[HN Gopher] Cancer Weakness Discovered: New Method Pushes Cancer...
___________________________________________________________________
Cancer Weakness Discovered: New Method Pushes Cancer Cells into
Remission
Author : thedday
Score : 62 points
Date : 2022-12-02 18:09 UTC (4 hours ago)
(HTM) web link (scitechdaily.com)
(TXT) w3m dump (scitechdaily.com)
| heisenbit wrote:
| This sounds very interesting. Being able to associate specific
| cancers with pathways worth dampening/shutting down may not just
| enable new medications but might allow us to leverage existing
| medications and engineer cocktails of medications for which we
| already know how they affect the cellular pathways.
| tinglymintyfrsh wrote:
| Considering the Western diet, human evolutionary history of
| constant near starvation, and how chemotherapy works, isn't
| cellular stress a near universal weakness of most neoplasmic
| cells?
| 0cf8612b2e1e wrote:
| I only skimmed the article, but the entire thing seemed like
| some fluff to make a connection between machine learning and
| biology research.
|
| Cancer and genetic instability has been known for a very long
| time (hallmarks of cancer). Many energy/maintenance pathways
| are impaired or outright broken in cancer cells. Despite this
| knowledge, effectively targeting these "weaknesses" is far from
| trivial. Broken pathway does not a cancer cure make.
| spfzero wrote:
| But they actually did effectively target them. Six out of six
| complete remissions.
| tinglymintyfrsh wrote:
| Which makes sense. Chemo (limiting cell division, etc.)
| and/or starvation are "nuclear" options which rely on healthy
| cells weathering stress more so than cancer cells. Targeting
| (essentially assumed-to-be-novel) cancer cells specifically
| (say oncolytic viruses, pathway-blocking molecules or
| antibodies) seems extremely difficult without sheer luck of
| prior research matching particular tissues.
| FollowingTheDao wrote:
| If they think this will not have side affects in humans they are
| mistaken.
|
| MTFHD2 is needed in our mitochondria and blocking it will be
| worse than using methotrexate. There will be such a huge build of
| of NAD in the mitochondria things will go haywire.
|
| Maybe you all should stop eating so much folate so you do not get
| cancer in the first place:
| https://bmjopen.bmj.com/content/2/1/e000653
|
| And what is weird is that these same oncologist were telling my
| father to take folate when he was dying of cancer.
| edgyquant wrote:
| Telling people to stop eating a type of food doesn't really
| help those who have cancer at the moment. How about we stop
| putting things in food until we can prove they don't cause
| cancer
| FollowingTheDao wrote:
| > Telling people to stop eating a type of food doesn't really
| help those who have cancer at the moment.
|
| I disagree. Telling to not eat folate will help them.
|
| If it was not true why are they giving you drugs to stop the
| folate cycle?
|
| https://www.nature.com/articles/s41392-022-01017-8
|
| https://www.nature.com/articles/bjc201711
|
| Why continue to eat something that has been proven over and
| over again to drive tumor growth?
|
| It was LITERALLY how they found out that methotrexate worked.
|
| https://cen.acs.org/food/diet-change-course-cancer/100/i33
| Indeed, the very first potent cancer drugs were based on the
| effects of cell metabolism. In the late 1940s, while
| pediatric pathologist Sidney Farber was treating children
| with anemia--a condition brought about because they had
| leukemia --he found that using folate (vitamin B9) could make
| the leukemia advance surprisingly quickly. That led him to
| successfully treat their leukemia with methotrexate, a drug
| that inhibits folate activity. Methotrexate is still widely
| used against cancer and several other diseases today.
|
| > How about we stop putting things in food until we can prove
| they don't cause cancer.
|
| I agree, but that doesn't really help those who have cancer
| at the moment.
| throwaway12245 wrote:
| >Telling people to stop eating a type of food .
|
| Some claim a ketogenic diet may help.
| https://pubmed.ncbi.nlm.nih.gov/31399389/ . "Major
| conclusions: The ketogenic diet probably creates an
| unfavorable metabolic environment for cancer cells and thus
| can be regarded as a promising adjuvant as a patient-specific
| multifactorial therapy."
| capitainenemo wrote:
| Intermittent fasting also triggers ketosis, possibly more
| effectively, has cancer prevention as one of the benefits
| and does not require diet changes (although they may help
| depending on what your diet was).
| [deleted]
| Gatsky wrote:
| Folic acid supplementation reduces the toxicity of a
| chemotherapy drug called pemetrexed, used in lung cancer and
| mesothelioma. That could be why it was recommended.
|
| Sorry about your father.
| tcj_phx wrote:
| > Maybe you all should stop eating so much folate so you do not
| get cancer in the first place:
| https://bmjopen.bmj.com/content/2/1/e000653
|
| Your link is about _folic acid_ supplements, NOT _folate_.
|
| Folic acid is shelf-stable pro-vitamin that about 60-70% of the
| population is able to turn into Vitamin B9. The other 30-40% of
| the population are "poor methylators" who struggle with folic
| acid, or are harmed by folic acid.
|
| Poor methylators are on a spectrum, from 'not very good
| methylators' to 'very poor methylators'. I don't really grok
| biochemistry, but I think more people should avoid _folic acid_
| , and aim to get their nutrients from food.
|
| https://twitter.com/JamesKnochel/status/1595562181692907520
|
| Edit: My understanding is that folic acid feeds the growth of
| inflammatory bacteria much more so than natural folate sources.
| [deleted]
| [deleted]
| FollowingTheDao wrote:
| > Your link is about folic acid supplements, NOT folate.
|
| It does not matter and this show you know little about the
| folate cycle. DHFR, the enzyme that metabolizes Folic Acid,
| also bidirectionally converts DHF and THF (folates).
|
| https://www.uniprot.org/uniprotkb/P00374/entry
|
| https://www.researchgate.net/profile/Jack-
| Fletcher-3/publica...
|
| > Folic acid is shelf-stable pro-vitamin that about 60-70% of
| the population is able to turn into Vitamin B9.
|
| That would mean 60 to 70% of the population cannot process
| folate, not just folic acid. When did you even get this
| number?
|
| > Poor methylators are on a spectrum, from 'not very good
| methylators' to 'very poor methylators'. I don't really grok
| biochemistry,
|
| No, you do not grok at all well. You know who does? Me.
| JPLeRouzic wrote:
| I am a lay person but:
|
| * In the introduction of the linked BMJ article you can read:
|
| " _Folic acid is a synthetic form of the essential B vitamin
| folate, also named folacin, pteroylglutamic acid or vitamin
| B9. Folic acid is in the human body converted to
| 5-methyltetrahydrofolate, which also is the form of folate
| found in dietary sources and is particularly abundant in
| vegetables, fruits and grains._ "
|
| * In Wikipedia "folic acid" is redirected to "folate".
|
| https://en.wikipedia.org/wiki/Folic_acid
|
| In the "folate" WP page you find this sentence:
|
| " _Manufactured folic acid, which is converted into folate by
| the body, is used as a dietary supplement and in food
| fortification as it is more stable during processing and
| storage._ "
| gardenfelder wrote:
| > My understanding is that folic acid feeds the growth of
| inflammatory bacteria much more so than natural folate
| sources.
|
| That comment warrants justification. Web searches are hard to
| formulate to support that. In the general literature, [1] is
| fairly typical and benign, not supportive. Can you provide
| some references?
|
| [1] https://www.medicalnewstoday.com/articles/327290
| stouset wrote:
| > but I think more people should avoid folic acid
|
| And of course, there's people on the opposite end of the
| spectrum. For stroke survivors with certain kinds of vascular
| causes, folic acid supplementation is encouraged to reduce
| the risk of future strokes.
| thaumasiotes wrote:
| > If they think this will not have side affects in humans they
| are mistaken.
|
| Sure, everything has side effects.
|
| This is a case where the side effects don't matter so much;
| people will put up with things in order to avoid dying a
| horrible death that they wouldn't tolerate in other
| circumstances.
___________________________________________________________________
(page generated 2022-12-02 23:01 UTC)