[HN Gopher] In Re-Analysis, Ivermectin Benefits Disappeared as T...
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       In Re-Analysis, Ivermectin Benefits Disappeared as Trial Quality
       Increased
        
       Author : nradov
       Score  : 21 points
       Date   : 2021-10-29 21:02 UTC (1 hours ago)
        
 (HTM) web link (www.medpagetoday.com)
 (TXT) w3m dump (www.medpagetoday.com)
        
       | 1680168l wrote:
       | Also as NIH funding increased, but what does that have to do with
       | it, anyway?
        
       | ImpressiveWebs wrote:
       | From the FLCCCA website: [1]
       | 
       | > All clinical trials suffer from risks of bias in their design
       | and conduct, as assessed by the Cochrane Risk of Bias 2.0 tool
       | that assesses trial biases with the grades of "some concern, low,
       | moderate, high, or serious". Although one group of authors has
       | assessed many of the trials as having moderate to severe risks of
       | bias, performing meta-analyses of these trials can more
       | accurately detect the true effects despite individual trial
       | biases. Multiple groups, including ours, have performed meta-
       | analyses of these trials, with all groups finding consistent
       | benefits amongst the trials. In fact, the consistency of trial
       | results from both sets of randomized and observational controlled
       | trials from varied centers and countries and trial sizes and
       | disease phases lend even more validity to the estimates of
       | benefit.
       | 
       | [1) https://covid19criticalcare.com/ivermectin-in-
       | covid-19/faq-o...
        
         | Uehreka wrote:
         | Looking at the FLCCCA's Wikipedia page:
         | https://en.wikipedia.org/wiki/Front_Line_COVID-19_Critical_C...
         | 
         | It doesn't start out great:
         | 
         | > According to its co-president, Paul E. Marik, the group has a
         | shared interest in vitamin C.
         | 
         | Apparently they've pushed a lot of unproven and not-so-great
         | stuff:
         | 
         | > The group initially started promoting Marik's discredited
         | sepsis treatment protocol as a treatment for COVID-19, and in
         | April 2020 it circulated press releases promoting vitamin C,
         | heparin, hydroxychloroquine and other drugs, before pivoting to
         | ivermectin promotion in October 2020.
         | 
         | A former member of the group expressed skepticism about their
         | approach and resigned over his concerns (there were only 10
         | people to start with)
         | 
         | > In August 2021 one doctor, Eric Osgood, resigned from the
         | FLCCC because the group "may be contributing to people making
         | the choice not to get vaccinated". Osgood commented: "If you're
         | going to have a page that's dedicated to 'How do you prevent
         | yourself from getting COVID?' that page can't not have vaccines
         | at the top of it".
         | 
         | And apparently one of their members did this:
         | 
         | > In 2021, Fred Wagshul, a member of the FLCCC, prescribed
         | ivermectin for a patient in a hospital in Ohio where he did not
         | have admitting privileges.
         | 
         | Granted, I guess if you were cool with fringe ideas like
         | Vitamin C cures coming into this, none of what I quoted here
         | will change your mind. But this doesn't strike me as a group
         | I'd trust, even though they have a well-designed website.
        
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       (page generated 2021-10-29 23:01 UTC)