[HN Gopher] Nasal spray treats Delta variant infection in mice
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Nasal spray treats Delta variant infection in mice
Author : geox
Score : 88 points
Date : 2022-03-28 17:08 UTC (5 hours ago)
(HTM) web link (science.ubc.ca)
(TXT) w3m dump (science.ubc.ca)
| hotcrossbunny wrote:
| Can I say this really is great news for mice
| viralresearch wrote:
| londons_explore wrote:
| I'm wondering under what conditions this will be used if it makes
| it to humans...
|
| If it needs to be used within 12 hours of exposure, and 1 in 16
| people is currently infected [1], then any day you visit a place
| with more than ~16 people, you have more than likely been
| exposed, and ought to be taking this medication. Even if you just
| meet _one_ other person each day, then after 16 days
| statistically you 'll probably have been exposed.
|
| So I guess this nasal spray should be taken every day you leave
| the house?
|
| [1]:
| https://www.ons.gov.uk/peoplepopulationandcommunity/healthan...
| [deleted]
| maxerickson wrote:
| If it was effective and widely used the percent infected could
| be a lot lower.
| geraneum wrote:
| There are privacy preserving tracking applications (i.e.
| Corona-Warn in Germany, etc.) that can tell you if you had a
| longer significant exposure. Maybe that's helpful. The caveat
| is that not everyone uses the app but I think it might still be
| helpful.
| blumomo wrote:
| Curious to know, how does the app measure/decide if the
| exposure was "significant"? And what is "exposure" in that
| context? Curious to learn!
| _Microft wrote:
| Have fun: https://github.com/corona-warn-app
| TrispusAttucks wrote:
| Seems similar to the Diluted Povidone Iodine Nasal Spray [1]
| promoted by Dr. McCullough for awhile now. Unfortunately Povidone
| is available OTC for cheap so not very profitable.
|
| [1] https://covid19.onedaymd.com/2021/09/could-simple-saline-
| nas...
| amluto wrote:
| In what way? The spray in question contains a TMPRSS2
| inhibitor. It seems similar to povidone iodine the way that
| penicillin is similar to bleach.
| TrispusAttucks wrote:
| It's a nasal spray for preventing and treating covid.
| PostOnce wrote:
| For any readers who might be caught off guard, Peter McCullough
| has been on a notorious press circuit talking every quack
| medicine theory under the sun; I'm not sure if he's after
| infamy, money, or both, but what he is not after is public
| health.
|
| He's affiliated with
| https://en.wikipedia.org/wiki/Association_of_American_Physic...
| which is a political--not medical--organization.
|
| He was sued by Baylor for claiming an affiliation he didn't
| have.
|
| https://en.wikipedia.org/wiki/Peter_A._McCullough#COVID-19_m...
|
| https://en.wikipedia.org/wiki/Association_of_American_Physic...
|
| I've been sent links to his videos by colleagues (who, aside
| from the covid-19 conspiracies, seem like smart people), so I
| looked into everything that was wrong with this guy 6 months
| ago.
|
| Anyway, he's full of shit, don't take it from me, just go
| digging before you appeal to his authority.
| TrispusAttucks wrote:
| Yikes.
|
| I see him get shit on a lot but what exactly did he say or do
| that was so wrong? Some of his original "fringe" ideas are
| now supported by science. Like having the audacity to say
| nature immunity is a thing.
| pezo1919 wrote:
| www.c19early.com has iota-carrageenan on top of the list and is
| used nasally too.
| nonomaybeyes wrote:
| I've used the diluted povidon-iodine solution (Betadine) with
| great success for myself. Not as a spray but as a gargle and
| nasal rinse with a neti pot. This was during the delta wave and
| I had a sore throat and 39.5C fever. The rinsing pricked in a
| good way for a few minutes and then subsided, at which point
| all viruses seem to be quite dead. Next morning I was
| completely better.
|
| I do this for the the flu as well. It starts in the nose and
| throat and if treated early it won't make it's way down into
| the lungs.
| mikeyouse wrote:
| It also has ivermectin, melatonin and fennel flower near the
| top... I'd get my medical advice elsewhere.
| trhway wrote:
| from my understanding the virus continue to exist in the cells of
| the nasal surfaces well after (like weeks) the immune system has
| already beaten it up inside the body. That virus naturally
| continues to attack the body from those surfaces and thus
| continuously triggers the immune system resulting in that low-
| symptom prolonged period in the people with normally working
| immune system.
| BiggsHoson wrote:
| "So how was work today?" "Well, I got to grab mice and force
| inhaler sprays into their tiny little nostrils against their
| wills." "Sounds better than my day."
| jaynetics wrote:
| "All ten of the treated mice survived infection, compared with
| only 20 per cent of the untreated mice. [...] The compound has
| the potential to be used as a broad-spectrum treatment against
| other viruses which use the same mechanism [...] including
| influenza viruses such as influenza A, H1N1, and influenza C."
|
| But apparently it is most effective very soon after exposure.
| From the paper [1]:
|
| "in the K18-hACE2 mouse model, treating with N-0385 resulted in
| complete protection against SARS-CoV-2 induced mortality and
| significantly protected against weight loss, lung pathology, and
| viral infection when treatment occurred at the time of, or 12
| hours after, infection with the SARS-CoV-2 B.1.617.2"
|
| [1] https://www.nature.com/articles/s41586-022-04661-w
| Tagbert wrote:
| Glad to see "in mice" spelled out in the title. Too often it is
| an unstated condition in early tests like this.
| dheera wrote:
| Often it's because it wouldn't make the front page otherwise.
| In general, society has democratically agreed to upvote
| clickbait and downvote accuracy, but glad to see that isn't the
| case here.
| freedomben wrote:
| I don't disagree, but I'd more specifically say "society has
| democratically agreed to upvote news they want to hear and
| downvote news they don't, with little to no
| concern/consideration for how accurate or true it is."
|
| HN community is among the better at this IMHO, but it still
| happens here quite a bit true. The good news is, over the
| course of a few hours to a day or so it usually
| balances/corrects itself and ends up in a good state, but
| sometimes not before true but hard truth comments are killed
| and resurrected by vouches.
|
| As I think about it, maybe the correlation is more with
| reaction time? The rapid downvotes tend to early and often,
| so it could be that people who vote on feelings are also the
| ones to react very quickly? Interesting to think about
| [deleted]
| jchw wrote:
| A more charitable explanation: the title length limit of 80
| characters makes it difficult to keep all of the important
| information in the HN title.
|
| No doubt that news publications absolutely do sometimes
| intentionally bury the lede and leave important information
| out of the _original_ title, but I don't think HN users are
| all optimizing just to hit the frontpage.
| dheera wrote:
| Could we just post gzipped titles and distribute a plugin
| to overcome the limitation? This is _hacker_ news after
| all.
| cbhl wrote:
| Pretty sure the entire page is already served with
| Content-Encoding: gzip.
|
| An 80 character limit is great for scanning by humans,
| though.
| dheera wrote:
| Yeah but this is less about actual transfer efficiency
| and more about novel ways to overcome the limits of what
| is allowed to be submitted.
| version_five wrote:
| What kind of overhead does gzip have? I'd be interested
| to know how many characters you could fit into 80
| compressed characters. Some mapping of (2 byte?) unicode
| characters to 3ish lowercase letters could be effective.
| Is there any standard way like that?
| dheera wrote:
| This is an interesting question. I haven't researched the
| overheads.
|
| Separately, I feel like if you account for grammatical
| rules, it is possible to eliminate certain "filler" words
| in a lossy fashion but add them back later based on
| grammatical rules. For example, you don't need to say "in
| mice", you could just say "mice", the meaning is obvious,
| and "in" could be fixed in post-processing at the client
| end.
|
| You could also quite possibly eliminate all vowels and
| still reconstruct everything accurately.
| version_five wrote:
| > For example, you don't need to say "in mice", you could
| just say "mice", the meaning is obvious, and "in" could
| be fixed in post-processing at the client end.
|
| > You could also quite possibly eliminate all vowels and
| still reconstruct everything accurately.
|
| My guess is that 10 minutes after that is rolled out,
| someone will have found a collision that decompresses to
| some kind of dirty joke
| jazzyjackson wrote:
| There's base2048 [0], which can cram 11 bits into each
| code point, or 110 bytes into 80 characters.
|
| [0] https://github.com/qntm/base2048
| doubtfuluser wrote:
| A new one for https://twitter.com/justsaysinmice
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(page generated 2022-03-28 23:02 UTC)