[HN Gopher] Palm oil favors tumor expansion
       ___________________________________________________________________
        
       Palm oil favors tumor expansion
        
       Author : kleiba
       Score  : 132 points
       Date   : 2021-11-18 17:53 UTC (5 hours ago)
        
 (HTM) web link (www.irbbarcelona.org)
 (TXT) w3m dump (www.irbbarcelona.org)
        
       | jszymborski wrote:
       | Well, this study passes the "we dumped a bunch of X on cancer
       | cells in a petri dish and they did a funny thing" red flag test.
       | 
       | Xenographs (implanting human cancer cells into mice) have their
       | own caveats (the immune system is almost always severely
       | compromised), but this seems like a cool study. I'm no expert on
       | oral cancers however.
       | 
       | Curious to see the implication of the neuronal cells here, I'm
       | looking forward to reading the whole manuscript.
        
         | Quatih wrote:
         | Cancer cells can consume multiple energy sources, not exactly
         | news here. Concluding that dietary palmitic acid is a problem
         | is questionable. Palmitate is produced endogenously and dietary
         | palmitic acid does not even influence tissue concentration [1].
         | 
         | [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682332/#B81
        
           | akiselev wrote:
           | _> Palmitate is produced endogenously and dietary palmitic
           | acid does not even influence tissue concentration [1]._
           | 
           | If there's no uptake by tissue, then wouldn't the tumor have
           | a plentiful energy source once it vascularizes? (Assuming
           | they can metabolize palmitic acid)
        
             | Quatih wrote:
             | Yes, in addition to other free fatty acids, glucose and
             | ketones.
        
         | csours wrote:
         | Is nerve growth commonly considered critical in tumor growth
         | and metastasis?
         | 
         | So much of this sounds weird to me and I'm not sure if it's my
         | ignorance or if this is some wacky theory.
        
           | jszymborski wrote:
           | I've personally not come across it, but it just might be a
           | blind spot for me (I've mostly studied breast and ovarian
           | cancers).
           | 
           | It's why I'm interested to read the manuscript closely and
           | see what they reference re: this neuronal growth.
        
       | l30n4da5 wrote:
       | Interesting article. One thing to note is that this study seemed
       | to (correct me if I'm wrong) focus on palmitic acid, which can be
       | found primarily in palm oil, but can also be found in meat,
       | cheese, and butter, to name a few other sources.
        
         | laluser wrote:
         | Palm oil seems to be in everything.
        
           | radicaldreamer wrote:
           | It's a cheap oil in Asia due to a bunch of countries trying
           | to develop their agriculture by planting palm (Indonesia
           | etc.)
           | 
           | Makes me think twice about having yan yan snacks and pocky's.
        
             | obiwan14 wrote:
             | And in parts of West Africa, palm oil is the principal oil
             | used in many recipes. Before Western vegetable oils were
             | introduced to that part of the world, palm oil was the
             | number one oil used in cooking, followed by groundnut
             | (peanut) oil. A place like that would be the ideal place to
             | study the effects of palm oil.
        
             | gambiting wrote:
             | The reason why palm oil is so widespread nowadays is
             | because about 30 years ago it was widely promoted as THE
             | best oil to grow - it has much higher yield than many other
             | oils, and was seen as a "green" alternative since
             | comparatively it takes less land than say, peanut oil.
             | 
             | The problem is that yes, it takes less land, but the land
             | that it can be suitably grown on is very important for
             | other things.
        
               | Nition wrote:
               | To be fair, so is much of our other land, but we have the
               | excuse that we already destroyed it many years ago.
        
         | moffkalast wrote:
         | Well that's the most horrifying sentence I've read in the past
         | few months.
        
           | QuercusMax wrote:
           | Why is it horrifying? That a naturally occurring long-chain
           | fatty acid is found in multiple natural sources? The parent
           | comment is NOT indicating that palm oil is in these things.
        
             | moffkalast wrote:
             | Well the article was about palm acid, not palm oil.
        
         | obiwan14 wrote:
         | Starting from about 6 years ago, Palm Oil began showing up in
         | practically everything, even those foods you wouldn't expect to
         | find it. Check the ingredient list in that jar of peanut or
         | almond butter. I make a point of buying peanut or almond butter
         | that has only one ingredient.
        
         | vmception wrote:
         | _Everything at this market contains substances known to the
         | State of California to cause cancer_
        
         | QuercusMax wrote:
         | To clarify - you're not saying that meat, cheese, and butter
         | include _palm oil_ , but rather just one particular naturally-
         | occurring chemical component of palm oil which occurs naturally
         | in many sources. Palmitic acid is just a long-chain fat
         | molecule.
        
           | Vetch wrote:
           | The study is primarily about palmitic acid, claiming that it
           | promotes a prometastatic memory via Schwann cells. Palmitic
           | acid is found in many foods, oils, lotions and occurs
           | naturally in the body. That fact and also the artificial
           | environment required to get the mouth and skin cancer cells
           | grafted into the fragile mice makes it difficult to form any
           | meaningful conclusions regarding diet.
           | 
           | What is interesting about the study is it adds to a growing
           | body of work on how tumors hijack nerve pathways to promote
           | metastasis. The claim of this work is that the presence of
           | palmitic acid potentiates a robust cancer partly by stable
           | epigenetic changes in the tumors, recruiting a type of glia
           | and promoting a regenerative environment via the neural
           | network which forms about the tumor cells, even after changes
           | in the availability of the fatty acid.
        
         | phonypc wrote:
         | There's some amount of palmitic acid in pretty much every
         | dietary fat. Animal sources tend to be higher than seed oils,
         | but e.g. olive oil, that many people like to tout as the
         | healthiest, is something like 10-20% palmitic acid.
         | 
         | It's also the most abundant fatty acid in _you_ , even if you
         | don't eat any.
         | 
         | There's also a skeleton inside you right now! Spooky.
        
         | r00fus wrote:
         | It's the most common saturated fatty acid. So this isn't just
         | about palm oil, this is about saturated fats causing cancer.
        
           | l30n4da5 wrote:
           | more reason to limit saturated fat intake.
           | 
           | i say that as i consume primarily meat and cheese on a daily
           | basis.
        
       | scythe wrote:
       | Title is bad.
       | 
       | The article says _palmitic acid_ , formally hexadecanoic acid,
       | which is one of the most common -- if not _the_ most common --
       | saturated fatty acids. It 's named for palm oil, where it is
       | predominant, but it is also found in coconut oil, lard, butter,
       | cacao, and in _smaller_ amounts in practically all liquid oils,
       | with higher concentrations generally in solid fats.
       | 
       | Better to say "Palmitic acid favors tumor expansion" or even just
       | "Common saturated fat favors tumor expansion".
        
       | hdjjhhvvhga wrote:
       | A nice quote[0]:
       | 
       | > Nutella maker, Ferrero, launched an advertising campaign in
       | response to reassure customers that their product is safe. The
       | company insists on keeping their recipe the same, claiming that
       | "making Nutella without palm oil would produce an inferior
       | substitute for the real product, it would be a step backward,"
       | according to Fererro's purchasing manager, Vincenzo Tapella. The
       | smooth texture Tapella is referring to could be achieved by more
       | expensive oils like sunflower or rapeseed but would increase the
       | cost of production by as much as $22 million.
       | 
       | This was basically the same BS that Johnson & Johnson used to
       | defend BPA baby bottles before the ban.
       | 
       | [0] https://www.prescouter.com/2017/02/dangers-palm-oil-
       | nutella-...
        
         | debacle wrote:
         | Funny, because hazelnut spread without palm oil tastes 500%
         | better than with.
        
       | f6v wrote:
       | For everyone spooked by this. Cancer thrives on many things. And
       | there's little survival advantage for people who can effectively
       | fight cancer after their reproductive age. All novel carcinogens
       | aside(radiation, air pollution, baby powder), humans often are
       | just not equipped to fight cancer. Certain diets probably can
       | make it a bit better or worse, but they might not be the game
       | changer. Our best bet is technology, like CAR T cells and
       | whatever is invented next.
        
         | clairity wrote:
         | > "humans often are just not equipped to fight cancer."
         | 
         | blanket statements like this are almost never correct. our
         | bodies are certainly equipped to fight cancer, having evolved a
         | number of mechanisms in that regard, it's just that cancer is
         | relentless and the cumulative probabilities tend to catch up
         | with a number of us eventually, which necessarily skews
         | mortalities older.
         | 
         | with that said, we're certainly unlikely to naturally evolve
         | ourselves out of cancer risk in the next few millenia, so yes,
         | technology is one of our best bets (along with developing tech
         | to reduce novel carcinogen risks).
        
           | f6v wrote:
           | There's a big difference between "often" and "not at all".
        
         | outworlder wrote:
         | > humans often are just not equipped to fight cancer
         | 
         | But we are? The immune system is constantly at work killing
         | malignant (or otherwise dysfunctional) cells. Cells themselves
         | have mechanisms to commit suicide (apoptosis) if they are not
         | working properly.
         | 
         | It's only when the _several_ mechanisms we have get defeated at
         | the same time (often due to mutations) that cancer can even
         | develop.
         | 
         | If you mean, we are not as equipped as elephants or whales to
         | fight cancer, then that's true.
         | 
         | > there's little survival advantage for people who can
         | effectively fight cancer after their reproductive age
         | 
         | There's some advantage, but as far as nature's concerned,
         | there's indeed diminishing returns. As in, for the individual
         | that has already reproduced there's no reason to stay alive,
         | but this is beneficial for the offspring - until they are
         | adults. So there's some selective pressures there, specially if
         | you are competing against another group.
        
           | f6v wrote:
           | I'm not disputing that, just stating that there's no
           | evolutionary pressure on keeping adults cancer-free. There is
           | a big pressure at eliminating child cancers from the
           | population.
        
           | dtech wrote:
           | > If you mean, we are not as equipped as elephants or whales
           | to fight cancer, then that's true.
           | 
           | There's some debate as to whether they have better cancer
           | fighting mechanisms, or whether their size means they are
           | less fast affected by cancers, and/or whether they are large
           | enough that their cancers split into competing cancers before
           | they are affected.
        
           | TedDoesntTalk wrote:
           | My understanding is there are cancer cells in all adults.
           | They are constantly killed off and never develop into tumors
           | or anything of significance until ... they do in some people.
           | 
           | So to say we are not equipped to fight them is incorrect.
        
         | wongarsu wrote:
         | We have selective pressure to survive cancer for the first 40
         | years of our life (and not just barely survive but be
         | unhindered by it). After that there are more subtle selective
         | forces at work: having grandparents that are in good health and
         | helping find food or care for children can certainly improve
         | your survival chances. And of course the machinery we have
         | developed to survive the first 40 years doesn't suddenly stop
         | working after that.
         | 
         | But you're right insofar as there's fairly little selective
         | pressure to prevent cancer over the entire lifespan of a human.
         | We probably could have much better protection from cancer, but
         | the energy investment for that isn't worth it from an
         | evolutionary perspective.
        
           | caeril wrote:
           | > having grandparents that are in good health and helping
           | find food or care for children
           | 
           | Maybe, certainly since the advent of nuclear families. But
           | our much longer genetic lineage selects around tribes, such
           | that direct grandparents' longevity may not be as critically
           | important. Third-and-fourth cousins likely easily filled this
           | role.
        
             | wongarsu wrote:
             | If your great-great-grandfather has a random genetic
             | mutation, he can pass that down to both you and your third
             | cousin. If that mutation helps your third cousin help you
             | bring children to the world, you have a selective
             | advantage. Of course that chain grows exponentially less
             | likely the further you are from each other on the family
             | tree, as the gene has to spread far enough by pure chance.
        
         | podgaj wrote:
         | Palmitic acid affects oxidative stress. This is not only
         | important in cancer, but in heart disease as well.
         | 
         | https://www.sciencedirect.com/science/article/abs/pii/S00144...
         | 
         | https://www.karger.com/Article/Abstract/354235
         | 
         | On the role of Oxidative Stress and cancer, it's complicated,
         | but it is there:
         | 
         | https://www.med.or.jp/english/pdf/2001_12/535_539.pdf (PDF)
         | 
         | Go to Trader Joe's and look at the ingredients, everything has
         | Palm Oil as an ingredient.
         | 
         | This is important, and having a diet that suits your oxidative
         | stress profile is important. And I do not care what anyone
         | tells me, these oils are not something the body can handle well
         | and are probably healthy only at low levels.
        
         | humanrebar wrote:
         | > And there's little survival advantage for people who can
         | effectively fight cancer after their reproductive age.
         | 
         | I don't know how to quantify it, but having healthy
         | grandparents in the picture is a survival advantage.
        
           | f6v wrote:
           | Having old grandparents who can't hunt or forage and need to
           | be fed is a big handicap. I'd like to see a cost/benefit
           | analysis if there's any.
        
           | RosanaAnaDana wrote:
           | Its different when your grandparents are in their late 30's,
           | early 40's. Modern reproductive ages are much, much later
           | than they have been both historically and prehistorically.
           | 
           | Grandparents 600-4k years ago would have been in their late
           | thirties, mid forties for all but a very few. Still unlikely
           | to generate significant selection pressure considering that
           | the vast majority of cancers are late in life.
           | 
           | https://www.ncbi.nlm.nih.gov/books/NBK97292/
        
             | humanrebar wrote:
             | OK. Replace "grandparents" with "elderly relatives".
        
         | btown wrote:
         | > there's little survival advantage for people who can
         | effectively fight cancer after their reproductive age
         | 
         | While there's _less_ evolutionary advantage, it 's far from
         | trivial. See, for instance,
         | https://www.pnas.org/content/100/16/9637 :
         | 
         | > In some species, postreproductive females make substantial
         | contributions to their descendants, either through direct
         | parental care or through grandparental care. Such contributions
         | continue after birth in all mammals (most notably primates),
         | all birds, many insects, and some fish (15). Postreproductive
         | bottle-nose dolphins and pilot whales baby-sit, guard, and even
         | breastfeed their grand-children (15). Selection against the
         | mortality of postreproductive individuals in such species would
         | be expected to continue.
        
       | heavyset_go wrote:
       | Palmitic acid also has tomes of evidence pointing towards its
       | consumption contributing to the development of cardiovascular
       | disease, as well.
        
       | dt3ft wrote:
       | Who sponsored this study?
        
         | mleonhard wrote:
         | The sponsors are listed at the end of the article. In the
         | future, please read the article before commenting. Please
         | refrain from posting low-effort comments.
        
         | deusum wrote:
         | "Big Coconut" and the Keto Kids.
        
           | goboronshka wrote:
           | I suggest you read Good Calories, Bad Calories by Gary Taubes
           | before spending more time mocking keto. Ketogenic diets have
           | lots of backing in science and have changed many lives and
           | posts like these can be very hurtful.
        
           | heavyset_go wrote:
           | Palmitic acid is a major constituent of coconut oil.
        
       | whalesalad wrote:
       | Take one look at the modern production process for vegetable oil
       | and this sort of effect is starting you right in the face.
       | 
       | Palm, Canola, Rapeseed, Soybean, etc, they're all terrible. I
       | avoid this shit like the plague.
        
         | tpush wrote:
         | What effect are you talking about? And what does the production
         | process for vegetable oils have to do with anything? This
         | article is about palmitic acid which apart from obviously palm
         | oil, is most abundant in animal fats like butter (~30%), tallow
         | (26%) etc. since its a saturated fatty acid.
         | 
         | Most vegetable oils like canola and soybean have much less
         | palmitic acid.
        
           | whalesalad wrote:
           | Palm oil is a vegetable oil. The production of vegetable oil
           | (read: palm oil) creates an end product that looks and feels
           | like oil, but has all kinds of other bad shit in it. It gets
           | refined, heated, bleached, heated, deoderized, etc...
           | 
           | The same thing happens to flour. We process the living shit
           | out of it, then bleach it, then we have to add-in all the
           | stuff we removed so that it still has some semblance of
           | nutrition.
           | 
           | It's like the deep fried pickle. A pickle in and of itself is
           | a pickle, but when you deep fry it, is it still a pickle?
           | Some will argue yes. Does it still have the same general
           | health characteristics, or more importantly, the lack of
           | negative characteristics as the deep-fried one? No.
        
             | phonypc wrote:
             | Palm oil isn't really in the same category as the vegetable
             | oils that have had concern raised about them recently. It's
             | not from a seed, so doesn't need a highly involved process
             | to get meaningful amounts of it. Cold pressed palm oil has
             | been in use for thousands of years. It's more like olive
             | oil in this regard. (Of course, you _can_ still refine it,
             | and it often is refined. But it 's not as easily oxidized
             | as oils with a higher proportion of polyunsaturated fatty
             | acids, so less concerning in that regard.)
        
             | tpush wrote:
             | The palmitic acid content of palm oil (or anything else)
             | has nothing to do with what you're describing here. Like,
             | absolutely nothing.
        
         | headmelted wrote:
         | Honest question - how? Isn't it in almost everything?
        
           | guruz wrote:
           | Check the "What To Eat" section here:
           | https://fireinabottle.net/the-croissant-diet-specification/
           | 
           | This is also sometimes the topic in those subreddits:
           | https://www.reddit.com/r/StopEatingSeedOils/
           | https://www.reddit.com/r/SaturatedFat/
        
           | heavyset_go wrote:
           | If you cook, you can choose not to use those oils.
        
         | gruez wrote:
         | >Take one look at the modern production process for vegetable
         | oil and this sort of effect is starting you right in the face.
         | 
         | Mind elaborating? Without specific details it reeks of the
         | naturalistic fallacy or the "good old days".
        
           | AamosSinervo wrote:
           | How would the opposite not be true? "an appeal to the
           | modern". Just because something like palm oil is new, must it
           | be better? Consider that for years the "new" advice was to
           | recommend aspirin to prevent heart attacks. [https://www.ahaj
           | ournals.org/doi/10.1161/CIR.0000000000000678] If you ignored
           | this advice some smarmy pill pusher would say you're
           | appealing to nature. What about non-addictive painkillers
           | like oxycotton. From wikipedia: "A genetically engineered
           | rapeseed that is tolerant to the herbicide Roundup
           | (glyphosate)". "Exposure to glyphosate-based herbicides and
           | risk for non-Hodgkin lymphoma: A meta-analysis and supporting
           | evidence" [https://www.sciencedirect.com/science/article/abs/
           | pii/S13835...]. So from the beginning the product is tainted.
           | Then the oil is bleached for a more palatable color. It
           | refined like other industrials oils and often interchangeable
           | for machining uses.
           | 
           | Mouse experiments showed weight gain and memory
           | loss/alzheimers
           | [https://www.nature.com/articles/s41598-017-17373-3]
           | 
           | While mice are not humans, American obesity has grown since
           | the use of seed oils has grown.
           | 
           | Seed oil advocates themselves appeal to "the good ol days",
           | as many peoples have allegedly used rape seed oil over
           | history.
        
             | gruez wrote:
             | >How would the opposite not be true? "an appeal to the
             | modern". Just because something like palm oil is new, must
             | it be better?
             | 
             | What gave you the indication I was appealing to modernity?
             | Being against naturalistic fallacy or the "good old days"
             | doesn't mean I'm arguing "well it's new so it must be
             | better!". I'm simply saying that we shouldn't give either
             | side preference just because it's new or old.
             | 
             | >Consider that for years the "new" advice was to recommend
             | aspirin to prevent heart attacks. [https://www.ahajournals.
             | org/doi/10.1161/CIR.0000000000000678] If you ignored this
             | advice some smarmy pill pusher would say you're appealing
             | to nature. What about non-addictive painkillers like
             | oxycotton.
             | 
             | This seems like a massive strawman/misrepresentation.
             | People weren't taking/recommending asprin because it was
             | new, they were taking it because it's what the clinical
             | evidence was suggesting. Some _reasonable_ objections might
             | be that the studies were poorly done, or wasn 't
             | replicable, but "it's not natural" isn't one of them. Just
             | because "it wasn't natural" produced the right result,
             | doesn't really mean we should endorse it, or continue using
             | it. After all, even a broken clock is right twice a day.
             | See also:
             | https://en.wikipedia.org/wiki/Justification_(epistemology)
             | 
             | >Exposure to glyphosate-based herbicides and risk for non-
             | Hodgkin lymphoma: A meta-analysis and supporting evidence" 
             | [https://www.sciencedirect.com/science/article/abs/pii/S138
             | 35...].
             | 
             | >Mouse experiments showed weight gain and memory
             | loss/alzheimers
             | [https://www.nature.com/articles/s41598-017-17373-3]
             | 
             | Early studies showed that aspirin was beneficial for
             | preventing heart attacks. You seemed to suggest that was
             | bad. However, trusting one study saying that glyphosate
             | causes cancer is okay? The wikipedia article for glyposate
             | describes the overall evidence for glyposate causing cancer
             | as "inconclusive". The IARC also said there was "limited
             | evidence" for the type of cancer you described. If you want
             | to make the case that appeal to nature is good, you really
             | should have used something less contentious.
             | 
             | >Then the oil is bleached for a more palatable color.
             | 
             | Well is that bad? If they're literally dumping household
             | bleach into the oil, I might be a little worried. Then
             | again, they also put bleach (chlorine) into tap water, so
             | should we be worried about that too?
             | 
             | > It refined like other industrials oils and often
             | interchangeable for machining uses.
             | 
             | We also put nuclear plant coolant (dihydrogen monoxide)
             | into our foods. Should we be worried about that as well?
             | 
             | >Seed oil advocates themselves appeal to "the good ol
             | days", as many peoples have allegedly used rape seed oil
             | over history.
             | 
             | Right, and that's bad regardless of which side it's on.
        
           | MrBuddyCasino wrote:
           | > naturalistic fallacy or the "good old days"
           | 
           | This is not a fallacy:
           | https://en.wikipedia.org/wiki/Lindy_effect
           | 
           | Ray Peat has been warning about seed oils for decades, I'm
           | not sure if its bullet-proof but at least its interesting:
           | https://raypeat.com/articles/articles/unsaturated-oils.shtml
        
             | ldiracdelta wrote:
             | Also, those "good old days", might describe "natural
             | selection". You can't be certain that some of the survival
             | benefits of your ancestors are NOT an adherence to
             | traditions that give them a survival or reproductive
             | advantage.
        
               | whalesalad wrote:
               | You can't possibly be comparing the wisdom of our
               | ancestors with the agricultural-industrial complex? They
               | do everything in their power to produce the lowest-cost
               | version of "food" (some could argue it is not food) that
               | people will pay for.
        
               | ldiracdelta wrote:
               | I'm not sure you parsed my post correctly. My post argues
               | in favor of your post.
        
           | JohnWhigham wrote:
           | https://www.youtube.com/watch?v=rQmqVVmMB3k
        
         | hypertele-Xii wrote:
         | Fortunately there's olive oil. Approximately 0.5 liters/month
         | per person at $10/liter for organic extra virgin from Tunisia.
         | 
         | Heard it too causes cancer if you fry it though...
        
           | heavyset_go wrote:
           | > _Heard it too causes cancer if you fry it though..._
           | 
           | Frying at low temperatures with olive oil is one of the
           | "healthier" ways to fry, though. Less volatile aromatic
           | hydrocarbons are produced when frying with olive oil compared
           | to other fats, and some of the compounds in non-extra virgin
           | olive oil reduce the production of free radicals.
        
         | base698 wrote:
         | Do you not eat out? Most restaurants of all caliber use that
         | garbage.
         | 
         | I know I'm still consuming it when I eat in a restaurant. Best
         | you can currently do is just not buy it for home use.
        
       | mountainboy wrote:
       | any hydrogenated oil is toxic. The article does not state if the
       | tested palm oil was hydrogenated or not.
        
       | uhtred wrote:
       | Hopefully good news for Orangutans if this leads to less palm oil
       | consumption.
        
         | asdff wrote:
         | If palm oil wasn't as profitable they will just grow the next
         | most profitable thing in the orangutan habitat. The problem is
         | one of not setting aside land for preserves vs one particular
         | industry or another. Anything will expand to fill the space if
         | land is offered for sale and zoned for industry.
        
         | goalieca wrote:
         | Dish soap and other applications remain important.
        
         | dnautics wrote:
         | bad news for nutella eaters, though
        
       | kazinator wrote:
       | If palm oil _killed_ cancer cells, would that make it appealing
       | and safe to eat?
       | 
       | If errantly reproducing cells can use a substance, it must be
       | bad: is that the reasoning here?
       | 
       | I would imagine that a source of water also favors tumor
       | expansion. Cut a tumor off H2O and it will shrivel and die.
        
         | mleonhard wrote:
         | I think you did not read the article. In the future, please put
         | more effort into your comments or refrain.
        
       | alliao wrote:
       | Is this the same as 3-MPCD? basically any hydrogenated oils would
       | have this, seeing this popping up recently
        
       | ndosnfiwjaijx wrote:
       | Lots of "do your own research" folks here.
        
       | ravenstine wrote:
       | How does it compare to glucose/sugar?
        
       | moffkalast wrote:
       | Yet another thing on the cancerogenic pile _sigh_
       | 
       | At some point you have to ask yourself if everything but water
       | gives us cancer.
        
         | laluser wrote:
         | Gotta watch out for lead in the water too!
        
           | moffkalast wrote:
           | But if my veins aren't lead lined, what will protect me from
           | banana radiation?
        
             | mbg721 wrote:
             | A plantain vest. The rows of plantains attach to all of the
             | body's normal banana receptors before the lethally
             | radioactive bananas can, leaving you unscathed.
        
         | artificialLimbs wrote:
         | If I couldn't grow it or raise it 100 years ago, I don't want
         | to eat it. Open to being convinced otherwise.
        
           | voz_ wrote:
           | What happened in 1921? Or is this one of those baseless
           | "before we had cancer" comments?
        
             | tyingq wrote:
             | I suppose there's some merit in the "before we had cancer"
             | thing. Certainly many people were dying of other stuff long
             | before they would have gotten cancer.
        
             | malfist wrote:
             | Cancer wasn't invented then.
             | 
             | In all seriousness, things like pasteurization and
             | refrigeration make our food supply a lot safer than it used
             | to be.
        
             | mbg721 wrote:
             | I realized at some point that "It's food iff your
             | grandparents would call it food" either has to be amended
             | to add a generation, or we have to accept Oreos pretty
             | soon.
        
               | bluGill wrote:
               | Margarine was invented in 1869. You need to go back a lot
               | farther.
               | 
               | You are also skipping out a lot of newer stuff that
               | wasn't possible back then, but after serious study seems
               | safe. Most of what was done 200 years ago is accepted as
               | safe, but there is no actual evidence for it, and in many
               | cases we know it wasn't. (the obvious example of using
               | lead in finishes for food contact items)
        
           | WarChortle wrote:
           | Do you not take Advil? Tums? Antibiotics? or a myriad of
           | other useful medicine?
        
             | heavyset_go wrote:
             | Aspirin is more than 100 years old and people have been
             | eating calcium carbonate for quite some time. I get your
             | point, though.
        
           | rileyphone wrote:
           | Of note is the monstrosities we call chickens today are a
           | product of breeding contests in the 1940s [0] (but does that
           | mean there is anything wrong with eating them? who's to say).
           | 
           | It seems a lot more people today are taking a critical look
           | at what they eat, though often excluding broad categories
           | based on feeling rather than hard science. At first this
           | looks reactionary, but on closer inspection one realizes that
           | the science involved is typically biased or just lacking.
           | We've invested comparatively little into understanding the
           | downsides of modern food products like vegetable oil, but the
           | little windows we have indicate they may be causing whole
           | hosts of human maladies from dementia to type 2 diabetes [1].
           | Nutrition constitutes the inputs to the complex biological
           | system, and large changes (eg disease) can end up being the
           | result of nonlinear processes started by changing these
           | inputs. Another example is a lack of magnesium in the western
           | diet, through both soil depletion and food processing,
           | leading to large scale deficiencies [2].
           | 
           | What's really dizzying, though, is that this information
           | isn't widely known, and is typically found through either
           | self-directed study or through listening to podcasts. When
           | the average person makes decisions regarding their nutrition,
           | they're relying on outdated and probably harmful advice,
           | despite intending to make "healthy" choices. Maybe we need an
           | app to scan a barcode or read a list of ingredients and
           | respond with the known potential for harm and confidence. All
           | I know is I'll never look at fried chicken the same way again
           | (unless it's fried in lard, of course).
           | 
           | [0] https://livestock.extension.wisc.edu/articles/the-
           | chicken-of... [1] https://web.archive.org/web/20190303234503i
           | d_/http://pdfs.se... [2]
           | https://link.springer.com/article/10.1007/s11104-013-1781-2
        
           | skymt wrote:
           | Not the worst place to start, but considering palm oil has
           | been used in cooking for thousands of years it's not clear
           | what that principle has to do with this story.
        
           | gambiting wrote:
           | You do realise palm oil is older than 100 years, right? Used
           | literally for thousands of years.
           | 
           | "Humans used oil palms as far back as 5,000 years. In the
           | late 1800s, archaeologists discovered a substance that they
           | concluded was originally palm oil in a tomb at Abydos dating
           | back to 3,000 BCE.[4] It is believed that traders brought oil
           | palm to Egypt"
           | 
           | https://en.wikipedia.org/wiki/Palm_oil
        
           | yupper32 wrote:
           | Is your medicine cabinet empty?
        
             | artificialLimbs wrote:
             | No, I have ibuprofen for when I have a headache lasting
             | more than a day. (It's caffeine... every ... time.)
        
               | yupper32 wrote:
               | So you eat ibuprofen, but you couldn't grow or raise it
               | 100 years ago. It was invented in the 60s and wasn't
               | available over the counter until the 80s.
        
             | [deleted]
        
           | [deleted]
        
           | outworlder wrote:
           | > If I couldn't grow it or raise it 100 years ago, I don't
           | want to eat it
           | 
           | Humans have been barbecuing meat for millennia. Possibly even
           | before Homo Sapiens Sapiens was around. And yet, it has
           | carcinogenic properties, specially if charred.
           | 
           | What's so special about 100 years ago anyway? 1000 might make
           | a difference - but then again, life expectancy wasn't that
           | great back then.
           | 
           | It's only because we are living so much that cancer is such a
           | large problem. Also because, due to modern medicine, we can
           | often diagnose the person before they just get sick and die
           | from 'unknown' reasons.
           | 
           | Your best bet is to eat food from as many different sources
           | as you can and not eat too much of any single specific thing
           | (which is a modern thing btw, 100 years ago, it wouldn't be
           | as easy to do) and let averages do the rest.
        
           | f6v wrote:
           | Ultra-processed foods are probably a consequence of trying to
           | feed billions of people. Do you think there's enough farm
           | land, water, etc. for the earth population to only grow
           | bio/eco produce?
        
           | [deleted]
        
           | tshaddox wrote:
           | Do you mean if you personally wouldn't have been to grow it
           | or raise it 100 years ago? Or do you mean something more like
           | "if it wasn't widely accessible 100 years ago"?
        
         | rackjack wrote:
         | being alive gives you cancer
        
           | hypertele-Xii wrote:
           | Cancer is alive.
           | 
           | That's so weird.
           | 
           | Some part of you decided to go in a different direction.
           | You're not advanced enough to support both. The strain on
           | resources starves you both.
           | 
           | Kind of like a cannibal parasite. That sure sounds like a
           | death metal band.
        
         | jszymborski wrote:
         | With every cell division, we are not only closer to death, but
         | roll for a "cell transformation"[0].
         | 
         | A transformed cell is most likely to occur in a "cancerised
         | field" of cells. Those fields might be induced to be
         | transformed in-turn by the original transformed cell(s).
         | 
         | It's in this way that the snowball turns from a pea to a
         | boulder, but all along the way there are trees ready to stop
         | its momentum. Be it DNA repair systems, the immune system, the
         | extra-cellular matrix, etc...
         | 
         | An oncologist once told me (and its not hard for me to
         | conceive), that we're all likely die with a number of tumours
         | in us... just not likely from them.
         | 
         | All this to say, yes everything causes cancer. When you
         | consider the molecular biology behind it all, it's a wonder
         | we're anything but giant, spherical, innervated tumours.
         | 
         | Just like everything else, you make your own risk assessments
         | in life, but the advice boils down to: avoid undue risks of
         | cancer if you can. What "undue" and "if you can" here mean is
         | deeply personal.
         | 
         | [0] A fun euphemism for a cell that is cancer-like.
        
         | justinator wrote:
         | To be honest, we're in a constant state of almost having
         | cancer, it's just that our immune system handles the little
         | stuff before it gets out of control. Nothing causes cancer, but
         | certain things tip the scales towards the cancer getting out of
         | control.
         | 
         | (about is all simplified of course)
        
           | vmception wrote:
           | And _also_ things can directly cause cancer by directly
           | damaging DNA in the right places at the right time.
           | 
           | No need to take the optimistic route.
           | 
           | If it makes you feel better: _some_ cancers.
        
             | justinator wrote:
             | Oh, well: I didn't think conceptualize, "we are always in a
             | state of having cancer" was an optimistic view, just
             | realistic :). But DNA gets damaged all by itself, but
             | you're right: something like smoking for decades doesn't
             | help matters.
        
         | DoingIsLearning wrote:
         | Not trying to be pedantic but carcinogenic is something that
         | _causes_ cancer, that is not the mechanism this study is
         | describing with palmitic acid.
         | 
         | The study claims that palm oil promotes the growth of
         | metastasis of an original cancer tumour. So it is not that palm
         | oil _causes_ cancer but that it will _potentially_ promote more
         | agressive copying of tumurous cells into other regions of the
         | body.
        
       | sebirocs wrote:
       | if this helps saving orangutans in borneo, i welcome it
        
       | gremloni wrote:
       | Basic question-- is coconut palm? Are there multiple types of
       | palms? Where does the oil come from?
        
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