[HN Gopher] Emmanuel Mignot wins Breakthrough Prize for discover...
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       Emmanuel Mignot wins Breakthrough Prize for discovering cause of
       narcolepsy
        
       Author : crescit_eundo
       Score  : 32 points
       Date   : 2022-09-23 16:38 UTC (6 hours ago)
        
 (HTM) web link (med.stanford.edu)
 (TXT) w3m dump (med.stanford.edu)
        
       | JoeAltmaier wrote:
       | So, can I take an orexin pill and stay awake? The obvious
       | question, not addressed by the article.
       | 
       | Googling, I see only dire reviews of orexin tablets, usually due
       | to the other ingredients. What gives?
       | 
       | I have episodes of dire fatigue, and a way out of that mess would
       | be very welcome.
        
         | archi42 wrote:
         | Judging only by that article, I'd say: Not generally. Its
         | described as inhibiting REM sleep, not sleep or sleepiness in
         | general.
         | 
         | Ask a doctor to help you figure this out. Wild guess, as a
         | random layperson on the internet with no formal qualification:
         | Could be lack of vitamins (E, D3, B5 or B6) or a melatonin
         | insufficiency or a irregular sleep schedule or due to
         | psychological causes. Alcohol and other drugs have quite the
         | impact (especially in sleep quality). Or a combination or
         | something completely different; it's like asking "My program is
         | slow, what can I do?" ;-)
        
         | googlryas wrote:
         | Probably not, because you already have a functioning orexin
         | system, and presumably whatever modulates that would just
         | module the extra orexin as well. And anyways, who knows if
         | consumed orexin even makes it out of your gut and past the
         | blood-brain barrier.
         | 
         | You could just take modafinil if you wanted to stay awake.
        
       | sorethescore wrote:
       | This helps explain why Cannabidiol may help with excessive
       | sleepiness in hypocretindeficient rats.
       | 
       | https://pubmed.ncbi.nlm.nih.gov/31642794/
        
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       (page generated 2022-09-23 23:00 UTC)