[HN Gopher] High-dose Vitamin B6 reduces anxiety and strengthens...
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High-dose Vitamin B6 reduces anxiety and strengthens visual
surround suppression
Author : bookofjoe
Score : 61 points
Date : 2022-09-01 20:24 UTC (2 hours ago)
(HTM) web link (onlinelibrary.wiley.com)
(TXT) w3m dump (onlinelibrary.wiley.com)
| poglet wrote:
| After doing a Google news search for "high dose vitamin b6" I
| know now I'm going to have either less anxiety or major health
| issues.
| djmips wrote:
| It gives a whole new meaning to "You can rest when you're dead"
| basicplus2 wrote:
| Beware Vitamin B6 Toxicity above 200mg per day
|
| "However, none of the studies had sensory nerve damage at a daily
| intake below 200 mg pyridoxine per day"
|
| Vitamin B6 Toxicity Hemminger A, Wills BK.
|
| https://www.ncbi.nlm.nih.gov/books/NBK554500/
| lxe wrote:
| The participants of study referenced here tool 100mg tablets
| daily for 30-35 days. Before you start popping B6, keep in mind
| that supratherapeutic doses of >500mg pyridoxine have been linked
| to peripheral neuropathy and other CNS issues.
|
| Furthermore, the whole subject of B6/B12 supplementation and
| dosage is muddied by all sorts of facebook groups and self-
| reported anecdotes as well.
|
| I personally would stick to improving my diet rather then
| experimenting with supplements.
| kypro wrote:
| Maybe worth noting there's different kinds of B6 - Pyridoxal 5
| Phosphate and Pyridoxine Hydrochloride and that pyroxidine
| hydrochloride was used here.
|
| PLP has some interesting effects at higher doses such as lowering
| prolactin levels and increasing dopamine, but can also be quite
| toxic when taken at higher doses.
| JamesBarney wrote:
| There is also a supplement called emoxypine which is a b6
| derivative which also is quite potent anxiolytic.
| whiterock wrote:
| The outcome is not very strong is it? I looked at the table where
| they show the depression and anxiety scores. I mean sure I guess
| 52 -> 47 matters statistically - but does it for an individual? I
| doubt it. Also I'd be highly dubious of the opening statement
| that almost everybody is ,,borderline deficient in vitamin B6"...
|
| mhm and also quite funnily: ,, [...] were randomised to receive
| either Vitamin B6, Vitamin B12, or placebo tablets. However, due
| to technical problems that resulted in some missing data and also
| because no single outcome measure was included in all phases of
| data collection the number of participants completing each
| outcome measure was in all cases less than the full sample size."
| JamesBarney wrote:
| That's about the same effect size as the better therapy
| studies. And it's a lot cheaper than meeting with a counselor
| once a month.
| bluedino wrote:
| Vitamin B stores seem to be a big trend here, popping up in malls
| and such.
|
| Surprised the FTC doesn't stop them. Making all kind of claims
| etc.
| candiddevmike wrote:
| YMMV, Vitamin B6 does the opposite for me. Any large amounts of
| it in vitamins gives me crazy anxiety and restlessness.
| andybak wrote:
| _Any_ vitamin?
|
| Considering how diverse they are in mechanism and effect, that
| seems like a rather broad statement.
| astrange wrote:
| Think you misread the comment!
| andybak wrote:
| Yes. I did.
|
| Apologies.
| MisterBastahrd wrote:
| > Any large amounts of it in vitamins
|
| it = B6
| gautamdivgi wrote:
| I would second that. I get dizzy and tingly all over. Weird
| heartbeat mechanism, etc. I take vit-d and fish-oil supplements
| but stay away from regular multivitamins. It just causes my
| system to go all crazy on me.
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