[HN Gopher] CBD Inhibits SARS-CoV-2 Replication and Promotes the...
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       CBD Inhibits SARS-CoV-2 Replication and Promotes the Host Innate
       Immune Response
        
       Author : weare138
       Score  : 29 points
       Date   : 2021-08-09 20:41 UTC (2 hours ago)
        
 (HTM) web link (www.ncbi.nlm.nih.gov)
 (TXT) w3m dump (www.ncbi.nlm.nih.gov)
        
       | thedudeabides5 wrote:
       | No way. Hilarious, and great, if true
        
       | throwaway192874 wrote:
       | > The purity of CBD and, in particular, the composition of the
       | materials labelled as CBD are also important, especially in light
       | of our findings suggesting that other cannabinoids such as THC
       | might act to counter CBD antiviral efficacy. This essentially
       | eliminates the feasibility of marijuana serving as an effective
       | source of antiviral CBD, in addition to issues related to its
       | legal status.
       | 
       | Well shit
        
         | criticaltinker wrote:
         | > This essentially eliminates the feasibility of marijuana
         | serving as an effective source of antiviral CBD
         | 
         | To elaborate, it's not exactly impossible to do but likely out
         | of reach for the average joe.
         | 
         | Steam and hydro distillation methods only require a bit of
         | readily available laboratory gear, but new and improved
         | techniques such as microwave assisted extraction [1] will only
         | be available to large scale industrial producers for quite some
         | time.
         | 
         | [1] Cannabidiol-enriched hemp essential oil obtained by an
         | optimized microwave-assisted extraction using a central
         | composite design
         | https://bhas.unicam.it/bhas/sites/www.unicam.it.bhas/files/C...
        
       | LargoLasskhyfv wrote:
       | I'm wondering if this could be combined with the nose spray from
       | https://sanotize.com/enovid/
        
       | Bellamy wrote:
       | Great news, but very expensive compared to a vaccine.
        
         | nradov wrote:
         | It's not either / or. Vaccines are great but they aren't 100%
         | effective so we still want additional treatments. Hopefully
         | drug researchers will figure out how to mass produce the active
         | ingredients at a lower cost.
        
           | landemva wrote:
           | The issue with natural products is lack of patent protection,
           | so drug developers are unwilling to develop plant extracts.
           | It could be reasonable to anticipate non-profits such as
           | Johns Hopkins or Vanderbilt to pursue ideas like this, but it
           | doesn't happen.
        
         | criticaltinker wrote:
         | You can't grow the vaccine in your garden though.
         | 
         | Jokes aside, there's a long way to go before this line of
         | research leads to a product anywhere near as effective as
         | vaccination.
         | 
         | Quoting from the OP:
         | 
         | - "CBD is quite hydrophobic and forms large micellar structures
         | that are trapped and broken down in the liver, thereby limiting
         | the amount of drug available to other tissues after oral
         | administration."
         | 
         | - "other means of CBD administration such as vaping and smoking
         | raise concerns about potential lung damage"
         | 
         | - "The purity of CBD and, in particular, the composition of the
         | materials labelled as CBD are also important, especially in
         | light of our findings suggesting that other cannabinoids such
         | as THC might act to counter CBD antiviral efficacy"
         | 
         | - "The necessary human in vivo concentration and optimal route
         | and formulation remain to be defined"
        
       | Zelphyr wrote:
       | I'm not well versed in reading studies like this. Could someone
       | who is tell if there is any mention of a correlation to a
       | reduction in inflammation caused by CBD?
        
         | spfzero wrote:
         | They do mention activity to inhibit Cytokines, which is an
         | important inflammation cause in Covid. The paper said nothing
         | about inflammation from CBD itself. Since CBD is a medicine for
         | the treatment of epilepsy many people take it already. The
         | paper mentioned only mild side effects.
        
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       (page generated 2021-08-09 23:02 UTC)