[HN Gopher] A Chemical Hunger: Mysteries
       ___________________________________________________________________
        
       A Chemical Hunger: Mysteries
        
       Author : apsec112
       Score  : 125 points
       Date   : 2021-07-10 21:22 UTC (2 days ago)
        
 (HTM) web link (slimemoldtimemold.com)
 (TXT) w3m dump (slimemoldtimemold.com)
        
       | EMM_386 wrote:
       | Fascinating read. At first I was thinking things like the
       | introduction of high fructose corn syrup, or microwave dinners,
       | but that doesn't completely explain all of those data points.
       | 
       | This is an interesting comment someone left ... it's one of the
       | only ones that could potentially explain all of the results,
       | outside of some outliers like the altitude effect.
       | 
       | > With these premises it seems almost obvious to attribute the
       | obesity pandemic to an external factor - for instance, virus or
       | bacteria. My money is on gut bacteria being altered by some
       | bacteria/virus, of which transmission is relatively hard (but it
       | persists), which spread like wildfire in the last forty years and
       | which thrives on cafeteria diets (which would explain its
       | emergence in the second half of the 20th century).
        
         | elliekelly wrote:
         | You might find Tim Specter's "The Diet Myth" interesting. He's
         | a geneticist specializing in twin studies who sort of stumbled
         | into the role of the microbiome in obesity. It's been a while
         | since I've read it but IIRC he points to pasteurizing as one of
         | the contributors to America's obesity compared to Europe.
        
         | dobin wrote:
         | I've heard something of overuse of antibiotics destroying the
         | gut microbes
        
       | guerrilla wrote:
       | I don't know about this, there's a lot of factors listed
       | individually here but not in comnination. It could be something
       | like "eats lots of sugar and doesn't move", like are those honey
       | and starch eaters as sedentary as us?
       | 
       | Then again, it woildn't totally surprise me if it were something
       | like indoor lighting or something.
       | 
       | Edit: The second article accounts for some combinatiins but not
       | to my satisfaction. Also:
       | 
       | > The USDA Economic Research Service estimates that calorie
       | intake in the US increased from 2,016 calories per day in 1970 to
       | about 2,390 calories per day in 2014. Neither of these are jaw-
       | dropping increases.
       | 
       | That does seem like a jaw-dropping increase if sustained over
       | time and other varianles are held constant. So, huh?
       | 
       | I have another idea though since it talks about lipostat theory:
       | Isn't it known that cortisol exposure causes weight gain? What if
       | it's simply that our life is morr stressful despite being
       | objectively less chaloenging in some sense. This could be due to
       | anything from less cardio to a bad news diet.
        
       | garganzol wrote:
       | It's not just calories.
       | 
       | It's how fast those calories get into bloodstream as a glucose.
       | 
       | "Fast" carbohydrates are extremally efficient in this regard; you
       | can eat a ton before hunger leaves you. And this is a big gotcha
       | as we constantly overeat being fooled by our mind and
       | carbohydrates with high glycemic index.
       | 
       | So, it is not just calories: it's the amount and speed of insulin
       | response to those calories.
        
         | andylei wrote:
         | This is covered in the second part of the article:
         | https://slimemoldtimemold.com/2021/07/11/a-chemical-hunger-p...
        
       | [deleted]
        
       | mysterypie wrote:
       | > _We should start seriously considering other paradigms. If diet
       | and exercise are out as explanations for the epidemic, what could
       | possibly explain it? And what could possibly explain all of the
       | other bizarre trends that we have observed?_
       | 
       | > _[Next Time: A CHEMICAL HUNGER]_
       | 
       | That's the part I really wanted to see. I've now bookmarked it so
       | I can read the next instalment. I expect to hear some fascinating
       | theories -- perhaps some modern equivalent of lead poisoning of
       | ancient Rome.
        
       | SavantIdiot wrote:
       | > Combined with all the sugar they get from eating fruit, they
       | end up eating about the same amount of sugar as Americans do. ...
       | These are all unrefined sugars, of course
       | 
       | Isn't it important to distinguish the type of sugar?
       | 
       | I thought the 5-10% increase in proportion of sucrose to fructose
       | was sufficient enough to result in significant difference between
       | how types of sugar impact insulin response. E.g., the shift to
       | more easily-metabolized fructose results in even more available
       | calories to convert to fat than the 50/50 sucrose/fructose found
       | in fruits.
       | 
       | > even when statistically adjusting for variables like age, BMI,
       | and physical activity.
       | 
       | I find this hard to believe, that the statistics were adjusted
       | _correctly_ for physical activity. You can talk about !Kung,
       | Maasi, and Inuits all day long, but these tribes are wildly
       | active compared to the typical desk-jockey westerner. That can 't
       | be shrugged off so easily.
        
         | code_duck wrote:
         | Is fructose considered easy to metabolize? It takes drastically
         | longer to convert to glucose than other sugars, requires liver
         | enzymes and can creates gastric upset in excess. It seems quite
         | inefficient compared to carbohydrate sources like starch which
         | are simply chains of glucose molecules that your body
         | separates.
        
           | SavantIdiot wrote:
           | I think you have it backwards: fructose is a monosaccharide
           | which is metabolized almost instantly, and sucrose is a
           | disaccharide which requires additional energy to metabolize.
           | Glucose is the end result, but glucose isn't what is added to
           | industrial foods. So more effort is required to use sucrose
           | than fructose, and I believe that is the source of the issue.
        
       | irthomasthomas wrote:
       | It is not really a mystery any more. There was a heart disease
       | epidemic in the mid 20th century (the rate doubling every
       | decade). A scientist named Ansel Keys did an epidemiological
       | study comparing rates of heart disease to fat intake in 6
       | different countries and found a strong correlation: countries
       | that ate more fat had higher rates of heart disease. Therefore
       | fat causes heart disease.
       | 
       | This is the lipid hypothesis, which still drives nutrition advice
       | and laws today.
       | 
       | Ansal Keys joined the board of The American Heart Association
       | which adopted the lipid hypothesis and started telling everyone
       | to cut out fat and eat more carbohydrates (carbs are sugars
       | strung together which are quickly chopped up and metabolised as
       | sugar, what could go wrong? ;). Numerous clinical trials,
       | involving tens of thousands of people, all failed to find a link
       | between fat and heart disease (often actually finding the
       | opposite). The government ignored these trials and supported
       | Ansal Keys instead.
       | 
       | The Mcgovern senate committee was tasked with creating a national
       | nutritional policy in 1977, but when scientists told the
       | commission that there was no evidence supporting the low fat/high
       | carb diet and that more research was needed to confirm the
       | hypothesis, they where told that the government does not have the
       | luxury of waiting for scientific research [0] and in 1980 the
       | USDA published the dietary pyramid that we still use today,
       | recommending that people get the bulk of their calories from
       | carbs.
       | 
       | The single epidemiological study by Keys was all they had to go
       | on at that time. Since then, there have been many more rigorous
       | diet trials which failed to confirm the lipid hypothesis and
       | actually show a strong link between carb consumption and obesity.
       | So the scientists introduced an entirely new scientific method,
       | now called teleoanalysis[1][2] to prop up the lipid hypothesis.
       | No causative link between dietary fat and heart disease could be
       | found in controlled trials. But, they did find an association
       | between fat and cholesterol, and then they found an association
       | between high cholesterol and heart disease. So now using
       | teleonalysis we can say that fat is associated with high
       | cholesterol and high cholesterol is associated with heart disease
       | therefore fat causes heart disease.
       | 
       | The American government officially supports the lipid hypothesis
       | and promotes the high carb diet pyramid at all contact points.
       | Schools, universities, government agencies all must promote the
       | lipid hypothesis or be sacked or defunded; "The dietary dogma was
       | a money-maker for segments of the food industry, a fund raiser
       | for the Heart Association and busy work for thousands of fat
       | chemists... To be a dissenter is to be unfunded because the peer-
       | review system rewards conformity and excludes criticism"[3]
       | 
       | Carbs have low nutritional content and most vitamins are fat
       | soluble so by eating less fat you feel more hungry because your
       | body needs those nutrients and you are forced to eat more. When
       | you eat a lot of carbs, your liver gives you an insulin shot.
       | Insulin tells your fat cells to absorb the carbs to bring the
       | body back to balance. So your fat cells swell and then divide,
       | making your body bigger, and a bigger body requires more food to
       | sustain it.
       | 
       | The result is that obesity and heart disease have increased about
       | 10x since 1980 [4]
       | 
       | [0] https://www.youtube.com/watch?v=xbFQc2kxm9c
       | 
       | [1] https://www.bmj.com/rapid-
       | response/2011/10/30/teleoanalysis-...
       | 
       | [2] https://stats.stackexchange.com/questions/65372/what-is-
       | wron...
       | 
       | [3]
       | https://books.google.co.uk/books?id=CxKQ2Ak6_p4C&pg=PA144&lp...
       | 
       | [4]
       | https://www.ahajournals.org/cms/asset/d4e7b1a9-3093-4507-984...
        
         | andylei wrote:
         | the author of the post refutes the carbohydrate hypothesis
         | here:
         | 
         | https://slimemoldtimemold.com/2021/07/11/a-chemical-hunger-p...
        
           | irthomasthomas wrote:
           | That one graph from one epidemiological study is not enough
           | to refute 60 years of data from many clinical trials. There
           | is probably a confounding variable.
        
       | Tabular-Iceberg wrote:
       | I know exactly why I'm fat. I consistently continue eating after
       | already feeling full. Regardless of whether it's socially
       | designated as a "health food" or "junk food".
       | 
       | Most of the pleasure of eating and drinking comes from the first
       | few bites and sips, after that the senses start dulling and
       | diminishing returns start to set in, so it's really no big loss
       | to stop when full. Certainly not worth getting indigestion over.
       | 
       | A few weeks of disciplined eating seriously diminishes the urge
       | to overeat, but all it takes to settle into old habits is a
       | single slip-up. I think making food artificially unpalatable by
       | cutting salt, fat, or whatever ingredient is currently being
       | vilified is just unproductive. It will just make the experience
       | frustrating and unsatisfying no matter how much or little you
       | eat.
        
       | jinpa_zangpo wrote:
       | People are getting fat because they are consuming more calories.
       | And they are consuming more calories because processed foods are
       | engineered to make you overeat them. To lose weight, stop eating
       | processed foods and learn to cook simple foods from scratch,
       | minimizing the use of sugar, salt, and oil, three common appetite
       | stimulants.
        
         | nradov wrote:
         | For most people there's no particular need to minimize salt and
         | oil in order to avoid getting fat. However certain oils,
         | especially vegetable oils, tend to have other bad health
         | effects.
        
         | Tabular-Iceberg wrote:
         | >And they are consuming more calories because processed foods
         | are engineered to make you overeat them.
         | 
         | I've heard this being claimed a lot, and have therefore often
         | thought about it while eating fast- and other processed foods,
         | picking around in it trying to discover the big conspiracy, but
         | I can't seem to find any substantial differences with what I
         | make at home from raw ingredients.
         | 
         | The engineering seems to be geared more towards reproducibility
         | of all the dishes over a large network of franchises around the
         | world. It's still the same ingredients, they're just less
         | tolerant of substitutions and deviations from the specs.
         | 
         | Maybe it's really a matter of fast food being compared to food
         | cooked by unskilled home cooks who just happen to be suffering
         | from a socially induced panic about some arbitrary ingredient,
         | and therefore tends to produce a result that's just plain
         | unpalatable compared to something made by a professional or a
         | seasoned home cook.
         | 
         | No cook with any amount of self respect will make intentionally
         | unpalatable food, and the French paradox clearly demonstrates
         | that it's not necessary for food to be unpalatable to avoid
         | obesity.
        
       | joseluis wrote:
       | Insulin is the big elephant in the room that's barely talked
       | about. Everybody should watch this lecture
       | https://youtu.be/RuOvn4UqznU
        
         | guerrilla wrote:
         | Could you do more to motivate us to watch the nearly 1.5 hour
         | video than "insulin"? Who is this guy and what's the thesis?
         | Summary?
        
           | joseluis wrote:
           | Ok, I didn't realize it might be necessary, since the speaker
           | is so good and engaging since the first minute but I'll try.
           | 
           | He basically exposes the underlying physiological mechanisms
           | of fasting and nutrition. And puts it in context of our
           | biological evolution and current first-world diseases.
           | Explains the enormous power fasting has for healing the
           | physiology, regulating insulin levels, even reverting insulin
           | resistance, how when you stop eating for a day the body
           | activates the expression of certain genes in every cell for
           | producing all the antioxidants known to man, promote
           | autofagie of dead cells, producing growth hormones, start
           | growing bone marrow cells, stem cells... How insulin is a key
           | piece in that mechanism, how in western societies are junkies
           | of processed food, specially sugar, carbohidrates and, and
           | how by eating too often and too much we keep our insulin
           | leves always high, which impedes our body to begin that
           | innate process of self-healing we have, and we instead just
           | saturate the body with things it doesn't really need and
           | don't give it the opportunity to get rid of them, deriving in
           | preventable diseases.
           | 
           | He speaks about 24h, 36h, 3day and 7 day fasting... How it
           | affects multiple things, including response to chemoterapy,
           | diabetes, dementia...
           | 
           | He has a previous talk called "The bittersweet truth" where
           | he dives more deeply on how exactly fructose basically
           | poisons the body and talks more about insulin, fructose,
           | nutritional myths... Just one fascinating fact after another,
           | supported by data, studies and clinical experience. He tryes
           | to relate the facts in order to give you a very powerful big
           | picture.
        
       | dawnerd wrote:
       | Since bing on Keto for a few months I've noticed a lot of the
       | keto friendly processed foods are close enough to the real thing
       | that it really makes me wonder why companies are not making their
       | products lower carb to begin with. Obviously it costs more, but
       | maybe at scale it doesn't. I suspect companies want higher carbs
       | so people feel hungrier and eat more which in turns means they
       | buy more.
       | 
       | Take for instance this Nick's brand ice cream. It's 7 net carbs
       | per pint and texture and flavor is pretty much identical to
       | 'real' ice creams out there.
       | 
       | Franz makes a wonderful 0 net carb bread (and hamburger and
       | hotdog buns now which are honestly just as good as the regular
       | cheap buns).
       | 
       | Not saying companies need to strive to be 0 carb, that's crazy.
       | If they just stopped putting 50g of sugar in everything that
       | alone would go a long way. Ps: Allulose/Psicose is amazing.
        
         | GordonS wrote:
         | > it really makes me wonder why companies are not making their
         | products lower carb to begin with
         | 
         | Cost has got to be one of the biggest factors, but I'd also say
         | the overwhelming majority of people still have "fat is bad"
         | _firmly_ ingrained into them - it 's going to take a very long
         | time to diminish that.
         | 
         | And of course, people like sweet things.
        
       | kwertyoowiyop wrote:
       | I was thinking it could be partially due to food getting cheaper
       | in recent years, but the data doesn't show a big decrease in
       | total amount spent on food during the recent period of increased
       | obesity. The big changes happened much earlier:
       | 
       | https://www.npr.org/sections/thesalt/2015/03/02/389578089/yo...
        
       | imtringued wrote:
       | I remember some HN threads about impossible burger and other
       | imitation meat. There were comments about how food engineering
       | can produce food that tastes even better than regular meat. That
       | was shocking to me. We already have hyper palatable processed
       | food and they want it to be even worse?
        
         | gambiting wrote:
         | I think there are different goals here which aren't necessarily
         | overlapping. I would support making plant-based meat subtitutes
         | that are so frikking delicious that people want to eat them
         | instead of meat. Not because I'm vegetarian(I'm not) but
         | because it simply makes sense from the point of view of
         | ecological impact of animal farming. The modern western diets
         | where people eat meat 3 times a day are crazy(in my opinion) -
         | we just don't need that much meat.
         | 
         | So from that point of view, yeah, it would be great if at least
         | some people switched to plant based substitutes instead.
         | 
         | Now obviously the problem is that we possibly have the science
         | to make these substitutes so delicious, people will overeat
         | them and in the process make themselves worse than had they
         | just had meat. That is also a concern, absoluteley.
        
         | pif wrote:
         | The root problem is that current technology doesn't help us:
         | processed food can only be either palatable or calorie poor.
         | 
         | The person who will invent low-calorie bread and cheese, she'll
         | be the Messiah :-)
        
       | faichai wrote:
       | The lipostat theory is quite interesting. This is pure
       | conjecture, but its already known that plastics can impact
       | estrogen levels, I wonder if plastics also have some, yet
       | unknown, impact on metabolism that is upsetting lipostatic
       | homeostasis.
       | 
       | Estrogen, cortisol and testosterone all operate in a delicate,
       | interrelated balance, so it's not too big a leap.
        
         | Pyramus wrote:
         | I don't think you have to go all the way to plastics and
         | chemicals (not saying that they aren't potentially playing
         | their part).
         | 
         | Take a simple model with a combination of all the factors the
         | author discusses (type of diet, sugar, trans-fats, caloric
         | intake, processed foods, exercise, genetics etc), allow
         | interaction between the factors, and have the lipostat as the
         | dependent variable. I.e. several factors together will, over
         | time, upregulate the lipostat.
         | 
         | A relatively simple model that evades the authors objections,
         | yet might fit the data.
        
         | BBC-vs-neolibs wrote:
         | Also the increase in thyroid disease, especially among women,
         | may be related.
        
         | derbOac wrote:
         | For some reason when I read the lipostat section I was reminded
         | of decreases in average body temperature trends over time --
         | probably because of the temperature analogies.
         | 
         | I've sometimes wondered if microbiome factors are in play, and
         | by extension, things like antibiotic use (maybe there are some
         | studies about antibiotic exposure and weight gain?). I've
         | usually thought of it in terms of microbiome -> gut ->
         | digestion though, and the lipostat section made me wonder if
         | it's more like microbiome -> "immune response" -> caloric
         | expenditure.
        
           | elliekelly wrote:
           | Where can I read more about this?
        
             | derbOac wrote:
             | The body temperature decreases?
             | 
             | This study was being discussed quite a bit when it came
             | out, although there was prior work on it:
             | 
             | https://elifesciences.org/articles/49555
             | 
             | https://www.scientificamerican.com/article/are-human-body-
             | te...
             | 
             | One hypothesis is that there's been a decline in baseline
             | immune activity with decreased exposure to pathogens,
             | better sanitation, better treatment of infections, etc. But
             | people don't know for sure.
             | 
             | I'm not sure that it applies to the obesity crisis as temps
             | have been declining over a longer time period than what
             | seems to be involved in that. But it got me wondering if
             | there's something like that that might have came into play
             | later. My guess is _no_ , that it's something else, but I
             | could see how antibiotic use might somehow be involved.
        
         | nradov wrote:
         | In particular phthalates (plastic softeners) are suspected to
         | reduce testosterone. Lower testosterone is linked to fat gain.
        
       | MrPatan wrote:
       | Saying "Calories In Calories Out" is what makes you fat is as
       | interesting as saying "Money In Money Out" is what makes you
       | poor.
       | 
       | It's tautologically true but doesn't help anybody.
        
         | ju_sh wrote:
         | Losing fat without any attempt to track calories in vs calories
         | out is like trying to improve the performance of an algotighm
         | without profiling it or tracking how the changes made affect
         | the outcome.
         | 
         | If you're serious about losing fat, it's essential helps to
         | track the calories you eat, calories you burn, macro nutrient
         | split (carbs, fats, proteins) and your weight.
         | 
         | - Calculate your TDEE (Total daily energy expenditure, also
         | known as `maintenance calories`) There are many online
         | calculators to do this - Calculate your daily calorie intake to
         | lose weight (Subtract 15-20% from your `maintenance calories`)
         | - Decide on a rough macro nutrient split (40% protein, 40%
         | carb, 20% fat is a good place to start) - Track the calories
         | you eat and burn. There are apps for this that make it very
         | easy (myfitnesspal is one example) - Weigh yourself regularly
         | and record it (Daily is better, first thing in the morning,
         | without clothes and after any restroom activity) - If you're
         | not losing weight, increase your daily exercise or reduce your
         | calories by a further 5% until you see your weight going down -
         | Note: A healthy weight loss strategy is to aim to lose 1-2 lbs
         | per week
         | 
         | You can absolutely loose fat without doing any of this but it's
         | 100x harder and will take much longer.
        
           | oezi wrote:
           | I think there are two things to embrace:
           | 
           | - Saving more than 500 calories per day is very hard, thus
           | you are likely to only loose 1 lb per week/10 days of body
           | fat.
           | 
           | - You need the will power to stay on course and fight off the
           | hunger sensation. This is the hardest of any diet.
           | 
           | I don't believe that people can change their diet mix / macro
           | nutrient split because there isn't enough choice to change
           | your diet fundamentally without becoming bored quickly or
           | being unhealthy or eco-unfriendly (for instance eating more
           | meat).
        
         | black_puppydog wrote:
         | > "Money In Money Out" is what makes you poor.
         | 
         | Actually many programs for social welfare are exactly based on
         | the idea that it is more complicated than that.
         | 
         | The proponents of universal basic incomes for example have been
         | fighting tooth and nail to even get this "tautological" fact
         | accepted, and it is only now taking hold. The consequences of
         | that would be that "simply" giving people money makes them less
         | poor. It sounds simple when put like that, but it is a real
         | struggle to have the conclusions of that be put into policy.
        
         | gadders wrote:
         | It helped me. I wanted to lose 16kg by a certain date. I put my
         | details into the Precision Nutrition calorie calculator. It
         | told me how many calories I would need to consume per day to
         | hit my goal.
         | 
         | I tracked my calories, and stuck to the daily allowance it
         | recommended. I lost nearly all the weight by the agreed
         | timeline (I lost 14.9kg in the end).
        
           | EMM_386 wrote:
           | It really is as "simple" as that. While there are many
           | biological processes that try to maintain homeostasis and
           | weight, if you ingest less calories you will eventually lose
           | weight.
           | 
           | Think of it this way ... if you were thrown in prison today
           | and they gave you only essential nutrients to survive, you'd
           | lose a lot of weight. Your body might go into starvation mode
           | first and try to fight against it, but without any calories
           | coming in, you will lose weight 100% of the time.
           | 
           | I decided after years of wanting to lose weight, but doing
           | nothing about it, I would just give up and do 1,000 calorie
           | max / day for 3 months.
           | 
           | I lost 20 pounds to bring my BMI in-range without any other
           | changes, and I'm middle aged.
           | 
           | That's not the healthiest way to go about this, but it does
           | work.
        
             | gadders wrote:
             | I actually wanted to lose the weight for my 50th birthday,
             | so I'm not some 25-year old with the metabolism of a
             | greyhound.
        
         | phreeza wrote:
         | It's obvious to scientifically literate folks, but not to
         | everyone.
         | 
         | Much weight loss advice is equivalent to saying "spending money
         | in cash is fine, credit cards are what make you poor", which
         | actually may contain a grain of truth but kind of obscures the
         | actual mechanism.
        
         | SavantIdiot wrote:
         | If you swallow 16oz of dried corn kernels whole or 16oz of
         | cornflour, they have the same calories but you are going to
         | metabolize them in a very different way. I don't understand the
         | CIN/COUT argument when different calories are metabolized
         | differently. Perhaps I am misunderstanding how calories are
         | approximated for foods.
        
         | jwdunne wrote:
         | It also assumes that the human body is a machine with singular
         | inputs and singular outputs, as though it's a pure function.
         | 
         | But it's more complicated than that. Especially when you bring
         | homeostasis into it, where the body will adjust calorific
         | expenditure downwards in response to sustained reduced
         | calorific intake, as just a single example.
         | 
         | But there's lots of things going on that influence the calories
         | coming in, the calories stored and the calories expended. It's
         | unfair to reduce it down so far.
         | 
         | It leads to fat shaming by people whom have never struggled
         | with their weight who justify their cruelty by parroting
         | "calories in calories out".
         | 
         | Even worse, some of those will do silly experiments where they
         | put on weight really really fast and then lose it just as fast,
         | totally ignoring the fact that their body has been in the
         | original state for a long time.
        
           | DJBunnies wrote:
           | It's not cruel, it's science. If it's not working it's not
           | being done correctly. I struggled when I was younger.
        
             | jwdunne wrote:
             | Not sure if science ever justifies the cruelty of fat
             | shaming mate?
        
               | gadders wrote:
               | It's value neutral. It's just a fact. It's like saying
               | the sky is blue, or the earth is a sphere. How people
               | react to that information is up to them.
               | 
               | What other science would you like prevented to spare
               | people's feelings?
        
               | jwdunne wrote:
               | So, really, you agree that science cannot justify the
               | cruelty of fat shaming? As you said, it's value neutral.
               | 
               | Which part of my comment says I'd like science to spare
               | people's feelings?
               | 
               | Show me the science that justifies fat shaming and
               | inappropriate behaviour.
               | 
               | Fat shaming somebody because "science" doesn't make you
               | any less of shit person. In fact, you can't really use
               | any science to excuse poor behaviour.
               | 
               | So I think we might be in violent agreement? Do you talk
               | to your mother like that when you misunderstand her? Wow.
        
               | gadders wrote:
               | I'm saying that the phenomena of fat shaming should not
               | be used to suppress the fact that calories in/calories
               | out is how you lose weight and works.
               | 
               | Would I run up to a morbidly fat person and shout
               | "Calories in/Calories out"? No. Would I contradict an
               | obese person who said "Calories In/Calories Out" was
               | wrong? Yes.
        
               | jwdunne wrote:
               | Okay, which part of my comment says that fat shaming
               | should be used to suppress science?
               | 
               | Which part of my comment says that it's wrong? It IS a
               | simplified view and there ARE many more variables that
               | influence the success of dietary change. And there are
               | even more that influence the wider obesity problem. But
               | that doesn't mean I'm saying it's wrong.
               | 
               | As you said, the sky is blue. Is that wrong? No. Is it
               | simplified? Yes, sometimes it's grey. Sometimes it's a
               | deep blue. Sometimes it's pretty much black. But,
               | generally speaking, yeah it's blue.
               | 
               | Is CICO the solution to the obesity epidemic? No, because
               | it'd have worked to reduce the epidemic by now. It's
               | clearly _not_ the only thing we need to solve the
               | epidemic. There is a difference between the method to
               | lose weight and the solution to the obesity epidemic. The
               | latter has many more variables in play.
               | 
               | Next time you contradict an obese person who "says CICO
               | is wrong", make sure they're actually saying it's wrong.
               | 
               | I am, however, glad you wouldn't run up to people and
               | shout "calories in / calories out". That's a relief.
        
             | fredophile wrote:
             | It's science but it doesn't give very useful actionable
             | things you can do to change your weight. Generally people
             | interpret it to mean you get two inputs you can change,
             | food intake and exercise, and they're independent.
             | Unfortunately, those two things are not independent.
             | Increased exercise often leads to increased hunger which
             | leads to increased eating for many people in the real
             | world. Just saying "eat less" in this context is about as
             | useful as telling someone to be better at their job. Many
             | people will not have the willpower to sustain eating the
             | diet they currently eat but eat less of it. Decreasing
             | calories consumed can lower basal metabolic rate. You can
             | easily google for data on this from the Biggest Loser
             | contestants.
             | 
             | There are also other ways to modify those two parameters
             | that don't involve food and exercise. Are you a type 1
             | diabetic and want to lose weight? Just under dose your
             | insulin and the pounds will fly off. Want to lose weight
             | but you aren't diabetic? Take a little DNP. Want to lose
             | weight faster? Take a little more DNP. Just don't take too
             | much or instead of losing weight you'll die of
             | hyperthermia. Taking DNP or under dosing insulin are not
             | things I would ever recommend anyone do but they are both
             | examples of non food and activity related ways to affect
             | calories out.
        
         | amelius wrote:
         | It's basically differentiating the original equation wrt the
         | only quantity you can say something about, which effectively
         | throws out all the things you know nothing about and which you
         | can then "conveniently" ignore.
        
         | karamanolev wrote:
         | In some way, you're right, but I think there's more to it.
         | Let's ignore for a moment whether it's true. I've seen it said
         | in the sense that if you eat too many "good" calories (from
         | salads or other healthy foods) and spend the same, you'll get
         | just as fat as from bad calories. So the money analogy in a way
         | works - if you get $100 cash, you'll be just as rich/poor as if
         | you get them via a bank transfer.
         | 
         | All of that glosses over a million details, like how full
         | you'll be feeling after 1000 cal from salad vs 1000 cal from
         | Coke, but that's a whole another can of worms.
        
         | defaultname wrote:
         | But it's the fundamental, most basic truth.
         | 
         | If there is anything that people who want to lose weight should
         | do, it's _eat less_. Skip the snack. Smaller portions. That 's
         | incredibly hard to do, of course, and easier said than done,
         | but ultimately it is behind virtually all successful weight
         | loss. What is behind an enormous number of failed weight loss
         | attempts are waving that away and believing some specific
         | macronutrient is really the cause, if you just subscribe to
         | whatever the current trend is.
         | 
         | People get really upset about the calories reality.
         | 
         | And indeed if you compare caloric intake between say 1970 and
         | 2010, there was a significant jump in the average diet. Grain
         | products rose, but not nearly as much as fats and oils rose.
         | People ate more and they got fatter. When excess accumulates
         | over time, the increase doesn't have to be large. More calories
         | in, BMI increased.
        
           | tzs wrote:
           | People in the 2000's weighed about 10% more than people in
           | the '80s who ate the same amount of calories, with the same
           | micronutrient distribution, and did the same amount of
           | exercise [1].
           | 
           | And what about non-humans? Animals are getting fatter, too
           | [2]. Some of this can be explained by humans eating more,
           | hence making more food available to those animals that eat
           | human leftovers or steal human food. But this weight gain has
           | also been noted in laboratory animals which are on controlled
           | diets.
           | 
           | [1] https://www.theatlantic.com/health/archive/2015/09/why-
           | it-wa...
           | 
           | [2] https://www.nature.com/articles/news.2010.628
        
             | defaultname wrote:
             | The nonsensical "lab animal" argument has been debunked a
             | dozen times. It is bullshit. For animal rights reasons,
             | labs switched to rats and mice being given a perpetual,
             | self-serve diet of food. Unsurprisingly they ended up
             | fatter than mice and rats given portioned foods. When they
             | are given portioned foods...what do you know, they're not
             | fat any more.
             | 
             | "People in the 2000's weighed about 10% more than people in
             | the '80s who ate the same amount of calories, with the same
             | micronutrient distribution, and did the same amount of
             | exercise [1]"
             | 
             | To say that the cited study is laughable gives it far too
             | much credit. For instance it specifically and only
             | considers _leisure_ activities. As to self-described
             | dietary results, the only takeaway is that people are far
             | more full of shit now than then. It is Ginny in the
             | Sopranos boasting about their diet while eating chocolate
             | bars in the laundry room.
             | 
             | It's interesting how gullible people who are otherwise so
             | discerning are when it comes to diet, particularly for
             | dietary _excuses_. There is no field that has been so rife
             | with study that upsets study, and gross scientific
             | malpractice, as nutrition. But hey, here 's one study where
             | they mangled numbers from sets decades apart and drew some
             | viral result. Serious groan.
        
           | matthewdgreen wrote:
           | TFA, and particularly the second part (link near the bottom)
           | does quite a bit to refute this. It's worth reading it all
           | the way through.
        
             | Raidion wrote:
             | I mean, I think you can make a case that calories in
             | calories out might not make as much sense for some thinner
             | people in that, almost regardless what they eat, they can
             | find ways to either burn or not process the calories. I
             | don't think he does such a good job making the case it
             | doesn't apply the other way. A body needs a set amount of
             | energy to function, you reduce intake enough and weight
             | drops. No lack of figeting or slightly lower core temp is
             | going to be able to outweigh the lack of calories going in.
             | That being said...
             | 
             | I think the real question raised by this article is why
             | eating at the level required to maintain a specific body
             | weight is second nature to some and torture to others.
             | 'Calories in calories out' starts to sound a lot like 'if
             | you don't want to be addicted don't do drugs'. It's much
             | easier said than done by someone who doesn't understand
             | addiction. In fact it's almost worse than addiction, as
             | someone hooked on heroin or booze can do rehab or some
             | other form where you just can't get ahold of those. But if
             | you're addicted to food, you have to deal with the subject
             | of your addiction 3 meal times a day (plus advertising!).
             | That's a hard place to be.
        
               | defaultname wrote:
               | We've known for decades that cigarettes are addictive.
               | We've known that opiates are addictive. We know that
               | alcohol in excess can be addictive.
               | 
               | Loads of people took in that information and never became
               | addicted (at least until the medical industry tricked
               | them into addiction). The information "if you don't want
               | to be addicted don't do the thing that is sure to get you
               | addicted" is _very_ good advice. It is irrefutable
               | advice.
               | 
               | Once you're addicted it's an entirely different, much
               | more difficult problem. But it isn't a better
               | understanding of addiction to say "Whoa, look I used
               | heroin at a bunch of parties and now I crave heroin,
               | therefore you shouldn't tell people to not do drugs". It
               | doesn't follow.
        
               | sdenton4 wrote:
               | None of this explains the cross species effects, though.
               | Zoo and lab animals are also seeing a rise in obesity
               | under controlled diets. There's clearly an additional
               | environmental and/or chemical effect involved here.
        
               | qvq wrote:
               | It's likely there's another factor but no evidence this
               | would cause a human to go from normal BMI to obese on a
               | controlled diet.
               | 
               | It seems like the decrease in satiety has a stronger
               | effect.
        
               | defaultname wrote:
               | It isn't clear at all.
               | 
               | a) Humans are spectacularly efficient at turning solar
               | energy into bioavailable calories. This impacts virtually
               | every animal.
               | 
               | b) Lab and zoo diets have dramatically changed. For
               | instance in the lab there was a change from specific
               | portioned diets to the notion that food should always be
               | provided. Any study that claims that there was some
               | mysterious rise in obesity is simply lying. And again
               | there is a push for controlled, restricted diets because
               | having sedentary rats and mice who can eat whenever they
               | want is yielding unhealthy subjects.
               | 
               | c) The study this article links was lead by a guy who is
               | an advisor to Coca-cola, Kraft, Frito-Lay, the Restaurant
               | Association, among others. It is a _profoundly_ corrupt
               | industry, and yeah the notion that some mysterious
               | unknown cause is to blame is convenient in that
               | situation.
        
             | defaultname wrote:
             | I read the article to the point where it awaits the next,
             | sure-fire cure-all outing. It is filled with the same
             | delusions and misrepresentations that virtually every
             | snake-oil, magical diet fix is.
             | 
             | Haven't people gotten a little less gullible about this
             | stuff yet?
             | 
             | Look, some tribe had fruit on the ground and they weren't
             | obese. Stuff that pizza is your mouth while we get to the
             | bottom of this.
             | 
             | The reality is that calories have never been as available
             | and _cheap_. And there is an absolutely lock-step
             | correlation between dietary calories and obesity rates. No,
             | it isn 't the great mystery that it is held as. Indeed,
             | this article spends most of its time debunking "it isn't
             | the calories" dietary trends -- low fat, low carb, low
             | sugar, low fat.
        
               | AnIdiotOnTheNet wrote:
               | > The reality is that calories have never been as
               | available and cheap.
               | 
               | Don't forget _addictive_. We 've become incredibly good
               | at making food that makes you want to keep eating more of
               | it. Once you pop, you can't stop.
        
           | kiba wrote:
           | I don't try to measure how much calories I eat. I just skip
           | meals. Turn out it's a lot easier than eating less per meals.
           | Fasting is much easier for me to do.
           | 
           | However, when your parents constantly ask you if you want to
           | eat, it's a bitch to resists the temptation.
           | 
           | I had lost 20 lbs without needing to keep track of how much
           | food I eat, as opposed to how many meals I eat.
           | 
           | Anyway, I doubt reduction of calories is how you're going to
           | keep your desired weight. CICO in the long term is a failure.
           | Partly, because our model is actually wrong. Exercise is
           | basically useless for reducing calories, because it's both
           | very hard to do a lot of it, and your basal metabolism
           | adjusts in the long run by adjusting itself to be lower. You
           | should still do exercise, and if you can around 750 minutes
           | per week, which is when you start hitting diminishing return.
        
             | defaultname wrote:
             | > Anyway, I doubt reduction of calories is how you're going
             | to keep your desired weight
             | 
             | People at a healthy weight consume less calories. Caloric
             | intake has a _perfect_ correlation with obesity. The
             | psychological element is hugely difficult, but the science
             | of  "if you eat more you're going to be heavier" is very
             | firm.
             | 
             | The Japanese eat, on average, 25% less calories than
             | Americans. They have an obesity rate of 4% versus 36% in
             | the US. This despite eating loads of "bad" calories like
             | simple carbs (white processed rice).
        
               | kiba wrote:
               | _People at a healthy weight consume less calories.
               | Caloric intake has a perfect correlation with obesity.
               | The psychological element is hugely difficult, but the
               | science of "if you eat more you're going to be heavier"
               | is very firm._
               | 
               | It is uncontroversial that by reducing calories in one's
               | diet that it will cause weight loss. The controversy is
               | centered around weight control, whether an individual can
               | keep the weight at a stable level over the long run. In
               | that sense, all diet fails.
               | 
               | I would contend that how many calories a person eat is
               | only a proximal cause of obesity, especially since CICO
               | is actually an incorrect model of how our body work.
        
               | nradov wrote:
               | Almost all diets succeed, if you actually follow them
               | instead of just complaining. But it requires making a
               | permanent lifestyle change. I know several people who
               | have done that over the long run.
        
               | kiba wrote:
               | _Almost all diets succeed, if you actually follow them
               | instead of just complaining. But it requires making a
               | permanent lifestyle change. I know several people who
               | have done that over the long run._
               | 
               | Several people as in how many out of those that failed.
               | If the statistics tell us that 90% of people failed, then
               | these diets or programs are still an utter failure. By
               | saying it is some kind of moral failing or willpower
               | means we decided to be lazy about investigating the cause
               | of obesity.
               | 
               | Remember, the obesity epidemic is a modern phenomenon.
               | There are countries around the world that are still
               | relatively lean.
        
               | tsimionescu wrote:
               | > People at a healthy weight consume less calories.
               | Caloric intake has a perfect correlation with obesity.
               | The psychological element is hugely difficult, but the
               | science of "if you eat more you're going to be heavier"
               | is very firm.
               | 
               | The word 'psychological' is doing a lot of heavy lifting
               | here. We have no reason to believe it is more or less
               | likely for overeating to be caused by psychological
               | rather than metabolic or other systemic reasons.
               | 
               | The fact of the matter remains that some people struggle
               | with their weight while others don't. CICO doesn't
               | address this at all.
               | 
               | Of course, CICO also doesn't work very well when
               | comparing between people, despite your claim. For
               | example, people with endocrin disorders are well known to
               | lose or gain weight disproportionately in relation to
               | their diets. Base metabolic rates vary significantly
               | between people, even healthy ones. There are other
               | discrepancies as well, which mean that, knowing person A
               | and person B eat the same amount of calories and exercise
               | the same amount will not help you to predict the weight
               | gain/loss difference between them.
        
               | nradov wrote:
               | Except in rare cases of severe disease, basal metabolic
               | rates only vary by a few percent between people with the
               | same sex, height, and weight. Some people are too quick
               | to blame a "slow metabolism" for gaining weight. I always
               | recommend they quantify it will a simple resting
               | metabolic rate test. Those are cheap and non-invasive.
        
               | JoeAltmaier wrote:
               | Yes of course. But its a fact: a given person can
               | restrict calories from where they are at, and lose more.
               | That's physics. Anything getting away with that simple
               | algorithm is fairly classed under "psychological".
        
               | tsimionescu wrote:
               | It's true, but uninteresting. Insisting on this truth is
               | harmful, because it makes an assumption that people can
               | just choose to eat less without any negative
               | consequences. People love pretending that calories in is
               | simply a matter of rational choice, not a complex result
               | of our inner machinery.
               | 
               | We are biological machines, and the amount we eat is
               | biologically determined by our bodies (assuming food is
               | widely available). We can somewhat influence that with
               | rational thought, but to a limited degree, just like we
               | can choose to breathe in faster or slower, but we can't
               | maintain that for any length of time.
        
               | JoeAltmaier wrote:
               | Hey I'm all aboard that. It's under the umbrella of
               | "psychological".
        
               | kiba wrote:
               | Your body adjusting itself to burn less energy is also
               | physics.
               | 
               | It's like having a thermostat that adjust the temperature
               | to 70 degrees, and you want it to be 75. So your solution
               | is to bring in more heat while ignoring the thermostat.
               | The thermostat adjust by engaging the air conditioner.
               | Which certainly will work, but also very inefficient.
               | 
               | Your body isn't that stupid and it's not certainly a dumb
               | engine.
        
               | JoeAltmaier wrote:
               | Adjust within limits. And the limits are fairly narrow.
               | It's also true that hard exercise will blow away those
               | limits, and require more food. Every single time.
               | 
               | But hard exercise is hard! Folks don't want to do it.
               | They want to stretch and walk around a track and pretend.
               | But they don't want to do 20 miles on a bike. They
               | convince themselves that they can't. Or they try and get
               | aches and pains and decide that's bad. Pretty much
               | throwing up roadblocks right and left, anything to avoid
               | the work.
               | 
               | We all know this. It's why there are 1000 books about
               | tricks and diets and how to fool yourself. Because we
               | want to do that instead. But we can stop enabling that;
               | stop making excuses for small issues about body
               | adjustments and so on.
        
               | kiba wrote:
               | OK? You and I can do these things, but we are outliers.
               | For example, 750 minutes of exercise per week is a lot is
               | what I estimated from a study for diminishing return for
               | health. That's 12.5 hours, let alone meeting the weekly
               | minimum requirement.
               | 
               | Most people are busy, they have jobs or families or kids.
               | Yet decades ago, these same people aren't fat.
               | 
               |  _We all know this. It 's why there are 1000 books about
               | tricks and diets and how to fool yourself. Because we
               | want to do that instead. But we can stop enabling that;
               | stop making excuses for small issues about body
               | adjustments and so on._
               | 
               | There's certainly no magic trick, but being dogmatic or
               | smug isn't helpful either.
        
           | MaysonL wrote:
           | > That's incredibly hard to do, of course
           | 
           | Only for fat people. People like me find it fairly easy.
           | 
           | Over my adult life[currently 75yo], my weight has fluctuated
           | modestly year to year (as measured by the tightness of my
           | belt). When my abdominal circumference has grown by a couple
           | belt notches, I tend to eat less for a while, until the belt
           | is less tight. THIS REQUIRES ALMOST NO WILLPOWER OR CONSCIOUS
           | ATTENTION ON MY PART. Why????
        
           | pydry wrote:
           | It no more fundamental or surprising than the "truth" that
           | giving up smoking is done by not smoking cigarettes.
        
             | defaultname wrote:
             | The point is that it's _entirely unsurpising_. It 's the
             | most basic, trivial thing possible.
             | 
             | But there are massive industries[1] that exist to tell
             | people that no, it's really that you aren't eating enough
             | food that is red. Or that fell to the ground. Or whatever.
             | Whatever magical, simple fix means that they can still eat
             | an excess of calories. These diets have a failure rate
             | approaching 100%. The US is the most diet focused country
             | in planetary history, yet also one of the fattest.
             | 
             | Maybe pretending that the basic thermodynamics are just
             | some unachievable mirage is a really profoundly stupid
             | approach?
             | 
             | And yes, people who have actually lost weight (or, more
             | often than not, not gain it in the first place) simply ate
             | less (it's magnitudes harder to burn more calories to any
             | meaningful amount). Virtually universally.
             | 
             | But this makes obese people angry. It always makes them
             | angry.
             | 
             | [1] - And authors. This paper cites Stephen Guyenet
             | casually dismissing "CICO". The guy makes his living
             | pitching easy "AHA" moments to fat people. It is,
             | ironically, his bread and butter.
        
               | throwawaycities wrote:
               | Your fundamental truth is based on a false premises that
               | the goal is weight loss as opposed to health, more
               | specifically metabolic health.
               | 
               | But lets assume it all boils down to calories in/calories
               | out, your solution is singularly focused on calories in
               | (eating less), that in a vacuum has no effect of calories
               | out except generally a negative effect (your body will
               | adapt and try to burn less calories). Thus, you are
               | ignoring that the form of calories in directly effects
               | the calories out, and that there are better ways to
               | balance the equation by increasing calories out without
               | necessarily reducing calories in, or in some cases
               | increasing calories out might even require a caloric
               | surplus (such as muscle building).
        
               | AnIdiotOnTheNet wrote:
               | > Your fundamental truth is based on a false premises
               | that the goal is weight loss as opposed to health
               | 
               | I think you're the one with the misconception. Obesity is
               | consistently a contributor to health problems. Losing
               | weight is definitely healthier for anyone who is obese
               | and the way you lose weight is to _eat less_. Period.
               | Full stop.
               | 
               | There are strategies for _eating less_ that may or may
               | not be more effective for most people, but it when it
               | gets right down to it anyone telling you that you don 't
               | have to _eat less_ is a snakeoil salesman.
        
               | throwawaycities wrote:
               | > Losing weight is definitely healthier for anyone who is
               | obese and the way you lose weight is to eat less. Period.
               | Full stop.
               | 
               | What if someone eats the same but creates the caloric
               | deficit through increased exercise? Will they lose
               | weight?
               | 
               | Just like OP you want to simplify things as calories
               | in/calories out while entirely ignoring calories out.
               | 
               | Losing weight is not healthy in and of itself, even in
               | obese people, however, losing weight can be a byproduct
               | of making healthy dietary and lifestyle changes.
               | 
               | Calories is just a unit of measurement of metabolic
               | energy, that energy comes in 3 forms fat (ketones),
               | glucose, and alcohol and is metabolized into energy
               | (adp), but that energy production (metabolism) is more a
               | measurement of health than a measurement of the total
               | number of calories in. That is what you are ignoring.
               | 
               | Edit: I'm sure you have lost your weight through eating
               | less. But have you changed and improved the actual foods
               | you consume also? Have you begun to burn more through
               | improved dietary metabolism and/or increased exercise? I
               | have a hard time believing one day you were eating
               | nutritionally deficient and caloric dense foods and lost
               | 150 by making no other changes than simply eating less of
               | the same calorically dense and nutritionally deficient
               | food. Even more unlikely would be you being obese eating
               | low calories nutritionally dense foods, and lost 150lbs
               | reducing the calories.
        
               | defaultname wrote:
               | How does it ignore it while specifically citing it, over
               | and over again?
               | 
               | However the basic reality is that it's a lot
               | easier/achievable to significantly change calories in.
               | Simple keeping your body and brain operating is actually
               | a pretty energy expensive function, such that
               | dramatically increasing your activity is only going to
               | mildly increase your daily energy use.
               | 
               | You can not eat that muffin....or exercise on the stair
               | climber for an _hour_ , for instance. As an aside, loads
               | of exercise equipment and guides effectively lie about
               | this by including basal calories with active calories,
               | grossly overstating the calories "burned" by activities.
               | 
               | So _again_ , exercise. Eat healthy. But most importantly
               | of all, eat less.
        
               | AnIdiotOnTheNet wrote:
               | > What if someone eats the same but creates the caloric
               | deficit through increased exercise? Will they lose
               | weight?
               | 
               | Yes, but there's a reason for the saying "you can't
               | outrun a bad diet". I get it though, you're technically
               | correct and that's the best kind according to meme
               | science.
               | 
               | > I'm sure you have lost your weight through eating less.
               | But have you changed and improved the actual foods you
               | consume also?
               | 
               | Yes, because that's one of the things that makes it
               | easier. Some foods are more satiating than others. And
               | yes, I did increase in exercise. In fact, the exercise
               | preceded the weight loss because the activity I took up
               | (rock climbing) was what finally provided enough
               | motivation for me to overcome my desire to eat more.
               | 
               | > I have a hard time believing one day you were eating
               | nutritionally deficient and caloric dense foods and lost
               | 150 by making no other changes than simply eating less of
               | the same calorically dense and nutritionally deficient
               | food.
               | 
               | It's harder, but definitely possible: http://www.cnn.com/
               | 2010/HEALTH/11/08/twinkie.diet.professor/....
               | 
               | My point being, you can add all the exercise you want but
               | if you're not paying attention to your caloric intake
               | then chances are you're just going to eat more to make up
               | for the expended calories.
        
               | defaultname wrote:
               | Obesity has an _extremely_ high correlation with poor
               | health. But that 's irrelevant as this thread is
               | specifically on weight.
               | 
               | "that in a vacuum has no effect of calories out except
               | generally a negative effect (your body will adapt and try
               | to burn less calories)"
               | 
               | This is comically overstated. No, your body doesn't
               | magically become super efficient. This is, again, feel
               | good pablum to make people feel better about their
               | situation, sure it is an unwinnable battle without Magic
               | Product or System ("buy my new book and subscribe to my
               | It's Everyone Else's Fault newsletter!"). But the feel
               | good stuff clearly is astonishingly ineffective. This
               | tact hasn't worked.
               | 
               | Find any person who is overweight but claims they starve
               | themselves and log and count calories. In 100% of cases
               | you will find a calorie excess, likely significant. Find
               | someone who is a healthy weight but claims they "eat
               | anything they want". In 100% of cases -- okay 99.9% maybe
               | they have a big tapeworm -- they will have a lower
               | caloric intake.
               | 
               | The latter is someone who likely skips meals. They don't
               | snack. They don't drink giant sugary drinks. And then
               | when it's pizza day they have four slices and all of the
               | high BMI sorts lament how they wish they had such a "high
               | metabolism" and that they can "eat anything". It's all
               | bullshit.
               | 
               | There is a significant, very difficult psychological
               | component to eating in excess. It is a very hard problem.
               | But I'll take every angry downvote by people who
               | seriously want to refute the core, fundamental truth
               | about calories, likely while parroting nonsensical myth.
        
               | AnIdiotOnTheNet wrote:
               | It angers me that your comments have been consistently
               | grey. As I've mentioned elsewhere I've lost significant
               | amounts of weight (>150lbs, about half my peak body
               | weight) and so am excruciatingly painfully aware of the
               | absolute truth of what you're saying.
        
               | tsimionescu wrote:
               | > Find any person who is overweight but claims they
               | starve themselves and log and count calories. In 100% of
               | cases you will find a calorie excess, likely significant.
               | Find someone who is a healthy weight but claims they "eat
               | anything they want". In 100% of cases -- okay 99.9% maybe
               | they have a big tapeworm -- they will have a lower
               | caloric intake.
               | 
               | I take great issue with you saying 'they _claim_ to
               | starve themselves '. The entire point is that people who
               | are obese can feel that they are starving while eating
               | twice the calories that they should. Some other people
               | feel full after eating half the calories that they
               | should. This is the almost the entire problem, the
               | unexplained difference.
               | 
               | And, despite your claim, there are also demonstrable
               | differences in the base metabolic rate between people.
               | One of the most basic is the difference between men and
               | women, which is usually estimated to be about 25% -- men
               | are generally accepted to have to eat about 2500 Cal per
               | day to keep their weight, while women should only eat
               | about 2000 Cal (for example, by the NHS [0]). There is no
               | reason to think that, if there can be a 25% difference in
               | the BMR between men and women, there can't be similar
               | differences between individuals as well. Of course, you
               | won't find anyone who eats 10k Cal and is not gaining
               | weight (outside professional athletes, perhaps), or
               | anyone who is eating 100 Cal and not losing weight. But
               | it's quite plausible for someone to eat two extra pizza
               | slices and still lose weight compared to someone else.
               | 
               | [0] https://www.nhs.uk/common-health-questions/food-and-
               | diet/wha...
        
               | defaultname wrote:
               | >I take great issue with you saying 'they claim to starve
               | themselves'.
               | 
               | I'm being pretty overt that when people make that claim
               | they are often being dishonest. They know they are eating
               | too much. There are psychological issues underlying this,
               | but if someone tells you how little they eat yet they're
               | gaining weight, they're likely lying.
               | 
               | > And, despite your claim, there are also demonstrable
               | differences in the base metabolic rate between people.
               | 
               | Nowhere did I contest this. Men have more muscle mass
               | than women and are generally larger. But between people
               | otherwise equal, claims about varying metabolisms are
               | largely _bullshit_. It is magnitudes less of an influence
               | than it is held as.
               | 
               | I've been cited as a "fast metabolism" examples many
               | times in my life. I skip meals constantly, can manage to
               | go through a movie without eating a bucket of butter-
               | soaked popcorn and a jug of coke, etc. I eschew all of
               | those things. Then there's a bbq and I eat two burgers
               | and the upper BMI people all gather around to tell the
               | tale about how easy it is for me, what with my "fast
               | metabolism". It's horseshit. It's destructive, self-
               | enabling nonsense.
               | 
               | Another guy mentioned that when his belt size starts
               | getting tight he knows it's time to cut back. Precisely
               | my tactic. There have been a few times where suddenly
               | slacks are a little tight and it isn't a signal that I
               | need to buy new clothes or go to the next rung, but
               | instead means it's time that I skip the occasional snack.
        
           | AnIdiotOnTheNet wrote:
           | I'm not surprised to see your comment in the grey even though
           | everything you're saying is absolutely true. I've lost
           | >150lbs and kept it off[0] and I can assure everyone that the
           | one thing that absolutely 100% works for losing weight is
           | eating less. It's also the most difficult thing, which is why
           | everyone wants to believe bullshit marketing that says
           | otherwise.
           | 
           | [0] put about 30lb on during the pandemic period that I'm
           | working off again.
        
             | tsimionescu wrote:
             | That is well known and undisputed. The question is: when
             | can you stop eating less than your body is telling you that
             | you should? Did you ever get rid of the hunger?
             | 
             | I lost about 30kg (105 -> 75) by eating less, excersing
             | more, all in about the span of a year. I never stopped
             | feeling hungry overall for this period, constantly had to
             | fight the urge to eat more. In periods where high stress
             | reduced my willpower, I started putting back weight. I've
             | put on about 10kg back in the following 5 years, so on
             | balance I'm still in pretty good shape, but the trend is
             | clear.
             | 
             | The mystery is why I have this relationship with food, and
             | why other people don't. Most thin people are not going to
             | bed dreaming of tomorrow's meal.
        
               | defaultname wrote:
               | "That is well known and undisputed."
               | 
               | Unfortunately, loads of people in this very thread are
               | disputing it. This submission is based upon the bizarre
               | hope that there's a mysterious external influence that's
               | actually causing people to gain weight, and not the
               | merely coincidental simultaneous rise in caloric intake.
               | 
               | The psychological element is complex and profoundly
               | difficult. That is without question.
        
               | inglor_cz wrote:
               | I am not sure whether we can reduce this to psychological
               | elements. After all, laboratory rats and wild animals
               | that eat our food leftovers grow fatter too, not just us
               | humans. Arguably, rat or raccoon psychology is rather
               | different from ours.
               | 
               | I believe that the problem is not that different from the
               | problem of alcoholism. Everyone lives in a society soaked
               | with alcohol, some people do not feel an urge to drink at
               | all, some people manage to keep their consumption in
               | healthy limits for 50 years, some end up as hopeless
               | wretches in 10 years.
        
               | tsimionescu wrote:
               | It's very possible that there is an external influence
               | that's causing people to feel the need to eat more and
               | gain more weight from what they're eating - this is
               | precisely my point, and the point of the article.
               | 
               | The fact that you can force yourself to eat less than you
               | feel the need to and lose weight in the process does not
               | prove, as you seem to think, that weight gain is simply
               | explained by people being weak willed and eating burgers
               | instead of salad. You still have to ask why this change
               | actually occurred, since it seems that it has occurred in
               | the general US population about 50 years ago and most of
               | the world has been following suit.
        
               | AnIdiotOnTheNet wrote:
               | Where did they say it had to do with being "weak willed"?
               | That's your projection.
        
               | PeterisP wrote:
               | The whole point of the article is that the rise on
               | caloric intake isn't merely coincidental and
               | simultaneous, but there's some mysterious external
               | influence that causes people in comparable conditions to
               | eat more calories.
               | 
               | People in cushy office jobs eating as much calories as
               | they want in 1900 are much less obese than similar people
               | in 2000. How come? It's not that the 1900s office workers
               | put in more effort or attention to limit their calorie
               | consumption and burn more calories, it's entirely the
               | other way around.
               | 
               | People in another culture eating a very sweet-heavy diet
               | (and eating as much of it as they want) apparently
               | consume much less calories than similar people in USA.
               | How come?
               | 
               | The psychological element apparently wasn't as difficult
               | some decades ago - people in 1960s who had as much food
               | as they wanted, and the same kinds of tempting calorie-
               | rich snacks available, were much less obese not because
               | they were better at overcoming some psychological
               | difficulties, but because apparently much fewer of them
               | had such difficulties to overcome. How come?
               | 
               | It would be valid to reduce weight gain to "How to eat as
               | much calories as you should instead of as much calories
               | as you intuitively want" if and only if wanting to eat
               | much more calories than you should is some innate,
               | natural thing. The article points out that the spread of
               | this tendency is a _novel_ thing, it used to be rare, and
               | perhaps it can be made rare again, so it 's worth
               | investigating the cause of that unhealthy appetite
               | miscalibration instead of having people fight through the
               | symptom (which they're failing at, because it's hard).
               | 
               | If someone's organism was working properly, they should
               | not need to pay attention to CICO as the body will
               | balance both "CI" and "CO" to get a decent non-obese
               | result - the experience of earlier times and other
               | cultures shows that the human body almost always (96% of
               | non-obesity) does that naturally. If now the same
               | mechanism is failing for 40% of the population instead of
               | 4%, that is not caused by a change in ignoring CICO,
               | people were ignoring CICO hundred years ago as well.
        
               | AnIdiotOnTheNet wrote:
               | Yep, that's basically the same with me and as far as I
               | can tell pretty much everyone else who's had to lose a
               | lot of weight. The only thing I've ever found that
               | allowed me to not feel hungry was amphetamines. Until
               | that brief period where I was on them I'd never before
               | had the experience of forgetting to eat that people
               | sometimes talk about. Unfortunately, amphetamines bring a
               | lot of undesirable effects with them too.
               | 
               | I eagerly await the day science figures out how to stop
               | my food cravings and delivers it in a form I can obtain
               | easily.
        
         | skinkestek wrote:
         | > Saying "Calories In Calories Out" is what makes you fat is as
         | interesting as saying "Money In Money Out" is what makes you
         | poor.
         | 
         | But that is not what anyone I've heard is saying.
         | 
         | At least I think of "calories in / calories out" is a an
         | attempt to defend against people believing in miracle diets or
         | that they "cannot" lose weight.
        
         | AnIdiotOnTheNet wrote:
         | Absolutely. CICO is the kind of thing that is so obviously true
         | that anyone claiming it isn't shouldn't be taken seriously. I
         | wouldn't say CICO doesn't help anyone though, because there's a
         | whole lot of people out there trying to make money by telling
         | you you can ignore CICO _with this one simple trick_. CICO is a
         | useful thing to keep telling yourself when trying to lose
         | weight because the calories are everything and there 's no
         | cheating it. Trust me, I have tried.
         | 
         | Source: lost >150lbs and kept it off until the pandemic where I
         | gained about 30 of it back. Stress is a bitch.
        
           | BitwiseFool wrote:
           | CICO makes sense as a rule of thumb, but the _kind_ of
           | calories certainly matters. I 'm no dietician, but
           | carbohydrates, sugar, and fat each react differently with the
           | body's digestive and endocrine system. Surely that has some
           | effect beyond mere CICO calculations. I'd love to see a study
           | that compares change in bodyfat with 2000 calories of cake
           | frosting vs 2000 calories of red meat.
        
             | AnIdiotOnTheNet wrote:
             | I'm not aware of any such study, however there was this: ht
             | tp://www.cnn.com/2010/HEALTH/11/08/twinkie.diet.professor/.
             | ..
             | 
             | In which a man loses 27lbs on a diet of twinkies and was
             | even healthier overall according to all metrics.
             | 
             | Between this and personal experience I'm prepared to say
             | that as far as weight loss is concerned it really doesn't
             | matter. Granted, different foods may have an effect on
             | mood, energy level, and satiety which will all contribute
             | to the CO part of the CICO equation, but all other
             | variables kept constant a calorie is a calorie.
        
         | dobin wrote:
         | If someone can't eat less calories than he expends, thats
         | usually called addiction (boredom, food as reward etc.), and
         | should be treated accordingly
        
         | captainmuon wrote:
         | I've never understood calories. Sure if you eat less but keep
         | the food composition and exercize the same, you loose weight.
         | That's trivial. But calories is energy and weight is mass. I've
         | joked if you eat a bar of plutonium you won't gain a ton. And
         | if you eat a kg of sugar, you'll get a stomach ache but won't
         | suddenly gain a lot.
         | 
         | I think something that is often neglected is: What portion of
         | the calories you eat is used, what portion is stored, and what
         | portion is discarded? It seems there is an adjusting screw that
         | makes us store more of the consumed calories than before. If we
         | just eat less calories total, we also gain less (sure), but we
         | often won't have enough power to go around.
         | 
         | I can't find the source anymore, but I read a theory about high
         | fructose corn sugar, or glucose-fructose sirup. Many debunkers
         | say there is no problem with glucose-fructose sirup over
         | sucrose (plain sugar), since sucrose is just split in the body
         | into glucose and fructose, so it's the same. But the theory
         | went that the body regulates sugar intake by regulating the
         | breakdown of sucrose. If it is already broken down, there is
         | nothing stopping the cells from taking all the simple sugars
         | and using them.
         | 
         | I don't know if there is any merit to that idea - it doesn't
         | matter, it's just the pattern of the argument I find
         | interesting - that you have to understand the metabolic
         | pathways and what the body does with the nutrients, rather than
         | just count calories.
        
           | guerrilla wrote:
           | When people say calories they mean calories that can be
           | converted to ATP. This is why fiber is not considered to have
           | calories (for humans, but is for cows) despite containing
           | forms of energy.
        
             | nradov wrote:
             | Soluable fiber does have calories for humans.
             | 
             | https://www.fiberfacts.org/fibers-count-calories-
             | carbohydrat...
        
             | readonthegoapp wrote:
             | You're saying fiber content is actually stripped out of
             | calorie counts on packaging?
        
               | guerrilla wrote:
               | I oversimplified but yes almost.
               | 
               | > Determining whether or not fiber calories should
               | "count" depends on context and requires some background.
               | Calories are a basic unit of energy that measure, among
               | other things, how much burning power they provide to the
               | body. Fats, proteins, carbohydrates and alcohol provide
               | the body with energy or calories. The traditional
               | estimates are that 1 gram of fat provides 9 calories,
               | each gram of either proteins and carbohydrates provide 4
               | calories, and a gram of alcohol provides 7 calories.
               | However, this doesn't account for differences in how well
               | food is digested and the nutrients available to the body.
               | Poorly digested foods may not release as much energy for
               | the body to use. This is particularly important in the
               | case of fibers.
               | 
               | > Dietary fibers are complex carbohydrates, so some
               | people estimate that they provide 4 calories per gram
               | just like any other carbohydrate. However, others say
               | that calories from fiber don't count since your body's
               | digestive enzymes can't break down fiber. However, fibers
               | differ in how well they are digested or how much energy
               | is available to the body. Some fibers, called soluble
               | fibers, either absorb water and become gels or dissolve
               | in water and reach the intestine where they are digested
               | by bacteria. As they are digested by bacteria, soluble
               | fibers produce short-chain fatty acids (SCFAs) that
               | provide your body energy. The US Food and Drug
               | Administration (FDA) estimates that fibers fermented by
               | bacteria provide about 2 calories per gram of fiber.
               | Insoluble fibers travel to the intestine with very little
               | change. Instead of being digested, insoluble fibers
               | increase bulk, soften stool, and shorten transit time
               | through the gastro-intestinal tract. Because these fibers
               | are not digested at all, the FDA estimates that insoluble
               | fibers do not contribute any calories.
        
         | magicalhippo wrote:
         | It helped me a lot. It was very easy to use, and by not having
         | any off-limits foods or similar, just a calorie target, it
         | helped me find meals that I enjoyed while keeping me full.
         | 
         | It also was a nice perspective to have in mind for me. Calories
         | in, calories out means it doesn't really matter what I do
         | today, it's what I do each day that matters.
        
           | joflicu wrote:
           | How do you know the calories of home-cooked or restaurant
           | meals to estimate the targets accurately?
        
             | magicalhippo wrote:
             | Restaurants are usually difficult, so I treated them as an
             | "off day", and hence would not go to them too often. One
             | might order a salad, but who knows how much sugar, oils and
             | whatnot they put in there.
             | 
             | For home-cooked I would do rough estimation based on weight
             | and some quick web searches for calorie content of the
             | ingredients.
             | 
             | After a short while I got a pretty decent hang of where the
             | calories were, so could focus more on those. I had a small
             | kitchen weight for the "heavy hitters", for the rest I just
             | estimated based on listed weight and how much I used (~1/3
             | of package fex).
             | 
             | In the beginning I did weigh slices of bread and so on, and
             | quickly built up a good overview over how many calories
             | there were in such recurring items. Except for oils, butter
             | and similar I wouldn't be super-accurate.
             | 
             | But having a fairly good idea of how many calories was in
             | my food really helped me plan portion sizes and
             | compositions to roughly match the deficit I wanted, as
             | determined by a web page estimating my calorie
             | requirement[1].
             | 
             | Like I said, focusing purely on calories in, calories out,
             | rather than say "yes foods" and "no foods", made it a lot
             | easier for me as I could eat what I wanted, just perhaps
             | not as much.
             | 
             | For example, I quickly found out that my weekend favorite
             | of steak with french fries and bearnaise was way over
             | target. However, I found that if I ensured my steak was no
             | more than 250g, swapped french fries for quality green peas
             | and reduced the butter in the sauce by half, the calories
             | were around my target value. So I could still enjoy my
             | weekend treat.
             | 
             | One potential issue was to feel full while reducing portion
             | sizes. For that I leaned on some studies I read about which
             | seemed to suggest high protein and high fiber. So I tried
             | to have at least 20% of my calories in proteins, and also
             | have as much fiber as possible. My breakfast bread is 90+%
             | whole grain, my pasta is whole grain, I swapped out iceberg
             | lettuce for romain lettuce (which has much more fiber) etc.
             | 
             | Based on this I had a almost entirely linear decrease in
             | weight over a year, without feeling like I was on a diet.
             | In the end I lost 30kg.
             | 
             | [1]: https://nhi.no/skjema-og-
             | kalkulatorer/kalkulatorer/diverse/b...
        
             | tracedddd wrote:
             | You measure everything as best you can, and generally avoid
             | restaurants.
        
             | PeterisP wrote:
             | Weighing of components. Keep digital kitchen scales on the
             | table and use them all the time. E.g. if you eat breakfast
             | cereal, put the bowl on scales, press button, put in
             | cereal, remember the weight, press button, pour milk,
             | remember the weight. The same for everything you put on a
             | pan. Don't forget to include the cooking oil, it makes a
             | surprisingly large contribution to the total calories of
             | the meal. If you're sharing meals, then you know the "total
             | calories" you put in it, weigh the final product (it
             | generally will be significantly different than what you put
             | in) and weigh what's on your plate - so you know that _you_
             | ate e.g. 40% of the total. It doesn 't take much time
             | (unless your scales suck), but it does take much attention
             | and looks weird. It's a pain in the ass when starting out,
             | but becomes easier when I can just reuse the numbers from
             | when I made the same thing last week.
             | 
             | Some types of meals are easier than others, though - e.g.
             | if you make a large pot of "non-uniform" soup for the whole
             | family for multiple meals, then it's going to be an
             | estimate. It's socially inappropriate to do it at some
             | situations (e.g. if you're visiting your grandma who's
             | providing a meal), but on most days you should be able to
             | track how much calories you got on that single day.
             | 
             | Some restaurants will provide numbers for their dishes,
             | some won't. For takeaway/home orders weighing gives a good
             | estimate - if you don't have the numbers for some kebab or
             | sushi or pizza, then you can assume that it's going to be
             | the same per unit of weight as someone else's similar
             | product, what matters is _how much_ of double cheese
             | pepperoni pizza you eat, not the particular pizza maker.
        
       | pif wrote:
       | > Mystery 8: Diets Don't Work
       | 
       | As an obese person who tried several times to follow medical
       | advise, this does not surprise me, not at all!
       | 
       | Every diet is about calories and sport, which cannot hurt. But
       | every diet completely misses the elephant in the room: hunger!
       | 
       | Any medical procedure is only worth pursuing if it gives you a
       | higher quality of life in the long term. A constant hunger cannot
       | compensate for any weight loss.
        
         | gadders wrote:
         | >> Any medical procedure is only worth pursuing if it gives you
         | a higher quality of life in the long term. A constant hunger
         | cannot compensate for any weight loss.
         | 
         | As long as you're consciously making that trade off. Hunger vs
         | shorter life, health conditions etc. I think that's a personal
         | choice for the individual.
        
         | garganzol wrote:
         | Constant hunger is a hallmark sign of insulin resistance. The
         | good thing is you can actually measure it in HOMA-IR test.
        
         | Ueland wrote:
         | > But every diet completely misses the elephant in the room:
         | hunger!
         | 
         | And this is why a new drug just approved in the US for obesity
         | is hailed as a game changed, NovoNordisk's semaglutide.
         | (Wegovy) The "only" thing it does is mange the hunger levels in
         | your body so you dont feel hungry all the time.
         | 
         | I think there was a study back in February for it which gave
         | something like a 15% weight loss after a year, *on average*.
        
           | EMM_386 wrote:
           | One such study is here:
           | 
           | https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
        
         | LQexplanation wrote:
         | Metformin and myo-inositol solved this issue for me. Only after
         | solving issues with pre-diabetes I was able to start losing
         | weight without constant hunger.
        
         | treeman79 wrote:
         | The Satiety Index is for measuring how satisfied you are with
         | various food. Enter the humble potato.
         | https://scottabelfitness.com/potato-and-the-satiety-index/
         | 
         | I did a sweet potato diet for a month a couple of years ago for
         | medical reasons.
         | 
         | I was never hungry.
        
         | wickoff wrote:
         | I've always been a somewhat active person (at least 10 hours
         | spent walking/cycling every week). Did it just because I liked
         | it, but it never helped with weight loss.
         | 
         | Switching cardio for resistance training (5x5) helped immensely
         | with no changes in diet. My weight has dropped slightly, but my
         | body composition changed a lot. Cardio became much easier after
         | building some muscle mass.
         | 
         | There is also something addictive to increasing the weight you
         | can lift, fits right in with gamer/nerd mentality.
        
           | handrous wrote:
           | I've found most cardio to have practically no weight-loss
           | benefit for me, while weight lifting has _way_ more than it
           | should according to e.g. calorie-burn calculators or tables.
           | All I can figure is that lifting does something to my
           | metabolism, on the order of hours to days after, that running
           | or cycling doesn 't.
           | 
           | Swimming also seems very effective, though I've not checked
           | whether that effect's outside what's expected, or just
           | normal.
        
       | readonthegoapp wrote:
       | I thought we already figured out at least part of the problem or
       | the main problem
       | 
       | Sugar
       | 
       | Yutkin Lufkin Etc
       | 
       | Book: Pure, White, and Deadly
        
         | EMM_386 wrote:
         | The article covers this, and sugar is not the root cause:
         | 
         | > A Tanzanian hunter-gatherer society called the Hadza get
         | about 15 percent of their calories from honey. Combined with
         | all the sugar they get from eating fruit, they end up eating
         | about the same amount of sugar as Americans do. Despite this,
         | the Hadza do not exhibit obesity.
        
           | readonthegoapp wrote:
           | you have a lot of confidence in a theory that sugar is not a
           | main or the root cause of obesity, all based on...a single
           | tribe?
           | 
           | that eats unprocessed sugar? including that found in fruits??
        
             | EMM_386 wrote:
             | The article clearly explains all of this. It's more than
             | one tribe.
             | 
             | Part II is equally interesting.
             | 
             | https://slimemoldtimemold.com/2021/07/11/a-chemical-
             | hunger-p...
             | 
             | > We can further cite the fact that many cultures, such as
             | the Hadza of Tanzania, the Mbuti of the Congo, and the Kuna
             | of Panama all eat diets relatively high in sugar (sometimes
             | as high at 80%), and yet none of these cultures have
             | noticeable rates of obesity, diabetes, cardiovascular
             | disease, etc.
        
               | readonthegoapp wrote:
               | ok, _multiple_ tribes, that -- unlike us
               | westernized/modernized/uncivilized people -- eat
               | _un_processed sugars, _un_processed foods, etc.
               | 
               | i'm all for looking at populations of folks and then
               | looking at the effects of their new diets -- whether they
               | moved to the food, or the food moved to them -- but i
               | don't even see the beginnings of an apples-to-apples
               | comparison here.
               | 
               | to me, a layman, i don't see Nutrasweet and sugar and
               | honey and cookies and apples to be all the same in terms
               | of the effects of their 'sugars' on the body.
               | 
               | i must be missing something.
        
         | brazzy wrote:
         | The article cites evidence showing that this is simply not
         | true.
        
           | readonthegoapp wrote:
           | bold statement. i wonder why you're so completely convinced?
           | 
           | is it that the author is The Smahtest Guy To Evah Live?
           | 
           | or....i mean, s/he has a long list of Nobel Prizes in
           | Physiology?
           | 
           | or maybe just some long history of unbelievably incredibly
           | insightful comments/writing/literature/research on this or
           | any other topic?
           | 
           | i figure i've read and listened to at least dozens but
           | probably hundreds of articles, books, youtubes, etc. over the
           | past few years, and i'm not convinced i have the answer, but
           | one blog post citing one tribe and you're all in? seems
           | strange to me.
           | 
           | i suspect a plurality of folks would say that there are
           | multiple contributing factors to obesity, something like:
           | - sugar (in particular, highly processed sugar in all its
           | forms/delivery mechanisms),        - highly processed foods
           | generally (don't send 'full' signals to the brain, lack of
           | fiber, etc.),        - modern lifestyle/quick eating/lack of
           | exercise, cheap sugary/processed/fatty foods, etc.
           | 
           | ...but to rule out sugar....bold.
        
       | fithisux wrote:
       | Fantastic series of articles. I tend to believe that food has
       | become some kind of additive drug that cheats the way homeostasis
       | work in order to sustain spending. Can't wait to read all.
        
       | syamilmj wrote:
       | What about stress?
       | 
       | Elevated cortisol level induces over-eating; moreover, increases
       | craving for high-sugar, high-fat foods.
       | 
       | The big change in human behavior in the last 2 decades is that
       | now people consume more information that leads to depression,
       | anxiety and stress.
        
         | fredophile wrote:
         | The article also talks about changes in the weight of zoo and
         | lab animals. Stress may be a factor in weight gain in humans
         | but it wouldn't explain the animal data so I don't think it's
         | the only, or primary, factor.
        
           | syamilmj wrote:
           | The article pointed out a paper on an increase of 1.4%
           | overweight horses. It does not seem to have a meaningful
           | relationship with the steep increase of overweight population
           | in human (~24%).
        
       | helloworld11 wrote:
       | The obesity epidemic, as the author describes it, isn't a good
       | thing, and for us to have BMI tendencies similar to those of late
       | 19th century Americans would probably be better (excepting of
       | course their other major health problems from that time) but in
       | relative terms, I'd consider today's obesity problems in most of
       | the population much better than the near starvation that most of
       | humanity lived in during the vast majority of history, even up to
       | the early 20th century.
       | 
       | For all but our most very recent ancestors, periods of chronic
       | hunger was just a missed crop or bad harvesting season away and
       | mass starvation was only slightly more distant. Famines were
       | common in most of the world and often killed many millions per
       | year, almost every year during millennia, of all ages, including
       | children and infants. Obesity-caused deaths are still deaths but
       | at least they tend far more towards killing later in life and are
       | much more in the hands of any given individual to avoid, as
       | opposed to starving because your whole region no longer has
       | enough food to keep you living regardless of your dietary
       | choices.
       | 
       | Generations of people prior to all but the last century or so of
       | history would be amazed, and possibly even envious at how
       | abuntantly and cheaply most of the population can feed itself
       | today, even to the point of chronic obesity.
        
       | briefcomment wrote:
       | > "Something seems to have changed. But surprisingly, we don't
       | seem to have any idea what that thing was."
       | 
       | We have ideas. Polyunsaturated fats (shortening, margarine,
       | soybean oil, canola oil, even chicken fat) is a promising
       | culprit. Consumption of those have skyrocketed in the last half
       | of the 20th century [1]. Full study here [2].
       | 
       | It seems that polyunsaturated fats induce hibernation like
       | symptoms, which could explain weight gain. This blog is a
       | fascinating look at some of the literature [3]. Good summary post
       | [4].
       | 
       | [1]
       | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076650/figure/...
       | 
       | [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076650/
       | 
       | [3] https://fireinabottle.net/every-fire-in-a-bottle-post-
       | from-t...
       | 
       | [4] https://fireinabottle.net/are-you-in-deep-torpor-
       | scd1-theory...
        
         | jpitz wrote:
         | I thought polyunsaturated fats ( fish, soybean ) were fairly
         | prevalent in Japanese diets?
         | 
         | How does that square up with the lower prevalence of obesity
         | there?
        
           | briefcomment wrote:
           | Eating isolated oils is decidedly different from eating whole
           | foods, as there are compounds that counteract each other when
           | taken as a whole. For example, fish have long chain fatty
           | acids which counter some effects of the Omega oils.
           | 
           | I think it's much easier to consume large portions of soybean
           | oil if you're using it as an all purpose oil, than if you
           | were just eating tofu, bean curd, natto, etc.
        
       | Pyramus wrote:
       | This series of blog posts is a fascinating read into conjectured
       | factors behind the obesity epidemic.
       | 
       | I wish the author had continued their rigor in reasoning
       | throughout the two blog posts. Step by step the author is lured
       | into proving a single factor explains the rise in obesity. That
       | maybe a futile attempt from the outset.
       | 
       | To make an example, the author notes, correctly and to the point,
       | 
       | > "Calories are involved in the math but it's not as simple as
       | "weight gain = calories in - calories out"."
       | 
       | but then moves on to claim that "X provides evidence against
       | CICO" when in fact the article cites numerous examples where an
       | increase/decrease in calories results in a (short-term)
       | increase/decrease in body weight. So what the author really meant
       | was "X provides evidence against CICO as the single factor".
       | 
       | I'm not an expert in nutrition science but it seems very unlikely
       | that a single factor (sugar! trans-fats! exercise! genetics!)
       | will explain a real-world, highly non-linear phenomenon. I
       | personally find the paragraphs where the interactions of factors
       | are discussed the weakest and least convincing.
       | 
       | That is not to say the article is excellent and hammers home two
       | very important points: Firstly the idea of the lipostat and as a
       | result a short and a long-term time scale ('system') for body
       | weight gain/loss. Secondly that factors relevant on one time
       | scale may not be relevant to the other time scale. And of course
       | that there is still a lot we simply don't understand (yet).
        
         | msteffen wrote:
         | My interpretation was: "what is responsible for the inflection
         | point that occurred in 1980?"
         | 
         | Perhaps it's still not a single factor (which, I agree, would
         | make a lot of sense) but IIUC that does raise the question of
         | why there seems to be a single inflection point.
        
         | sdenton4 wrote:
         | The short term overeating studies produce what we might call
         | highly nonlinear results, which also undermines CICO (which is
         | a linear equation). It's pretty obvious the body has other ways
         | to dump exceeds calories than turning them into fat stores.
         | Those studies, and the obvious tendency of diets to fail in the
         | long term, are strong support for some kind of lipostat system,
         | to my mind.
         | 
         | Others have mentioned gut biomes... My uneducated guess is
         | plastics or some other chemical that was introduced into
         | industrial use in the 20th century. The cross species effect
         | (lab and zoo animals getting father on the same controlled
         | diets) is also a really big clue that were dealing with a
         | molecule. And, as with lead poisoning from gasoline, perhaps a
         | hard to pinpoint one due to prevalence.
        
       | heax wrote:
       | I think the simple truth is we simply eat too much.
       | 
       | Possible the worldwide most known modern food product is the Big
       | Mac. Named Big Mac, not Best Mac, think about it. And it doesn't
       | stop there, large pizzas, pizzas with a lot on top, XXL
       | Schnitzels, All you can eat Chinese.
       | 
       | A lot people make quantity a priority over quality, guess what
       | happens :)
        
         | frabjoused wrote:
         | This. There's so many ideas and theories on diets, but it seems
         | the bottom line is, are you eating more than you're burning?
        
         | stronglikedan wrote:
         | > we simply eat too much
         | 
         | Hear, hear. I dropped ~70 pounds just by learning my portions.
         | It took about 6 months, but now I can just look at a plate of
         | food and separate out the amount that will fill me, before I
         | even start to eat (the 2-fist rule is a good start). I can make
         | 2-3 meals out of a typical restaurant dinner portion, or I can
         | just order an appetizer as my meal if I'm not taking leftovers.
         | 
         | I dropped another ~20 pounds by cutting out processed foods,
         | preservatives, and chemicals. I likely won't eat something that
         | I couldn't otherwise make a home using whole ingredients.
         | 
         | Restrictive diets never worked for me. I eat whatever I want,
         | whether it be loaded with carbs or fried. I just make sure to
         | include plenty of fiber in my diet, only eat when hungry, and
         | never over eat. It's the only diet that I've been able to
         | sustain for more than a year (~5 years now, to be exact).
        
         | elil17 wrote:
         | The whole point of the article is that this is an inadequate
         | explanation. First, the author points out that the increase in
         | calorie consumption has been modest compared to the amount of
         | weight gained. Second, why are we eating more? Moral failure
         | and weak will are the popular explanations, but this fails to
         | explain a variety of observations (Why now - haven't humans
         | always wanted to eat delicious food? Why do some hunter
         | gatherer societies with surplus food not experience the same
         | thing? Why are wild animals also effected?).
        
           | oezi wrote:
           | I wouldn't say 400 extra calories is modest, if you consider
           | Calories in/Calories Out then even a modest increase in
           | calories is leading to a continued accumulation.
           | 
           | By the authors examples eating 1.000 calories extra for 10
           | days gives you 1kg of weight gain. Assuming that the average
           | diet went from 2.000 to 2.400 calories, it makes sense that
           | people should gain 400*365/10.000 = 15kg per year until that
           | extra body mass is increasing base level energy need or
           | people are more physically active (but 1 hour of physical
           | exercise is only 600 calories for many sports).
        
       | mads wrote:
       | There is something I dont understand about this. Is it really
       | true that carb consumption has gone down? My own anecdotal
       | experience is that people are drinking way more sodas and eating
       | way more candy than they used to (in 70/80'ies my childhood).
       | 
       | Like where I live now every other street corner has those "mix-
       | your-own candy bag" shops, where you pay by the 100g. There must
       | be someone buying that stuff, since they keep popping up.
        
         | ginko wrote:
         | >My own anecdotal experience is that people are drinking way
         | more sodas and eating way more candy than they used to (in
         | 70/80'ies my childhood).
         | 
         | This doesn't seem to match the data:
         | https://www.businessinsider.com/americans-are-drinking-less-...
        
           | kwertyoowiyop wrote:
           | Maybe "energy drinks" (Monster et al) aren't counted as soda?
           | There are also several other sugary non-soda drinks I now see
           | in most convenience stores: sweet tea, Frappuccinos & other
           | cold coffee drinks, slurpees, hot sugary coffee and cocoa,
           | etc.
        
       | JohnJamesRambo wrote:
       | https://wtfhappenedin1971.com/
       | 
       | This popped in my mind since everything seemed to go off the
       | rails with an abrupt change in obesity in the mid 70s...
        
         | magneticnorth wrote:
         | This is fascinating, thanks for sharing.
         | 
         | Many (most?) of these plots have known, and different
         | explanations - e.g. the wage stagnation at the top is due to
         | public policy changes in the 70s; the rise in marriage age is
         | probably due to birth control becoming prevalent in the 60s,
         | but it is really interesting to see all the effects gathered in
         | one place of the repercussions in the past 50+ years from all
         | the societal and political changes that happened in the 60s and
         | 70s.
        
       | djmips wrote:
       | I alarms went off when the author used a rather poor analogy and
       | very little science to hand wave past the effectiveness of
       | gastric bypass surgery.
        
       | ajuc wrote:
       | > Kitavans didn't even seem to gain weight in middle age. In
       | fact, BMI was found to decrease with age. Many lived into their
       | 80s or 90s, and Lindeberg even observed one man who he estimated
       | to be 100 years old. None of the elderly Kitavans showed signs of
       | dementia or memory loss. The Kitavans also had no incidence of
       | diabetes, heart attacks, stroke, or cardiovascular disease, and
       | were unfamiliar with the symptoms of these diseases. "The only
       | cases of sudden death they could recall," he reports, "were
       | accidents such as drowning or falling from a coconut tree."
       | 
       | Maybe it's survivorship bias? Without modern medicine only
       | healthiest people survive to adulthood so later they live long
       | healthy lives. In modern society these people would be healthy
       | too, but they would be a small percentage of the whole society.
       | 
       | This would also explain why domesticated animals show similar
       | problems. Because we keep them alive :/
       | 
       | And then since it's at least partially inheritable - the effect
       | would compound with each generation. With unsettling
       | implications.
        
       | swamp40 wrote:
       | The sad part is, there exists some tight-lipped 90+ year old
       | former Philip Morris chemist, who moved over to General Foods and
       | discovered/invented some chemical that inhibits satiety, just to
       | increase their bottom line. And now every big food company uses
       | it.
        
         | neonnoodle wrote:
         | Are you serious about this? Or just dark humor?
        
           | readonthegoapp wrote:
           | I'm assuming dark humor.
           | 
           | But prob also true.
           | 
           | Or, truthy.
           | 
           | Think something like 'HFCS', or 'remove all the fiber', etc.
           | 
           | If you put enough power/money/ideology behind something,
           | people will believe it, or not question it, etc. Probably,
           | they/we, won't even be able to 'see' it.
        
         | runnerup wrote:
         | Enough people read all the ingredients on every food package
         | that if there was a common theme like this, it would be common
         | knowledge. I don't know of a singular ingredient in common
         | among the category of foods which would be targeted for this
         | enhancement. Charitably, perhaps you are thinking of the
         | "ingredient" of complex food engineering, which is any
         | concerted effort by food engineers/scientists to modify
         | "cafeteria food" to be more addictive and harder to stop
         | eating.
         | 
         | This focuses more on ingredients, which is relatively common
         | knowledge. But it does go into some history with interesting
         | backstories from board rooms to flesh it out: "NYT: The
         | Extraordinary Science of Addictive Junk Food" -
         | https://archive.is/DJ0fC
         | 
         | This one I find super fascinating. It focuses less on
         | ingredients and more on the physical forces/sensations of the
         | foods: sound, crunchiness, meltiness, airiness, and how those
         | drive compulsion to grab another handful: "Food cravings
         | engineered by industry" https://www.cbc.ca/news/health/food-
         | cravings-engineered-by-i...
        
         | yissp wrote:
         | Details? This sounds interesting.
        
       | petemir wrote:
       | And the 2nd. part:
       | https://slimemoldtimemold.com/author/slimemoldtimemold/
        
         | amelius wrote:
         | > A popular theory of obesity is that it's simply a question of
         | calories in versus calories out (CICO).
         | 
         | > (...) I think at this point, few people in the research world
         | believe the CICO model.
         | 
         | It is popular on HN too, as evidenced by the replies I got
         | here:
         | 
         | https://news.ycombinator.com/item?id=27777157
        
           | imtringued wrote:
           | It's popular because it's thermodynamics but it completely
           | ignores that our body doesn't know how to count calories. It
           | only knows how to count macro nutrients and how full your
           | stomach is and palatable food is engineered to avoid the
           | feeling of satiation.
        
             | tomxor wrote:
             | So much this.
             | 
             | Simple self experiment: If you are super hungry, try
             | compare:
             | 
             | 1. Eat a bowl of plain steamed rice (in hot water can make
             | it go down easier) - you will very very quickly become
             | satiated and stay that way, probably on less than a small
             | bowl.
             | 
             | 2. Eat cake, croissants, stuff that is sweet but not too
             | sweet that you can keep eating it... initially you will
             | stop, but then you will feel hungry again and keep going
             | back for more - you can just keep eating on this stuff,
             | even though the energy density is way higher.
             | 
             | The other difference is the speed at which the energy is
             | released, the rice will keep you going through the day,
             | your body gradually extracting energy from it... the cake
             | and stuff get's absorbed almost instantly and so your body
             | has nothing to do but make fat with it - the only way your
             | getting that energy back is through ketosis, which wont
             | happen so long as you keep eating cake.
             | 
             | It makes a lot of sense when you start to think about how
             | things have been modified from their natural state, even
             | orange juice is kinda bad in this sense - you can drink a
             | glass of orange juice pretty easily, but there is no way
             | you will be able to eat the number of oranges it took to
             | make it in a single day.
        
               | getlawgdon wrote:
               | Not explanatory. White rice has a high GI and brown rice
               | still has a moderately high GI.
        
         | pedrocr wrote:
         | _> It's true that people eat more calories today than they did
         | in the 1960s and 70s, but the difference is quite small.
         | Sources have a surprisingly hard time agreeing on just how much
         | more we eat than our grandparents did, but all of them agree
         | that it's not much. Pew says calorie intake in the US increased
         | from 2,025 calories per day in 1970 to about 2,481 calories per
         | day in 2010. The USDA Economic Research Service estimates that
         | calorie intake in the US increased from 2,016 calories per day
         | in 1970 to about 2,390 calories per day in 2014. Neither of
         | these are jaw-dropping increases._
         | 
         | A 20% increase in food intake seems huge. The data I could find
         | on weight over the same period puts people at only 15% heavier,
         | so this seems to be underselling the difference.
        
           | imtringued wrote:
           | Increased calorie intake and conversion to fat is the problem
           | but why do humans increase their calorie intake and decide to
           | convert their calories into fat? What button are they
           | pressing that says "I want to be fat!".
        
             | garganzol wrote:
             | An average consumer good contains tons of sugar by default
             | nowadays. Being a fast carbohydrate, it fools the mind of a
             | human into believing he/she is still hungry and thus needs
             | more. This leads to inadequate glucose overshoots on daily
             | basis.
             | 
             | When the time of insulin comes (approx. 2 hours after food
             | intake), the insulin curve is sharp and overshoots over the
             | peak in response to monstrous amounts of glucose in the
             | blood. Despite clearly peaking, no amount of insulin can
             | cover all previously consumed glucose at this stage, and
             | the rest of it gets transformed into the fat.
        
             | PicassoCTs wrote:
             | Funny Wild speculation time: In ancient times, when the
             | times got rough, there was always a pre-crisis-phase, aka
             | you witnessed something traumatic, but were not yet
             | impacted by it yourself.
             | 
             | Stressing yourself out and triggering that "horror"-phase
             | (movies/ evening news) makes your body go into the "binge"
             | for reserves during crisis mode.
             | 
             | Testable Hypothesis: End of the World screaming makes you
             | fat, Continuous bored calm and mental safety feelings make
             | you thin.
        
               | taneq wrote:
               | Should be able to see a significant uptick in BMI across
               | the population between 2019 and now if this is the
               | case...
        
               | PicassoCTs wrote:
               | A correlation between BMI and media consumption would be
               | rather blatantly obvious i guess.
        
               | taneq wrote:
               | I'd expect one of those regardless of stress levels /
               | doom and gloom levels, purely due to most media
               | inherently lowering aerobic activity.
        
           | AnIdiotOnTheNet wrote:
           | Not to mention that jobs are more sedentary on average than
           | they were in the 60s and 70s. So not only did we increase
           | intake but also likely reduced expenditure.
        
           | kwertyoowiyop wrote:
           | It seems like a VERY significant increase, yet the author
           | glided right by it. How much would he have considered to be
           | 'jaw-dropping'?
        
             | dobin wrote:
             | If people before 1970 eaten approximately their TDEE (2000
             | calories?), than a 20% increase in calories eaten means
             | something like 400 calories over TDEE per day - every day,
             | all your life. Of course people get fat like this.
        
             | Pyramus wrote:
             | This issue caught my eye as well, and I find the
             | argumentation quite sloppy in some parts. Also see my other
             | post https://news.ycombinator.com/item?id=27808936
             | 
             | Now take several of these "insignificant" factors, add
             | interaction effects, and we potentially get a much richer
             | picture.
        
         | RobertoG wrote:
         | That was an interesting read.
         | 
         | I just left this comment in the site (maybe it would interest
         | somebody here too):
         | 
         | "Have somebody checked a correlation between breast feeding vs.
         | infant formula in early infancy and hungry feelings in
         | adulthood (or weight as a proxy of that)?
         | 
         | It's just an random idea, but it seems to me that the timeline
         | of increasing obesity and increasing of use of infant formula
         | could be correlated."
        
           | eukaryote wrote:
           | It is an interesting idea, but Australia has a breast feeding
           | rate of around 90% and a large obesity problem
        
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