[HN Gopher] On Longevity
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       On Longevity
        
       Author : kevin_hu
       Score  : 21 points
       Date   : 2022-05-02 19:08 UTC (3 hours ago)
        
 (HTM) web link (eriktorenberg.substack.com)
 (TXT) w3m dump (eriktorenberg.substack.com)
        
       | biguanide wrote:
       | Perhaps the most promising anti-aging drug is metformin.
       | 
       | Type 2 diabetics on metformin live 15% longer than non-diabetics.
       | This is remarkable, considering how big a health disadvantage
       | diabetes itself is.
       | 
       | Metformin seems to mimic fasting somehow, by interfering with
       | mitochondrial function.
       | 
       | For more information, I refer you to David Sinclair's numerous
       | discussions on this topic. He takes 1 gram of metformin per day,
       | with his evening meal.
       | 
       | This is not medical advice.
        
         | gorkempacaci wrote:
         | Recently I'd seen this on Metformin:
         | https://www.science.org/content/article/rare-genital-defects...
        
         | SemanticStrengh wrote:
         | It's not.. I could have shown you the most potent
         | geroprotectors but tragically the website is down...
         | https://geroprotectors.org/
         | 
         | You should look into SkQ1 + NAC instead.
        
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