[HN Gopher] Could long Covid be linked to herpes viruses? Early ...
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Could long Covid be linked to herpes viruses? Early data offer a
hint
Author : nope96
Score : 36 points
Date : 2022-08-28 20:38 UTC (2 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| FollowingTheDao wrote:
| Any infection you have will deplete one nutrient or another, and
| if you have a genetic susceptibility, this depletion might be
| much greater than someone else. To correct these nutrition
| depletion to keep these viruses in check, you will need to take
| mega doses of the supplement for a short period.
|
| If you are still one of these people that think zinc does not
| play a role in COVID outcomes I have nothing left to say but: By
| destroying the ACE2 receptor, SARS2 causes a depletion of zinc
| since zinc makes up the structure of ACE2 and prevents the
| recycling of zinc in the cell.
|
| https://www.sciencedirect.com/science/article/pii/S120197122...
|
| https://www.nature.com/articles/s41467-020-18880-0
|
| And hey and guess what. They find that people with zinc
| deficiency have more herpes out breaks!
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283972/
|
| Why? Because the same thing happens with herpes but with NECTIN1
| receptor and ADAM10. Low zinc means less ADAM10 activity and more
| NECTIN1 on the cell and therefor more herepes virus replication.
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906284/
|
| So what might be happening with the low cortisol they speak of in
| the study?
|
| ACE2 is all over the adrenal gland, and when ACE2 is destroyed
| the adrenal gland shuts down and cannot release as much cortisol.
|
| https://www.frontiersin.org/articles/10.3389/fendo.2020.5931...
|
| Now, many of you will come back as show me all the studies that
| reveal that zinc actually reduces cortisol. And I agree, but do
| you know why? When someone is not zinc deficiency, adding more
| zinc will trigger ADAM17 to cleave ACE2 off the cell and create
| Soluble ACE2. Zinc the ACE2 is not on the adrenal gland anymore
| cortisol will not be released.
|
| https://www.mdpi.com/viruses/viruses-12-00491/article_deploy...
|
| But in a zinc deficient state there is not enough ACE2 to start
| with and ADAM17 activity is also low. By taking zinc and
| correcting the deficiency you will increase activity for both
| ACE2 and ADAM17.
|
| If you know someone or if you have long covid, I highly suggest
| that you at least get your serum zinc levels tested.
| DoreenMichele wrote:
| It's probably related to Zinc deficiency caused by covid.
|
| https://pubmed.ncbi.nlm.nih.gov/3897803/#:~:text=Zinc%20ions....
|
| https://news.ycombinator.com/item?id=22845574
| FollowingTheDao wrote:
| Yes, have you seen my comment?
| DoreenMichele wrote:
| This one?
|
| https://news.ycombinator.com/item?id=32632583
|
| The parts I understand make sense. I'm not familiar with some
| of the things you talk about.
| mentalpiracy wrote:
| Just to add anecdata: both myself and partner got our booster in
| early december 2021. Right before christmas, my partner came down
| with covid. I didn't bother to isolate from her because it would
| have been ineffective given our living space.
|
| I never came down with symptoms myself - but 3 weeks later, I
| developed shingles, aka herpes zoster. Do not recommend the
| experience.
| swatcoder wrote:
| Shingles outbreaks are increasingly common for those of us too
| old to have gotten the chickenpox vaccine but still too young
| to receive the shingles vaccine.
|
| It's miserable, and maybe your case was indeed triggered by
| some immune system modulation at the time, but plenty of us
| were having it sneak up on us in the years before too. I
| wouldn't think too much of it as covid-related, _per se_.
| PaulKeeble wrote:
| They have been asking the same question about ME/CFS for decades.
| Either Herpes or Epstein Barr Virus, both of which often get
| reactivated after certain infections. So far anti virals that
| work against Herpes and EBV haven't done much to aid sufferers so
| if they are responsible no known treatments help most people.
| MontyCarloHall wrote:
| > It is common -- affecting anywhere from 5% to 50% of people who
| contract COVID-19
|
| Studies that claim these prevalences either suffer from massive
| selection bias (e.g. only use COVID cases that were severe enough
| to end up in health records [0]) or consider even minor symptoms
| lasting more than a few weeks (like a persistent cough) as "long
| COVID."
|
| Upwards of 80% of the US had been infected with COVID as of June
| 2022 [1]. If serious long-COVID symptoms indeed occurred in 5-50%
| of COVID cases, that would mean 4-40% of Americans are currently
| suffering from debilitating long-term illness, which would be
| obvious on a societal level. We simply do not see this [2].
|
| Do severe long term COVID cases exist? Absolutely, as is the case
| with other infections, like influenza [3]. But they are nowhere
| near as prevalent as otherwise reputable publications claim.
|
| [0] https://arstechnica.com/science/2022/05/more-
| than-1-in-5-cov...
|
| [1]
| https://www.healthdata.org/sites/default/files/files/Project...
|
| [2] https://www.theatlantic.com/health/archive/2022/06/long-
| covi...
|
| [3] https://www.bbc.com/news/health-58726775.amp
| bamboozled wrote:
| Does "long Covid" actually exist, can one get a blood test, scan
| or something like that done to have it diagnosed?
| Isinlor wrote:
| Yes, there are clear biological markers related to reported
| symptoms of Long COVID.
|
| Increases in exhausted immune T cells and lower levels of
| cortisol.
|
| Also, patient reported outcomes alone are sufficient to
| identify Long COVID patients with ~90% accuracy.
|
| https://twitter.com/VirusesImmunity/status/15573941922251571...
|
| https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v...
| SoftTalker wrote:
| vermooten wrote:
| Do you have any data to back this opinion up?
| MontyCarloHall wrote:
| Belief in having had COVID is more strongly associated with
| long COVID symptoms than actually having had COVID, as
| confirmed by antibody tests:
| https://jamanetwork.com/journals/jama/article-
| abstract/27877...
| FollowingTheDao wrote:
| Does the vaccine cause long COVID in some people?
|
| Does people faking having long covid mean that no one has
| long COVID?
|
| Can people have these symptoms from another disorder like
| ME/CFS for EBV infection?
| FollowingTheDao wrote:
| That's what people say about my mental illness as well.
|
| Also, In March I went into a bad psychosis, came out of it
| with Klonopin. The next day I did not feel well, took my temp
| that night; 99. Next day test COVID positive. Today my
| previous poor fatigue is even worse and my mood has been more
| unstable than ever.
|
| I do not thing that me wanting to kill myself after walking a
| mile is something you all experience from time to time so
| shhhhhhhh.....
| squidsoup wrote:
| Long covid, like ME/CFS and fibromyalgia, is not well
| understood - that does not mean that it does not exist, and
| suggesting that it does not is hurtful to the millions of
| people currently suffering with the condition.
| staticassertion wrote:
| I don't think that suggesting that a possible affliction X
| is actually psychological or caused by something else is
| inherently harmful. It could just as easily lead to people
| getting the right treatment.
| qbasic_forever wrote:
| The federal reserve believes it exists and is a big enough
| threat to the labor force (and economy) of the nation that we
| need take action. They released this paper a few weeks ago:
| https://www.federalreserve.gov/econres/notes/feds-notes/long...
|
| It seems pretty serious and real when the real money and power
| institutions in the country are getting concerned.
| pessimizer wrote:
| Covid reactivated my cold sores. I usually get one every year or
| two, can feel it when it's about to happen, and Abreva
| (https://en.wikipedia.org/wiki/1-Docosanol) kills it before it
| even breaks the skin.
|
| During covid I got a vicious one on my lip like I've never had
| before and that Abreva had no effect on, and another awful one
| _in my nose_ which has never happened before. Almost the only bad
| effect of covid that lasted longer than the first day.
|
| Can covid damage some immune subsystem that usually suppresses
| herpes?
| FollowingTheDao wrote:
| COVID infection causes nutrient deficiencies that weaken the
| immune response, yes. Zinc, B6, and few others maybe like
| selenium.
| thewizardofaus wrote:
| Doesn't the herpes virus generally reactivate when the immune
| system is being run down?
|
| I know there is literature to suggest that Cold Sore outbreaks
| in an individual generally occur during cold and flu outbreaks.
| fotta wrote:
| My cold sores will break out after any sort of physical
| stress (excluding exercise). Ironically I get them most often
| after heat exhaustion.
| pessimizer wrote:
| I'm pretty sure that's why they're called cold sores, and
| I've had them happen during flus before, although not during
| the vast majority of them. Nevertheless, I haven't ever had a
| situation like I got with covid, and the actual covid
| symptoms were minor (after the first day, which was a weird
| intense generalized weakness that eventually went away.)
|
| Covid is a cold, anyway. A strong, strange cold.
| i_have_an_idea wrote:
| As a long-time cold sore host, I have figured out several
| things that are true:
|
| 1) Generally _any_ viral infection that runs down my immune
| system can create a cold sore. A flu, a bad cold or covid.
|
| 2) Sometimes just stress and/or being sleep deprived will do
| it, but there usually needs to be at least 3-4 months since the
| last outbreak for that to happen.
|
| 3) You're lucky if Abreva works for you. For me, the creams do
| almost nothing. The only thing that seems to help is
| Valaciclovir oral tablets. If taken early enough, they can
| prevent the outbreak or make it a very small cold sore.
|
| So, in summary, I don't think there's anything special about
| covid with regard to cold sores. It breaks me out about the
| same as any other virus that runs me down / gives me a few days
| of fever.
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