[HN Gopher] Guillain-Barre Syndrome After Covid-19 Vaccination i...
___________________________________________________________________
Guillain-Barre Syndrome After Covid-19 Vaccination in US Vaccine
Safety Datalink [pdf]
Author : walterbell
Score : 56 points
Date : 2021-12-09 20:39 UTC (2 hours ago)
(HTM) web link (www.medrxiv.org)
(TXT) w3m dump (www.medrxiv.org)
| NikolaeVarius wrote:
| > Conclusions and Relevance: In this interim analysis of
| surveillance data of COVID-19 vaccines, the incidence of GBS was
| elevated after Ad.26.COV2.S. Surveillance is ongoing.
|
| > NOTE: This preprint reports new research that has not been
| certified by peer review and should not be used to guide clinical
| practice.
| ianhawes wrote:
| I'm not sure the preprint matters here, what is being stated is
| a statistic generated by several fully integrated healthcare
| providers that have access to the data required to measure such
| factors as rare side effects of a new vaccine.
| mrjangles wrote:
| I keep seeing comments like this on the internet and I don't
| know where this idea comes from the "peer review" is some kind
| of double checking and reproducing of the scientific research
| done.
|
| Peer review is where the journal makes sure the claimed work
| done is of high enough quality, and that the results are
| interesting and significant enough to be worthy of publication
| in that particular journal. If not, the work either needs to be
| improved or published in a journal that does not have as much
| "esteem". If anything peer review is the reason that so many
| fake and fraudulent results are published these days (though
| I'm not suggesting I know of any better alternative).
| neogodless wrote:
| The short summary of what this paper describes is an increase in
| GBS specific to the Johnson & Johnson vaccine (Ad.26.COV2.S),
| with no significant change for recipients of mRNA vaccines.
|
| > The incidence of GBS in the 21 days after Ad.26.COV2.S was 34.6
| per 100,000 person-years, which was substantially greater than
| the expected background rate of 1-2 per 100,000 person-years.
| orangepurple wrote:
| Meta question: What statistical methods can be used to combat
| under reporting of a particular event?
| walterbell wrote:
| Kirsch, Rose, Crawford:
| https://downloads.regulations.gov/CDC-2021-0089-0024/attachm...
| & https://www.skirsch.com/covid/Deaths.pdf
|
| _> One method to discover the VAERS underreporting analysis
| can be done using a specific serious adverse event that should
| always be reported, data from the CDC, and a study published in
| JAMA. Anaphylaxis after COVID-19 vaccination is rare and occurs
| in approximately 2 to 5 people per million vaccinated in the
| United States based on events reported to VAERS according to
| the CDC report on Selected Adverse Events Reported after
| COVID-19 Vaccination. Anaphylaxis is a well known side effect
| and doctors are required to report it. It occurs right after
| the shot. You can't miss it. It should always be reported._
|
| Critique/response: https://medium.com/microbial-
| instincts/debunking-steve-kirsc...
| kokanator wrote:
| This is a significant and life changing side effect. One that
| should be getting more coverage than it is. Additionally there
| appears to be no followup with individuals in the at risk
| categories post vaccination.
| spullara wrote:
| Huh. I got a survey every day for weeks and then once a week
| for a few months. (In the US)
| nerdponx wrote:
| What are the at-risk categories for GBS? Are the categories
| different for mRNA vaccines vs. viral-vector vaccines vs. other
| kinds of vaccines?
| neogodless wrote:
| In the linked paper, it describes the most common
| ages/genders, and also specifies that there was _no increase_
| in GBS incidence for recipients of mRNA vaccines. This is
| specific to the J &J vaccine.
| jeroenhd wrote:
| I think it should receive quite a lot of coverage, but not
| until it's been peer reviewed.
|
| I can write a whole paper about how the vaccine turns your skin
| magnetic and upload it to medRxiv, but that doesn't mean much.
|
| Many of the most worrying news stories about the vaccines have
| been either disproven or taken out of proportion because of
| early drafts like these. We'll have to be patient for a bit
| longer before we can draw any conclusions from this paper.
|
| As their homepage says:
|
| > Caution: Preprints are preliminary reports of work that have
| not been certified by peer review. They should not be relied on
| to guide clinical practice or health-related behavior and
| should not be reported in news media as established
| information.
| mrjangles wrote:
| You don't know what peer review is.
|
| >I can write a whole paper about how the vaccine turns your
| skin magnetic and upload it to medRxiv, but that doesn't mean
| much.
|
| Yes you could, and, provided you wrote it in such a way that
| people didn't think it was a joke, you would get published in
| Nature for sure. Only later when people try to reproduce your
| work would they realize you are a fraud, and depending on
| what country you work in, different disciplinary action might
| be taken (though probably not).
| throwaway193727 wrote:
| The following is not nor should be interpreted as medical advice,
| talk to your doctor...
|
| I've had GBS twice and decided to get Moderna after doing my own
| research -- neurologists offices I called locally refused to
| advise me on what to do at the time (understandably, because they
| are not necessarily experts with vaccines). I get my booster this
| weekend, because I fear the effects of covid more than the
| potential side-effects of the vaccine; even having recovered from
| GBS twice, at least I know that's something that I could recover
| from and I'm not sure whether or not the same thing can be said
| about any long term consequences of getting covid.
| cwkoss wrote:
| What is the best source to get a breakdown on covid-19 vaccine
| side effects?
|
| I've tried googling for this a few times recently and find an
| overwhelming amount of discussion from the anti-vax or anti-anti-
| vax perspectives, but hard to find a solid accounting based on
| hard facts.
| NikolaeVarius wrote:
| https://www.cdc.gov/vaccines/covid-19/info-by-product/pfizer...
| nickff wrote:
| I tried to find the information on that website, and could
| not; is it there? If it is there, how do I find it?
| benbayard wrote:
| It's a list of tables with a breakdown of each side effect.
| What are you looking for that isn't there?
| nickff wrote:
| Was hard to find the J&J page (parent commenter linked to
| Pfizer), and I can't find anything about Guillain-Barre
| Syndrome.
|
| In my view, the CDC site seems to be designed to promote
| confidence and authority, and hide any reason for doubt.
|
| https://www.cdc.gov/vaccines/covid-19/info-by-
| product/jansse...
| nl wrote:
| This preprint paper was published 7 days ago. The CDC
| doesn't move that fast on non-urgent updates with only a
| single paper published.
|
| As per the paper though, the FDA does have a warning
| about this potential side effect.
| nerdponx wrote:
| You can look up data on adverse side effects in the US HHS
| VAERS database: https://vaers.hhs.gov/data.html but keep in
| mind that side effects tend to be under-reported. There might
| be other issues with the VAERS data that I'm not aware of.
|
| When I last checked the data, the risks of Covid-19,
| particularly the risk of severe infection and/or "long hauler"
| symptoms, seemed to outweigh the risks of vaccination by ~10:1.
| But that was several months ago, and I am wondering if/how
| things have changed when it comes to booster shots and omicron
| variant.
| XorNot wrote:
| > keep in mind that side effects tend to be under-reported.
|
| If you're looking at VAERS then this statement is objectively
| wrong.
|
| VAERS records _every_ medical event that happens within 6
| weeks of any vaccination and does not establish causation.
| colechristensen wrote:
| I had a little inflammation in one of my eyes immediately
| after my second dose. It went away, I didn't report it to
| anyone. It might have been an immune reaction, I might have
| just gotten something in my eye, everything was better in a
| few days.
|
| It didn't seem worth the trouble or expense to try to do
| anything about it.
|
| That is the kind of underreporting.
|
| A second kind of underreporting is having only very mild
| symptoms which would only be caught with a timely test.
| buffington wrote:
| > VAERS records every medical event that happens
|
| This statement is also objectively wrong. VAERS has no data
| for unreported medical events.
| walterbell wrote:
| There's a requirement to report, but no legal penalty for
| failure to report.
|
| There's a legal penalty for incorrect/false reporting, i.e.
| reporting = risk.
|
| In the current contested environment, there can be
| institutional pressure against reporting.
| spfzero wrote:
| You're right in that when someone creates a VAERS report,
| every type of post-vaccination medical event is to be
| included. But you're wrong if you are assuming _every_
| event gets reported by the patient, to a doctor who then
| _always_ creates a VAERS report.
|
| Some people don't associate symptoms with the previous
| vaccination, don't go to the hospital because symptoms
| recede, etc. Sometimes health care workers are overworked
| and can't be bothered, or assume someone else reported,
| etc.
| nerdponx wrote:
| Case in point: having a fatigue, fever, chills, sore arm,
| etc. is so common after any of the "big 3" vaccines that
| people come to expect it and take sick days from work in
| anticipation. How many of those cases ever get reported
| to anyone? I definitely didn't report mine.
| CamperBob2 wrote:
| Of course, you've already done a search on the _disease 's_
| side effects, right?
|
| I mean, just for comparison with whatever you learn about the
| vaccine's side effects?
| cwkoss wrote:
| Yep, mostly curious for deciding which vaccine I want to
| boost with.
| infamouscow wrote:
| Because of a confluence of institutional capture and heavy-
| handed censorship by big tech companies, I don't think you'll
| find much except on fringe "anti-vax" websites, and at that
| point you'll have to wade through everything yourself.
|
| In a perfect world we'd have productive discussions where
| nuanced topics like this can be explored in depth, but morale
| narcissism is rampant and everyone believes they know best.
| walterbell wrote:
| For global data, search for "covid-19 vaccine" at
| http://vigiaccess.org/. Be sure to read the long disclaimer on
| the page.
|
| _> VigiAccess was launched by the World Health Organization
| (WHO) in 2015 to provide public access to information in
| VigiBase, the WHO global database of reported potential side
| effects of medicinal products. Side effects - known technically
| as adverse drug reactions (ADRs) and adverse events following
| immunization (AEFIs) - are reported by national
| pharmacovigilance centres or national drug regulatory
| authorities that are members of the WHO Programme for
| International Drug Monitoring (PIDM). WHO PIDM was created in
| 1968 to ensure the safer and more effective use of medicinal
| products._
|
| The US VAERS database has about 50/50 US and foreign reports.
| It is simultaneously criticized as unverified (i.e. GIGO) and
| missing data due to disincentives against reporting. If you
| have a vaccine lot number, replace the last six characters in
| this sample query URL, for a summary of adverse events. The raw
| data can be download and imported into a SQL database for
| deeper analysis:
| https://medalerts.org/vaersdb/findfield.php?TABLE=ON&GROUP1=...
|
| US Vaccine Safety Datalink (the source for the paper in this
| article) has data from some HMOs. The raw data is not available
| to the public. https://pubmed.ncbi.nlm.nih.gov/21502240/
|
| _> The Vaccine Safety Datalink (VSD) project is a
| collaborative project between the Centers for Disease Control
| and Prevention and 8 managed care organizations (MCOs) in the
| United States. Established in 1990 to conduct postmarketing
| evaluations of vaccine safety, the project has created an
| infrastructure that allows for high-quality research and
| surveillance. The 8 participating MCOs comprise a large
| population of 8.8 million members annually (3% of the US
| population), which enables researchers to conduct studies that
| assess adverse events after immunization._
| superfad wrote:
| https://sharylattkisson.com/2021/10/exclusive-80-of-the-most...
| Rebelgecko wrote:
| This seems to just be random data from VAERS. So the "deaths"
| column includes things like people who got hit by a bus 6
| months after being vaccinated. I think OP is looking for a
| comparison of side effects _caused by the vaccine_ (for
| example, comparing death rates b /w vaccinated and the
| general population, without falling into the common traps you
| see on websites like this one that is hawking "miracle cures
| for cancer")
___________________________________________________________________
(page generated 2021-12-09 23:02 UTC)