[HN Gopher] Derek Lowe: Omicron Update (Dec 17)
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       Derek Lowe: Omicron Update (Dec 17)
        
       Author : herodotus
       Score  : 71 points
       Date   : 2021-12-19 17:56 UTC (5 hours ago)
        
 (HTM) web link (www.science.org)
 (TXT) w3m dump (www.science.org)
        
       | kevinmchugh wrote:
       | A minor point in here corrected a misconception I didn't realize
       | I held:
       | 
       | > T-cell mechanisms are also crucial, and T-cell data are much
       | harder to come by. Since you don't see the number of papers in
       | that area as you do for antibody profiling, it easy to think that
       | they don't matter as much, but that's not true.
        
         | ethbr0 wrote:
         | I'd be really interested to hear someone in microbiology opine
         | on the difficulties in measuring T-cell and other non-antibody
         | data? What makes it so much harder?
        
           | VeninVidiaVicii wrote:
           | You're probably looking for an immunologist.
        
           | rossdavidh wrote:
           | Not the expert you're looking for, but I recall a past Derek
           | Lowe article mentioned in passing that it was much more
           | labor-intensive (presumably by a trained lab tech) to get
           | T-cell data. Again, this is just my memory of a past Derek
           | Lowe article, which I might be misremembering.
        
           | KaiserPro wrote:
           | There are mechanisms for t-cell testing in reasonably wide
           | use now. from what I understand its not done that much
           | comparatively is because its bloody expensive.
           | 
           | I think one of the mechanisms is here: https://en.wikipedia.o
           | rg/wiki/ELISpothttps://en.wikipedia.or...
           | 
           | However I would take all of this with a pinch of salt. I
           | asked my doctor friend about it, they said "We use t-cell
           | tests for a bunch of things, but its really expensive. I
           | can't remember what thing we were looking for, probably TB,
           | everyone had TB in that ward, so it might be that."
        
       | thatsamonad wrote:
       | One thing I'm curious about and on which I haven't been able to
       | find any good data/information is whether the drop in vaccine
       | efficacy is a function of time since last dose (i.e. due to
       | waning over time) or whether the third dose drives up total
       | antibody or T-cell activity and/or broadens the immune response
       | which leads to it being more effective against Omicron.
       | 
       | My spouse and I have both had boosters but my child has only had
       | two doses because they only recently authorized use for children
       | ages 5-11. I think my spouse and I are fairly well protected but
       | it's uncertain if my child is well protected or not given the
       | timing of everything.
        
         | jlokier wrote:
         | No scientific data unfortunately, but this BBC article explains
         | that even though it's the same substance each time, the effect
         | develops further over multiple doses, and goes on to describe
         | what that means using metaphors.
         | 
         | BBC News - Omicron: Why do boosters work if two doses struggle?
         | https://www.bbc.co.uk/news/health-59639973
         | 
         | Excerpt:
         | 
         | "Fortunately for us - while the contents of the syringe may be
         | identical, a booster is not just more of the same for the
         | immune system.
         | 
         | The protection you're left with after the third dose is bigger,
         | broader and more memorable than you had before."
        
         | SkyPuncher wrote:
         | We have a 1 year old. We try to avoid intentional exposure, but
         | the knowledge I have indicates COVID is no more of a threat for
         | children than many other viruses. Flu, RSV, etc all have
         | similar risk profiles in young kids. As such, we approach COVID
         | the same way we approach many other things.
         | 
         | Wash hands, avoid known sick people, monitor conditions, avoid
         | known bad situations.
         | 
         | We are avoid daycare facilities for now since that would
         | introduce a many-to-many situation where an outbreak is
         | inevitable.
        
         | johnisgood wrote:
         | I am not updated on this, but is COVID-19 much of a concern
         | when it comes to your child, especially after having received
         | two vaccines already?
        
           | Loic wrote:
           | 3 boys at home, all with a COVID-19 infection last December.
           | The one already after the puberty got long COVID, the one "in
           | the start of puberty" had only mild long COVID and the
           | youngest one (7) was asymptomatic.
           | 
           | Some friends noticed also this puberty "cut". But
           | statistically, I cannot tell if this is significant or not,
           | because you never have the information "12 good in puberty"
           | or "11 no signs of puberty yet".
        
           | thatsamonad wrote:
           | Fair question. My general understanding is that the risk is
           | very low for children, especially when it comes to severe
           | disease and/or death (though there are still some questions
           | about long-term effects), and even more so now that they have
           | been fully vaccinated with two doses.
           | 
           | I'm mostly just curious if we'll see booster recommendations
           | for children as we have for adults and if the efficacy impact
           | of Omicron is due to time or something inherent to the two-
           | dose vs three-dose mechanisms at play.
           | 
           | And generally as a parent I'd prefer to see my child not get
           | sick at all, though I know that's basically unavoidable. That
           | being said, I like to understand what the risks involved are
           | if possible.
        
             | [deleted]
        
           | pygy_ wrote:
           | I'm in a similar position: I've had three mRNA doses,
           | vaccines here may start to be available to my children next
           | week
           | 
           | I wouldn't want them to be the weak link, but having them
           | partially immunized during a delta/omicron peak may be sub-
           | optimal...
           | 
           | Any data/analysis on the subject would be welcome
        
       | johnisgood wrote:
       | > South Africa is the furthest along in the Omicron world, from
       | what we can see, and although their cases have rocketed up, their
       | rates for hospitalization and death have only been a fraction of
       | what was seen in the earlier waves.
       | 
       | That is pretty good though, all things considered. Spreads fast,
       | but is mild enough. If the next variant is going to be even
       | better in this regard, we should be happy. It may, given enough
       | people catch this variant with mild symptoms and develop
       | immunity. Maybe we should re-think the strategies involving
       | restrictions and vaccination.
        
         | [deleted]
        
         | mdp2021 wrote:
         | > _given enough people catch this variant_
         | 
         | Please see the point Derek Lowe makes in the first article, of
         | Dec 2 (point which I have abridged in this page): cases of mild
         | immune response which let the virus dwell for a long time in
         | the organism can be the proper places for a virus to develop
         | mutations.
         | 
         | Also, the paragraph closing this article of Dec 17: that the
         | main future mutations will be of high contagiousness and low
         | impact is a non granted possibility.
        
           | johnisgood wrote:
           | Yeah, fair enough. I mean, after all, mutations are random,
           | it can get worse.
        
           | 2-718-281-828 wrote:
           | > cases of mild immune response which let the virus dwell for
           | a long time in the organism can be the proper places for a
           | virus to develop mutations.
           | 
           | that's practically irrelevant or you'd have to demand
           | lockdowns for any virus and its uncle because they all mutate
           | all the time. is that what you want?
        
         | Zababa wrote:
         | I'd really like to see an analysis comparing covid to the flu.
         | There's the vaccine and omicron making it less deadly than
         | before, but I have no idea by how much.
        
         | TheSocialAndrew wrote:
         | If the mutations continue, at some point the mortality rate
         | will likely meet the mortality rate of the seasonal flu.
         | Hopefully we can then compare COVID to the season flu on any
         | large media outlet / platform without being canceled, so that
         | we can accept it as such and not rework our lives a dozen times
         | a year around restrictions.
        
           | GDC7 wrote:
           | > Hopefully we can then compare COVID to the season flu on
           | any large media outlet
           | 
           | It will never happen, humans take more and more to recover
           | from traumatic events and people who claim that it's time to
           | put the traumatic event behind our back and go on with our
           | lives are singled out as irresponsible .
           | 
           | See the 2008 financial crisis, we are still doing QE, Fed
           | balance sheet would never go back to normal , we have scam
           | companies worth hundreds of billions and perhaps the most
           | scammy one just went above a trillion in financial value with
           | no real tangible product presence in a market in which
           | commands a 1% presence.
        
             | saila wrote:
             | I guess it depends on the person, but this doesn't square
             | with what I see, and I live in what's considered a very
             | liberal area with relatively strict mandates. People are
             | going to bars & clubs, eating out, holiday shopping, etc.
             | Even people who are being more cautious right now are
             | itching to get out and do stuff. I think we'll recover just
             | fine.
        
           | dnautics wrote:
           | > likely meet the mortality rate of the seasonal flu
           | 
           | We should consider the possiblity that _we are already there_
           | with omicron.
        
           | 1shooner wrote:
           | I thought the pushback on the comparison to flu was the
           | conclusion that's intended to draw. The 2018 flu outbreak
           | hospitalized approximately 710,000 Americans[0]. Public
           | health professionals generally thing flu should have more
           | public attention, so saying we should be unconcerned because
           | now we have another disease as impactful as flu, I can see
           | them objecting.
           | 
           | 0. https://www.cdc.gov/flu/about/burden/index.html
        
           | gentleman11 wrote:
           | There is no guarantee of that at all. Many diseases get worse
           | over time
           | 
           | https://www.politifact.com/factchecks/2021/dec/08/facebook-p.
           | ..
        
           | mkolodny wrote:
           | According to the CDC, the flu caused 12,000-52,000 deaths a
           | year in the US between 2010-2020 [0]. While covid caused more
           | than 800,000 deaths in the US over the past two years, and
           | more than 36,000 US deaths over the past month alone [1]. At
           | this point, covid is still orders of magnitude deadlier than
           | the flu.
           | 
           | [0] https://www.cdc.gov/flu/about/burden/index.html [1]
           | https://covid.cdc.gov/covid-data-tracker/#trends_totaldeaths
        
             | wk_end wrote:
             | ...it's 12k-50k _per year_. So just ("just") one order of
             | magnitude or so.
        
             | ipspam wrote:
             | Can't compare apples and oranges. For flu seasons, regular
             | classification applies. For pandemics, all persons that die
             | with Covid are Covid deaths.
             | 
             | Apples and oranges.
        
               | 2-718-281-828 wrote:
               | is this also a thing in the states? in germany even
               | people who died from accidents but have tested positive
               | for covid (either pre or post mortem) are counted as died
               | from corona - not kidding.
               | 
               | - https://www.zdf.de/nachrichten/panorama/corona-tote-
               | rki-stat...
               | 
               | - https://www.heise.de/tp/features/Wer-zaehlt-als-Corona-
               | Toter...
        
         | ugjka wrote:
         | If only we had endless medical capacity for those who will not
         | have it "mild"
        
           | johnisgood wrote:
           | Well, it is better than the mild ones not having it mild
           | either, but worse.
        
         | matthewmacleod wrote:
         | I think it's _really_ important to stress that while it is
         | obviously great to see fewer people in hospital, that alone
         | doesn 't tell us very much about the severity of the variant,
         | or the expected outcome in other countries.
         | 
         | We would already expect the number of hospitalisations second
         | wave to be way lower, because of the effect of higher levels of
         | immunity through vaccines and previous infection versus the
         | first wave. The Discovery Health research from South Africa [1]
         | suggests that Omicron might result in about 30% fewer
         | hospitalisations versus an equivalent Delta infection, but it's
         | still early days and it's hard to get clear data given the
         | number of confounding factors. The early research from Imperial
         | in the UK [2] says:
         | 
         | "The study finds no evidence of Omicron having lower severity
         | than Delta, judged by either the proportion of people testing
         | positive who report symptoms, or by the proportion of cases
         | seeking hospital care after infection." with the notable
         | qualification that "hospitalisation data remains very limited
         | at this time."
         | 
         | Even if it's substantially less severe, it does seem certain
         | from the way it's ripping through the UK at the moment that it
         | spreads extremely quickly - and even with a lower chance of
         | hospitalisation, we could quickly see a very large spike in the
         | number of people requiring care, with the corresponding stress
         | on already overstretched healthcare.
         | 
         | I'm definitely a bit concerned about the amount of "it's
         | basically just a cold now!" chat we've been seeing - something
         | we'd all like to be the case because pandemics are shite. But
         | anecdotally I have witnessed first-hand quite a few people I
         | know here in the UK being pretty blase in the run up to
         | Christmas and getting quite sick as a result.
         | 
         | [1] https://www.discovery.co.za/corporate/news-
         | room#/pressreleas...
         | 
         | [2] https://www.imperial.ac.uk/news/232698/modelling-suggests-
         | ra...
        
         | gentleman11 wrote:
         | > And notably, the virus that causes COVID-19 is most
         | transmissible before symptoms set in, so its harmfulness to its
         | host may not be as strong an influence on how it evolves as the
         | trade-off model suggests.
         | 
         | > "The virus, speaking anthropomorphically, just wants to
         | spread and have its genes replicated," said Dr. Amesh Adalja,
         | an infectious disease specialist at Johns Hopkins University,
         | in an interview. "If the best way for it is to spread by
         | causing severe symptoms, it will continue to do that."
         | 
         | https://www.politifact.com/factchecks/2021/dec/08/facebook-p...
        
           | Barrin92 wrote:
           | not sure I understand the reasoning here because the
           | behavioral response to covid at a collective level will
           | always depend on the harmfulness of the disease regardless of
           | when symptoms set in.
           | 
           | We are going to take stronger measures against harmful
           | diseases, and that reduces their fitness inevitably. The
           | claim that a disease _always_ evolves towards being more
           | harmless is obviously not true due to mere chance, but in the
           | long run there is a clear advantage to it. Rather than
           | cherry-picking examples to prove the point I think it 's more
           | accurate to say the article cherry-picks counterexamples like
           | multiple Malaria strands competing against each other in the
           | same host or a rabbit disease that became more deadly to
           | overcome an immune response. None of which is long-term
           | adaptive.
        
         | k__ wrote:
         | As far as I know, mild cases are only confirmed for vaxxed
         | people.
        
           | juanani wrote:
           | Interesting, you must not know far.
        
           | gentleman11 wrote:
           | Did you find any statistics saying that?
        
           | wk_end wrote:
           | SA was only around 20% vaxxed when the omicron wave started
           | and everyone with boots on the ground there seems to be
           | saying it's milder.
        
             | k__ wrote:
             | Could be.
             | 
             | I also heard SA has a much younger population than most
             | western countries, so "mild" should be used with caution.
        
           | johnisgood wrote:
           | I wonder about, say, how non-vaccinated 16-25 years old
           | people are affected by Omicron vs. Delta.
        
       | soperj wrote:
       | Where were all the people saying "I told you so" about viruses
       | getting milder over time when Delta came around?
        
       | mdp2021 wrote:
       | > _A team in Hong Kong has announced that in their cell assays
       | the Omicron variant seems to reproduce up to 70 times faster in
       | the upper respiratory tract, while at the same time being much
       | slower to reproduce in lung tissue_
       | 
       | > _What About Immune Evasion? How Much Protection Do Vaccines
       | Provide? This part of the story isn 't completely worked out
       | yet... Most of that [information] is antibody-based data, and ...
       | while this is important, it is not the last word on real-world
       | immune protection[: ]T-cell mechanisms are also crucial, and
       | T-cell data are much harder to come by_
       | 
       | > _the Pfizer protease inhibitor ... does appear to be just as
       | effective against Omicron, but its supply will not be enough to
       | make any real difference at all in the coming weeks_
       | 
       | From the "introduction" of Dec 2:
       | 
       | > _Where Did It Come From? Omicron ... is not a direct descendant
       | of the Delta strains ... An immediate hypothesis was that Omicron
       | may have developed in a single immunocompromised human patient
       | over a period of weeks or months[: ... y]ou don 't just
       | immediately kill everything off - you give the virus or bacterium
       | a chance to overcome a lesser challenge before turning up the
       | pressure a bit more, letting mutations accumulate and try their
       | worth over and over as the challenge slowly increases. That's
       | just what's going on inside a coronavirus patient if they can't
       | mount a full immune response. The virus and the immune system
       | engage in a prolonged battle where neither one can land a
       | decisive blow, and things just keep on evolving. This is why they
       | tell you to take your full course of antibiotics when you have a
       | bacterial infection, and why effective vaccines actually suppress
       | variant formation: if you kill off the pathogens as quickly as
       | possible, they don't have time to explore their mutational
       | landscape_
        
         | loeg wrote:
         | > the Pfizer protease inhibitor ... supply will not be enough
         | to make any real difference at all in the coming weeks
         | 
         | Tautalogically so in the US, anyway, where the FDA has
         | inexplicably still has not approved (or emergency authorized)
         | it for use.
        
           | tempnow987 wrote:
           | For those following - these treatments are 40 pill
           | treatments. For the 50M odd cases we've had we'd need 40*50M
           | pills (2 billion pills).
           | 
           | Assume a daily global rate of around 600K cases per day we'd
           | need 24M pills per day.
           | 
           | USA alone is perhaps 100K cases, so 4M pills per day. Do they
           | really have this volume ready to go?
           | 
           | --
           | 
           | I'm not aware of a single study showing that for vaccinated
           | folks the pills do anything. Not saying they don't, but it
           | would be helpful to have ONE study.
           | 
           | --
           | 
           | As to why the FDA has not approved, they are reasonably
           | clear. One issue is that COVID, and particularly omicron
           | variant which dominates, is just not that lethal.
           | 
           | EDIT: This part is incorrect below
           | 
           | These pills work in interesting ways, ie, generating MORE
           | mutations.
           | 
           | b-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal
           | Mutagenesis But Is Also Mutagenic To Mammalian Cells
           | https://pubmed.ncbi.nlm.nih.gov/33961695/
           | 
           | So before you jam 2 billion doses into folks there is going
           | to be a bit of an evaluation.
           | 
           | If Omicron turns out to have high fatality rates then I
           | suspect things like these therapies will be fast tracked a
           | bit more.
        
             | tguvot wrote:
             | you describing here merck treatment, not pfizers
        
             | loeg wrote:
             | > For those following - these treatments are 40 pill
             | treatments.
             | 
             | > These pills work in interesting ways, ie, generating MORE
             | mutations.
             | 
             | > b-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal
             | Mutagenesis But Is Also Mutagenic To Mammalian Cells
             | https://pubmed.ncbi.nlm.nih.gov/33961695/
             | 
             | You're way off-base. You're talking about Merck's
             | Molnupiravir (Lagevrio), which is both _less effective_
             | (~30% vs ~88%) and _already approved_.
             | 
             | Pfizer's Paxlovid (Nirmatrelvir) is not mutagenic.
             | 
             | It is a 15 pill course (5 days x 3 per day), not 40.
             | 
             | Also, Pfizer thinks as of Nov 29 that they can make 80M
             | _courses_ by EOY. The US has purchased at least 10M of
             | them.
        
           | rossdavidh wrote:
           | On one level I agree, but realistically I think they may not
           | feel much of a hurry to do so since there isn't a significant
           | supply ready to distribute. My understanding is that they
           | already have authorization to use whatever they have,
           | essentially as additional testing.
        
             | loeg wrote:
             | As of Nov 29,
             | 
             | > Pfizer now expects to make 80 million courses of COVID
             | drug Paxlovid by the end of 2022
             | 
             | That's a ton of supply!
        
           | mcguire wrote:
           | Has Pfizer submitted the clinical trial data to the FDA? The
           | last I heard (a week ago?) was that they were going to do it
           | "in a few days".
        
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       (page generated 2021-12-19 23:02 UTC)