[HN Gopher] Moderna says Omicron-containing booster outperforms ...
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       Moderna says Omicron-containing booster outperforms current vaccine
        
       Author : gmays
       Score  : 16 points
       Date   : 2022-06-09 18:06 UTC (4 hours ago)
        
 (HTM) web link (www.statnews.com)
 (TXT) w3m dump (www.statnews.com)
        
       | netsharc wrote:
       | Geezus christ, what a terrible title, "Omicron-containing"?!?!
        
         | Vecr wrote:
         | Probably means the "NIH spike" updated with Omicron genes (or
         | parts of them? I don't know for sure.) The "NIH spike" is
         | "full-length ... pre-fusion stabilised conformation variant
         | (K986P and V987P) of the SARS-CoV-2 (severe acute respiratory
         | syndrome 2, GenBank: MN908947.3) spike (S) glycoprotein"
         | according to the WHO. It is used by all current US vaccines,
         | including NovaVax. I know Pfizer does other things to the "NIH
         | spike" gene, including codon optimization, flanking 5 and 3
         | prime untranslated regions, 3 prime poly(A) tail, with all
         | uridine replaced with N1-methylpseudouridine. They also have
         | the secret lipid nanoparticle formulation, that not even the
         | FDA advisors know about.
        
           | sn0wf1re wrote:
           | Sure, but why not "Omicron-aware" or something less alarmist?
        
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       (page generated 2022-06-09 23:02 UTC)