[HN Gopher] Covid spike protein induces cognitive deficit and an...
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Covid spike protein induces cognitive deficit and anxiety-like
behavior in mice
Author : IdEntities
Score : 46 points
Date : 2022-04-03 21:46 UTC (1 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| Traubenfuchs wrote:
| Does the same happen to humans?
|
| Does that kind of damage heal in the majority of humans?
|
| How long does healing usually take?
| Gatsky wrote:
| > Eight-week-old mice were used for the spike protein injections.
| S1 protein was purchased from Acrobiosystems (Cat #S1N-C52H4,
| Newark, DE, USA), and used after polymixin B (Cat #P1004, Sigma-
| Aldrich, St. Louis, MO, USA) treatment (30 ug/ml). The animals
| were anesthetized with isoflurane, and the injection paths were
| drilled into their skulls. Then, 5 ug of S1 protein (1 ug/ul)
| were bilaterally injected into each hippocampal region using a
| Hamilton syringe (Cat #80330, Hamilton Company, Reno, NV, USA)
| attached to a syringe pump (Cat #53311, Stoelting Co., Wood Dale,
| IL, USA) at a constant volume of 0.5 ul/min.
|
| I think we can all agree that injecting huge amounts of viral
| protein into your brain is not recommended.
|
| This study did not include a control group which received non-
| spike protein viral antigens (from say influenza which is also
| known to cause neurocognitive problems). As such it does not
| prove any specific neurotoxic effect of Covid19. The mechanistic
| studies in the paper suggest it is non-specific inflammation
| which causes neuronal cell death.
| civilized wrote:
| Reminds me of the study that said long COVID symptoms were
| strongest in people who thought they had COVID but never actually
| got it.
|
| Some areas of science experience a lot of swirl. Eggs are good
| for you on Tuesday and bad for you on Thursday.
| foolfoolz wrote:
| something like 80%+ covid deaths were co-morbid with obesity.
| this idea that everyone is susceptible to long covid or
| permanent outcomes is garbage
| thanatos519 wrote:
| Over here, too! I feel like I've had a lobotomy and even after
| the other symptoms were gone, I have been sleeping an extra 6h a
| day. I feel like I need a little nap and wake up 3h later.
| codezero wrote:
| We still have a lot to learn from this plague.
| hkt wrote:
| I too have become a nap fiend since a bout with covid last
| year. I can't get through a working day without one now. (I do
| extend the day afterwards, if anyone is wondering)
| 0des wrote:
| I also noticed my needs for sleep went up
| Traubenfuchs wrote:
| > I feel like I've had a lobotomy
|
| I have been feeling like this for years. But I do know there
| was a time where I didn't feel like that. I wonder if anxiety,
| an unknown past (viral?) illness, past medication
| (Isotretinoin, SSRI?) or something else is at fault.
| treeman79 wrote:
| Consider looking at autoimmune if you have weird issues. Took
| me 20 years of vague symptoms to get diagnosed.
| thenerdhead wrote:
| It took me a little over a year to feel back to normal. That's
| cognitive function and reduced anxiety. It introduced depression
| and anxiety to my life that I never had prior. I've had to learn
| to cope with this and sought solutions every new day. What helped
| me most was exercise, little to no mainstream news or social
| media, and getting clearer on my purpose of life. It was a very
| rough 14 months, but I got through it and feel back to normal.
| ren_engineer wrote:
| how much of this could be attributed to the world events
| surrounding Covid and basically correlation vs causation? There
| have been studies that the majority of people claiming "long
| covid" when tested have never actually been infected. Most of
| the symptoms described could be depression due to being locked
| in your home and your normal lifestyle disrupted for nearly 3
| years now. Plus general anxiety from the negativity of the news
| in general creating constant doom and gloom
|
| even this study is somewhat suspect to me, they injected spike
| protein directly into the mouse's brain rather than using a
| natural infection. There's only a single study saying Covid can
| cross the blood brain barrier, so I'm not sure this methodology
| translates to real world infection
| pydry wrote:
| My first thought as well. I never caught covid but social
| isolation definitely induced anxiety and cognitive deficit in
| me.
| fffobar wrote:
| What if it was caused by both?
|
| I'm in your shoes, and pondering this very question.
| encoderer wrote:
| I used to think long covid was total bullshit. Now here I am
| with tinnitus for 3 months after a pretty mild case. Probably
| it's best just to trust people about their own experience, if
| this pandemic has shown us anything it's that nobody knows
| anything. No masks! Wait, wear masks! Surfaces are the
| problem! Nevermind on surfaces! Close playgrounds! Wait,
| outdoors is where we should be! -- and all this from the
| professionals.
| thenerdhead wrote:
| I used to think the same way as you until I got it pre-
| vaccine. When you get it and there's no treatment available,
| you glue yourself into the current events for hope. Yes all
| of this begets more anxiety because of all of the
| misinformation and disinformation out in the world. I had to
| shut up the world and do my own thing to recover.
|
| For what it's worth I had antibodies doing a blood test
| multiple months after suspected infection.
| sjmm1989 wrote:
| You people acting toxic are the fucking worst. I hope you all
| catch the supervirus about to hit the world after you all fuck up
| yet again for yet another wave of covid.
|
| Fuck you.
| superkuh wrote:
| It's a bit of paranoia. This isn't about mRNA vaccines. This is
| about massive viral load and protein production for days due to
| infection and direct infection of the brain tissues by sars-
| cov-2. "neurotoxic effects in COVID-19 patients." to quote
| them.
| sjmm1989 wrote:
| Well, I still felt a bunch of anxiety, and shit was foggy for
| the first month or so.
|
| So forgive me for being a little quick to take the jump on
| this one. Seems pretty apt quite frankly.
| superkuh wrote:
| I don't mean to be rude, but it's about as apt as
| homeopathy in terms of dilution when comparing what was
| tested here (and is possible by infection) and a couple
| tens of micrograms of transiently expressed mRNA in your
| muscle tissues. And no, the potential for mis-splices
| leading to soluble spike protein like what happened in a
| tiny subset of the adenovirus DNA vaccines is not there.
| IdEntities wrote:
| Do you have a link to any research papers demonstrating
| "direct infection of brain tissues by SARS-CoV-2"? The last
| and most compelling evidence I saw on this was a study where
| about 50 cadavers from people who had recently died from
| aggressive COVID infections (with symptoms of anosmia) were
| examined, and they found no evidence of the virus infecting
| neurological tissues.
|
| There is at least some evidence that spike protein may
| circulate in exosomes for up to four months after
| vaccination, although whether any of this would be likely to
| cross the blood-brain barrier, I don't know:
| https://pubmed.ncbi.nlm.nih.gov/34654691/
| BoredTurtle wrote:
| andybak wrote:
| Just to throw in a data point: 2 doses of AZ and one of Pfizer
| and I feel fine. (well - just the normal cognitive decline :) )
| sjmm1989 wrote:
| Interesting. Thanks.
|
| I don't think I truly lost anything cognitively. I think I
| may have restored most of any loss that happened. But... I
| also forced my body to do a niacin flush and other things
| like that. Not recommending it. Just adding on what I was
| doing.
| manwe150 wrote:
| Unless they injected the shot into your hippocampus like the
| research article (which would be most irregular), the brain-
| blood barrier probably kept it out?
| sjmm1989 wrote:
| Probably correct, but I still felt very similar effects to
| what is described. Or so I think.
|
| So... what am I supposed to say? Nothing? Fuck that.
| manuelabeledo wrote:
| The paper clearly states that mice were injected the full spike
| protein, not mRNA, nor only the bit of the protein generated
| after the vaccine is administrated.
|
| What you are describing is completely unrelated.
|
| > Anyways. Omega 3 helped me.
|
| Helped you on what?
| jdc wrote:
| It certainly does make wonder what would happen if they did
| inject an mRNA vaccine, though.
| sjmm1989 wrote:
| It is spike protein after all...
|
| Forgive my mistake folks. I did say I'm not a doctor
| afterall...
| sjmm1989 wrote:
| Get rid of the anxiety feeling, and my headaches subsided
| almost immediately.
| tonymet wrote:
| better late than never i guess .
| andybak wrote:
| There's such a range of bizarre opinions and hot takes about
| anything Covid related that it's impossible to even guess what
| point you're trying to make.
| mckirk wrote:
| He's had a lifelong feud with the lab mouse population and is
| happy about every blow we can deal to them.
| JaimeThompson wrote:
| Having read Hitchhikers Guide to the Galaxy I am not sure I
| would ever be against mice.
| treeman79 wrote:
| New alert. Research causes cancer. In mice.
| emerged wrote:
| Our entire family was sick and it crushed us for 2-3 weeks. This
| description sounds like it applies to us too. I take anxiety
| medicine and it's like it completely stopped working. Yet none of
| us tested positive for COVID.
|
| I don't know what that means. It could mean we had COVID but the
| tests were wrong. It could mean we didn't have COVID but the flu
| has similar impact.
|
| Just have no idea what to think about anything anymore.
| Traubenfuchs wrote:
| What about the proteins the mrna and vector vaccines turn your
| cells into factories for, at various locations in your body, for
| a various amount of time?
|
| Is there a difference?
| simondotau wrote:
| The vaccine is a measured, limited, non-self-replicating dose
| of spike protein RNA which your cells fold into spike protein.
| Nearly all of it ends up in the lymph nodes near your armpit,
| where your immune system learns how to destroy it (and then
| does).
|
| A COVID infection is a self-replicating, theoretically
| unlimited dose of spike protein RNA which your cells fold into
| spike protein. If you're lucky, it'll mostly affect your
| respiratory system. But if your immune system can't respond
| quickly enough, it will spread and replicate all over your
| body.
| The_rationalist wrote:
| Nearly all of it ends up in the lymph nodes near your armpit
|
| Source needed.
| scubadude wrote:
| Thank you for such a clear and succinct explanation!
| [deleted]
| netizen-936824 wrote:
| That's the spike protein
| WithinReason wrote:
| The title refers to the spike protein
| realreality wrote:
| There's one important difference: _not_ everybody who 's
| exposed to SARS-CoV2 will become infected and replicate a large
| amount of viral proteins. But everybody injected with mRNA will
| become a spike protein factory.
| vkou wrote:
| It's the same thing, the main difference is that those cells
| only work that way for a few days, while with an infection,
| they work that way until the infection clears.
| flenserboy wrote:
| And that's part of why it's best to stay as far away from this
| virus and its nasty little bits as possible, no matter its method
| of entering the body.
| rubyist5eva wrote:
| Unless you go live on a deserted island somewhere or dee in the
| woods away from civilization for the next 50 years that's not
| realistic at all.
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(page generated 2022-04-03 23:01 UTC)