[HN Gopher] Melatonin may decrease risk for and aid treatment of...
___________________________________________________________________
Melatonin may decrease risk for and aid treatment of Covid-19
Author : marz0
Score : 12 points
Date : 2021-08-30 20:19 UTC (2 hours ago)
(HTM) web link (openheart.bmj.com)
(TXT) w3m dump (openheart.bmj.com)
| criticaltinker wrote:
| _> A retrospective analysis of 791 intubated patients with
| COVID-19 has found that, after adjustment for pertinent
| demographics and comorbidities, those treated with melatonin had
| a markedly lower risk for mortality (HR: 0.131, 95% CI: 0.076 to
| 0.223)--suggestive of a profound anti-inflammatory benefit. _
|
| _> Moreover, recent epidemiology suggests that melatonin usage
| may reduce the risk for contracting COVID-19. A recent
| retrospective study, examining data from 26 799 subjects in a
| COVID-19 registry and using propensity score matching to account
| for a range of covariates, found that current supplementation
| with melatonin was associated with a significant 28% reduction in
| risk for serologically detectible COVID-19 infection. Among Black
| Americans, this reduction in risk was a remarkable 52% (OR=0.48,
| 95% CI 0.31 to 0.75). _
|
| _> More generally, it might be feasible to define a simple
| nutraceutical regimen that could reduce the risk for COVID-19 and
| a range of other viral infections. There is growing evidence,
| both case-control and ecologic, that replete vitamin D status not
| only markedly improves the clinical course of COVID-19, but also
| is associated with decreased risk for clinically detectible
| infection. _
|
| _> COVID-19 epidemiology also suggests that higher zinc status is
| associated with both a better clinical course in this disorder
| and lower risk for infection.42 43 Especially in the elderly, who
| are more prone to poor zinc status, zinc supplementation has been
| found to boost acquired, antigen-specific immunity, while also
| exerting an anti-inflammatory action; such supplementation of the
| elderly was associated with a marked decrease in total infections
| in a 12-month randomised controlled trial. _
|
| _> Hence, it is not unreasonable to suggest that a
| supplementation programme incorporating vitamin D, zinc,
| melatonin and possibly additional nutraceuticals could reduce
| risk for and aid control of COVID-19 and a range of other viral
| infections. _
| denysonique wrote:
| What if it is not melatonin itself, but the fact that it helps to
| get more sleep which generally boosts the immune system and has
| anti-inflamatory effects.
|
| Sleep length/quality should have been taken into account.
|
| Have scientists rediscovered the importance of sleep?
| dangom wrote:
| Well, we could turn your question around. What if it is not
| sleep itself, but the fact that it is related to the release of
| melatonin which potentially mediates immune system responses
| and inflammation?
|
| The paper offers interesting hypothesis into why this could be
| the case.
| smt88 wrote:
| The study is of intubated patients, I think they're asleep a
| lot...
|
| But I'm sure poor sleep habits are a risk factor for severe
| Covid anyway.
| Andys wrote:
| After 12+ months of suffering, melatonin with high dose nicotinic
| acid totally cured my long covid.
| Something1234 wrote:
| Can you provide proof of this or links to research? Making
| claims like this is counter productive and only helps to
| empower the antivaxxers.
| xyzzy21 wrote:
| Why do you hate free speech and open discussion?
|
| Why do you hate antivaxxers - are you trained in medicine,
| molecular biology, etc. or is this nothing more than orthodox
| ideological position?
|
| The scientific method and science itself is NEVER SETTLED.
| And it is always advanced from discussion including anecdotes
| that become more formal research.
___________________________________________________________________
(page generated 2021-08-30 23:02 UTC)