressure.
               | 
               | Went from fine one day with the caveat that one day I'd
               | need oral surgery to have them removed, to burning with a
               | fever while finding an oral surgeon ASAP.
               | 
               | Needed invasive oral surgery. Had to be put under twice-
               | once before operation, and once when bringing me out
               | after, as I had a paradoxical reaction and was thrashing
               | about. Me screaming I didn't know the surgeon and
               | anesthesiologist and thrashing about isn't super good
               | after oral surgery.
               | 
               | Hurt like the dickens afterwards and had to eat soup for
               | a good while.
               | 
               | They gave me ibuprofen and tylenol with codeine
               | afterwards. I only used the ibuprofen and was fine. It
               | only blunted the pain but was definitely manageable after
               | the first day or so.
               | 
               | I've had doctors try and prescribe narcotics for some
               | weird things. I've always denied them as I had a friend
               | who became addicted to heroin after being prescribed oxys
               | for serious 3rd degree burns.
               | 
               | Every time I have to deny narcotics multiple times before
               | they relent and offer something non-narcotic.
               | 
               | Anyways just one person's experience.
        
               | hotpotamus wrote:
               | I paid $400 for it because the last time I had a tooth
               | taken out was among the worst pains of my life. At one
               | point they had to split my tooth apart and I perceived it
               | as a light tapping, so I think it did the job. I did also
               | get a few vicodin for after they were taken out, but I
               | didn't have very much pain so I ended up not using them
               | and actually cancelling the PTO I had scheduled for
               | recovery.
               | 
               | So from my perspective, as a very acute surgical drug, it
               | would seem to be a great innovation, but it's probably
               | not something you want to use to relax after a tough day
               | at the office.
        
               | jstarfish wrote:
               | I get the impression it's to keep patients stupefied so
               | they don't do anything that would complicate the recovery
               | process.
        
               | jeffbee wrote:
               | Yeah I don't get that either. I took a Motrin after I got
               | my teeth removed and I gave the Vicodin to my friends.
               | And these days Vicodin looks like Pez because the
               | dentists are dealing fentanyl for reasons nobody can
               | understand.
        
             | xyzzyz wrote:
             | This is wrong. There is no heroin anymore, only fentanyl.
             | The addicts know what they are getting.
        
               | jeffreyrogers wrote:
               | You're getting downvoted but I have heard the same thing
               | directly from addicts. And many prefer fentanyl.
        
               | ROTMetro wrote:
               | Why is this being downvoted? I'd expand it to almost all
               | pills are now just mexi's being called 'xyz' as well.
               | Dudes are just ordering fentanyl analogs off the web from
               | China, testing it on themselves so they don't get hit for
               | selling bunk work, then moving it. If you are desperate
               | and addicted yourself this route is preferred to sketchy
               | alternatives and dealing with super scary individuals.
               | Your biggest risk of getting caught isn't the trafficking
               | but people so easily dying sticking you with a case with
               | a body on it. The reverse opium war has begun with China
               | but no one wants to talk about it. Over half the dudes I
               | did time with with drug charges went this route and got
               | it all over the intermail/international shipping vs
               | cartel and the only reason a case would get strong enough
               | to convict was if it got a body put on it.
        
             | throwaway82388 wrote:
             | That is a reasonable assumption, however, many opioid users
             | deliberately use fentanyl.
             | 
             | https://www.sciencedirect.com/science/article/abs/pii/S0955
             | 3...
        
               | rhaway84773 wrote:
               | That's interesting. I had no idea that was the case.
               | 
               | That being said, a needle exchange program could always
               | require the testing of fentanyl and if fentanyl is found
               | decline service.
               | 
               | So the people who apparently want fentanyl and are
               | encouraged by the needle exchange programs would not have
               | them as an incentive anyways.
        
               | rhaway84773 wrote:
               | To be clear, I think the research is excellent and
               | important. My problem is with the spin the Economist puts
               | on it (and it's always more egregious with the economist
               | because of the lack of a byline).
               | 
               | The Economist predisposes it's readers to believe that
               | this indicates needle exchange programs are bad, as
               | opposed to leaving open the possibility that due to
               | changing circumstances needle exchange programs which
               | have proven to be extremely successful, also need to
               | adapt, much like every other individual, program, company
               | or non-profit at any time.
        
               | throwaway82388 wrote:
               | One thing is clear: the problem--the problems--are too
               | multivariate for any one solution. Programs like these
               | are triage, the root causes are distant and largely
               | unaddressed.
        
         | d0mine wrote:
         | <<SEPs increase rates of opioid-related mortality>> is a direct
         | quote from the study.
         | 
         | https://news.ycombinator.com/item?id=33845544
        
         | photochemsyn wrote:
         | Opiate users can't distinguish any 'quality of intoxication'
         | differences across the opiate analog spectrum. Remember, this
         | class of drugs exert their effects via the endorphin system:
         | 
         | https://en.wikipedia.org/wiki/Endorphins
         | 
         | > "Endorphins are released from the pituitary gland, typically
         | in response to pain, and can act in both the central nervous
         | system (CNS) and the peripheral nervous system (PNS). In the
         | PNS, b-endorphin is the primary endorphin released from the
         | pituitary gland. Endorphins inhibit transmission of pain
         | signals by binding m-receptors of peripheral nerves, which
         | block their release of neurotransmitter substance P. The
         | mechanism in the CNS is similar but works by blocking a
         | different neurotransmitter: gamma-aminobutyric acid (GABA). In
         | turn, inhibition of GABA increases the production and release
         | of dopamine, a neurotransmitter associated with reward
         | learning."
         | 
         | All that matters is that the drug molecule binds to the
         | receptor proteins in the brain and peripheral nerves. Studies
         | show that the active dose is directly related to the binding
         | strength of that specific molecule (fentanyl binds more
         | strongly than heroin, so less is needed to get the same effect,
         | oxycontin is about as strong a binder as heroin, about twice as
         | potent as morphine).
         | 
         | Overdose deaths are generally due to (1) unusually high
         | concentrations of active substances or (2) Users who've lost
         | tolerance for some reason taking too much.
         | 
         | Legalization would likely eliminate most accidental overdose
         | deaths as products would be clearly labeled as to contents.
        
       | googlryas wrote:
       | Do exchanges even require an exchange? Here in Boulder city
       | funded groups will just give junkies needles for free. And then
       | you end up with needles littered all over the place. At least
       | with an exchange junkies would keep their needles if they can
       | manage. A few years ago 4 year old was pricked multiple times by
       | a used needle that they found in a park.
        
         | OmahaBoy69 wrote:
         | Where in Boulder are you finding needles? I'm yet to see one
         | after ~4 years here, but I've mostly stuck around CU campus and
         | Pearl and the surrounding areas. Plenty of discarded vapes
         | everywhere, though.
        
           | googlryas wrote:
           | Boulder Creek is the most glaring spot, but you might have
           | trouble finding them until the homeless campers tents are
           | forcibly removed once every 9 months. Scott Carpenter is
           | another good spot. Park East Park is where the aforementioned
           | kid was pricked.
        
         | PaulHoule wrote:
         | I am definitely seeing them on the ground within a few blocks
         | of the needle exchange in Ithaca, NY and this is something
         | that's become noticeable in the last few years. It's part of a
         | general coarsening of urban life, where it is not unusual to
         | hear gunshots at night, you hear about fatal stabbings just a
         | few blocks from where a friend of mine lives downtown, etc.
        
       | theptip wrote:
       | A general point in drug harm reduction - the "classic" drugs are
       | mostly surprisingly safe. MDMA, LSD, cocaine, even heroin (when
       | pure) have quite favorable safety profiles compared to, say,
       | alcohol as a benchmark.
       | 
       | Also, the long-term health effects are well understood, and
       | treatments for overdose established. For example, it's safe to
       | take (pure) heroin regularly (though I wouldn't personally
       | advocate for this of course).
       | 
       | On the other hand, the new families of synthetic drugs
       | (Cathinones that replaced MDMA, random novel psychedelics, and
       | fentanyl replacing heroin) all have far worse safety profiles.
       | 
       | When you make drugs illegal, the market responds by finding the
       | cheapest illegal substitute, with little concern for safety. On
       | the other hand, if we made heroin legal, then nobody would mess
       | with fentanyl. Ditto with MDMA over m-cat or whatever. And while
       | drug use would increase a bit at the margin, harm to society
       | would dramatically decrease. Most people don't actually want to
       | be junkies it turns out!
       | 
       | The money saved from not criminalizing drugs could provide
       | extremely good addiction counseling for anyone that wanted it,
       | further reducing the harm.
       | 
       | And lots of crime is just stealing to buy drugs; it's plausible
       | that overall crime would go down substantially if we gave heroin
       | prescriptions to addicts. I'd rather prescribe heroin (with free
       | access to good addiction counseling) to someone who is addicted
       | than have them breaking into cars stealing stuff to fund their
       | habit.
       | 
       | Finally, another related argument - the geopolitical harm of the
       | drug trade is immense. Drugs flow north to the US, and money and
       | weapons flow south to the cartels. If we legalized cocaine, then
       | we'd stabilize many regimes (eg Mexico, Columbia) that are
       | currently struggling with cartel violence. On net you'd see a
       | massive flourishing of humanity under this policy. A little bit
       | more drug addiction in countries that can afford to treat it, and
       | way less murder and kidnapping in countries that are trying to
       | catch up. (Surprisingly, the Economist recently advocated for
       | legalizing cocaine:
       | https://www.economist.com/leaders/2022/10/12/joe-biden-is-to...)
        
       | jpm_sd wrote:
       | No, fentanyl kills drug users.
        
       | ahoy wrote:
       | No way, The Economist, a right wing publication, is against non-
       | carceral drug policy. Who could have predicted that.
        
         | slavik81 wrote:
         | The Economist favours legalization. No, they are not against
         | non-carceral drug policy.
        
         | wisemang wrote:
         | The case for legalisation (2001, but still):
         | https://www.economist.com/leaders/2001/07/26/the-case-for-le...
        
         | boeingUH60 wrote:
         | The Economist is definitely not a "right-wing"
         | publication...not everything must be turned to tribal politics.
        
         | vorpalhex wrote:
         | Their front page is a sex positive article and an anti-Musk
         | twitter article.
         | 
         | Just because they say something you dislike doesn't make them
         | "right wing".
        
           | edgyquant wrote:
           | Because the economist (a left liberal organization) is
           | evidence based all far leftists will see it as right wing
           | even though it never endorsed conservative candidates.
        
         | edgyquant wrote:
         | The economist is a center left publication
        
       | jupp0r wrote:
       | https://archive.ph/fzBoE
        
       | tinus_hn wrote:
       | Paywall bypass:
       | 
       | https://archive.ph/fzBoE
        
       | jeffbee wrote:
       | I used to live in San Francisco at the corner of Guerrero and
       | Market, about 200m from where some do-gooders operated the needle
       | exchange on Duboce between Market and Church. On the day after
       | the needle exchange I always had to 1) remove some unconscious
       | drug addict from my stoop, either by just shoving him out of the
       | way or by calling an ambulance in extreme cases, then 2) put on a
       | disposable Tyvek suit and pressure-bleach all the feces and vomit
       | off my porch. Meanwhile the "harm reduction" perpetrators were at
       | their own homes which were evidently in far-away neighborhoods.
       | 
       | The only way needle exchange fits into civilized life is as one
       | aspect of a shelter-first treatment scheme that gets these people
       | to a place where they can vomit in their own rooms for a change.
        
         | ROTMetro wrote:
         | This. A shelter first scheme is where taxes on legalized drugs
         | should go. Gas tax funds the highways, drug taxes should fund
         | mitigating drug's harmful effects on society first, with any
         | other use secondary.
        
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