[HN Gopher] Vaccine made of live malaria parasites shows early s...
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Vaccine made of live malaria parasites shows early success
Author : gmays
Score : 111 points
Date : 2021-07-01 15:36 UTC (7 hours ago)
(HTM) web link (www.nature.com)
(TXT) w3m dump (www.nature.com)
| pokemonz wrote:
| This post violates the "no politics" rule of HN. ergo:
|
| KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE!
|
| KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE! KILL FAUCI!
|
| SHOVE YOUR VACCINE UP YOUR ASS!
|
| MASK FASCISTS MUST FUCKING DIE!
|
| want more? keep posting CLEARLY political, non-hacking, non-
| startup bullshit - fucking fascist pieces of shit.
| smallpipe wrote:
| Fantastic news. It's such a debilitating disease even for people
| who don't die from it. A whole life of frequent crises.
| unclewalter wrote:
| "Participants were then intentionally infected with malaria three
| months later to test the vaccine's efficacy."
|
| I did not know that purposely infecting people with a deadly
| parasite for research was a thing!
| ch4s3 wrote:
| It's called a challenge trial. It's done to compress later
| stages of clinical trials and only uses low risk volunteers.
| It's also generally only done when theres effective treatment
| for expected negative outcomes.
| oseibonsu wrote:
| Parasite, not a virus. For some parts of the world, it's like
| getting the flu. You expect to get it every year.
| unclewalter wrote:
| Thanks, updated. My ignorance of this practice extends to all
| deadly pathogens, really.
| cwkoss wrote:
| I wonder how disclosure works for the "field study testing the
| vaccine in adults is under way in Mali."
|
| Do they screen enrollees based on scientific literacy? Seems
| like there could be significant moral hazards here.
| jdavis703 wrote:
| I've been the "lab rat" in many US studies, and generally all
| we get is a disclosure stating the purpose, risks and methods
| of the experiment. There's no test for "scientific literacy"
| at all. I'm not even sure the point of this. What people care
| about is the risks and methods.
| cwkoss wrote:
| How do vaccines with live parasites work? Does attenuation
| somehow guarantee that the live parasites won't replicate to the
| point of becoming a full-on infection?
|
| Can these vaccines only be used on patients with healthy immune
| systems, and those with weakened immune systems have the
| potential for cascading replication and full infections?
| lucioperca wrote:
| There are other vaccines such as the polio (the one which was
| swallowed) which had a similar mechanism. You could even infect
| others with it (which has benefits for herd immunity). But the
| chances of vaccine-associated paralytic poliomyelitis was
| extremely low 1:2.700.000 (it was not given to people with
| immunity defects).
| canadianfella wrote:
| Why "but"?
| passivate wrote:
| As per their publication, they simultaneously give you anti-
| malaria medication in addition to the sporozoites. Its called
| chemoprophylaxis vaccination. (Just learned of it today)
| tmp538394722 wrote:
| The article mentions that the parasites are treated if they
| infect the blood or liver...
|
| So I guess they are monitoring the vaccinated closely. Honestly
| sounds a bit touchy.
| Exmoor wrote:
| I'll be interested to see how this compares to Malaria vaccine,
| R21, which was recently announced to be highly effective[0]. It
| seems like R21 is similarly effective and may not have the
| perception or scalability issues that a "live parasite" vaccine
| might have. That said, I'm just happy to hear that there's
| progress being made. Hopefully we can see the vaccine rolled out
| to the millions at risk ASAP.
|
| [0]
| https://blogs.sciencemag.org/pipeline/archives/2021/04/23/gr...
| Previous HN Discussion:
| https://news.ycombinator.com/item?id=26916237
| vanderZwan wrote:
| That vaccine is mentioned in the article:
|
| > _The vaccination protected 87.5% of participants who were
| infected after three months with the same strain of parasite
| that was used in the inoculation, and 77.8% of those who were
| infected with a different strain. This is a significant
| improvement on earlier efforts to use live parasites in a
| malaria vaccine, which did not perform as well against
| different strains._
|
| > _Another vaccine, called R21, was recently shown to be up to
| 77% effective in a trial of 450 young children, and a larger
| study is under way._
|
| I assume we can't rally make direct comparisons between the two
| based on these very different studies, but both appear to be
| working really well.
| jvanderbot wrote:
| Someday, perhaps the vaccine will be the major disease vector, as
| it is now for Polio.
|
| This is not an anti-vax position. This is desirable, but I'm
| really curious how to manage the message of "The only way you'll
| catch this disease nowadays is from this vaccine, but you still
| have to get it".
| zaysan01 wrote:
| This is great news, would probably rephrase the whole "injecting
| you with live parasites" thing though
| Vecr wrote:
| Nice idea, but there's no way something like this would pass FDA.
| Even for the live VSV Ebola vaccine that contains no Ebola at all
| in it, except for the encoded spike, it's recommended for a
| doctor to do administration, and it's not commercially available,
| so you have to justify your need for it to the federal
| government. You are also supposed to avoid close contact with
| anyone else for quite a while after, to prevent transmission of
| the vaccine virus.
|
| https://www.cdc.gov/vaccines/hcp/acip-recs/vacc-specific/ebo...
| babypuncher wrote:
| An RNA vaccine is starting human trials next year, and likely
| won't have these problems.
|
| https://academictimes.com/first-vaccine-to-fully-immunize-ag...
| evanrich wrote:
| Does the FDA have to approve it for American NGOs to distribute
| it internationally? Definitely would make more of a difference
| to African and India
| Vecr wrote:
| I don't think so, especially if it's nominally part of a
| trial. US Ebola drugs and vaccines were used in Africa before
| approval.
| pkaye wrote:
| No it only requires the approval of the destination country.
| But in the case of Ebola, some of those countries didn't have
| an established infrastructure to run trials so the WHO
| initially hesitated. But in the end they got Merck to run the
| trials and FDA and EMA to evaluate the results.
|
| https://www.statnews.com/2020/01/07/inside-story-
| scientists-...
| shusaku wrote:
| > The sporozoites must be harvested from mosquito salivary glands
| and then stored at extremely low temperatures, complicating their
| distribution in resource-poor areas. No vaccine has ever been
| mass-produced using mosquitoes before. Alonso remembers someone
| asking him about the possibility years ago: "It is a crazy idea,"
| he replied at the time.
|
| Crazy indeed, it's amazing the things people think up.
| 908087 wrote:
| I sincerely hope the mods here are sharing any information they
| have about the deranged dead post here in this thread with the
| relevant authorities.
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