[HN Gopher] Vitamin D and Depression (2020)
___________________________________________________________________
Vitamin D and Depression (2020)
Author : pmoriarty
Score : 147 points
Date : 2022-05-08 17:34 UTC (5 hours ago)
(HTM) web link (www.ncbi.nlm.nih.gov)
(TXT) w3m dump (www.ncbi.nlm.nih.gov)
| [deleted]
| jokoon wrote:
| I recently wondered if bad dental hygiene can increase or cause
| more depression.
|
| Since oral hygiene can cause bad stuff in the stomach, maybe it
| can also lead to bad stuff in the digestive system...
| jghefner wrote:
| Vitamin D supplementation didn't affect my depression. Going for
| walks to get more sunlight made it worse.
|
| I understand that not everything works for everyone and I wish
| those around me, including my doctor, did as well so they'd stop
| blaming me when their "cure" doesn't work on me.
| pcurve wrote:
| Would you mind sharing in what ways going for walks made it
| worse for you?
| jamal-kumar wrote:
| If going out and walking in the sun made it worse I can only
| imagine where you live must be pretty depressing.
|
| Portland?
| jghefner wrote:
| This is what I'm talking about. The idea that "going for a
| walk and getting sunlight is good for depression" is so
| universally unchallengable that I must live somewhere
| terrible if it doesn't work for me.
| chasebank wrote:
| Book a two week long float down the middle fork of the
| Salmon river and let me know how you feel after.
| jamal-kumar wrote:
| Yeah, I don't know anyone happy there.
|
| In before excuses - Leave
| resfirestar wrote:
| There can be underlying anxiety issues that make going out
| like that quite a stressful event, especially at first, and
| even traumatic if something bad does end up happening. Or
| sensory processing issues associated with autism spectrum
| disorders that make bright sunlight feel unpleasant. Not to
| downplay the general idea: certainly for most people who feel
| a little blue, or even crappy enough for long enough to
| qualify for a diagnosis of major depression, getting out more
| is likely to be helpful on its own (and that's why therapists
| generally recommend it). But to the GP's point, the lack of
| distinction between people with a more ordinary (but quite
| painful!) set of problems and people with a bunch of
| comorbidities that they're likely not aware of is really
| frustrating, especially if they're using the internet to look
| for ideas and find a bunch of people generalizing the easy
| fix that cured their depression to the entire population.
| docmechanic wrote:
| Off topic, but perhaps of interest to anyone dealing with
| depression. Twenty five years or so ago, someone recommended that
| I try St. John's Wort. I had a negative reaction - bad skin rash
| - but the Mayo Clinic mentions that some studies show it "can be
| effective for treating mild to moderate depression."
|
| https://www.mayoclinic.org/drugs-supplements-st-johns-wort/a...
| lordentropy wrote:
| Daily morning and afternoon exposure to bright light might
| actually be more important to reducing depression than direct
| vitamin D supplementation. Low vitamin D might just be an
| indicator that you are not getting enough sunlight. Sunlight also
| affects melatonin and serotonin levels, and synchronizes your
| Circadian rhythm. Not sure why that article doesn't talk about
| Seasonal affective disorder (SAD), and how bright light therapy
| is considered an effective treatment for it.
| kingcharles wrote:
| I just went over 8 years without seeing the sun (jail). I
| wonder what the long term effects are?
| adfjalkfja wrote:
| Had a consult with a sleep doctor, he stressed the importance
| of getting out for morning light for at least 30 minutes with
| no sunglasses.
| juve1996 wrote:
| Anecdotally agree with this. I have vitamin D deficiency, was
| given 50,000 IU a week vitamin D to get it up. Never worked.
|
| Went to the beach one week and got blood tested again and my
| vitamin D levels climbed significantly. Now I make it a point
| to get outside and sunlight
| treeman79 wrote:
| Had super low Vit D. Was stuck in bed for a year. A few
| months of Vit D and a few other diet and supplements changes
| and I was out kayaking every weekend.
|
| My experience anyway
| donthellbanme wrote:
| The heaviest man in Mexico was bedridden for years. He was
| depressed, but besides being humongous, and trapped in a
| bed; one of his biggest complains was muscle aches.
|
| A doctor gave him vitamin D supplements and he said the
| pain went away.
|
| It made a bit of sence to me, but the amount of food this
| guy consumed daily was staggering. I just wouldn't think a
| person would be deficient in D with the amount of animal
| products this man consumed. I just assumed even though he
| never saw the light of day for 15 years.
|
| My point is it just suprised me.
|
| Antidotially, I have been depressed (dysthymia--low level)
| for a good 30 years, and found sunlight didn't help me. I
| don't eat a lot, but i'm not a vegetarian either.
|
| I actually feel better during the winter. I do have
| allergies though.
|
| According to my doctor, all he ever said about depression
| is "All my patients are different. Oh, my fee will be
| $----. Your depression is situational.". I know he is
| partially right. (He doesn't overcharge me compared to the
| horror stories I have heard here. I just believe most
| psychotropic drugs should not require more one office
| visit, especially if you are on a low dose, and not abusing
| them.)
| interactivecode wrote:
| What dose and diet changes did you do?
| treeman79 wrote:
| 3,000u daily. Switched to AIP diet.
|
| Six months earlier had started. Started magnesium, b12,
| fish oil, Vit E.
|
| Now I take a 5000u/k2 combo.
|
| Now on LDN in addition That seems to be the final major
| piece to fully normal life.
| csdreamer7 wrote:
| > was given 50,000 IU a week vitamin D to get it up.
|
| It should have gone up significantly. I wonder if your body
| has a problem with Vit D absorption. I was put on the same
| dose of vit d for a treatment and I felt it within 20
| minutes.
| chrisco255 wrote:
| Is vitamin D fat soluble? If so, pretty sure it needs to be
| consumed with fat. That's partly why it's common in milk.
| Jtsummers wrote:
| It is fat soluble, but it doesn't _need_ to be consumed
| with fat. It 's believed that that will help improve
| uptake, though. (I don't, I take it in the mornings long
| before my first meal and that seems to be effective for
| me based on my test results.)
| chrisco255 wrote:
| https://www.jandonline.org/article/S2212-2672%2814%290146
| 8-3...
|
| "The mean peak (12-hour) plasma vitamin D-3 level after
| the dose was 32% (95% CI 11% to 52%) greater in subjects
| consuming fat-containing compared with fat-free meals
| (P=0.003)."
| nanidin wrote:
| It's common in milk because it helps with calcium
| absorption.
| trompetenaccoun wrote:
| A lot of modern "problems" can be solved this way. The term
| _koyaanisqatsi_ comes to mind, life out of balance.
| geoduck14 wrote:
| >Went to the beach one week and got blood tested again and my
| vitamin D levels climbed significantly.
|
| Well, I think I just justified my beach vacation. Thanks!
| hammock wrote:
| The point was that sunlight does more than raise vitamin D,
| not that it's better than supplementation at raising vitamin
| D.
| annamargot wrote:
| Latitude matters though. The farther north you are the more
| time in the sun you'd need. In some far north places, the sun
| you do get is not strong enough to get any Vit D.
|
| http://web.archive.org/web/20210302053343/https://jaoa.org/a...
|
| https://www.grassrootshealth.net/document/sunshine-calendar/
| thinkingemote wrote:
| Indeed, the UK which is further north than the majority of
| Canada's population has effective vitamin D from the Sun only
| from March to September. Spring Equinox to autumn equinox
| basically. The sun is too low even though it might be much
| warmer than lower latitudes!
| noneeeed wrote:
| Yurp. I live in the south of England and even here I take
| vit D for pretty much that time period or I end up with
| little to no energy. I always make sure to go outside as
| much as I can, but when the sun is coming up at 8am and has
| gone down by 6pm it's pretty hard to get enough daylight
| and also work.
| AnthonBerg wrote:
| Sunlight's effects on body chemistry also have a damping effect
| on inflammation. It's a funny thing.
|
| Sunlight has an impact on many chemical processes in and on the
| body. One example: Our skin is coated with a bunch of
| chemicals. There's a number of different acidic chemicals.
| These are known as the "acid mantle":
| https://en.wikipedia.org/wiki/Acid_mantle
|
| One of these substances is _urocanic acid_. The body
| manufactures it as the trans-isoform. UV light - as in sunlight
| - causes it to change into _cis-_ urocanic acid. (Ultraviolet-
| induced isomerization.)
|
| Cis-urocanic acid fits a certain serotonin receptor - type
| 5-HT2A. Cis-urocanic acid is a 5-HT2A agonist. That receptor is
| known to be profoundly immunomodulatory.
|
| It's super interesting! There are some recent papers on it like
| " Cis-urocanic acid, a sunlight-induced immunosuppressive
| factor, activates immune suppression via the 5-HT2A receptor" -
| https://pubmed.ncbi.nlm.nih.gov/17085585/
|
| "Molecular basis for cis-urocanic acid as a 5-HT2A receptor
| agonist" -
| https://www.sciencedirect.com/science/article/pii/S0960894X0...
|
| This is absolutely fascinating. I think people take me as a
| crackpot when I point to these papers. These are just simple
| and solid papers from molecular biology :)
| honkdaddy wrote:
| > That receptor is known to be profoundly immunomodulatory
|
| Any change for a layman's explanation on what that means?
| This seems super fascinating but admittedly above my
| understanding.
| lisper wrote:
| immunomodulatory (immuno-modulatory) = modulates (i.e.
| controls) the immune system
| supertofu wrote:
| Anecdata: I grew up in LA. I was always relatively healthy.
| Moved to NYC. Developed autoimmune disease by my 6th year in
| NYC.
|
| I often wonder if I would have developed the disease if I had
| stayed in LA.
| pram wrote:
| I think changing location does have a huge effect.
| Personally when I go to LA or SF (from Texas) I get sick
| 100% of the time, without fail.
| Tijdreiziger wrote:
| For some reason I was often sick when I lived in
| Stockholm (Sweden). A friend there mentioned having the
| same problem.
| nradov wrote:
| Sunlight exposure also stimulates nitric oxide production,
| which is important for circulatory system health.
| desro wrote:
| Thank you for this fascinating comment! I can't wait to read
| through all of your links.
| gabereiser wrote:
| You, sir, just blew my mind. I have some reading material to
| go through. This is fascinating indeed!!
| BiteCode_dev wrote:
| And yet lots of dermatologists will tell you to avoid
| sunlight.
|
| The medical community is full of contradictions.
| 2muchcoffeeman wrote:
| Until recently not going out much wasn't a big factor.
|
| I've been feeling sicker than usual lately. Stupid amount
| of rain in NSW. Went out yesterday morning on a bright
| sunny day and suddenly I felt much better.
| herodoturtle wrote:
| Everything in moderation.
|
| EDIT: Except lava.
| BiteCode_dev wrote:
| At first I read "except Java"
| blep_ wrote:
| Lowercase L looks like capital i in some fonts.
|
| Clearly it's Iava, the Latin word for Java. Quidquid Iava
| quondam scribum, omni currum, sed delenda est.
| _Algernon_ wrote:
| Still true
| SnowHill9902 wrote:
| It's actually quite reasonable and intuitive that an integral
| part of our environment i.e. the sun is beneficial or at
| least has modulatory effects on ourselves. It's too much a
| reductionist approach to think sunlight -> bad because of
| it's immediate associations with some types of skin cancers.
| anoplus wrote:
| I am thinking the same, and in a midst of self experiment where
| I ensure I get a decent dose of just seeing the world in bright
| daylight. Week into it and my sleep feels pretty solid. Easy to
| avoid daylight when working indoors all day.
| jollybean wrote:
| Came here to say this:
|
| VD may be it, or even indirectly a measure of 'not getting
| outside' enough.
|
| Even the sunlight may not be it, literally a walk in the woods
| might be providing the effect.
|
| Or rather 'spending too much time in our own minds' etc..
| digisign wrote:
| Bright, direct light seems to be a major component, which is
| not what most people think of being in the "woods." See:
|
| https://news.ycombinator.com/item?id=31306477
| ahmedfromtunis wrote:
| Maybe the relation is not as direct as we might think at first.
|
| Maybe the vitamin D deficiency is keeping people from going out
| more, which makes them feel isolated, not engaged fully with
| their friends and family which, in turn, pushes them to
| depression if they're prone to it.
|
| And that may explain why it seems that, as the writers of this
| paper mentioned, when some of the subjects get vitamin D the
| depression goes away. This can be caused by the effect of the
| intake on their ability to gain their more active way of life.
| jimhefferon wrote:
| I live pretty far north. For months at a time here there is
| basically no sunlight. Sometimes people try to sell you
| artificial light of one kind or another. Do they work?
| SapporoChris wrote:
| Some UV lamps have been shown to help the body make Vitamin D.
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846322/
|
| I would recommend checking to see if you're actually getting
| low Vitamin D level during the winter and talk to a doctor to
| get their opinion on best treatment.
| drited wrote:
| My understanding is that 10000 lux bulbs are accepted treatment
| for SAD. I live in a dull country and bought one despite not
| suffering from SAD. Anecdotally I find it great to help wake up
| in the dark winter mornings.
| tkiolp4 wrote:
| I'm from Portugal. I've been living in Germany for 3 years. Last
| winter I was feeling very tired when walking, even dizzy. Doctor
| said I got very low levels of vitamin D. I never felt depressed,
| though.
| [deleted]
| SirensOfTitan wrote:
| Interestingly the fix to my seasonal affective disorder was a
| move a couple years ago into an apartment with no blinds and tons
| of sun in the morning (our previous place had black out blinds).
| We never got to adding blinds, and we have no intention to at
| this point--I wake up with sunrise naturally nowadays around 6am
| and haven't had SAD since.
|
| I'm of the impression that black out blinds are generally poor
| for sleep hygiene (unless you're in a really bright place and
| they're a necessity), as they disrupt some of the most natural
| and most potent zeitgebers available. That isn't to say that a
| knowledgeable and enterprising person couldn't employ black out
| blinds when crafting their sleep environment, but most people
| won't balance the different influencing factors thoughtfully.
| ta988 wrote:
| Depends, they can hide streetlight too which can be disturbing
| sleep pretty intensely...
| hirundo wrote:
| I'm a remote worker. After an early morning standup I go outside
| and do yardwork in a big yard for a half hour to an hour,
| whenever I can. This is a pleasure that I've come to defend
| fiercely. When I sit back down at the keyboard my improved
| attitude and energy are such that I believe I make up that time
| in productivity before lunch. Don't know how much of that benefit
| is from increased vitamin D, from the forest bath, or from the
| exercise oxygenating my neurons. I doubt I could replace it with
| a pill.
| ralusek wrote:
| Sunlight and gardening have had such a dramatic impact on the way
| that I feel, it's unbelievable.
| alleskleber wrote:
| For me sunlight and some light exercise everyday were a game
| changer. I had tried Vitamin D supplements (1000 IU daily)
| before but there was barely any noticable effect.
| floppydiskette wrote:
| I don't think that's enough, I needed 5k daily before it
| started working. My blood tests all come back in the correct
| range now.
| k__ wrote:
| Good to know.
|
| I was diagnosed with low VitD and they said I should take
| like 1k-2k, but I didn't feel much.
| stjohnswarts wrote:
| 1000 is actually way below what you need probably, my doc put
| me on 2500 a day and it wasn't enough, I've moved to 5000 and
| been "normal" level ever since for several years for my
| annual checkout/blood/urine tests. If you have brown/black
| skin it can be even more, but better to start low and figure
| out what is enough under observation of a doctor.
| throckmortra wrote:
| My first winter in NYC was very rough and I didn't understand why
| at first. I got a blood test at the doc and he said my vitamin D
| was very low. I committed to walking in the sun at least a half
| hour a day, weather permitting, and I never really had issues
| again. Part of the issue was I was spending a lot of time walking
| outside but not in sunlight due to the tall buildings. Just my
| anecdotal 2c
| tayo42 wrote:
| I finally got a chance to move south and this was the first
| winter I didn't spend being weird and existential about
| everything. Just kind of enjoyed life.
| carabiner wrote:
| I live in Seattle and have been depressed for a while. I had my
| Vitamin D3 levels checked via blood test, and they were really
| low. Started taking 5,000 IU per day, and I feel exactly the
| same as before.
| numinoid wrote:
| Anecdotally, I had to bump up to 10,000 IU to see a
| difference.
| olah_1 wrote:
| I have never felt an affect from oral vitamins in _any_
| situation.
|
| Sitting in the sun however seems to do more than just
| "increase vitamin d levels". The sensation is just
| overwhelmingly lovely. It seems to reduce cortisol, makes you
| feel tired in a euphoric way. Animals love to warm their fur
| in shafts of sunlight too.
|
| Perhaps we should be thinking more in terms of joyful
| activities in general and less trying to biohack.
| AlbertCory wrote:
| > Animals love to warm their fur in shafts of sunlight too.
|
| Indeed. My dog _always_ lies in the sun for a while when he
| goes outside. Once he 's warm enough, he moves to the
| shade. Animals know.
| supertofu wrote:
| My blind cat always seeks sun spots as well!
| __ryan__ wrote:
| That narrative might work for you, but the bio-hack
| narrative might work for others.
|
| Maybe the takeaway is to go into things with a positive
| attitude but also take a personal inventory and adapt if
| something that is _supposed_ to work doesn't work for you.
| DoreenMichele wrote:
| Seattle is extremely damp and temperate, so you see a lot of
| mold and allergens there year round.
|
| If redressing your vitamin D levels doesn't fix it, look for
| hidden mold and/or allergies.
| TameAntelope wrote:
| 5k IUs is well beyond anything your body has a use for, and
| in fact is above what your body can tolerate! [0]
|
| > RDA: The Recommended Dietary Allowance for adults 19 years
| and older is 600 IU daily for men and women, and for adults
| >70 years it is 800 IU daily.
|
| > UL: The Tolerable Upper Intake Level is the maximum daily
| intake unlikely to cause harmful effects on health. The UL
| for vitamin D for adults and children ages 9+ is 4,000 IU.
|
| So it's possible your 5k IUs were causing you more harm than
| good.
|
| [0] https://www.hsph.harvard.edu/nutritionsource/vitamin-d/
| mikenew wrote:
| Those numbers are wrong by an order of magnitude, because
| the original estimation was based on faulty math. The
| actual dose needed to bring serum levels up for most people
| would be far higher.
|
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210929/
| TameAntelope wrote:
| I'm going to go ahead and trust Harvard Medicine over a
| single study that has since gone largely uncited, and was
| published in "Nutrients" which carries an h-index of 115
| (Nature, for example, carries an h-index of 1226) [0][1].
|
| [0] https://www.scimagojr.com/journalsearch.php?q=1970018
| 8323&ti...
|
| [1] https://www.scimagojr.com/journalsearch.php?q=21206&t
| ip=sid&...
| wholien wrote:
| Highly doubt 5k IUs is the issue. Some select quotes from
| "Vitamin D Is Not as Toxic as Was Once Thought: A
| Historical and an Up-to-Date Perspective" by Michael Holick
| in Mayo Clinic Proceedings [0]:
|
| > Ekwaru et al recently reported on more than 17,000
| healthy adult volunteers participating in a preventative
| health program and taking varying doses of vitamin D up to
| 20,000 IU/d. These patients did not demonstrate any
| toxicity, and the blood level of 25(OH)D in those taking
| even 20,000 IU/d was less than 100 ng/mL.
|
| > The evidence is clear that vitamin D toxicity is one of
| the rarest medical conditions and is typically due to
| intentional or inadvertent intake of extremely high doses
| of vitamin D (usually in the range of >50,000-100,000 IU/d
| for months to years).
|
| [0]: Holick, https://www.mayoclinicproceedings.org/article/
| S0025-6196(15)...
|
| [1]: Ekwaru et al,
| https://pubmed.ncbi.nlm.nih.gov/25372709/
| TameAntelope wrote:
| [0] is an editorial and [1] seemingly went unpublished,
| other than in PLOS One, which means it goes through a
| _very_ different peer review process than most other
| journals (that is, no peer review on its content, only on
| its methodology).
| nicoburns wrote:
| That assumes your body is absorbing all of it. I suspect a
| lot of people's aren't, hence the high doses. I have found
| for example that 1000iu in the form of drops under the
| tongue has dramatically more effect than 1000iu in the form
| of a chewable tablet.
| mupuff1234 wrote:
| Did you do another blood test to check if the levels changed?
| Trasmatta wrote:
| Since you're in Seattle, check out bright light therapy as
| well.
| civilized wrote:
| In this and the GP we have Vitamin D and depression in a
| nutshell.
| carabiner wrote:
| To answer a bunch of questions: Yes, I had bloodwork done
| later showing my D3 level in the typical range. Whether that
| was due to the supplement, or diet, or lifestyle I can't say.
| I take 1 pill (USP certified) on average 2-3x per week. So
| not every day.
|
| I've got treatment resistant depression and have tried
| probably everything else you're about to suggest. The only
| thing that kind of helped was dihydrotestosterone, but that
| is now illegal in the US.
| laurentlbm wrote:
| I have TRD too and tried so many things. It sucks.
| trts wrote:
| Also in Seattle, also recovered from treatment resistant
| depression. I recommend looking into TMS. I wish I had done
| it much sooner.
|
| Wish you luck, it's been an especially gloomy year here.
| carabiner wrote:
| Tried it through Neurostim in Bellevue. Didn't work.
| Waiting for the Stanford SAINT protocol to be approved.
| trash3 wrote:
| Check your diet. Just because you take vitamin d supplements
| doesn't mean it gets absorbed into your bloodstream.
| xwowsersx wrote:
| did you get blood work done again though after taking the 5K
| IUs for a while? it's possible that the supplementation
| didn't bring your Vit D levels to within range and you need
| 10K IUs+. Of course, I'm not suggesting this would
| necessarily help with your depression, but just pointing that
| you gotta be scientific/anecdotal when it comes to
| supplementation/blood panels
| femiagbabiaka wrote:
| 10k IU's a day is what it took me. I found that value almost
| by accident, while starting to follow Stan Efferding's
| Vertical Diet, which recommends that as a part of a suite of
| daily vitamins (it is much better than the name belies). IMO
| anyone who works a desk job should take 10k IU's daily. I
| fell out of the habit during covid quarantine and my levels
| (and my mood) were dangerously low when I came out on the
| other side.
| tomatowurst wrote:
| 5000 IU is really too much. At best 2000, 2500 IU is good.
| dralley wrote:
| 5000 isn't too much when you're catching up from a
| deficiency.
| Vecr wrote:
| No, 5000 IU per day is generally considered the highest non
| megadose. Make sure it is good quality (D3, USP in the US),
| and it should be fine. Some people say also to take K2
| (also make sure it's USP in the US), but I'm not sure the
| exact supposed mechanism of protection from adverse effects
| from D3. Something about preventing calcium from leaching
| from the bones and accumulating in the blood, I think.
| pmoriarty wrote:
| _" Vitamin D controls the absorption of calcium into the
| blood. Vitamin K2 controls where that calcium ends up._
|
| _" Over-supplementation of vitamin D3 without ample
| vitamin K2 leads to problems of excess calcium._
|
| _" If calcium isn't laid into bone, it will find itself
| in other tissues, like your arteries. Calcium in the
| arteries is BAD. It contributes to atherosclerosis and
| vessel stiffness."_
|
| https://dralexrinehart.com/articles/the-vitamin-d-and-
| vitami...
| LinuxBender wrote:
| I use 60,000 to 90,000 IU's per day and have been doing so
| for years. The most I have taken in a 24 hour period is
| 140,000 IU's. There is no way I could have started off at
| those levels however. It would have induced major
| hypercalcemia had I done that prior to mobilizing all the
| stored/misplaced calcium in my gut and vasculature. I am
| not suggesting anyone else do this. One must have a
| specific need when doing this.
|
| I only mention this to say that one can go well above the
| RDA/RDI that are highly contested to be far too low for
| modern diets, environmental inputs and lifestyles.
| TameAntelope wrote:
| > Taking 60,000 international units (IU) a day of vitamin
| D for several months has been shown to cause toxicity.
| This level is many times higher than the U.S. Recommended
| Dietary Allowance (RDA) for most adults of 600 IU of
| vitamin D a day. [0]
|
| I think you may be poisoning yourself.
|
| [0] https://www.mayoclinic.org/healthy-
| lifestyle/nutrition-and-h...
| LinuxBender wrote:
| That would certainly be true had I done that from day one
| as I had mentioned. Their documentation as with most
| medical documentation is based on the lowest common
| denominators. They will not risk explaining why one might
| do what I am doing.
| TameAntelope wrote:
| It seems true without qualification.
|
| What you're saying here has a lot in common with "woo", I
| hope you realize.
| LinuxBender wrote:
| I suppose time will tell. I've been doing this a number
| of years. I will check back in a few more years to see
| how things are going. Honestly the cholecalciferol levels
| are the least taboo of the biohacking I do with myself.
| The more risky testing I did was to see how high I could
| go on the tocotrienols, tocopherols and fibrinolytic
| enzymes before I ran into bleeding.
| TameAntelope wrote:
| Aren't you concerned that your data is super subjective
| as you're collecting it on yourself?
|
| It sounds like there are a _ton_ of confounding variables
| possible, not to mention your own personal biases in
| interpreting any potential causality.
| stjohnswarts wrote:
| That's a crazy amount. I had a very low blood test
| started supplementing with k2/5000 vitamin d several
| years ago and my blood levels have been fine ever since.
| mountainriver wrote:
| It really depends on the person. You just need to monitor
| your blood levels
| cashsterling wrote:
| It can take a while for your Vit-D levels to rise, even with
| supplementing 5k IU per day... I would check your levels
| again.
|
| And, of course, Vit-D is not the only contributor to
| depression so it might be good to see a GP and/or get a
| general blood panel done.
| KennyBlanken wrote:
| In the northeast during wintertime, it's impossible to
| accumulate enough vitamin D from sunlight, especially not from
| such a short period of time, fully clothed.
|
| Even if you were not fully clothed, there's so little UV making
| to you because of the sun's low angle and distance.
| pigtailgirl wrote:
| wildly speculating from an evolutionary perspective - it
| reasons that we'd evolve such that our moods are better in
| light - otherwise there would be another push to stagnate vs
| become exposed to more - such that evolution can do it's thing
| - evolution tends towards evolution after all -
| legulere wrote:
| > Overall findings were that there is a relationship between
| vitamin D and depression, though the directionality of this
| association remains unclear.
|
| Vitamin D really seems to be a good example of correlation does
| not imply causation. I'm looking forward to when the Vitamin D
| hype ebbs off and when we know what Vitamin D actually helps
| with.
| legopeice wrote:
| In Norlisk, Russia, the children get doses of Ultra voilet light
| to combat the lack of sunlight.
|
| https://allthatsinteresting.com/norilsk#8
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