[HN Gopher] Hormone links exercise with cognitive benefits
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       Hormone links exercise with cognitive benefits
        
       Author : chaimanmeow
       Score  : 23 points
       Date   : 2021-09-28 20:27 UTC (2 hours ago)
        
 (HTM) web link (www.nia.nih.gov)
 (TXT) w3m dump (www.nia.nih.gov)
        
       | xwdv wrote:
       | So is the conclusion that we should be exercising right up until
       | the day we die?
        
         | themodelplumber wrote:
         | My takeaway was googling "Irisin pills"~
        
           | captainbland wrote:
           | "Next, the researchers delivered irisin directly into the
           | mice's brains."
           | 
           | That sentence is not giving me much hope that they expect the
           | hormone to survive digestion.
        
             | serrel wrote:
             | Once it's in the bloodstream, the hormone passes the blood
             | brain barrier.
             | 
             | "In addition, the researchers found that irisin could cross
             | the blood-brain barrier to act on the brain."
        
         | throw1234651234 wrote:
         | "I don't exercise so I can live longer, I exercise so that when
         | I am dying, I don't get sad, but think 'at least I don't have
         | to exercise anymore'".
         | 
         | Anyway, there was a ton of research done that people over 60
         | can still put on muscle mass. Which obviously protects from
         | injuries, supports posture, etc.
         | 
         | We also have studies showing that long term runners don't have
         | a higher incidence of knee problems than non-runners, so it
         | does seem that the cartilage damage DURING exercise is
         | compensated by said exercise, assuming correct form and all
         | that.
        
         | helge9210 wrote:
         | Basically.
         | 
         | If you're lucky, you'll feel it couple of days before. Than you
         | can rest, say goodbye and die in your sleep.
        
       | chaimanmeow wrote:
       | "Past studies found that exercise induces production of FNDC5, a
       | protein found on the surfaces of certain cells. FNDC5 can
       | activate neuroprotective genes in the hippocampus, the brain
       | region in charge of memory formation. The outer part of FNDC5 can
       | be cleaved off to form a hormone called irisin, which is released
       | into the bloodstream."
       | 
       | see also
       | 
       | https://pubmed.ncbi.nlm.nih.gov/25952527/
       | 
       | "Irisin, as a new hormone-like myokine, is discovered in the
       | presence of exercise-induced peroxisome proliferator-activated
       | receptor gamma coactivator-1-alpha (PGC-1a)."
       | 
       | https://en.wikipedia.org/wiki/FNDC5
        
         | JamesBarney wrote:
         | I think sauna's also increase irisin.
        
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       (page generated 2021-09-28 23:01 UTC)