[HN Gopher] How the Gut Differentiates Artificial Sweeteners fro...
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       How the Gut Differentiates Artificial Sweeteners from Sugars
        
       Author : pseudolus
       Score  : 12 points
       Date   : 2022-01-23 19:59 UTC (3 hours ago)
        
 (HTM) web link (www.the-scientist.com)
 (TXT) w3m dump (www.the-scientist.com)
        
       | incrudible wrote:
       | > Animals and humans prefer sugar over artificial sweeteners in
       | experiments, and that could be because a specific gut sensor
       | cell...
       | 
       | I have an alternative hypothesis: It is because sugar tastes
       | better. In your mouth, on your tongue. Evolutionarily, this could
       | be explained by sugar _not_ being a calorically worthless
       | synthetic compound that happens to taste sweet and may act as a
       | laxative.
        
       | blakesterz wrote:
       | Is is often the case... [in mice]
       | 
       | The team anesthetized mice, perfused sucrose or sucralose
       | directly into their guts, and then analyzed the response of
       | neurons that make up the vagus nerve using calcium imaging. On
       | average, 40.7 percent responded to sucrose only, 22.2 percent to
       | sucralose only, and the remainder to neither stimulus, explaining
       | how the vagus nerve is able to react differently to the two
       | substances.
        
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       (page generated 2022-01-23 23:01 UTC)