[HN Gopher] Alpha Fold promises to revolutionize biochemistry
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Alpha Fold promises to revolutionize biochemistry
Author : evo_9
Score : 10 points
Date : 2021-12-17 18:06 UTC (2 days ago)
(HTM) web link (medium.com)
(TXT) w3m dump (medium.com)
| sillysaurusx wrote:
| https://12ft.io/proxy?q=https%3A%2F%2Fmedium.com%2Fpredict%2...
| COGlory wrote:
| Alphafold is interesting, but not a particularly big deal. It's
| just better homology modeling at the end of the day, and the
| difference between 60% and 90% is a lot less critical than the
| difference between 90% and 100%. Those I have talked to in
| pharmaceuticals are entirely unwilling to stake billion dollar
| projects on it.
| sillysaurusx wrote:
| "billion dollar projects" is telling. Work like this helps
| reduce the cost. I think you're underestimating the impact, and
| that in a decade or so it'll become clear that research like
| this laid the foundation for breakthroughs we then enjoy.
| Rochus wrote:
| And it is trained for a bias towards crystal structures.
| KarlKemp wrote:
| That 'just' is doing a lot of work in the sentence, considering
| protein structure was/is often named as the "holy grail" of
| computational biology, and homology was always the method to
| get there.
|
| I'm equally skeptical of the claim that this follows the 80/20
| (or 90/10) rule. If you use straightforward measurements (rmsd
| etc), reality may well be 10 % off considering these aren't
| static structures, but molecules in perpetual chaotic motion on
| several scales.
| [deleted]
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