[HN Gopher] Fabimycin and Its Activity against Drug-Resistant Gr...
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Fabimycin and Its Activity against Drug-Resistant Gram-Negative
Pathogens
Author : dsego
Score : 63 points
Date : 2022-08-16 09:07 UTC (13 hours ago)
(HTM) web link (pubs.acs.org)
(TXT) w3m dump (pubs.acs.org)
| wincy wrote:
| Interesting. Could this potentially kill the gram negative
| bacteria such as P. Gingivalis that causes destructive gum
| disease? Seems barbaric (and expensive!) that my dentist says the
| only treatment is to get my gums aggressively scraped every few
| months.
| bilsbie wrote:
| Are there any beneficial oral gram negative bacteria though?
| bmau5 wrote:
| It could! We need to invest in developing better treatments for
| oral pathogens like P. gingivalis. Gum disease is way too
| pervasive (over half of US adults have it), and yet we still
| treat it mechanically with manual cleanings. Moving towards
| using targeted therapies and rebalancing the oral microbiome is
| a much more effective (and ultimately affordable!) path
| forward. My company is focused on helping people improve their
| oral microbiome health, so developments like this are super
| exciting.
| wincy wrote:
| Oh yeah I keep seeing you around on dental threads and
| considered getting the test but I'm not really sure what
| action would be taken after knowing what's in my mouth? Like
| I'm pretty sure I just have destructive gum disease and need
| a scraping every three months forever, what comes after
| getting the test? What do I do with that knowledge?
| bmau5 wrote:
| Great question! There are a number of steps you can take
| beyond cleanings, some of which will depend on your current
| oral microbiome (which we'll provide coaching on once you
| get your results). We recommend a comprehensive approach,
| which includes certain products, diet, and lifestyle
| interventions to help reduce the levels of pathogenic
| bacteria and promote beneficial species (which are a
| natural defense against the pathogens!). Here are some
| resources on diet [1] + probiotics [2] to help get started
| in the meantime, though:
|
| [1] Diet: https://www.bristlehealth.com/post/improve-your-
| oral-microbi...
|
| [2] Probiotics: https://www.bristlehealth.com/post/a-guide-
| to-oral-probiotic...
| kurikuri wrote:
| Your company's information is interesting, but the large
| majority of non ADA/AMA health-forward businesses give me
| doubt. One of the reasons for this doubt that shows up in
| your [2] post is the lack of citations for the claims.
|
| It isn't that I distrust the writing (it seems convincing
| to me, the author does have a research degree and
| provides more credibility in my opinion), but what would
| push the belief home is citations for the
| studies/experiments which show the testable claims your
| company makes are not incorrect.
|
| While I can spend time looking up the information, life
| is too short and I'm likely to not do so and instead
| ignore it until a regulatory body checks it all out.
| bmau5 wrote:
| Thanks for taking the time to point this out! We will add
| more citations in the beginning sections, as I realized
| some of our links didn't come through. Most citations
| begin after the "S. salivarius and bad breath
| (halitosis)" section, but our blog formatting just shows
| them as bolded text links. We will make this more clear
| as well. Thanks again!
| pfdietz wrote:
| A MIC of 2 micrograms/mL is not great (penicillin is an order of
| magnitude lower), but I guess one has to walk before one runs.
| rex_lupi wrote:
| TL;DR: new antibiotic candidate effective against gram-negative
| bacterias, which are generally resistant against most antibiotics
| because of their thick cell walls and efflux pumps, which in
| combination prevents absorption of antibiotics in their cell.
| Favimycin shows promising results against common resistant
| strains of bacterias, including E.coli, further unlike other
| broad-spectrum antibiotics, this one doesn't affect the gut
| microbiome much. Current challanges include overcoming low
| stability in blood plasma and toxicity.
| csdvrx wrote:
| > TL;DR: new antibiotic candidate effective against gram-
| negative bacterias, which are generally resistant against most
| antibiotics because of their thick cell walls and efflux pumps
|
| Aren't mycins something very well known and not novel at all?
|
| I see them listed in
| https://en.wikipedia.org/wiki/List_of_antibiotics along with a
| link to https://en.wikipedia.org/wiki/Aminoglycoside that
| explain they work against gram-negative bacterias
| flobosg wrote:
| "Mycin" is a suffix used in antibiotics, but does not
| represent a specific category anymore. If you look at the
| structure of fabimycin you will see that it does not resemble
| an aminoglycoside at all.
| John23832 wrote:
| There are many bacteria that are developing resistance (or
| are totally resistant) to some mycins (macrolides,
| particularly azithromycin). Gonorrhea being a HUGE one.
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