[HN Gopher] Psilocybin clinical trial to treat anxiety disorder ...
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Psilocybin clinical trial to treat anxiety disorder receives
approval
Author : geox
Score : 102 points
Date : 2021-11-05 21:28 UTC (1 hours ago)
(HTM) web link (www.monash.edu)
(TXT) w3m dump (www.monash.edu)
| renewiltord wrote:
| We are on the cusp of a new Enlightenment post the nightmare of
| prohibition. MDMA, Ketamine, Psilocybin, LSD are now all
| available easily, the middle two in good quality to normal
| people.
|
| I love it. A couple of my friends take this stuff for the mood
| uplift. Personally, microdosing has never done the trick for me,
| but a solid 2.5 mg plus is a solid trip that just pushes me into
| the motivation zone so hard. I usually avoid it because of the
| length of the trip but hell is it awesome.
|
| Occasionally I leave the Bay Area and am astounded by the degree
| to which other people like to have Big Government dictate their
| personal lives. Texas, for instance, blew my mind. It was like
| taking three steps back from progress. There are trade offs, I
| know, but for me, my personal individual freedom is paramount.
|
| I love America's federal system. I wish more power would be
| devolved to the states.
| uptownfunk wrote:
| Totally 100% agree, Psilocybin is an incredible medicine.
| cyberbanjo wrote:
| Can you elaborate on how Texas has big gov in peoples life that
| SFBay doesnt?
| mpalczewski wrote:
| Both are authoritarian, just depends on if you like left vs
| right wing authoritarianism.
|
| Texas more strongly limits the drugs you can put in your
| body. Limits access to abortions. etc...
|
| California limits guns, has vaccine mandates. Limits smoking
| in your own condo. etc...
| nebula8804 wrote:
| Under Texas franchise laws, consumers can only buy cars from
| auto dealers and can't buy them directly from automakers.
|
| As it stands in the Lone Star State, Tesla's company-owned
| outlets can't legally sell a Tesla in Texas. This is even
| more hilarious given they are building the Cybertruck in
| Texas.
| j4hdufd8 wrote:
| I'm confused, how accessible is this stuff to you? Do you mean
| black market or prescription?
| jimbob45 wrote:
| Right there with you. Last I checked, LSD has been extremely
| scarce since Hardison got snapped up in 2005. Even if you can
| get your hands on the stuff (or any of the drugs mentioned
| for that matter), there's still no guarantee that what you're
| getting is what the dealer says it is.
| piethesailorman wrote:
| As a proud 4th generation Texan, I would like to say going to
| California in various ways would strike me as being a place
| that uses state power in backwards ways as well.
|
| Unfortunately for the both of us, not to speak for anything
| specifically to California, our states have managed to make
| some bad decisions. I believe I have standing to speak to
| recent Texas policy in regard to the recent abortion madness,
| illegalizing delta-8 THC products etc... sad times indeed.
|
| I am very pro federalism myself, and think that competition of
| polity would be a great unwinding of federal power. But it
| seems the iterim is going to be the states fighting against the
| Fed in extreme ways.
| varispeed wrote:
| Many people live in mental prison and because they don't know
| any better, they fear change. They fear that, perhaps they
| lived majority of their life trapped and only their own
| ignorance kept them in the cage. They fear to admit that to
| themselves, they fear the feeling they lost their life to
| easily preventable pain and misery.
| giantg2 wrote:
| "Occasionally I leave the Bay Area and am astounded by the
| degree to which other people like to have Big Government
| dictate their personal lives. Texas, for instance, blew my
| mind."
|
| I think it depends on the issues one is using for their
| perspective. Some people may find CA more oppressive.
| elevenoh wrote:
| >I wish more power would be devolved to the states.
|
| Doesn't everybody!? Why aren't we seeing more of this
| varispeed wrote:
| It's crazy that law enforcement actually participates in hounding
| people who self-medicate rather than going after corrupt medical
| and political establishment. This completely destroys any trust
| people have in government, laws and justice. Great that we can
| see some progress, but I have a feeling that it is only possible
| because people behind all that corruption finally figured out a
| way how to monetize it.
| giantg2 wrote:
| It makes perfect sense once you understand that the system is
| not about truth, justice, etc. It's about forcing conforming to
| societal expectations and holding on to or expanding the power
| society has delegated to them.
| travisd wrote:
| Just listened to an interesting podcast on psychiatry and
| capitalism today that mentioned just how desperate big pharma
| companies are to get their hands on psychadelics. Podcast
| essentially argues that psychiatry in large part serves to
| continue enabling capitalism while papering over the people who
| are incompatible with capitalism via medication. Very interesting
| pod for sure.
|
| https://www.madinamerica.com/2021/10/can-critiques-psychiatr...
| azinman2 wrote:
| Title should reflect this is in Australia
| jdavis703 wrote:
| Meh, these treatments are usually limited duration. Even if
| this is only ever approved in Oz folks could presumably travel
| abroad to seek treatment. Folks post US-only things here all
| the time.
| robbrown451 wrote:
| Sure but that kind of limits its capacity to make an impact,
| right?
|
| Pretty much everyone experiences some degree of anxiety. Tons
| of people here in California, before recreational cannabis
| was legal, got a medical use permit simply by truthfully
| telling the teledoc they have anxiety and cannabis might help
| them with it. Nobody cared whether this anxiety crossed some
| arbitrary threshold into being a serious medical issue, or if
| it was just regular old "my life can be stressful, but it
| sure is nice to relax with a sweet bong hit."
|
| I doubt a single person was turned away because their anxiety
| wasn't considered "serious" enough, and I'm personally ok
| with that.
|
| I'd be happy if the same situation happened with psilocybin.
|
| That's a big difference from having to go completely across
| the world to seek treatment.
| boomboomsubban wrote:
| Are foreign clinical trials meaningless for FDA approval? I
| only have knowledge from news stories, but I seem to recall
| oxycontin using sketchy foreign trials to get approval.
| elevenoh wrote:
| Psilo + mdma is a more effective way to treat anxiety disorder
| IME.
|
| Psilo alone can be a little adrenalizing.
| qwerty456127 wrote:
| I'm pleased the war on drugs and social stigma gradually stops
| blocking research on psychedelics but I wish they would also
| study lesser-known substances and compare. E.g. psilocybin (4-PO-
| DMT) has an interesting synthetic alternative psilacetin (4-AcO-
| DMT) - I would love to see it as an extra thing they would
| compare to in such studies.
| lstodd wrote:
| 5-MeO is also interesting.
|
| https://www.ghres.com/pipeline
| Alex3917 wrote:
| The issue is that they'd then have to pay for preclinical
| studies to determine safety, which would add millions of
| dollars to the budget. Whereas for psilocybin that work was
| largely done decades ago.
| elevenoh wrote:
| Distributed anecdotes derisk the lesser known substances before
| the $ & reputation flow in to study it w/ a hypothesis.
|
| I'm sure it'll happen sooner than later.
| shiado wrote:
| The worst anxiety I have ever experienced was from a bad trip
| that caused intense panic and days of anxiety and paranoia after.
| Can anybody anecdotally attest to psychedelics helping anxiety?
| mysecretaccount wrote:
| There are already completed studies that show positive impact
| from psilocybin on anxiety.
|
| My experience as someone who has mild anxiety (and always
| feared having a "bad trip") was that, though I had some
| challenging and uncomfortable (but ultimately rewarding)
| thoughts during the experience, the "afterglow" was a couple
| weeks of enhanced mood and little-to-no anxiety.
| amelius wrote:
| Any guesses about how effective this compound will be and to what
| percentage of patients?
| alexfrydl wrote:
| Very high percentage. At least in my experience, the effect is
| NOT subtle.
| seph-reed wrote:
| Depending on set and setting: anywhere from extremely good to
| extremely bad. I'm pretty sure they'll be cognizant of creating
| a positive environment though.
| fuckcensorship wrote:
| I think there is a high chance that the short-term results will
| seem miraculous with significant improvements for issues like
| anxiety and depression but there will be difficulty with
| maintaining these improvements long-term without continued
| sessions and therapy.
| mojomark wrote:
| I highly recommend the documentary "Fantastic Fungi" [1] (2019)
| to anyone interested in this topic. Can be viewed on Netflix.
| It will give you a good sense of what's driving the interest in
| this field.
|
| 1. Fantastic Fungi https://g.co/kgs/1UMWga
| uptownJimmy wrote:
| Just my own one little bit of anecdata, but I credit my handful
| of youthful psychedelic experiences with having shown me that
| it was possible to feel anything BUT anxious and depressed and
| afraid of the world.
|
| As a young dude with a lot of childhood trauma, it was
| revelatory and profound to feel peace for a day, to feel the
| world flow around me with a sense of joy and acceptance.
|
| Hard to say how this will all play out in the coming years, but
| I am excited to see this stuff getting at least a proper chance
| at being used to help damaged souls in a therapeutic
| environment.
| whalesalad wrote:
| 100%
| neom wrote:
| 100% is extreme, but I agree that if we're guessing, it will
| be a high net positive effect to the majority of users.
| WhitneyLand wrote:
| Are there other promising anxiolytics on the horizon? Even more
| basic, what are the best options available now?
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(page generated 2021-11-05 23:01 UTC)