[HN Gopher] Leaked documents: Ugandan government expects explosi...
       ___________________________________________________________________
        
       Leaked documents: Ugandan government expects explosion in Ebola
       cases
        
       Author : msyoung2012
       Score  : 212 points
       Date   : 2022-11-08 15:46 UTC (7 hours ago)
        
 (HTM) web link (www.telegraph.co.uk)
 (TXT) w3m dump (www.telegraph.co.uk)
        
       | max_ wrote:
       | Ebola is already out of control! There are reports of infectious
       | people collapsing all over the Kampala(on social media) but the
       | government hasn't initiated any covid level precautions.
       | 
       | [0]: https://www.instagram.com/p/CkkyFfrjv2D/?hl=en
        
       | Closi wrote:
       | The quality of forecasting here looks questionable IMO... Let's
       | take the only visible leaked slide below:
       | 
       | https://www.telegraph.co.uk/content/dam/global-health/2022/1...
       | 
       | 1) The forecast appears to be "200 new cases per month" (i.e.
       | Month 1 is 200 cases, Month 3 is 600 cases (3 _200) and Month 4
       | is 1200 cases (6_ 200)). This is far too simplistic, and should
       | probably follow an exponential/logistic curve if r>1.
       | 
       | 2) The graph has simple stats failures like plotting a line
       | between a bar chart.
       | 
       | Doesn't give me too much hope for the other 15 slides...
       | 
       | (The above isn't to say that it isn't a scary situation - clearly
       | this is an awful situation which needs a huge amount of support.
       | But the apparent quality of analysis does worry me that decision
       | makers might not be working on great information)
        
       | martey wrote:
       | I think the Telegraph article (
       | https://www.telegraph.co.uk/global-health/science-and-diseas... )
       | that this blog post is based on is a better read. It makes clear
       | that the idea that the outbreak will become "out of control" is
       | from an anonymous source, not the leaked documents.
        
         | dang wrote:
         | Thanks! changed to that from https://blog.ebola-
         | cases.com/leaked-ebola-projections-uganda....
        
       | cmrivers wrote:
       | The outbreak in Uganda is troubling, but a forecast that goes out
       | 6+ months is silly. No professional infectious disease modeler
       | will forecast out more than a few weeks because the trajectory of
       | the outbreak changes in response to interventions and behaviors.
        
         | thedorkknight wrote:
         | That doesn't make sense. I'm no epidemiologist, but have
         | friends who work in disease modeling, and used to follow some
         | virology blogs/podcasts. They usually make lots of models, each
         | with different assumptions, specifically to guess what the
         | intervention of different public health measures would do.
        
         | jryhjythtr wrote:
         | >a forecast that goes out 6+ months is silly.
         | 
         | Sure is, which is why it's odd we've been bombarded with
         | endless graphs with months of predictions, over the past 2.5
         | years.
        
           | ASalazarMX wrote:
           | I guess as it transformed from epidemic to pandemic to
           | endemic, it became increasingly predictable. The duration and
           | peaks of the last waves could even be predicted by months
           | indeed, as measures and behaviors remained practically
           | unchanged. Not one of these predictions encompassed six
           | months, though.
        
             | jryhjythtr wrote:
             | >Not one of these predictions encompassed six months,
             | though.
             | 
             | I beg to differ. Here's a sample of what we got, on a daily
             | basis, in the UK:
             | 
             | https://www.google.com/search?q=uk+covid+predictions&tbm=is
             | c...
             | 
             | Plenty of those are dated from the early months of 2020.
        
           | Finnucane wrote:
           | For ebola?
        
           | yamtaddle wrote:
           | How've I not noticed this? I've instead seen a whole lot of
           | graphs with no prediction whatsoever and lots and lots of
           | people in positions of authority who seem totally unable to
           | extrapolate from those in their heads, resulting in idiotic
           | back-and-forth on various restrictions for the first 18 or so
           | months of the pandemic.
           | 
           | Shit like schools releasing plans ahead of the school year
           | that they then immediately ignore because otherwise they'd
           | have to close in the first two weeks of school, when it was
           | _fucking obvious_ the numbers would be like that around that
           | time, just from looking at the graph and knowing more-or-less
           | how disease spreads. Or  "Ok stop masking and open up
           | restaurants wait oh shit it's going up again I thought the
           | tiny dip we saw would continue forever, for no good reason".
           | Just baffling levels of data-illiteracy.
           | 
           | But not a lot of long-term prediction graphs. Who was
           | publishing those?
           | 
           | [EDIT] Wait, I _did_ see total-deaths-at-time-X predictions
           | with /without measures, and with/without vaccination at high
           | rates. That's true.
           | 
           | [EDIT EDIT] Is there a tone issue or is my having seen
           | _vanishingly_ few graphs for all of COVID that tried to
           | predict trends more than a week or two out an outlier
           | experience, and those were in fact extremely common in,
           | perhaps, media I didn 't look at? Truly, the main problem I
           | saw locally was an astonishing near-complete _failure_ to
           | consider trends and likely projections, over and over again
           | and often by the same people, who seemed weirdly incapable of
           | learning a very clear lesson, rather than too many
           | projections looking too far out.
        
             | jryhjythtr wrote:
             | Sounds like you're in the UK. Do you consume _any_
             | mainstream media?
             | 
             | https://www.google.com/search?q=uk+covid+predictions&tbm=is
             | c...
             | 
             | I didn't take in much news, and now avoid it more than
             | ever, but what little I did was wall-to-wall with
             | projections complete with big scary peaks and steep rises
             | in numbers. I dread to think of the state of mind of
             | someone who watched more like the average number of TV
             | hours (for me it is zero), and took in all of this with an
             | uncritical mind.
        
             | lazyasciiart wrote:
             | My guess is a tone issue. It's hard to even tell that
             | you're saying you haven't seen long term graphs - the first
             | sentence comes across as sarcastic when followed by long
             | sentences complaining about other problems.
        
               | yamtaddle wrote:
               | I thought:
               | 
               | > I've instead seen a whole lot of graphs with no
               | prediction whatsoever
               | 
               | made it pretty clear, but maybe not. And the rest was
               | expressing that the actual on-the-ground problem I saw,
               | and the single biggest problem with my state & local-
               | level response to the whole thing, was a complete _lack
               | of_ attention to future trends, not too much. But perhaps
               | that doesn 't come across very well. _Mea Culpa_.
        
           | hamburglar wrote:
           | We have? I've certainly been bombarded with graphs showing
           | trends, but six month predictions? Where are you seeing
           | these? Can you point me to some?
        
             | [deleted]
        
             | jryhjythtr wrote:
             | Sure.
             | 
             | https://www.google.com/search?q=uk+covid+predictions&tbm=is
             | c...
             | 
             | There are plenty that stretch out for a year.
        
           | slenk wrote:
           | Doesn't seem odd for news outlets, unfortunately.
        
             | tinus_hn wrote:
             | Hyped up drama sells newspapers. Unfortunately.
        
         | unethical_ban wrote:
         | How is it disingenuous to use assumptions for modeling?
        
         | spywaregorilla wrote:
         | That sounds... wrong? What if the 6+ month forecast assuming no
         | interventions is useful to compel an intervention, and the 2-3
         | week one is not?
        
           | cmrivers wrote:
           | Then it's a scenario model, which asks what-if questions
           | usually for planning purposes (e.g., what's the most hospital
           | beds we might need?). Scenario models can have longer time
           | horizons than forecasts, but 6 months is still quite long.
        
             | knob wrote:
             | That is a quite cool way of separating those models. Can
             | you point me in a direction where I could learn more? RE:
             | Forecast vs Scenario?
        
           | mwint wrote:
           | If "useful to compel" is a criteria, we can jump straight to
           | flat-out lying and dispose with the statistics part.
        
             | tut-urut-utut wrote:
             | We already did quite a bit of lying during the Covid
             | pandemic.
        
             | jcelerier wrote:
             | welcome to government!
        
               | greesil wrote:
               | Or industry!
        
             | spywaregorilla wrote:
             | So you're in charge of making decisions. Hypothetically.
             | Your epidemiologists believe that if no action is taken, 10
             | people will die in the next two weeks, 100 people will die
             | in the next 4 weeks, and 1,000,000 will die in the next 6
             | months.
             | 
             | Which forecasts would you prefer they keep to themselves?
        
               | jakear wrote:
               | Starting an implication with "if no action is taken after
               | 100,000 deaths" is the same as "if false" -- you can put
               | anything in the "then" and have the statement be
               | logically sound - that doesn't mean it's in any way
               | useful.
               | 
               | End of the day that kind of talk just damages trust in
               | the scientific process, which has to be at an all time
               | low with regard to epidemiology, as a result of the
               | stream of certified lies that have been presented as
               | public policy over the past few years. ("Masks don't
               | work" being the first of many)
        
               | spywaregorilla wrote:
               | > Starting an implication with "if no action is taken
               | after 100,000 deaths" is the same as "if false" -- you
               | can put anything in the "then" and have the statement be
               | logically sound - that doesn't mean it's in any way
               | useful.
               | 
               | 1) Not when YOU are the person who determines if action
               | should be taken!
               | 
               | 2) You seem to be implying that action can be taken at
               | 100,000 which will be effective at preventing the spread
               | to 1,000,000 which may be true or may be false, but it's
               | going to be far easier to stop it at 10 regardless.
        
               | viraptor wrote:
               | > "if no action is taken after 100,000 deaths" is the
               | same as "if false"
               | 
               | Is useful as the higher bound and for judging the results
               | of actions.
               | 
               | But still... I think you're too sure about people in
               | charge following reasonable behaviours. We don't even
               | have to go as far as the great famine. There's lots of
               | things going wrong now where people responsible
               | explicitly do not address the issue.
        
               | [deleted]
        
             | wwweston wrote:
             | The GP is invoking the idea of a compelling understanding,
             | one that produces action by buy-in.
             | 
             | If you're confused on that point vs sinister authoritarian
             | actions, then the risk of other people lying to you is far
             | from your biggest problem.
        
         | hammock wrote:
         | How far out did the Covid forecasts look, to justify global
         | lockdowns?
        
           | beebmam wrote:
           | Are you claiming that the lockdowns that happened in the
           | first half of 2020 had zero effect on SARS-CoV-2 infections?
        
             | Jerrrry wrote:
             | They did not.
             | 
             | Florida vs California.
             | 
             | read up.
        
               | snowwrestler wrote:
               | In case anyone would like to actually read up on the
               | impact of restrictions:
               | 
               | States That Imposed Few Restrictions Now Have the Worst
               | Outbreaks (Nov 18, 2020)
               | 
               | https://www.nytimes.com/interactive/2020/11/18/us/covid-
               | stat...
        
               | mwint wrote:
               | I mean...
               | 
               | > Nov 18, 2020
               | 
               | Looks at deaths per capita, from Jan 2020 to today. The
               | position of peaks is barely relevant compared to their
               | cumulative impact.
        
             | hammock wrote:
             | I'm literally asking a question, since it is news to me
             | that "no professional infectious disease modeler will
             | forecast out more than a few weeks."
             | 
             | Do I sense attitude? If so, why?
        
           | thedorkknight wrote:
           | That's not quite the right way of phrasing that question.
           | Models are made with and without interventions taken into
           | account, and the lockdowns were a reaction to models showing
           | reduced deaths and hospital strain if lockdown measures were
           | in place. I'm not sure what that guy is talking about.
           | 
           | But if you're actually interested, you should go and read the
           | papers used for modeling yourself, since the odds of finding
           | a rando on hacker news who is an actual epidemiologists is
           | zilch. The ones who were public communicators that I followed
           | over COVID were the podcast "This Week in Virology" which is
           | just about the best resource you're going to find, and the
           | blog "your local epidemiologist", who is also fantastic
        
           | jimbob45 wrote:
           | The fear with COVID was mutation of the disease into
           | something more deadly and more contagious. What looks like
           | fearmongering now was cautious behavior around mutation at
           | the time. Conversely, Ebola isn't likely to mutate now, so we
           | don't need that same level of caution.
        
             | AnimalMuppet wrote:
             | > Conversely, Ebola isn't likely to mutate now
             | 
             | Can you explain why?
        
             | time_to_smile wrote:
             | > What looks like fearmongering now
             | 
             | We had over 1 million deaths in the US.
             | 
             | You travel back to 2016 and tell people we'll have a
             | pandemic in the US, 1 million people will die, and then
             | large groups of people will attempt to shrug that off as
             | "nothing to get concerned about", people would find that
             | incomprehensible.
             | 
             | If I were to post a comment on HN in 2016 suggesting that
             | people would shrug off 1 million deaths due to a pandemic
             | because it doesn't align with their worldview I would have
             | been downvoted into oblivious for holding such a laughably
             | ridiculous and cynical opinion.
             | 
             | Same could be said of the countless other climate related
             | impacts that people in the very near distant past would
             | consider horrific and impossible.
             | 
             | The power of the "this is fine" culture to not see reality
             | is terrifying.
        
               | bushbaba wrote:
               | 300k Americans die each year from obesity. Yet nobody
               | seems to view this as an urgent issue needing addressing.
        
           | refulgentis wrote:
           | They didn't need much more than noting Rt and experience of
           | Wuhan, if you're thinking "IMHE!", sort of a red herring:
           | yeah, they predicted X million of deaths, but it wasn't
           | anymore complicated than take Rt, use in formula, and yeah we
           | should probably see if we can eradicate this thing locally,
           | early. Was never a global decision.
        
         | cmrivers wrote:
         | Update, this comment refers to the original blog post
         | submission, which pulled out forecasted numbers with no
         | context. The Telegraph article is better.
        
       | 6stringmerc wrote:
       | The 60 Minutes episode that aired recently where they traveled to
       | the hot spots in Africa is fascinating. We know about the
       | inevitable. It is up to us humans what we do with this
       | information. Case in point: COVID mask hostility in spite of
       | caring for the health of fellow humans or getting it and denying
       | it until it kills them (source: nurse friend on a cardiac ward in
       | the Midwest). YMMV.
        
       | exhilaration wrote:
       | The headline is scary but #1 Ebola isn't airborne and #2 it's
       | super deadly which means it kills before it really has a chance
       | to spread widely.
        
         | Silverback_VII wrote:
         | I don't know if you have read some of the tweets but it seems
         | that ebola can remain dormant in some of the recovered
         | individuals and then be transmitted(sexually in this case)
         | years latter.
        
           | dendrite9 wrote:
           | https://arstechnica.com/science/2021/03/ebola-may-have-
           | lurke...
           | 
           | About a 2021 outbreak: "The Ebola virus is known to persist
           | in some survivors, particularly in places where it can lay
           | low from the immune system, such as the testicles or
           | eyeballs. A 2016 study reported resurgence of the virus in a
           | survivor's seminal fluid more than 500 days after the initial
           | infection.
           | 
           | Still, the more than five-year span was "shocking" to many
           | virologists and public health experts. And it raises a
           | variety of concerns for the many survivors of past outbreaks,
           | some of whom may have had mild cases of Ebola without
           | realizing it. In particular, many people known to have
           | survived Ebola face stigmatization, and the possibility of
           | years-long persistence is likely to amplify that problem."
        
         | pelorat wrote:
         | And the only reason it spreads is due to lack of education.
        
           | [deleted]
        
           | kramerger wrote:
           | Is there a particular program or degree that makes me immune?
           | 
           | Because multiple members of Doctors Without Borders died in
           | the previous outbreak.
        
             | kspacewalk2 wrote:
             | Basically, having universal or near-universal access to
             | modern sanitation is the "program". If you're not in a
             | community that has this, being a member of Doctors Without
             | Borders is insufficient as a guard against getting
             | infected. Conversely, having running water and flush
             | toilets as the norm makes it far less likely for dieases
             | like ebola to spread even among non-members of Doctors
             | Without Borders.
             | 
             | So, while "lack of education" is not the right diagnosis
             | here, lack of basic amenities certainly is.
        
             | wkearney99 wrote:
             | That's entirely disingenuous, and you know it. There's a
             | huge difference between the uneducated public in the
             | developing world (or, clearly, everywhere really) and those
             | that choose to enter into those challenging conditions to
             | try and help people.
        
             | dopidopHN wrote:
             | They should have had worked harder in schools. I thought
             | the message was out by this point
        
         | dwheeler wrote:
         | Right. Ebola spreads via contact with infected blood or body
         | fluids. That's terrible for those infected, and we should
         | definitely take steps to counter its spread. But that's not at
         | all the same level of risk as airborne spreading.
        
         | throwaway920102 wrote:
         | I mean it could evolve to be airborne in the wild or in a
         | research lab doing intentional gain of function research (a
         | practice for which funding was temporarily halted by Obama) and
         | hybridization much like has been done at BSL-4 facilities
         | worldwide unchecked including by EcoHealth alliance with bat
         | coronaviruses via US funding at the WIV prior to the Covid
         | outbreak in Wuhan.
         | 
         | https://www.science.org/content/article/nih-says-grantee-fai...
         | 
         | https://www.nature.com/articles/d41586-022-01209-w
         | 
         | https://theintercept.com/2021/09/09/covid-origins-gain-of-fu...
         | 
         | But it's probably fine and we probably shouldn't worry about
         | the possibility of a global pandemic or of mutation of Ebola
         | into a more transmissible form.
        
           | benreesman wrote:
           | Why is parent getting downvoted? The lab leak theory is
           | pretty mainstream these days.
           | 
           | And gain of function research is 1: real 2: fucking insane
           | and 3: a plausible way we would have a true captain trips
           | style pandemic.
        
             | justapassenger wrote:
             | Gain function is only way to research pathogens.
        
               | MichaelCollins wrote:
               | No it isn't.
        
               | mrguyorama wrote:
               | Nature has no qualms about performing GOF research if we
               | don't do it. How do we protect ourselves from future
               | viral and biological evolution otherwise? Virus's evolve
               | literally every day, and if we don't find a way to build
               | tools, processes, and countermeasures, we will absolutely
               | be strongly harmed by a future one.
               | 
               | This always feels like the "we can't afford to fix
               | climate change so we just will ignore the problem" take.
        
               | justapassenger wrote:
               | To study how they evolve and their potential to become a
               | problem? Yeah, that's the only way to go.
               | 
               | And given how fast viruses evolve, there's no real
               | alternative.
        
               | benreesman wrote:
               | I think everyone agrees that observing live virus in the
               | lab is a critical (if dangerous) part of studying them.
               | 
               |  _Intentionally_ engineering them as high as possible on
               | transmissibility and morbidity is bioweapon development
               | being money laundered through conventional science: it's
               | an insane thing to do.
               | 
               | Leaving SARS-COV-2 out of it completely: there have
               | indisputably been other leaks. It's the height of
               | irresponsibility and shortsightedness to engineer
               | civilization-ending viruses, which is why it's banned
               | under multiple international conventions that GoF is a
               | workaround for.
               | 
               | You don't need a vaccine for the fucking superflu if you
               | _never develop the fucking superflu_.
        
             | nonameiguess wrote:
             | It's a hell of a leap to go from gain of function research
             | has ever happened at all to gain of function specifically
             | on Ebola is a near-term serious risk. Is there any evidence
             | that gain of function has ever been conducted on Ebola?
             | I've never heard of it, and don't know where to look other
             | than a search engine, and conducting a search there returns
             | exactly two sources making that claim, one called
             | "scamdemic" and one called "goldismoney." Neither seems
             | like a particularly reputable source.
        
               | [deleted]
        
             | mikeyouse wrote:
             | It's really not mainstream amongst virologists.. as has
             | been demonstrated by repeatedly debunking the latest gish
             | gallop papers, there's literally zero evidence for lab
             | manipulation of the sars cov2 virus. It's vaguely plausible
             | that the virus could have been captured in the wild and
             | then leaked, but even that seems extremely unlikely given
             | the two separate market lineages and timeline of the
             | earliest cases.
             | 
             | Stricter control of GoF makes a lot of sense but the reason
             | everyone was studying coronavirus pandemics in the first
             | place is because we'd had several near misses and everyone
             | in the virology community knew it was only a matter of time
             | before the right circumstances allowed a spillover to do
             | exactly what Covid19 did.
        
               | pvarangot wrote:
               | > It's really not mainstream amongst virologists
               | 
               | I mean if you seriously believe that theory you are
               | probably going to either end, start thinking about how to
               | end, or significantly change how you develop, your career
               | as a virologist. Of course it's not mainstream.
        
               | Bukhmanizer wrote:
               | It's not common for virologists to work on GOF research
               | or to do anything close to as dangerous.
               | 
               | It's pure tin hat thinking to say that "my idea is
               | correct and everyone who has any expertise is
               | compromised". I don't know what is right or not, but I
               | know a lot of virologists (through work) without any
               | personal interest in the case who don't put much stock in
               | the lab leak hypothesis.
        
               | johndfsgdgdfg wrote:
               | Thank you for saying this. We know xenophobic racist
               | right wingers are saying that COVID came from China. But
               | WHO-China investigation definitely proved that COVID came
               | outside of China. Even western virologists have been
               | supporting Chinese scientists. [1]
               | 
               | [1] https://www.thelancet.com/journals/lancet/article/PII
               | S0140-6...
        
               | benreesman wrote:
               | I think there is a lot more controversy than you're
               | implying, even among serious scientists, but an HN
               | comment thread is probably not the right place to
               | litigate a complex issue that is also a partisan
               | political football.
               | 
               | I'll leave it at this: I would encourage everyone to do
               | their own research on this and try to look past the
               | elephant in the room of the politics angle.
        
               | idiotsecant wrote:
               | I find pretty often when people resolve conversations
               | like this by saying 'do your own research', particularly
               | when the research to be done requires any homework at
               | all, it is shorthand for 'find a loud voice saying things
               | that are compatible with the worldview you've decided on
               | already'.
        
               | AnimalMuppet wrote:
               | If "you do your own research" to confirm your own pre-
               | existing ideas, then yes, you're going to get where you
               | wanted to go.
               | 
               | I read "do your own research" differently. I think it can
               | go two different directions.
               | 
               | In the positive direction, it can mean "Ignore all the
               | loudmouths, all the liars, all the self-anointed experts.
               | Even ignore me, the speaker. Find out who really knows
               | what they're talking about, and listen to them." This
               | assumes, though, that the listener _can_ do that. Am I
               | actually capable to discern truth from lies, or even real
               | expertise from incompetence, in virology? Maybe, if I
               | devote enough time to it. Do I have that kind of time for
               | every topic on which someone tells me  "do your own
               | research"? Probably not. So what it really turns into is
               | finding someone who at least sounds like they are doing
               | their own research (and doing it well), and listening to
               | them.
               | 
               | More negatively, I suspect that "do your own research" at
               | least sometimes is a veiled way of saying "If you really
               | knew, then you would agree with me" in a much less in-
               | your-face way than just saying it. The person saying this
               | may have done their research as you say, finding a loud
               | voice that said what they wanted to hear, and now be
               | totally convinced that they are right, and that if you
               | did your research, you would wind up agreeing with them.
        
               | mikeyouse wrote:
               | I've got a busy day so don't want to get into it again --
               | but I cannot express how incapable the average (even
               | educated!) person is to "do their own research" on
               | something as complex and nuanced as molecular engineering
               | and the probabilities of covid genetic engineering.
               | 
               | Even some expert 'pre-reviewers' that received the
               | advance of the most recent bombshell paper that
               | supposedly proved an unnatural virus with lab origin
               | missed obvious tells that completely invalidated the
               | authors' claims. E.g. this thread; https://twitter.com/Ba
               | llouxFrancois/status/15870905072887767...
               | 
               | If people do want to make up their own minds on this -
               | I'd encourage you to track down people making falsifiable
               | claims _and then changing their priors based on the
               | results of that research_ instead of people jumping from
               | one conspiracy theory to the next to avoid changing their
               | views.
               | 
               | As one data point, several prominent "lab leakers" on
               | Twitter are now insisting that prior strains are fake and
               | were invented by virologists since those strains disprove
               | recent papers instead of considering that maybe those
               | recent papers were flawed. It's bizarre to watch. (One of
               | the authors of the most recent 'bombshell' LL paper
               | claiming that two related field-collected coronaviruses
               | are fake / manipulated:
               | https://twitter.com/VBruttel/status/1584920770605621248)
        
               | Melting_Harps wrote:
               | > I've got a busy day so don't want to get into it again
               | -- but I cannot express how incapable the average (even
               | educated!) person is to "do their own research" on
               | something as complex and nuanced as molecular engineering
               | and the probabilities of covid genetic engineering.
               | 
               | I don't think you can claim to have consensus on this
               | matter since Dr. Li-Meng Yan who worked at the lab and
               | got the CCP scrub when she went public had been speaking
               | out about this since 2020 after having been in hiding and
               | then fleeing China for her claims. Moreover she detailed
               | how people who worked at the lab in Wuhan have been in
               | retrospect beholden to the CCP for not discussing the
               | poor safety record of the lab.
               | 
               | And your position about how it's not worthy of discussion
               | makes it very clear you speak with a sense of bias
               | because ultimately a conclusive epidemiological study
               | will prove impossible since the floods in Wuhan in 2020
               | took place that coincided with the CCP's abject refusal
               | to have outside investigators come in and search for the
               | possible origin of the COVID, and even accused the US of
               | creating the virus and spreading it--much how Russia has
               | made to justify it's illegal invasion into Ukraine to de-
               | nazify it and now de-satanize it after claims of US COVID
               | biolabs in Ukraine.
               | 
               | For what's it worth, I have a BSc in cellular and
               | molecular biology, and I was also involved in the plight
               | of the HK people since the Umbrella Revolution, and had
               | people been actually abreast of that situation they would
               | have known that something was going incredibly wrong by
               | November 2019: the CCP/Lam regime forced the protests for
               | the extradition bill (and possibly declare independence
               | the way things were going since the Summer) in HK to be
               | quelled altogether for a fear of contagion of what had
               | been going around in order to prevent the calamity of the
               | Avaian Bird flu that is still in recent memory for many
               | in HK--which was much worse on the mainland than it was
               | in HK because of the abysmal health and safety practices
               | by the CCP.
               | 
               | And had people paid attention, the CCP not only arrested
               | many dissenters and created a massive diaspora in one of
               | the most affluent and well educated countries in Asia
               | that served as an economic hub to the West it got the NSL
               | to pass during this time, it also continued to arrest and
               | intimidate Hong Kong into abject repression all under the
               | pretense of COVID. when they themselves, via the Lam
               | regime, kept the borders open and allowed mainland
               | Chinese to enter HK and their were plenty of recorded
               | footage of them violating covid practices (quarantine)
               | and actively going into public areas and act as vectors
               | (coughing and spitting on elevators), going into
               | restaurants despite quarantine practices etc...
               | 
               | Lastly, Propublica released an investigative piece last
               | month about the lab leak theory [0] under the auspicious
               | of the US senate, which I'm not denying has glaring geo-
               | political overtones; especially given the CCP's saber-
               | rattling towards Taiwan and well documented tyrannical
               | behaviour in Xinjiang and Hong Kong; the latter violated
               | the Sino-British treaty and dismissed international Law
               | which effectively mean it illegally annexed a territory
               | imposed a repressive law (NSL) to suppress any dissent
               | which was to operate autonomously until 2037--which can
               | be seen as hostile as Russia violating both the Budapest
               | Memorandum and the Minsk agreements when it invaded
               | Ukraine in 2014 and illegally annexed and occupied
               | Crimea/Lugansk/Donetsk and has led to full invasion and
               | crimes against Humanity ever since with indiscriminate
               | shelling on civilian areas under the aforementioned
               | pretenses.
               | 
               | I'll leave it here because quite honestly I can't fathom
               | anyone to be so brazenly reductionist in their thinking
               | and claim to have the 'upper hand' when their is clear
               | violations all the way which implicate not just the CCP
               | but the US (via NIH funding) as well for funding the GoF
               | research in Wuhan [1] despite repeated safety record
               | violations.
               | 
               | And on a personal note: it's because the health sciences
               | is filled with people like you that I had to turn to tech
               | in the end. I was sent into such a forlorn depression
               | after a short career in it when I found the Industry is
               | was mainly filled with people who will cling on to any
               | party-line in order to continue their work and research.
               | In retrospect I wish I had chosen something else to give
               | so much of my time, effort and passion had I known how
               | quickly it becomes a way to legitimize the commonly held
               | narratives of the State or a Corporation, and how quickly
               | it willing compromise itself for such short-sighted goals
               | in the process.
               | 
               | 0: https://www.propublica.org/article/senate-report-
               | covid-19-or...
               | 
               | 1: https://www.nih.gov/about-nih/who-we-are/nih-
               | director/statem...
        
               | mikeyouse wrote:
               | Me: "Doing your own research on this is very difficult
               | due to people with credentials selling their reputations
               | to service political goals."
               | 
               | You: "What about this Chinese scientist who lied about
               | their experience and had no actual evidence of anything
               | but who was working with Steve Bannon and Guo Wengui and
               | repeatedly platformed on Tucker Carlson?![1] Oh and a
               | Senate Republicans minority committee just released a
               | report that mistranslates standard Chinese party doctrine
               | as menacing![2]"
               | 
               | Admitting that Covid19 was very likely a spillover of a
               | natural virus doesn't mean that you trust China, that you
               | think their labs are run well or are incapable of
               | accidents, that they've been transparent or helpful with
               | the investigations, or that the possibility of new
               | evidence pointing to a lab origin is foreclosed -- just
               | that the actual physical evidence we have today about
               | _this virus_ and _this pandemic_ overwhelmingly points to
               | a natural origin.
               | 
               | [1] -
               | https://www.nytimes.com/2020/11/20/business/media/steve-
               | bann...
               | 
               | [2] - https://twitter.com/janeqiuchina/status/15890981670
               | 51911169
        
               | we_never_see_it wrote:
               | > [2] - https://twitter.com/janeqiuchina/status/158909816
               | 7051911169
               | 
               | Since you put the Twitter handle as an evidence for your
               | argument. This particular Chinese jounalist is using
               | Twitter and publishing articles in Western journals *
               | _while living in China*_. What makes you think she is
               | more trustworthy than Steve Bannon? Even if she is an
               | honest and trustworthy person why would CCP let her
               | publish anything that goes against their narrative?
               | 
               | > just that the actual physical evidence we have today
               | about this virus and this pandemic overwhelmingly points
               | to a natural origin
               | 
               | actual physical evidence * _provided by China*_ FTFY. You
               | don 't think China will readily handover the data to you
               | if it came from lab, do you? And what physical evidence?
               | The evidences are just some early patient data and virus
               | gene sequences. By that logic HIV spillover happened in
               | US, not in Africa. Because early HIV cases have been
               | detected in USA.
               | 
               | > overwhelmingly points to a natural origin
               | 
               | according to whom? The virologists who also have a
               | history of covering up lab leaks. The virologists who
               | will have the most to lose if lab leak is true. [1]
               | 
               | [1] https://www.nytimes.com/2021/06/20/world/europe/coron
               | avirus-...
        
               | benreesman wrote:
               | Why are you so insistent that there shouldn't be a
               | discussion on this?
               | 
               | For you to say, e.g. "My bona fides are such and such, I
               | find this theory highly implausible for $REASONS" would
               | be eminently useful and helpful and very much in the
               | spirit of the site.
               | 
               | In case the multiple people saying this aren't saying it
               | clearly enough: you sound more like "Serious people all
               | agree about this, only cranks disagree with us, and you
               | plebs wouldn't understand even if I explained it".
               | 
               | Love #1. Fuck #2 in fucking particular.
        
               | mikeyouse wrote:
               | > _Serious people all agree about this, only cranks
               | disagree with us_
               | 
               | Mostly joking but if the shoe fits... As one example, one
               | of the authors of the famous 'Viral' book pointing to a
               | Lab Leak is a coal baron GW denier who chaired a bank
               | that failed due to subprime loans and who previously
               | claimed that HIV was a man-made virus derived from failed
               | polio vaccination experiments[1]. How much credence
               | should we give someone like that? How many hours of time
               | should be spent debunking every new theory he promotes
               | rather than just casting him aside and looking for non-
               | morons to engage with?
               | 
               | Or how should one engage with this comment:
               | https://news.ycombinator.com/item?id=33522713
               | 
               | It's just a smattering of grievances and debunked
               | conspiracy theories. How would virologists begin to
               | respond to that?
               | 
               | I mean I said it above, and I'll just copy/paste it here;
               | 
               | > _Admitting that Covid19 was very likely a spillover of
               | a natural virus doesn 't mean that you trust China, that
               | you think their labs are run well or are incapable of
               | accidents, that they've been transparent or helpful with
               | the investigations, or that the possibility of new
               | evidence pointing to a lab origin is foreclosed -- just
               | that the actual physical evidence we have today about
               | this virus and this pandemic overwhelmingly points to a
               | natural origin._
               | 
               | There _are_ well-intentioned scientists testing theories
               | that could point to a lab origin of Covid, it would be
               | extremely interesting and important if they find
               | something to indicate that 's the case. Unfortunately to
               | the casual observer of the actual state of science here,
               | they'd be led to believe that there's consensus about a
               | lab leak or at least a strong likelihood backed by
               | evidence when that's not remotely true.
               | 
               | [1] - https://www.bmartin.cc/dissent/documents/AIDS/River
               | /Prospect...
        
               | Melting_Harps wrote:
               | I'm not going to engage with the 'me vs you' narrative
               | you have going here, because you are forcing this into
               | the polarization tactics that social media uses: I
               | presented not just sources to those claims but I also
               | followed up with ACTUAL incidents that took place that
               | you could research yourself that make it impossible to
               | arrive to that conclusion that it's _overwhelmingly of
               | natural origin_ which has been at the core of the CCP 's
               | discourse (despite conflicting claims of it being a US
               | bioweapon) which absolves everyone involved and will
               | ultimately be the highly contentious but acceptable
               | narrative if you want any funding in the future and don't
               | want to rock the boat, or if you're a mainlander released
               | from indefinite lockdown.
               | 
               | I'd rather question your claims than your position,
               | because I know where you stand anyway, which is the crux
               | of my response: so, where was it revealed that Dr. Yan
               | lied about her credentials and her experience at the
               | Wuhan lab? To date that has never been proven despite
               | constant criticism, what has been proven is that she was
               | scrubbed from the Internet when she went public and that
               | the CCP targeted her family (she is a Chinese National)
               | while she was still in HK. She continues to publish her
               | work in peer-reviewed journals [0] and her work stands
               | alongside her colleagues who continue to publish their
               | work on other journals. I'm willing to review these
               | sources that discredit her in order to contrast with my
               | currently held position and arrive to a better informed
               | position, which is something I'm not sure you are willing
               | to do.
               | 
               | I will agree that those who ran with the story first have
               | a clear and unscrupulous bias, but that is the very
               | definition of shooting the messenger which never result
               | in her claims being thoroughly vetted--she released her
               | scientific papers after having arrived to the US and
               | fleeing from China then HK and finally to the US. That
               | takes resources she likely didn't have after the ordeal.
               | 
               | This has to be seen as dire as the exodus of Jewish
               | scientists fleeing Nazi Germany for it to be seen in
               | proper context, as that is what has happened in Hong Kong
               | since the Summer of 2019 and ultimately what set the NSL
               | doctrine in HK, but since so many dismiss things based on
               | association then you're making my point for me that is
               | continues even in the upper echelons of Academia as I
               | presume you are given what you have said and how you have
               | expressed yourself thus far.
               | 
               | > Admitting that Covid19 was very likely a spillover of a
               | natural virus doesn't mean that you trust China, that you
               | think their labs are run well or are incapable of
               | accidents, that they've been transparent or helpful with
               | the investigations, or that the possibility of new
               | evidence pointing to a lab origin is foreclosed -- just
               | that the actual physical evidence we have today about
               | this virus and this pandemic overwhelmingly points to a
               | natural origin.
               | 
               | Personally, I fully admit I do not have beyond an
               | undergrads understanding of genetics/virology; my career
               | was spent in the field of oncological diagnostics
               | (specifically Leukemia and Lymphoma), so it's hardly the
               | same field and I do not claim expertise. But, unlike
               | most, I have a very clear and documented history laying
               | out the violent hypocrisy of the CCP's held beliefs on
               | COVID and it's actions in HK that coincided with the
               | protests in 2019-2021.
               | 
               | But, it stands to reason that anyone who remains so
               | adamant of the claims (Natural origin) and is coaxing it
               | as much as you are the likely cause requires much more
               | compelling evidence and is otherwise ignoring the simple
               | fact that we will never know what happened due to the
               | refusal of the CCP to allow investigators into the
               | country in the onset while having cases in HK and still
               | forcing the borders open to the mainland when it was in
               | lockdown and that the subsequent floods removed any real
               | evidence that could identify the origin (on either side)
               | in order to create a consensus is done in order to get
               | back to business as usual while simultaneously trying to
               | absolve anyone guilt of this as something that needs to
               | be accepted--which is ironic since this naturaly caused
               | illness is still forcing people in China to be locked-
               | down due to China's zero-covid policy.
               | 
               | These are the (many) mental gymnastics I underscored in
               | my first post, and why I think it's deserving of such
               | ire. You make claims, you cannot support and instead will
               | play identity politics (entirely useless since I'm an
               | anarchist and I have no political affiliation) rather
               | than rebuttal with actual evidence and facts to support
               | your claim. Which thus far include:
               | 
               | - COVID is of Natural Origin due the evidence (that's not
               | conclusive)
               | 
               | - Dr. Yan is not a real scientist and lied about her
               | experience and is puppet of the MAGA crowd
               | 
               | - Lab Leak is absurd and should be dismissed because
               | reasons(?)
               | 
               | Again, I remain that any person with any shred of
               | credibility would question all positions and realize we
               | simply do not have, and will likely never have, enough
               | information to conclusively arrive to either.
               | 
               | But it's this forced narrative and consensus MO (and the
               | arrogance that follows with it) that is strikingly
               | consistent in my experience--not to mention this need for
               | a 'COVID amnesty' and the blanket immunity of
               | pharmaceutical corps got early on.
               | 
               | Do I know it definitely leaked from a lab? Absolutely
               | not, I felt it was rather convenient and compelling
               | evidence to quell the HK revolts against the extradition
               | bill (given who bird flu went down) and I saw to what
               | length the CCP was willing to go to do so, and has
               | continued on a belligerent war-path to achieve it's end
               | thorough out it's bloody history and will disspaear, kill
               | and enslave people who question it's position and
               | supremacy clause on the one china policy.
               | 
               | And this is why I think it's not beyond reason that they
               | used the pre-tense of a wet-lab based disease in order to
               | achieve their end(s), which ironically was supported by
               | the US via NIH grants to study GoF at the Wuhan lab until
               | 2017 and had a documented lengthy history of safety
               | violations and had reported cases of similar symptoms in
               | the Fall of 2019 which was critical in suppressing the HK
               | protests.
               | 
               | 0: https://www.scirp.org/(S(lz5mqp453edsnp55rrgjct55))/re
               | ferenc...
        
               | benreesman wrote:
               | No layperson is qualified to understand _any_ advanced
               | technical field these days. Semiconductor fabrication is
               | utterly out of reach for the typical voter, but they
               | still have to form an opinion on the CHIPS act. Most of
               | us aren't lawyers, but still sometimes need to hire them.
               | This is the dilemma inherent in not having a
               | /u/PhdInEverything.
               | 
               | But the answer isn't "go away and let the grownups
               | decide", the answer is to try to learn what constitutes
               | an expert, try to understand what degree of consensus
               | does or does not exist amongst those experts, try to
               | ferret out some obvious biases (e.g. red team / blue team
               | idiocy) and be as informed as possible.
               | 
               | The standard model of particle physics, or Wiles FLT
               | proof, or 1000 other things are every bit as technical as
               | _anything_ in virology, but you'll notice the
               | mathematicians all agree: the layperson doesn't have to
               | look very hard to know what the takeaway is there.
               | 
               | It's medicine's (including virology's) job to get its
               | shit together on the public's behalf, not the other way
               | around.
               | 
               | This kind of condescension infuriates me, I'm working
               | hard to be as polite as possible here.
        
               | mikeyouse wrote:
               | You can be as infuriated as you'd like, but I consider HN
               | to be one of the more responsible and educated forums for
               | casual discussion and the level of straight up
               | conspiracy-driven misinformation on _everything_ related
               | to Covid is astonishing. From origins to vaccines to
               | treatments (remember all of the threads extolling HCQ and
               | IVM?), it 's as sophisticated as you'd expect from people
               | "doing their own research" in fields they don't
               | understand and apparently aren't equipped to develop an
               | understanding of.
               | 
               | There's no political or financial implications to whether
               | Wiles' proof of FLT is correct or not, and the proof can
               | be checked with certainty by experts in the field -- so
               | of course they can come to a consensus about something
               | extraordinarily technical. Unfortunately with Covid,
               | every question has turned into a political shibboleth so
               | there will forever be FUD promoted by people who should
               | know better. How is the average reader supposed to weigh
               | the probabilities of some esoteric question like what the
               | potential presence or absence of IIS restriction sites
               | means when it's being promoted by people with advanced
               | degrees as evidence of an artificial origin, even though
               | it's nonsense?
               | 
               | So I retreat to my earlier advice for those trying to
               | form an opinion here -- look into the history of claims
               | from the various scientists, and see whether evidence is
               | guiding their claims or if their claims are guiding their
               | evidence.
        
               | benreesman wrote:
               | Neither the GP nor myself said that SARS-COV-2 escaped
               | from the Wuhan lab, let alone that it was the result of
               | GoF research.
               | 
               | I called it a _theory_ , as in, neither conclusively
               | proven nor conclusively disproven. It's a theory about
               | which there has been significant controversy. I didn't
               | even say there was significant evidence for it.
               | 
               | Acknowledging the existence of a controversy is not the
               | same thing as promoting a conspiracy theory, and as you
               | yourself point out, basically everyone, from word-
               | renowned virologists down to the man in the street, has
               | skin in the game on this one.
               | 
               | The world's medical community had a COVID response that
               | was a fucking disaster: inconsistent and constantly
               | changing guidance, conflicts of interest, geopolitical
               | 4th dimensional warfare, rushed and sloppy-looking
               | vaccine approvals.
               | 
               | It's no wonder the public believes a bunch of crazy shit:
               | the experts dropped the ball. Trying to blame that on the
               | ignorance and gullibility of the layperson and flip the
               | script like that set back the public's willingness to
               | take vaccines and listen to the authorities by 50-100
               | years.
               | 
               | Don't try to blame that on us plebs.
        
               | johndfsgdgdfg wrote:
               | Thank you for saying this. We know xenophobic racist
               | right wingers are saying that COVID came from China. But
               | WHO-China investigation definitely proved that COVID came
               | outside of China. Even western virologists have been
               | supporting Chinese scientists. [1]
               | 
               | [1] https://www.thelancet.com/journals/lancet/article/PII
               | S0140-6...
        
               | unethical_ban wrote:
               | It sounds like you and the other person agree (edit:
               | regarding the need to trust experts). You've just chosen
               | to trust different sources of information than the other
               | person.
               | 
               | I agree with the other person though, there is a
               | correlation between people I've heard say "do your own
               | research" and people with less reasonable beliefs. (Hi,
               | mom).
        
               | benreesman wrote:
               | I'm aware that "do your own research" is a common phrase
               | among people who want to believe that "9/11 was an inside
               | job" or whatever (also Hi Mom).
               | 
               | I meant it in the more nuanced sense of trying to
               | actually do research. A layperson who wants to be
               | informed has to start _somewhere_ , and when the stakes
               | are as high as with global public health, I think it
               | behooves the person in the street to try to at least read
               | the _abstracts_ of some papers, try to identify experts
               | on both sides of a controversy, and be aware that
               | credentials are no guarantee of reasonability.
               | 
               | Shockley played a big role in the transistor, IIRC got
               | the Nobel, and later spent years advocating for racist
               | eugenicist horseshit: credentials are a good guideline,
               | but they can't be blindly trusted.
               | 
               | I really wish the medical community just agreed about all
               | this stuff: then my job would be easy, do what they say.
               | 
               | Unfortunately you seem to get one group of MD/PhD people
               | saying those other MD/PhD people are cranks, we're the
               | "real" scientific consensus. This does not make it easy
               | for the well-intentioned layperson.
        
               | justapassenger wrote:
               | Most of controversy comes from scientists, often
               | biologists and doctors, yeah. But not virologists. You
               | know, people who actually know what they're talking
               | about.
               | 
               | Biology is such an enormously wide and diverse field that
               | opinions of someone who's not a virologist is often as
               | relevant as an opinion of the software engineer.
        
               | mrguyorama wrote:
               | It's like asking the DB admin about which machine
               | learning framework to use for the new project, instead of
               | your data scientist. Sure, the DB admin likely has an
               | opinion, but it will almost never be as well formed an
               | opinion as the one from your data scientist, even if
               | their opinions are in agreement.
        
             | LatteLazy wrote:
             | >The lab leak theory is pretty mainstream these days.
             | 
             | So is denying climate change or the moon landings...
        
               | johndfsgdgdfg wrote:
               | Thank you for saying this. We know xenophobic racist
               | right wingers are saying that COVID came from China. But
               | WHO-China investigation definitely proved that COVID came
               | outside of China. Even western virologists have been
               | supporting Chinese scientists. [1]
               | 
               | [1] https://www.thelancet.com/journals/lancet/article/PII
               | S0140-6...
        
               | Closi wrote:
               | > So is denying climate change or the moon landings...
               | 
               | Ah yes, so I would assume that the WHO would conclusively
               | say that the lab leak theory is incorrect then?
               | 
               | https://www.washingtonpost.com/world/2022/06/09/who-sago-
               | cov...
               | 
               | Oh... they say they are still investigating it and that
               | the theory should be left on the table... but I guess the
               | British Medical Journal would say it's total nonsense
               | right?!
               | 
               | https://www.bmj.com/content/374/bmj.n1656
               | 
               | Hmm... Maybe not, they say it's plausible too. Presumably
               | Nature just flat-out tells us that it's a total
               | conspiracy theory though right?!
               | 
               | https://www.nature.com/articles/d41586-021-01529-3
               | 
               | Ah, they stay on the fence and say that it's plausible.
               | 
               | So it's not exactly like denying the moon landings, as I
               | haven't heard NASA saying "the moon landings might have
               | been faked, but we can't prove either way" anytime
               | recently.
        
               | LatteLazy wrote:
               | And this is the amazing leap so many people seem to make:
               | If it is technically possible, then it must be true.
               | 
               | That's what baffles me here: "We cannot _conclusively_
               | say it 's wrong" so it must be right. When did that
               | become a popular mode of reasoning? I can only assume
               | people are so desperate to believe they will swallow this
               | rather than accept reality.
        
               | Closi wrote:
               | That's not what I'm saying - Where did I say it must be
               | true? I'm saying "We cannot conclusively say it's wrong,
               | thus it's not in the same category as the moon landing".
               | 
               | In reality nobody knows the origin for certain, but IMO
               | you seem to fall for the fallacy you are describing but
               | with the opposite premise - i.e. "We cannot conclusively
               | say that the lab leak theory is right or wrong, thus it
               | cannot possibly be a lab leak".
        
               | thedorkknight wrote:
               | Side note, but is the moon landing hoax popular still? I
               | got nostalgia when you mentioned it, boy howdy do I miss
               | the x files days of conspiracy theories
        
               | LatteLazy wrote:
               | 6% of Americans (10% of millennial Americans) supposedly.
               | 
               | https://en.wikipedia.org/wiki/Moon_landing_conspiracy_the
               | ori...
               | 
               | Despite actual pictures taken recently...
        
               | postalrat wrote:
               | You are claiming 6% is mainstream?
        
               | LatteLazy wrote:
               | I will say that the evidence is the same for either.
               | 
               | What percentage you think makes an idea mainstream I will
               | leave up to you...
        
               | serf wrote:
               | let's leave it up to the word definitions instead :
               | 
               | mainstream : the ideas, attitudes, or activities that are
               | regarded as normal or conventional; the dominant trend in
               | opinion, fashion, or the arts.
               | 
               | So, no, 6% is not mainstream. Moon landing conspiracies
               | are by no means a dominant trend anywhere aside from joke
               | books and parody.
        
             | chimprich wrote:
             | > The lab leak theory is pretty mainstream these days.
             | 
             | Mainstream, and conceivably true, but lacking in evidence.
             | Personally I find it rather implausible due to a lack of
             | motivation for why the lab in question would be doing
             | secret work on coronaviruses.
             | 
             | > fucking insane
             | 
             | I don't think this is a helpful way to have this debate. I
             | don't know enough to have a strong opinion on this, but a
             | majority of virologists seem to think it's necessary, so I
             | wouldn't automatically label them as lunatics.
             | 
             | > a plausible way we would have a true captain trips style
             | pandemic
             | 
             | Other plausible ways are a mutation from an existing
             | pathogen or another zoonotic spillover event, which gain of
             | function research could potentially predict or help
             | mitigate.
        
               | throwaway1777 wrote:
               | The new report by pro publica and vanity fair is about as
               | close to evidence as we are likely to get. The big issue
               | here is that we didn't get to hear real investigation of
               | it until 2 years after the fact aside from whistleblowers
               | with varying level of credibility.
        
               | mrguyorama wrote:
               | China was never going to let a legitimate investigation
               | happen, no matter what. They have nothing to gain by
               | letting people know exactly what happened (because they
               | think they can manage things on their own) and everything
               | to lose by letting someone prove that wet markets are
               | horrific or that bio labs in china have terrible safety.
        
               | rngname22 wrote:
               | > why the lab in question would be doing secret work on
               | coronaviruses
               | 
               | what was secret about it? the lab in Wuhan was literally
               | doing research in 2015 on how bat coronaviruses could
               | adapt to spread in humans vs ACE2 receptors and developed
               | their own strain: https://www.nature.com/articles/nm.3985
               | 
               | from the linked study: "Using the SARS-CoV reverse
               | genetics system, we generated and characterized a
               | chimeric virus expressing the spike of bat coronavirus
               | SHC014 in a mouse-adapted SARS-CoV backbone. The results
               | indicate that group 2b viruses encoding the SHC014 spike
               | in a wild-type backbone can efficiently use multiple
               | orthologs of the SARS receptor human angiotensin
               | converting enzyme II (ACE2), replicate efficiently in
               | primary human airway cells and achieve in vitro titers
               | equivalent to epidemic strains of SARS-CoV. Additionally,
               | in vivo experiments demonstrate replication of the
               | chimeric virus in mouse lung with notable
               | pathogenesis.... On the basis of these findings, we
               | synthetically re-derived an infectious full-length SHC014
               | recombinant virus and demonstrate robust viral
               | replication both in vitro and in vivo. Our work suggests
               | a potential risk of SARS-CoV re-emergence from viruses
               | currently circulating in bat populations."
        
               | chimprich wrote:
               | Thanks, that's exactly what I mean. They were publishing
               | their work and making public what viruses they were
               | working on with collaborators and public databases etc.
               | There doesn't seem to be a plausible explanation for why
               | they'd be working on a related but entirely new virus and
               | keeping it secret.
               | 
               | I suppose they could have just received some samples and
               | then that triggered an immediate outbreak before anyone
               | heard of it, but having an instant spillover event from a
               | handful bat samples with workers using biosecurity
               | measures doesn't seem to me especially likely compared to
               | the many more interactions humans have with animals
               | outside lab settings. (For example, the tens of thousands
               | of live animals kept caged in extreme proximity with each
               | other and unprotected humans in the huge Wuhan wet
               | market).
        
               | throwaway920102 wrote:
               | I'm totally trying to be good faith here, but are you
               | aware of the recent admissions by NIH that EcoHealth (the
               | funders of the research at WIV) basically did exactly
               | this?
               | 
               | "On Wednesday, the NIH sent a letter to members of the
               | House Committee on Energy and Commerce that acknowledged
               | two facts. One was that EcoHealth Alliance, a New York
               | City-based nonprofit that partners with far-flung
               | laboratories to research and prevent the outbreak of
               | emerging diseases, did indeed enhance a bat coronavirus
               | to become potentially more infectious to humans, which
               | the NIH letter described as an "unexpected result" of the
               | research it funded that was carried out in partnership
               | with the Wuhan Institute of Virology. The second was that
               | EcoHealth Alliance violated the terms of its grant
               | conditions stipulating that it had to report if its
               | research increased the viral growth of a pathogen by
               | tenfold."
               | 
               | Further in the article:
               | 
               | "As scientists remain in a stalemate over the pandemic's
               | origins, another disclosure last month made clear that
               | EcoHealth Alliance, in partnership with the Wuhan
               | Institute of Virology, was aiming to do the kind of
               | research that could accidentally have led to the
               | pandemic. On September 20, a group of internet sleuths
               | calling themselves DRASTIC (short for Decentralized
               | Radical Autonomous Search Team Investigating COVID-19)
               | released a leaked $14 million grant proposal that
               | EcoHealth Alliance had submitted in 2018 to the Defense
               | Advanced Research Projects Agency (DARPA).
               | 
               | It proposed partnering with the Wuhan Institute of
               | Virology and constructing SARS-related bat coronaviruses
               | into which they would insert "human-specific cleavage
               | sites" as a way to "evaluate growth potential" of the
               | pathogens. Perhaps not surprisingly, DARPA rejected the
               | proposal, assessing that it failed to fully address the
               | risks of gain-of-function research."
               | 
               | https://www.vanityfair.com/news/2021/10/nih-admits-
               | funding-r...
        
               | johndfsgdgdfg wrote:
               | > but lacking in evidence
               | 
               | Thank you for saying this. We know xenophobic racist
               | right wingers are saying that COVID came from China. But
               | WHO-China investigation definitely proved that COVID came
               | outside of China. Even western virologists have been
               | supporting Chinese scientists. [1]
               | 
               | [1] https://www.thelancet.com/journals/lancet/article/PII
               | S0140-6...
        
               | throwaway0x7E6 wrote:
               | >but lacking in evidence
               | 
               | so anything short of a public confession by a CCP
               | spokesman isn't enough?
        
             | timr wrote:
             | I'll go: because while the parent comment is (loosely,
             | tangentially) based in fact, it's an enormous leap to go
             | from the kind of differences we're talking about with SARS-
             | CoV2 engineering, and the differences of _type_ required to
             | aerosolize a filiovirus.
             | 
             | Is it "possible"? Yes, theoretically. But it's not at all
             | trivial, and far down my worry list. It's bit like worrying
             | that sharks are going to evolve wings and start flying
             | around eating people.
        
               | harvey9 wrote:
               | But what if lots of ebola was lifted up in a tornado and
               | deposited on Los Angeles?
        
               | ipaddr wrote:
               | Now we have the basis of a movie.
        
               | gatane wrote:
               | Better, a one hit song (8 years ago)
               | https://youtu.be/qlnsHiaAoYo
        
           | uoaei wrote:
           | Ebolavirus and coronavirus are very, very different. There is
           | little in the way of comparison, transmissibility being only
           | one of many differences.
        
             | MichaelCollins wrote:
             | He didn't say that ebolavirus is similar to coronavirus. He
             | said that Nurgle worshiping virologists are probably hard
             | at work trying to 'enhance' ebola to be more transmissible,
             | which is probably true.
        
               | uoaei wrote:
               | The point is, assuming that gain-of-function would have a
               | viable path at turning a bloodborne pathogen into an
               | airborne pathogen, rather than simply making an airborne
               | pathogen more transmissible, is disappointing in its
               | complete misunderstanding of virology. It de-legitimizes
               | the point they're trying to make.
               | 
               | Lab leak theory is more than a big "what if", it has
               | merit to it. To try to make an analogous argument toward
               | how ebola might become more transmissible in a similar
               | manner ruins their credibility.
        
           | duxup wrote:
           | It could evolve is a big if.
           | 
           | A lot of viruses could and become disastrous, but that's a
           | long shot.
        
             | mrguyorama wrote:
             | "It's a long shot" except for the several times in the past
             | few hundred years they have done just that? We can do
             | statistics on how often this happens. We know that we
             | should expect it periodically. Even Obama, while on his way
             | out, was able to tell Trump "hey expect a pandemic event
             | soon". We literally knew this was coming.
        
               | duxup wrote:
               | > except for the several times in the past few hundred
               | years they have done just that?
               | 
               | Compared to what? The times it didn't?
        
           | antupis wrote:
           | I think more plausible is sexual transmission
           | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111642/
        
         | bergenty wrote:
         | I mean it's not all that hard for it to become airborne. If
         | that happens it's doesn't kill fast enough to not spread like
         | crazy.
        
           | SoftTalker wrote:
           | Isn't it? Some viruses are airborne, and some are not. I'm
           | not aware that it's "not all that hard" for one type of virus
           | to become the other, but I'm no expert.
           | 
           | As far as I have heard, ebola outbreaks are almost
           | exclusively in poor third world areas with generally bad
           | sanitation and cultural practices (such as washing the
           | recently deceased body) that contribute to transmission by
           | contact with infected bodily fluids.
        
         | giantg2 wrote:
         | " it's super deadly which means it kills before it really has a
         | chance to spread widely."
         | 
         | I generally agree. I believe there is some lag time before
         | dropping dead. Fast air travel seems like a good way for this
         | to spread over a wide range. If I remember correctly, CDC was
         | involved in some Ebola cases about 10 years or so ago due to
         | travellers. The manpower required for the precautions to
         | prevent US spread for just 2-4 infected people was massive. I
         | would guess we would be overwhelmed and it would start
         | spreading here if the numbers were in the dozens.
         | 
         | I'm not saying that would be likely this time, but the
         | likelihood would go up if there was a less deadly mutation.
         | Operating on previously true beliefs is likely to cause the
         | most damage.
        
         | lucioperca wrote:
         | It spread through multiple countries till it was contained at
         | one outbreak with thousands of dead.
        
       | doodlebugging wrote:
       | For anyone who may be working in the epidemic response space I
       | read that there may be problems getting PPE for the health care
       | workers.
       | 
       | There is a place that accepts products that are obsolete and
       | reusable and they have a section dedicated to PPE since a lot of
       | outfits obsoleted their PPE inventories once Covid was better
       | controlled.
       | 
       | They also have a shit-ton or more of other things that can be
       | repurposed from their original tasks.
       | 
       | Repurposed Materials - Sanitary stuff [0]
       | 
       | [0]https://www.repurposedmaterialsinc.com/sanitarystuff/
        
       | ccbccccbbcccbb wrote:
       | Someone is just declaring their plans.
        
       | msyoung2012 wrote:
       | Leaked documents show the Ugandan government is not expecting the
       | current Ebola outbreak to be contained, but rather expect it to
       | spread rapidly into the deadliest in Ugandan history, killing 500
       | and infecting at least 1200 by May of next year.
        
       | VBprogrammer wrote:
       | This title made me wonder, what ever happened to monkey pox.
       | Turns out that it has more or less died away.
        
         | qzx_pierri wrote:
         | Monkeypox was always a money grab perpetuated by fear mongering
         | media conglomerates. Those companies found some other
         | "boogeyman" to chew on for the time being. And I'm not denying
         | Monkeypox was real, it was just completely overblown and being
         | used to scare people into clicking on spooky headlines.
        
           | michaericalribo wrote:
           | I think this is needlessly pessimistic. A virus spreading
           | uncontrolled in one of the world's largest cities? It would
           | be journalistic malpractice _not_ to report on it in the
           | current climate
        
             | uni_rule wrote:
             | Sometimes the tinfoil hat mindset is appropriate but
             | sometimes it also eats holes in your brain.
        
         | Izkata wrote:
         | Except it didn't, it fell off the news cycle before the peak in
         | August and people just stopped talking about it. New cases are
         | still happening:
         | https://www.cdc.gov/poxvirus/monkeypox/response/2022/index.h...
        
           | thrwawy4privcy wrote:
           | Community spread is now minimal and decreasing. 7D moving
           | average for US cases was over 400 in August and now it's 29.
           | https://www.cdc.gov/poxvirus/monkeypox/response/2022/mpx-
           | tre...
        
           | VBprogrammer wrote:
           | I didn't do exhaustive research but the first link I clicked
           | suggested it had dropped by 85%.
        
           | NotYourLawyer wrote:
           | Yes, it did. It's down 95% from its peak.
        
         | _djo_ wrote:
         | It was handled well by global public health authorities, with
         | education campaigns, targeted vaccinations, early warning,
         | treatment, and growing immunity in the most at-risk
         | populations.
        
           | mschuster91 wrote:
           | Additionally, most of the most-at-risk population has lived
           | through the AIDS horror. A good gay friend of mine roughly
           | summarized it as "we gays know how bad diseases can get, and
           | fuck it my dating life even after 2 years of pandemic is not
           | as important as is my life". Once it was clear that MSM were
           | (once again) a high-risk group, they all went back to either
           | reducing contacts or at least wearing condoms.
           | 
           | In contrast, the last time the general public has had an
           | issue with a pandemic has been so long ago that deniers and
           | downplayers had an easy game with their bullshit. Had wearing
           | fucking masks not been that politicized, I'd wager a very
           | good portion of the 6.6 _million_ people that died to COVID
           | would still be alive. And to come back to my gay friend, at
           | least in his community there were almost no COVID cases.
        
             | photochemsyn wrote:
             | People are strange... good handwashing standards are likely
             | as important as masks for preventing Covid transmission,
             | but that never got politicized or became controversial for
             | some reason. Also, wearing non-N95 masks appears to be most
             | effective as a means of preventing aerosolized droplets
             | _from_ infected people from spreading to others in public
             | situations. The full PPE system is more for protecting
             | nurses and doctors working with severely ill patients from
             | getting infected.
        
               | MichaelCollins wrote:
               | > _People are strange... good handwashing standards are
               | likely as important as masks for preventing Covid
               | transmission, but that never got politicized or became
               | controversial for some reason._
               | 
               | It's obvious isn't it? Handwashing isn't a badge you can
               | wear. Meet somebody in public and you'll know if they're
               | wearing a mask or not, but you won't know if they've
               | washed their hands recently.
        
               | photochemsyn wrote:
               | I don't know if that's enough to explain the hysteria...
               | for example, people have published studies on the
               | effectiveness of handwashing without fearing being
               | attacked on Twitter as agents of misinformation (results
               | are mixed, though generally beneficial, alcohol rubbing
               | seems somewhat less helpful than soap and water, and a
               | good scrubbing is better):
               | 
               | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250256/
               | 
               | > "To develop clear and simple guidance for the public,
               | further work should focus on identifying the specific
               | times when HH should be performed in different
               | communities and situations. In the meantime, current
               | guidelines should be followed and should be based on
               | evidence summarised here. Resources to support frequent
               | hand washing, if hand washing facilities are available,
               | or alternatively ABHR, should be provided in schools,
               | workplaces, and public spaces and HH should continue to
               | be promoted"
               | 
               | There are some more recent studies (2022) that take a
               | similar evidence-based approach to masking effectiveness,
               | noting for example:
               | 
               | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017682/
               | 
               | > "The author pointed out that with active COVID-19
               | patients, who may contaminate the environment, a mask
               | will not protect healthcare workers or other people if
               | they are not accompanied by hand hygiene, eye protection,
               | gloves and a gown."
               | 
               | The autopsy of the governmental and medical responses to
               | the pandemic (and the original source of the outbreak)
               | will make for interesting reading for years to come.
        
               | MichaelCollins wrote:
               | Another part of the puzzle is telling people to wash
               | their hands has been a mainstream message for decades. It
               | wasn't asking people do to something new and
               | uncomfortable.
        
               | mrguyorama wrote:
               | And predictably, about 30% of people utterly refuse to do
               | it. Usually for stupid reasons. Some people are just so
               | anti-authority that they would seemingly cut off their
               | own leg to spite an authority figure telling them legs
               | are important.
        
             | VancouverMan wrote:
             | Masking was never inherently a political issue, even if
             | some people tried to make it one.
             | 
             | From a purely scientific perspective, and regardless of
             | one's political leanings or preferences, it was obvious
             | from the start that widespread everyday masking simply
             | isn't effective, nor is it practical.
             | 
             | If such masking was even just somewhat effective, the
             | entire situation would have been over by mid-2020 at the
             | latest. That clearly wasn't the case.
             | 
             | Even in large regions with strictly-enforced masking (even
             | outdoors, in some cases!), combined with numerous other
             | onerous restrictions, we still saw massive case number
             | spikes. Those would not have happened if masking worked.
             | 
             | Of course, there are also the numerous harmful effects of
             | masking that must be considered. It causes many
             | accessibility problems, it causes childhood development
             | problems, it causes social strife (including
             | discrimination), it enables abusive policing, and so forth.
             | 
             | Hopefully, society as a whole has been reminded how masking
             | just doesn't work, and that's exactly why we didn't bother
             | with it until this recent debacle.
        
               | joshuamorton wrote:
               | I'm curious, when you say "masking works" what do you
               | mean?
               | 
               | Because you seem to mean it as "prevents 100% of
               | transmission", and therefore anything less than that
               | means masking isn't effective.
               | 
               | And that's simply untrue. Masking does, really, truly,
               | assist with covid spread. It doesn't prevent 100% of
               | transmission, because nothing does, especially something
               | that requires active participation, but yeah it helps a
               | lot _if people actually do it_.
               | 
               | It's likely a large part of the reason that I've never
               | caught covid, despite a fairly active social life and
               | continued in-person office work for almost a year now.
               | And why the social events I attend, where you can have a
               | hundred people in close quarters breathing on each other
               | haven't had recorded transmissions, despite recorded
               | isolated cases.
               | 
               | > It causes many accessibility problems, it causes
               | childhood development problems, it causes social strife
               | (including discrimination), it enables abusive policing,
               | and so forth.
               | 
               | There's no evidence for any of these claims, and in fact
               | you'll find the accessibility community strongly favors
               | masks as immunocompromised people exist. Widespread
               | seasonal masking has been common in other countries for
               | decades (since SARS-1, two decades ago), and there's no
               | evidence that it causes childhood development issues.
               | There's, like, one academic paper whose conclusion is
               | that mask wearing makes it difficult for preschoolers to
               | detect the emotion of a person wearing a mask. But any
               | extension of that to impacts on childhood psychological
               | development isn't academic, it's you making things up.
        
               | VancouverMan wrote:
               | As with other actions, it's the relationship between the
               | benefits that something brings versus the costs
               | associated with doing it that determine whether or not
               | it's "working".
               | 
               | The costs associated with widespread everyday masking are
               | severe. You even quoted the ones that I'd mentioned
               | earlier.
               | 
               | Just to overcome those severe costs, masking would have
               | had to consistently bring astounding benefits.
               | 
               | At a bare minimum, that should have been a nearly-
               | complete end to the transmission of not just this virus,
               | but others, as well.
               | 
               | Unfortunately, we didn't see that happen, because masking
               | isn't effective.
               | 
               | We experienced the severe costs of masking, but without
               | receiving any benefits from enduring those costs.
               | 
               | This was demonstrated by what's among the largest set of
               | scientific experiments ever performed, involving many
               | millions of people, in many nations, and over two years
               | of masking in some cases.
        
               | joshuamorton wrote:
               | > The costs associated with widespread everyday masking
               | are severe. You even quoted the ones that I'd mentioned
               | earlier.
               | 
               | Yes, and stated that they are, for the most part, not
               | actually costs.
               | 
               | Masks _don 't_ cause accessibility problems, they _don
               | 't_ cause child development issues, they _don 't_ cause
               | social strife when consistently warn and enforced, and
               | they don't cause abusive policing (police don't enforce
               | mask mandates anywhere in the US, and consistently were
               | one of the least compliant groups!).
               | 
               | You can't keep lying about these supposedly "severe"
               | costs when anyone with eyes can see that they're made up.
               | I mean you can, but it's your credibility lost.
        
               | apetersonBFI wrote:
               | What about people who have difficulty breathing, and have
               | to have their breathing hindered for hours by the mask?
               | 
               | I was in the hospital for 2 days when my wife gave birth,
               | and I was supposed to wear the mask 24/7. Luckily they
               | didn't enforce it strictly so I was able to sleep without
               | the mask.
        
               | VancouverMan wrote:
               | Josh, I recommend that you do even just some basic
               | research into this topic. It's quite complex, and I can't
               | do it justice here.
               | 
               | Masking certainly does cause accessibility problems for
               | many people.
               | 
               | For example, people with mobility and other issues
               | involving their fingers, hands, arms, shoulders, neck,
               | and ears can find it quite difficult, or even impossible,
               | to put on, to wear, or to remove a mask.
               | 
               | Masking can also aggravate respiratory and
               | cardiovascular-related medical issues.
               | 
               | Masking can aggravate PTSD and other psychological
               | issues.
               | 
               | Masking can cause problems for those with hearing-related
               | issues, as it can make it difficult to hear the muffled
               | voices of others, as well as making lip-reading
               | impossible.
               | 
               | In jurisdictions where accessibility is considered
               | important, the forced masking bylaws or legislation
               | typically had accessibility-related exemptions, because
               | masking does cause severe accessibility problems for many
               | people.
               | 
               | The harmful social impacts of masking take many forms.
               | 
               | Among the most egregious were when exempt individuals
               | were denied service, reasonable accommodation, and in
               | some cases employment.
               | 
               | Such people also faced significant harassment when in
               | public, even in so-called "tolerant" societies. Sometimes
               | this would involve verbal abuse. Sometimes it would
               | involve having creeps take and share photos of them, in
               | attempts to socially shame them. Sometimes it would
               | unfortunately involve physical abuse, even with the
               | police being the perpetrators at times.
               | 
               | A less-visible aspect to this very real threat of
               | harassment was how some people just stopped participating
               | in society as much as possible, even at the cost of
               | financial, psychological, and social harm to themselves.
               | 
               | Forced masking, especially in schools, has definitely had
               | a negative impact on the education and development of
               | children. This manifests in various ways, including
               | communication-related delays and difficulties,
               | trust/fear-related issues, immune system deficiencies,
               | and so on.
               | 
               | Perhaps you were spared the worst of this based on where
               | you happen to live, and luckily didn't have to experience
               | the costs of masking yourself.
               | 
               | Others, however, suffered significantly because of
               | masking, even if you may not realize it.
        
               | joshuamorton wrote:
               | > Josh, I recommend that you do even just some basic
               | research into this topic. It's quite complex, and I can't
               | do it justice here.
               | 
               | I have.
               | 
               | > For example, people with mobility and other issues
               | involving their fingers, hands, arms, shoulders, neck,
               | and ears can find it quite difficult, or even impossible,
               | to put on, to wear, or to remove a mask.
               | 
               | This is minimal and solvable. If someone needs assistance
               | putting on a mask, they need assistance with other daily
               | activities and so can get that assistance as well.
               | 
               | > Masking can cause problems for those with hearing-
               | related issues, as it can make it difficult to hear the
               | muffled voices of others, as well as making lip-reading
               | impossible.
               | 
               | This is also solvable, with for example clear masks that
               | are used in speech therapy contexts.
               | 
               | > Masking can also aggravate respiratory and
               | cardiovascular-related medical issues.
               | 
               | This is not true, there's no support for this in the
               | literature. While full-face respirators can reduce
               | airflow, facemasks like those commonly worn and
               | recommended don't decrease airflow or O2 intake
               | significantly enough to matter. As a rule of thumb, if
               | you cannot breath through a mask either the issue is
               | psychosomatic or you should be wearing a plastic face
               | mask that provides you supplementary oxygen, because you
               | are not sufficiently able to breathe on your own.
               | 
               | > In jurisdictions where accessibility is considered
               | important, the forced masking bylaws or legislation
               | typically had accessibility-related exemptions, because
               | masking does cause severe accessibility problems for many
               | people.
               | 
               | Please cite them.
               | 
               | > Among the most egregious were when exempt individuals
               | were denied service, reasonable accommodation, and in
               | some cases employment.
               | 
               | Please cite them. What is a reasonable exemption from
               | mask wearing if a building requires all present to wear
               | masks?
               | 
               | > A less-visible aspect to this very real threat of
               | harassment was how some people just stopped participating
               | in society as much as possible, even at the cost of
               | financial, psychological, and social harm to themselves.
               | 
               | Lots of people do this for many reasons, for example the
               | large swaths of people who (rightly or wrongly) still
               | feel unsafe going out and about because of the dangers of
               | Covid and the fact that most areas in society don't mask.
               | Personally, I feel those people, even most with
               | immunicompromisations, are overstating the risks
               | associated with involvement in society. By the same
               | token, I think the people you describe are overstating
               | the risks of masking. I cannot conclusively say whether
               | one faces a greater real issue than the other. What I can
               | say is that masks to provide conclusive benefits, so the
               | imagined risks of people who fear them are less of an
               | issue to me than the imagined risks of people who
               | overestimate the dangers of covid and other airborne
               | infectious diseases.
               | 
               | > Perhaps you were spared the worst of this based on
               | where you happen to live, and luckily didn't have to
               | experience the costs of masking yourself.
               | 
               | Given where I live and my social circles, I and those
               | around me masked far more aggressively and for far longer
               | than the majority of the united states. I'll reiterate
               | that there have been few to know _real_ negative impacts
               | from these policies.
        
             | delecti wrote:
             | > they all went back to either reducing contacts or at
             | least wearing condoms.
             | 
             | Also vaccination drives. I'm good friends with a few gay
             | guys, and they all rushed to get vaccinated, even despite
             | being in committed long term relationships. There was,
             | metaphorically speaking, absolutely no fucking around with
             | this one.
        
             | _djo_ wrote:
             | Great point, and yes that sort of behaviour change and
             | awareness was hugely important.
        
             | VBprogrammer wrote:
             | I started wearing a mask pretty early on. The first one was
             | a fabric one my mother in law made as it was still at a
             | time when PPE for healthcare workers was a bigger priority.
             | I kept wearing a mask until the overwhelming majority of
             | people around me had long given up. I believed it was the
             | right thing to do regardless but I'm not sure I'm as
             | optimistic as you regarding their effectiveness.
        
               | ajmurmann wrote:
               | I've been wearing masks from early on and only recently
               | stopped wearing them regularly. Now I only wear them when
               | in a crowded situation. I feel how masks were handled was
               | completely botched in many ways. There is the
               | politicization and communication errors. However, I also
               | remain somewhat shocked how we never made any effort to
               | address the biggest, obvious issues with masks to make
               | them more effective.
               | 
               | I saw so many studies that showed that a properly fitted
               | mask makes a massive difference in how protective it is
               | compared to other mask types. Where can I get a mask
               | fitted? Never even saw anything about fitting masks other
               | than "it makes a huge difference and we do this for
               | nurses".
               | 
               | Clearly much of the air goes around the mask. Sure a
               | little metal piece at the bridge of the nose makes this a
               | little better, but why did nobody seem to work on a
               | proper solution for this? How about a mask with a rubber
               | seal that goes around it?
               | 
               | This kind of stuff could have saved thousands of lives,
               | yet we seem to not even have tried.
               | 
               | I think the fatality of COVID was just right to create a
               | societal mess. Fatal enough to kill tons of people. But
               | not fatal enough to get everyone on the same page that
               | some sacrifices need to be made to rein it in. At the
               | same time some people also had practically no symptoms,
               | creating more opportunity for disagreement.
        
               | IX-103 wrote:
               | I still wear a mask when I go out. I'll probably stop
               | eventually -- probably next summer when it gets hot
               | again.
               | 
               | But I definitely agree that mask for should have been a
               | big push. I'm not sure that sealing the gaps around the
               | nose is that much of an issue from a transmissibility
               | perspective, but it can make a significant difference in
               | terms of comfort for those wearing glasses. And masks
               | that are not comfortable don't get worn.
        
               | jrussino wrote:
               | >How about a mask with a rubber seal that goes around it
               | 
               | I wore one of these: https://envomask.com/
               | 
               | They're relatively heavy compared to paper & fabric masks
               | (not to mention expensive), but the gel seal made it
               | quite comfortable and it was the only thing I found that
               | I could wear all day without ever fogging up my glasses.
        
               | ajmurmann wrote:
               | Thank you! These are exactly like what I wanted.
        
               | galdosdi wrote:
               | Think back to early 2020. A lot of the serious
               | deaths/damage were not due to covid per se, but due to
               | (1) covid being so novel we didn't know how to treat it
               | very well, eg using ventilators in cases that could have
               | just used O2 tanks (2) covid spreading so fast that it
               | was effectively a denial of service attack against the
               | local hospitals.
               | 
               | Both of these factors were improvable even by small
               | measures that don't prevent infection but just reduce the
               | severity or probability, slowing down ("flattening the
               | curve") the pandemic and postponing more of the cases
               | till later when there was more capacity as well as better
               | treatment knowledge.
               | 
               | As someone who suffered a lot in 2021 due to an illness
               | that was totally unrelated to covid, but that was only so
               | bad because of insufficient medical care available due to
               | the pandemic (literally, some simple better care and
               | tests earlier on would have definitely caught and
               | resolved it, but getting care during the pandemic was a
               | shitshow), I take this aspect quite seriously. I think
               | covid was best understood as a crisis for the medical
               | system than for individuals (relatively speaking)
               | 
               | EDIT: fwiw I'm not even disagreeing with you on anything
               | (yes, on HN, I know), just riffing :)
        
               | VancouverMan wrote:
               | The medical community as a whole, in numerous nations,
               | dropped the ball quite badly over the last three years.
               | 
               | It was obvious by mid-2020 that this situation was
               | severely overblown, and that pretty much every reaction
               | was far more harmful than beneficial.
               | 
               | Unjustifiable and baseless paranoia caused severe
               | inefficiencies within medical systems that are
               | inefficient even at the best of times.
               | 
               | A particularly unfortunate aspect was how the wider
               | medical community itself, including regulatory bodies,
               | immediately and ruthlessly shut down any of the
               | questioning and feedback from physicians, scientists, and
               | even some politicians that would have brought light to
               | the harmful policies much sooner.
               | 
               | Instead, we had to wait two years in some places for
               | common sense to even begin to return. It should never
               | have been like that to begin with.
        
             | georgeburdell wrote:
             | I'm glad the community was able to find a solution, and
             | luckily monkey pox was not inherently deadly, but they did
             | not comply with some efforts to mitigate the disease,
             | particularly contact tracing
             | 
             | https://www.sfchronicle.com/bayarea/article/S-F-all-but-
             | give...
        
               | _jal wrote:
               | Contact tracing in the Covid context has worked horribly
               | everywhere in the US, as far as I know, outside of more
               | or less defined communities where penalties could attach.
               | And even there is mostly failed when they didn't.
               | 
               | Did I miss an instance where it worked well enough to be
               | worth the effort?
               | 
               | Add in the fact that the gay community has reasons to be
               | less than thrilled with medical disclosure of this sort
               | and I'm not the least bit surprised.
        
               | georgeburdell wrote:
               | The CDC is still recommending contact tracing (for
               | Covid), so I imagine they have data to back up its
               | employment.
        
               | MichaelCollins wrote:
               | Or they simply don't want to relinquish whatever funding
               | they may have been allocated for contact tracing, or may
               | receive in the future.
               | 
               | Don't trust government agencies to tell you what they
               | need, they'll always ask for a Moon mission.
        
               | xienze wrote:
               | > Contact tracing in the Covid context has worked
               | horribly everywhere in the US
               | 
               | Well yeah, it's hard to recall the dozens or hundreds of
               | people you may have interacted with over the course of
               | days or weeks. It is however much easier to contract
               | trace sexual partners, unless of course you're engaging
               | in repeated anonymous sexual encounters...
        
             | johndfsgdgdfg wrote:
             | > we gays know how bad diseases can get, and fuck it my
             | dating life even after 2 years of pandemic is not as
             | important as is my life
             | 
             | That's a nice sentiment I guess. Meanwhile my gay friend
             | didn't stop "socialization" during the pandemic except
             | first few early months. According to him he must've had
             | COVID at least 4 times by now. If you add natural immunity,
             | vaccine and asymptotic transmission he was getting exposed
             | to COVID pretty much all the time.
             | 
             | This is nothing against gay community. This is against
             | idolozation of certain communities and demonization of
             | certain other communities to fit certain political
             | narrative. Reality is more complex and nuance.
        
               | MichaelCollins wrote:
               | > _Meanwhile my gay friend didn 't stop "socialization"
               | during the pandemic except first few early months._
               | 
               | Assuming he is a young man, then caution for the first
               | few months meant he was cautious until mortality
               | statistics revealed that the risk to himself, and
               | presumably his partners, was minimal.
        
             | thrwawy4privcy wrote:
             | As a bisexual man I think the LGBT community is getting far
             | too little credit for how they reacted to this. Men getting
             | vaccinated essentially saved the world from more spread at
             | a very critical time.
             | 
             | It wasn't just personal responsibility and willingness to
             | get vaccinated and reduce number of partners. Gay men
             | shouted from the rooftops at public health authorities to
             | get them to step up testing, treatment, and vaccination
             | campaigns very early, when many doctors were ignorant,
             | unable or unwilling to take it seriously.
        
               | hanselot wrote:
        
         | unixfg wrote:
         | The hardest hit community was downright enthusiastic about the
         | MPV vaccine. That makes a HUGE difference.
        
           | nonethewiser wrote:
           | The gay community?
        
       | tibbydudeza wrote:
       | They still have not identified the reservoir host (probably a
       | fruit bat). African traditions of caring for a sick person and
       | then bathing the dead is not helping either.
        
       | alexk307 wrote:
       | You're telling me Ebola-cases.com is not a reputable news source?
       | /s
        
         | [deleted]
        
       | photochemsyn wrote:
       | Comprehensive accessible review here:
       | 
       | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495366/
       | 
       | The virus apparently just wrecks the immune system right off the
       | bat, allowing it to rampage throughout the body unchecked. Hence
       | immune-system-support therapies are being worked on:
       | 
       | > "EBOV is able to evade innate and adaptive (both humoral and
       | cellular) responses by encoding for multiple viral proteins that
       | inhibit both type-I IFNs synthesis and response, by masking viral
       | epitopes by glycosylation processes, by deregulating inflammatory
       | response, by preventing DC maturation, thus resulting in a
       | catastrophic failure of innate and adaptive immunity. Thus host
       | factors have a key role for viral replication and release, and
       | may represent good targets for therapeutic strategies."
       | 
       | The for-profit pharmaceutical system isn't that interested in
       | this, as not many people or governments in Africa have the funds
       | to pay for research, production, and what is it now, a guaranteed
       | 15%+ profit margin?
        
         | Blahah wrote:
         | "right off the bat" is unfortunately apt for ebola!
        
       | [deleted]
        
       | nlitsme wrote:
       | just looking at the graph: why do they expect this to be linear?
       | 
       | Their graph has two lines: (month 0 == december)
       | 
       | - totalcases = 180*month+300
       | 
       | - totaldeaths = 83*month+84
       | 
       | Recent experience with covid shows that usually epidemics
       | initially grow exponentially.
        
         | Closi wrote:
         | You are right - the government analysis looks like garbage
         | IMHO.
         | 
         | The slide shows that they are actually just forecasting (month
         | * 200) cases which is obviously not the way you should do this.
         | The slide also has a bar chart with a line between the bars,
         | which is a stats-bad-smell too (at least shows that whoever
         | pulled this together doesn't understand how to display data).
         | 
         | I know this is a developing nation that won't have the same
         | level of availability of statisticians and epidemiologists, but
         | it's worrying how basic this is.
        
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