[HN Gopher] Ultra-processed food targets bone quality via endoch...
       ___________________________________________________________________
        
       Ultra-processed food targets bone quality via endochondral
       ossification
        
       Author : myth_drannon
       Score  : 101 points
       Date   : 2021-06-04 18:11 UTC (4 hours ago)
        
 (HTM) web link (www.nature.com)
 (TXT) w3m dump (www.nature.com)
        
       | pella wrote:
       | +"Nutritional Dark Matter"
       | 
       |  _" "We are what we eat," but do you really know what's in your
       | food? Our first paper on the Nutritional Dark Matter is in Nature
       | Food, about the 26,000+ chemicals that are in our diet, and their
       | impact on our health. "_ (2019)
       | 
       | https://twitter.com/barabasi/status/1204413768987361282
        
       | grendelt wrote:
       | What are the official definitions of the varying degrees of food
       | processing? When does food become processed and then move into
       | "highly processed" and then on to "ultra processed".
       | 
       | High fat and high calorie doesn't seem clear cut and scientific
       | enough.
        
         | mattmcknight wrote:
         | Exactly. Why isn't the control for this experiment a high sugar
         | diet without the "processing"? It's very unclear what
         | "processing" refers to. What the data suggest is that in
         | combination the elements are bad, but they were unable to
         | isolate which one was the cause and there is nothing to suggest
         | processing was the cause. (For example, the rats eating
         | processed corn oil or processed sucrose did fine.)
        
         | teddyh wrote:
         | I think it's the same as "chemical". When something's bad, it's
         | a chemical. When something's good, it's not.
         | 
         | I.e. nobody knows what "processed" means, they just know it's
         | bad somehow.
        
         | stronglikedan wrote:
         | Looks like even the "official" definitions vary.
         | 
         |  _Definitions vary, but the U.S. Department of Agriculture says
         | anything that changes the fundamental nature of an agricultural
         | product - heating, freezing, dicing, juicing - is a processed
         | food.
         | 
         | "Those little baby carrots that you get in a supermarket -
         | that's a processed food," said Penny Kris-Etherton, registered
         | dietitian and distinguished professor of nutrition at
         | Pennsylvania State University's Department of Nutritional
         | Sciences. So are frozen vegetables, or even broccoli that's
         | been cut into florets.
         | 
         | Ultra-processed food takes things further. Nutritionists
         | started using the term about 10 years ago, and again,
         | definitions vary. One diet classification system called NOVA
         | sums it up as "snacks, drinks, ready meals and many other
         | products created mostly or entirely from substances extracted
         | from foods or derived from food constituents with little if any
         | intact food."_
         | 
         | From here: https://www.heart.org/en/news/2020/01/29/processed-
         | vs-ultra-...
        
           | asiachick wrote:
           | So olive oil is a processed food (pressing is the same a
           | juicing). Bread is a processed food. Most salads with diced
           | tomatoes and onions are processed food. Like most similar
           | classifications (eg. organic) it's mostly nonsense.
        
           | smnrchrds wrote:
           | > _freezing, dicing, juicing_
           | 
           | I know it's not the correct interpretation in reality, but
           | it's fun thinking that by this definition, all beef is
           | processed unless you buy the whole live cow.
        
           | artful-hacker wrote:
           | Yeah, I feel there is no way we can have a clear definition
           | on it. Even these citations (thank you for extracting them by
           | the way) require more definitions. What exactly is a "intact
           | food"? Does that mean a plant or animal that could exist in
           | nature? Cause thats approximately zero percent of what I buy
           | or eat.
           | 
           | It's all subjective, feels very much like a "you know it if
           | you see it" kind of thing.
        
             | macNchz wrote:
             | It's definitely not always obvious but I think the
             | categories of "minimally processed" / "processed" / "ultra
             | processed" make some intuitive sense:
             | 
             | Raw fish filet / Canned Fish / Frozen Fish Fingers
             | 
             | Corn on the cob / Frozen Corn / Corn Chips
             | 
             | Raw chicken breast / Rotisserie Chicken / Chicken patty
             | 
             | Peanuts / Peanut Butter / Peanut M&Ms
             | 
             | Milk / Cheese / Powdered cheese sauce mix
             | 
             | Brown rice / White rice / Rice Krispies
             | 
             | Wheat / Simple bread / Chocolate chip cookies
        
               | ianai wrote:
               | I think ultra processed includes things like high
               | fructose corn syrup-which basically has nothing else from
               | corn within it. It's pretty much a naked solution at that
               | point.
               | 
               | This is tough. Maybe a good definition could involve how
               | the food hits your blood sugar levels compared to its
               | completely whole equivalent.
        
             | akiselev wrote:
             | How "intact" a food is basically how much of the original
             | nutrition remains after processing. Hand milling whole
             | grain into flour is a form of processing, for example, that
             | leaves the food almost completely intact because it gets
             | rid of the inedible chaff without destroying much of the
             | bran, germ, and endosperm. Industrially processed all
             | purpose flour, on the other hand, goes through a more
             | destructive process that destroys more of those layers and
             | more of the nutritional value (due to chemicals used, more
             | heat and force generated from machinery, etc). Processing
             | flour into bread, leaves even less of it intact because the
             | yeast and heat irreversibly change the chemistry of the
             | bread, but if the flour is made from intact grains it will
             | be significantly more nutritious, despite roughly the same
             | amount of processing.
             | 
             | "intact" food is important because of bioavailability of
             | nutrients as well as metabolic responses like insulin. You
             | can't add fiber or vitamins back into fruit juice with the
             | same effect as eating whole fruit, for example.
             | 
             | Edit: Even fully synthesized food that counts as "super
             | duper ultra processed" can be more nutritious than
             | unprocessed food, but as a general rule outside of medicine
             | it isn't.
        
             | xeromal wrote:
             | Yeah, my first thought was ground beef which to me still
             | feels like minimally processed. Sure, it's high in fat but
             | eaten correctly is a solid food choice in many dishes.
        
         | datameta wrote:
         | I presume what sets apart food in its "natural", "prepared" or
         | cooked state is the increased level (though industry regulated)
         | of potential contaminants introduced during separation of
         | protein, fat, and sugar from all the other constituent
         | compounds that may not have caloric value but have nutritional
         | or protective effects.
         | 
         | I would like to find the written definition myself.
        
         | yoz-y wrote:
         | The experiment itself only seems to consider imbalanced macros
         | and additional sugar inside water.
         | 
         | I too wish to know what exactly is meant by the term
         | "processed" and whether, say, an industrial sausage is any
         | worse than "all natural" shake having exactly the same macros
         | (- preservatives)
        
         | hombre_fatal wrote:
         | Ready-to-eat foods high in fat and refined sugars doesn't seem
         | as nebulous as this sort of cookie cutter HN comment seems to
         | assert though.
        
         | grawprog wrote:
         | I like to go with, if it's something that no longer resembles
         | food that's possible to make with unprocessed ingredients or if
         | more than half the ingredients in a product are chemicals. It's
         | probably ultra processed.
         | 
         | Say burgers. A home made Burger made of freshly ground meat is
         | a 'processed food.'
         | 
         | A Patty created in a factory out of a slurry of smooshed up
         | animal, parts, binders and preservatives then flash frozen and
         | shipped to various places where it's then thawed and cooked
         | using an industrial grill and assembled by a teenager for
         | minimum wage...that's ultra processed.
        
           | tomjakubowski wrote:
           | In case anyone is wondering how McDonalds beef patties are
           | made, they're minced from large whole cuts of meat and fat.
           | At industrial scale for sure, though not quite so harrowing
           | as parent's description.
           | 
           | https://www.businessinsider.com/i-went-to-a-mcdonalds-
           | factor...
        
           | chrisseaton wrote:
           | You're defining 'processed' as 'not unprocessed', there.
           | Obviously a cyclic definition. And how are you defining
           | 'chemical'?
        
           | TchoBeer wrote:
           | > chemicals
           | 
           | Do you have some special definition of that which wouldn't
           | include "everything".
        
             | rainbowzootsuit wrote:
             | Come now: there is energy, and probably dark matter too.
             | And space-time. And black holes. And neutron stars.
        
               | TchoBeer wrote:
               | Generally don't eat of that though
        
         | okareaman wrote:
         | I had the same question:
         | 
         |  _food we eat every day that has been significantly changed
         | from its original state, with salt, sugar, fat, additives,
         | preservatives and /or artificial colours added._
         | 
         | https://www.heartandstroke.ca/articles/what-is-ultra-process...
         | 
         | It's not clear to me what attribute of UPF is bad. I know sugar
         | is not good. But fat? Additives, preservatives and/or
         | artificial colors?
        
           | jfengel wrote:
           | It's more about concentration than about special ingredients,
           | and to a lesser extent about missing nutrients.
           | 
           | These foods tend to be very calorie-dense, which encourages
           | you to eat too much of them. They provide those calories
           | without a lot of other things (fiber, calcium, and possibly
           | other unknown micronutrients). There's some suggestion that
           | their high concentrations also throw off the complex balance
           | of gut flora, but that's harder to pin down.
           | 
           | The additives, preservatives, colors, etc. are probably safe
           | in and of themselves. They've generally passed at least some
           | basic level of safety testing (including being fed in
           | megadoses to rats). They tend to be added to convenience
           | foods to make them even more appealing and available. So
           | they're correlated with negative health outcomes, but without
           | being the cause of it.
           | 
           | It's still possible that there's something wrong with the
           | additives themselves, but if you avoid them by eating less-
           | processed products, you'll likely do better regardless of the
           | additive safety. Generally, that means doing more cooking
           | yourself, or at least selecting menu items that more closely
           | resemble home cooking.
        
             | symlinkk wrote:
             | If it's about calories then just say it. "High calorie
             | foods are unhealthy" makes perfect sense. This vague "ultra
             | processed" definition is confusing.
        
               | jfengel wrote:
               | The problem is that they've been saying "eat less
               | calories" for decades, and it hasn't fixed the problem.
               | 
               | Why? Lots of reasons, one if which is that calorie
               | counting is hard. Totting up every calorie you eat is
               | incredibly tedious. "Eat fewer calories" would be less
               | onerous, but only if you're eating regular and consistent
               | meals so that it's easy to identify what "less" means.
               | 
               | So they try to give easy-to-follow advice, like "eat
               | fewer foods with a lot of calories". How do you identify
               | those? Well, they're the ones that have been through a
               | lot of industrial processes that take out not-fun stuff
               | (water, fiber) and add in a lot of things that are
               | purified to the calorie-rich parts (sugar, oil, butter).
               | 
               | They're looking for another way to say "Don't go to
               | McDonald's and don't eat candy bars or drink soda" for a
               | long time. If those are things that you do, and you stop
               | it, you will almost certainly lose weight. But we can't
               | even get people to do that, even though it's been the
               | same advice for decades.
               | 
               | "Ultra processed foods" are convenience foods. If
               | "convenience foods" were to be their next iteration of
               | the advice, I'd be fine with that. It's not about the
               | fundamental nutrition; they've been trying to get people
               | to do the same thing for decades without any headway.
               | It's about communication and persuasion, which are far
               | harder jobs.
        
               | lbotos wrote:
               | The problem with calorie counting is that we cannot
               | reason about what a calorie looks like.
               | 
               | what does 1 calorie of ice cream looks like?
               | 
               | What about 1 calorie of broccoli?
               | 
               | 1 calorie of steak?
               | 
               | The solution is to switch to a macro focused diet, which
               | still uses calories under the hood.
               | 
               | With Macros you'll get a target of x g fats / y g protein
               | / z g carbs which makes it much easier for a person to
               | learn and reason about the food they are eating by sight
               | and weight.
               | 
               | The second factor is, our much more sedentary lifestyle
               | means that often a 2000 calorie diet is 200-400 calories
               | off or a lot of people.
        
               | jfengel wrote:
               | Counting anything is hard, so I prefer to develop a feel
               | for it, if you can.
               | 
               | Cut the obvious junk. Cook more for yourself, with more
               | focus on vegetables. Don't worry about trying to limit
               | yourself; just aim for sensible foods. Try that alone for
               | a few months, and see if your weight stabilizes and
               | declines a little, which it should.
               | 
               | If that works, you can start substituting more processed
               | stuff, as a treat or convenience. There you can look at
               | calories or macros to help: "Ok, I was going to eat
               | dinner, which is ordinarily around 800-1000 calories.
               | This frozen pizza is... holy crap!" Have it anyway; you
               | just know what it means now.
               | 
               | Overall, what I recommend is not to go on a restrictive
               | diet, but to start eating for the weight you wish to be,
               | and plan to remain there forever. (If you're a lot
               | overweight, you may need to do that in stages.) A lot of
               | people want to diet and then switch to a maintenance
               | phase. I think it's better to go directly to maintenance,
               | and let that asymptotically lower your weight. You suffer
               | less and thus bounce back less.
               | 
               | But that's just my $.02. This is all brain stuff;
               | whatever persuades you to eat right and exercise is good.
        
           | lambdaba wrote:
           | There are issues with heat treatment in those foods that
           | create advanced glycation end products.
           | 
           | Fats in ultra-processed tend to be low quality industrial
           | seed oils, like soybean, sunflower, etc.
        
             | symlinkk wrote:
             | And this "low quality seed oil" is bad...why? It seems to
             | me that all of food science besides the basic "calories and
             | macronutrients" that everyone knows is complete
             | pseudoscience bullshit.
        
               | [deleted]
        
               | [deleted]
        
           | ianai wrote:
           | It's usually got a huge amount of fat or sugar compared to a
           | healthy amount of a whole food. So chips are soaked with fat-
           | on par with nuts. But unlike nuts, chips often come with less
           | protein, no fiber, and fats that have been refined highly.
           | 
           | Additives/preservatives/artificial colors can be of dubious
           | safety as the standards for "safe to eat" are very lax.
        
         | armchairhacker wrote:
         | In this specific study
         | 
         | > The diet chosen here exemplifies the Western UPD with
         | unbalanced levels of micro- and macronutrients
         | 
         | Generally speaking, "unprocessed" foods are raw whole foods.
         | "Processing" means cooking, cutting, adding stuff, etc. (of
         | course none of this is bad in any way). "Highly processed" and
         | "ultra processed" mean there's high calorie density without
         | protein, fiber, micro-nutrients, etc. AKA it's very easy to
         | overeat and throw your nutrient balance off. Of course products
         | like Soylent are technically highly "processed" but that's
         | rarely what these articles mean.
        
         | 6foot4_82iq wrote:
         | Real meat to plant-based "meat" is one instance.
        
       | dukeofdoom wrote:
       | My personal anecdotal position on this, is there's something with
       | the wheat in America. European wheat tastes different. Wheat is
       | the number one component of food that is over eaten by those that
       | are obese.
        
         | occamrazor wrote:
         | Arandom fact: most durum wheat used to make pasta in Italy is
         | imported from Canada.
        
           | kortex wrote:
           | That'll be a fun one to throw at my kooky aunt, who insists
           | that pasta in America gives her problems, but the stuff in
           | Italy does not. She thinks it's GMO. I told her "GMO wheat"
           | isn't even a thing.
           | 
           | > As of 2020, no GM wheat is grown commercially, although
           | many field tests have been conducted, with one wheat variety,
           | Bioceres HB4, obtaining regulatory approval from the
           | Argentinian government.
           | 
           | > https://en.wikipedia.org/wiki/Genetically_modified_wheat
           | 
           | https://grainstorm.com/blogs/blog/is-wheat-genetically-
           | modif....
        
       | jimrandomh wrote:
       | Hidden in the supplementary material (which you have to import an
       | MS Word doc to read): the "ultra-processed diet" they fed the
       | rats has multiple severe micronutrient deficiencies, probably
       | because rather than being a mixed diet of many different
       | ultraprocessed foods, it's: a hamburger and fries and soda, and
       | nothing else ever, in a blender. Which is not remotely
       | representative of any human diet.
        
         | virtue3 wrote:
         | That's basically been my depression diet during this whole
         | pandemic. :/
         | 
         | n=1 applies to you ya know.
        
         | 6foot4_82iq wrote:
         | > Which is not remotely representative of any human diet.
         | 
         | People don't come to weigh 350lbs eating vegetables daily.
        
           | klyrs wrote:
           | Fries and soda is a vegan meal. Some vegans eat like crap and
           | gain weight, suffer malnutrition, or both.
        
             | 6foot4_82iq wrote:
             | Sure, there are very few (if any) 350lb vegans though.
             | Vegetables (even processed and deep fried) are too light on
             | calories.
             | 
             | The most redeeming ingredient in a burger, fries, and soda
             | combo is the meat patty.
        
         | Animats wrote:
         | Yes, the "ultra-processed" claim seems way off. It's not the
         | processing in this experiment, it's the choice of raw
         | materials.
        
         | jimrandomh wrote:
         | Control: 1000mg calcium/100g Intervention: 62mg calcium/100g
         | 
         | OMG PROCESSED FOOD CAUSES BONE PROBLEMS </s>
         | 
         | They even avoided including cheese, to increase the size of the
         | calcium deficiency.
        
           | defaultname wrote:
           | This is the sort of study that just feels like animal abuse
           | without the justification. They pursued a study where they
           | knew the results beforehand -- an intentional macronutrient
           | deficiency yields, unsurprisingly, a deficiency. And they
           | knew it would earn press because it serves a particular
           | worldview.
           | 
           | One could contrive a "zero processed food" study that yielded
           | identical results.
        
         | ed25519FUUU wrote:
         | Minus the soda, that's actually not a badly balanced diet
         | depending on the hamburger toppings.
        
         | mywittyname wrote:
         | > Which is not remotely representative of any human diet.
         | 
         | I know many humans who have diets not far off from that. Maybe
         | deep fried chicken tenders as a substitute for hamburgers.
         | Granted, most of them eat ketchup, which is a serving of
         | vegetables in some states.
         | 
         | Seriously though, this problem is more common that I think a
         | lot may realize. Something about a high-sugar, high-salt, fast
         | food diet has the long-term effect of destroying peoples'
         | ability to eat other foods. I've seen kids grow up on fast food
         | who find the idea any green vegetable completely revolting.
        
           | ethbr0 wrote:
           | Of all the things my mother did for me, the one I'm second
           | most grateful for was not catering to my childish tastes.
           | 
           | I see some of my friends not far beyond chicken fingers for
           | every meal and shudder...
           | 
           | So thanks, Mom! You were right. Here's to "Dinner is what I
           | cooked, and if you want something else then breakfast is in
           | 12 hours."
        
             | mod wrote:
             | My best friend and his wife are the best parents I've ever
             | seen in practice, in many ways. Quality time, attention,
             | simulating activities etc. They're both schoolteachers.
             | 
             | BUT! Their kids eat 3 meals for dinner: pizza, chicken
             | nuggets with French fries, or easy Mac. For lunch they have
             | pb&j, for breakfast eggs or cereal. Chips and candy for
             | snacks. Throw in some applesauce you suck out of little
             | pouches. That's it.
             | 
             | I'm pretty much appalled. The kids seem healthy, although
             | I'm not an expert. But man, they're missing out on
             | literally all the good stuff.
             | 
             | I hope they come around in a couple years. I haven't asked
             | them their plan or anything.
             | 
             | I'm firmly in the camp of not cooking around kids unless
             | they really hate one particular thing, or it's too spicy
             | perhaps, or an allergy.
        
               | brandonmenc wrote:
               | I became an extremely picky eater suddenly around age 4.
               | 
               | I literally didn't eat a single vegetable or fruit that
               | wasn't an onion or tomato sauce until age 20, and my diet
               | consisted mostly of "kid food" - hamburgers, hot dogs,
               | breakfast cereal, milk, etc.
               | 
               | Meanwhile, my family was eating lots of home cooked
               | mediterranean meals. I can't count the number of times
               | I'd be eating a hot dog while they were enjoying
               | something like stinky artichokes.
               | 
               | My parents cooked around me. Never forced me to eat
               | anything I didn't like. Never insisted I "just try" a
               | food that was going to make me gag.
               | 
               | Shortly after I turned 20, something just clicked and I
               | started eating everything. Now my diet is more varied
               | than the rest of my family.
               | 
               | Don't force your kids to eat stuff they hate.
               | 
               | If they're not actually malnourished or obese, they'll
               | likely turn out fine. The last thing you want to do is
               | establish a pattern of stress and anguish re: meals and
               | food. That probably never turns out well in the long run.
        
               | vasco wrote:
               | This is very strange to me, coming from a culture of
               | "food is what is cooked". There was no stress around it
               | because that's the way the world worked, sometimes you
               | don't like the food but you still eat it. The same way
               | you'd prefer to play all day instead of going to school.
               | I can't fathom how one would call this traumatic, it's
               | just part of learning to not be a spoiled brat that gets
               | everything their way.
        
               | thepratt wrote:
               | I'm western, but almost all of my childhood and early/mid
               | teens was spent in Asia. I think growing up seeing all
               | the variety of odd and stinky things made me much more
               | willing to try; they were having it, so _I want it_.
               | 
               | I wonder how much environment shapes how open one will be
               | to food. Most picky eaters I've met come from places with
               | cultures of TV-centric dinners (America, Australia, UK)
               | opposed to family-centric ones (Japan, Germany,
               | Singapore), which makes me wonder if there's a link or
               | just coincidence in experience.
        
               | ivraatiems wrote:
               | Good-sounding advice I have heard from professionals is a
               | middle ground between your approach and the grandparent
               | comments' "this is what the meal is" approach: Don't cook
               | separate meals for your kids, but include at least one
               | food in the meal the child will definitely eat, even if
               | it's just bread, crackers, etc. (I have also heard "don't
               | make dessert separate from the rest of the meal.") Also,
               | if your kids are old enough, don't pre-portion the food
               | or serve it to the kids; let them make their own plates.
               | If they just eat bread and cheese, that's up to them -
               | but it doesn't set up the idea that they are going to get
               | something "special" if they don't like what's being
               | offered.
               | 
               | Not being a parent, I have no idea whether this works.
               | I'd be interested to hear whether anyone has tried an
               | approach like this. I'm sure kids can find some way to
               | defeat it no matter how good it sounds.
               | 
               | Personally, my biggest issue growing up was less
               | pickiness (like a lot of kids, I went through a picky
               | phase and emerged from it not picky), and more that my
               | parents had the classic "finish what's on your plate"
               | rule, which I think has definitely contributed to
               | unhealthy eating habits in adulthood.
        
               | hathawsh wrote:
               | One of my daughters finds almost all foods revolting. She
               | accepts rice, ketchup, ramen, breakfast cereal, and most
               | sweets. Sometimes she'll accept pickled beets. She
               | doesn't tolerate veggies, fruits, most meat, most breads,
               | and most restaurant food (including fast food).
               | 
               | We have convinced her to eat other foods, but she gags
               | every time. I suspect she has an eating disorder. She has
               | been seeing a therapist. I wonder if she needs to see a
               | different therapist who specializes in eating disorders.
               | In any case, she seems physically healthy. She runs and
               | plays and doesn't get hurt.
               | 
               | What's amazing to me is I was completely unaware of these
               | kinds of disorders before she came along. I think she
               | wants to eat veggies (because she really believes us when
               | we say they are good for her), but her body strongly
               | resists.
        
               | hamburglar wrote:
               | One problem with parenting is that there is so much
               | simple advice out there that "works" for some people so
               | they become quite sure they've found the one true answer.
               | We have raised both kids with the same "this is dinner"
               | attitude and it worked wonderfully on the first kid and
               | not at all on the second kid. It's hubris for people to
               | think they have figured out what works enough to tell
               | others they should do the same.
        
           | dragontamer wrote:
           | > I know many humans who have diets not far off from that.
           | 
           | The minute you add Tomatoes + Cheese (found in pizza), you're
           | suddenly fixing a major vitamin A deficiency (that Hamburgers
           | / Potatoes lack).
           | 
           | Like, at least round out the meal with other ultraprocessed
           | foods if you want to prove something.
           | 
           | -----------
           | 
           | What causes bone deficiency? Well, a lack of calcium (also
           | found in cheese) and Vitamin D (needed to process calcium
           | more efficiently), which potatoes also lack.
           | 
           | Pizza, Tacos, and Ice Cream would fix that, no joke, if I'm
           | thinking about the "worst foods" that still hit those
           | vitamins.
        
             | mywittyname wrote:
             | So I looked up the Vitamin A contents of Heinz ketchup and
             | Kraft Singles (the highly processed "cheese" used in fast
             | food cheeseburgers). Each say 2% RDV per serving, that's
             | roughly 20mcg per serving.
             | 
             | I'm not sure below what level constitutes deficiency.
             | Perhaps that small amount is enough.
        
               | mlyle wrote:
               | Hitting 4-6% of the recommended daily value over a
               | sustained time is likely severe deficiency.
        
               | lazyasciiart wrote:
               | Hitting 50% over time is noticeably inadequate at a
               | population level.
               | https://academic.oup.com/jn/article/132/9/2920S/4687708
        
           | wyager wrote:
           | Most green vegetables have barely any nutritive content.
           | Babies naturally find them disgusting as well - this is an
           | example of instinctive flavor preference actually working
           | correctly. The problem is that evolved palatability is not
           | well-calibrated for things like widely available sugars
           | (including starches)
        
             | chrisco255 wrote:
             | You're getting downvoted, but this is correct. Most green
             | veggies have high oxalates and high phytic acid
             | (antinutrients) that actively prevent the absorption of
             | certain nutrients. For example, Spinach has calcium oxalate
             | that prevents the absorption of calcium (it binds to
             | calcium instead and passes through your digestive system).
             | 
             | Unless those veggies are soaked & boiled, fermented, or
             | sprouted, chances are they're adding little nutritional
             | value to your diet and can even cause anemia or other
             | issues if you're just eating them raw.
        
               | klipt wrote:
               | This seems like a good argument for eating varying things
               | over the day. E.g. you don't have to have greens with
               | your breakfast, but it's probably good to eat them every
               | so often for fiber.
               | 
               | And yes fermented greens like sauerkraut or kimchi may be
               | better in many ways.
        
           | SomewhatLikely wrote:
           | The hamburger in the study had tomatoes and lettuce (but they
           | explicitly pointed out no pickles or onions). So there was
           | some vegetable material there already.
        
         | mrandish wrote:
         | I agree that the study really doesn't support what the headline
         | conveys nor does it support the opposite. Thanks for doing the
         | work of downloading the supplemental data and pointing out the
         | rather important details.
         | 
         | A few years ago I decided to get serious about my many years of
         | chronic obesity and started deep-dive studying nutrition
         | science. I was appalled by the pervasive lack of scientific
         | rigor in most nutrition science. Even widely accepted parts of
         | public health policy, like the "food pyramid" that was preached
         | to kids in elementary school, were based on shockingly weak
         | observational studies with many uncontrolled confounding
         | variables. Most of the "Large N" studies are based on "diary
         | data." Essentially, asking people via written surveys to
         | estimate what they typically eat and extrapolating that over
         | years. Yeah, not kidding.
         | 
         | In short, I used to assume "nutrition science" was a somewhat
         | rigorous field akin to biology or chemistry but discovered, for
         | the most part, it's not. My N=1 experience has been that
         | cutting out most carbs was tremendously effective for my
         | metabolism type and I lost 85 pounds in 7 months without
         | increased exercise. Since then I've kept it off for four years
         | by sticking to a rigorous low-carb diet. It was difficult for
         | the first few months but my palette and preferences adapted and
         | now I plan to never go back. Eating low carb has the side
         | benefit of cutting out most processed foods which may have
         | helped improve my health. However, I don't recommend what I did
         | for everyone because I've learned that metabolisms vary enough
         | that what worked great for me may not work great for you.
         | Instead, my advice is to do your own reading, develop
         | hypotheses and experiment on yourself until you find a
         | combination that works for your body, lifestyle and goals.
         | Ultimately, weight loss is obviously a function of calories in
         | vs calories out but in practice there are different ways of
         | achieving the necessary caloric deficit. For me, low carb
         | worked because it altered my blood sugar-driven hunger cycle.
         | In all my years of failed dieting I'd never tried cutting carbs
         | before cutting calories. Turns out it's _much_ easier to cut
         | calories when you 're not hungry!
        
           | SturgeonsLaw wrote:
           | > Even widely accepted parts of public health policy, like
           | the "food pyramid" that was preached to kids in elementary
           | school, were based on shockingly weak observational studies
           | with many uncontrolled confounding variables.
           | 
           | It's even worse in fact. The Food Pyramid was originally
           | developed by the US Department of Agriculture, and then
           | edited by the Secretary of Agriculture's Office, which
           | represent the interests of the farming industry. USDA
           | nutritionists initially made some healthier recommendations,
           | but were overruled to cater for farmer's interests.
           | 
           | Here's an excerpt from an essay by Luise Light, one of the
           | USDA nutritionists who's recommendations were rewritten:
           | 
           | "Back in the early '80s, I was the leader of a group of top-
           | level nutritionists with the USDA who developed the eating
           | guide that became known as the Food Guide Pyramid.
           | 
           | Carefully reviewing the research on nutrient recommendations,
           | disease prevention, documented dietary shortfalls and major
           | health problems of the population, we submitted the final
           | version of our new Food Guide to the Secretary of
           | Agriculture.
           | 
           | When our version of the Food Guide came back to us revised,
           | we were shocked to find that it was vastly different from the
           | one we had developed. As I later discovered, the wholesale
           | changes made to the guide by the Office of the Secretary of
           | Agriculture were calculated to win the acceptance of the food
           | industry. For instance, the Ag Secretary's office altered
           | wording to emphasize processed foods over fresh and whole
           | foods, to downplay lean meats and low-fat dairy choices
           | because the meat and milk lobbies believed it'd hurt sales of
           | full-fat products; it also hugely increased the servings of
           | wheat and other grains to make the wheat growers happy. The
           | meat lobby got the final word on the color of the saturated
           | fat/cholesterol guideline which was changed from red to
           | purple because meat producers worried that using red to
           | signify "bad" fat would be linked to red meat in consumers'
           | minds.
           | 
           | Where we, the USDA nutritionists, called for a base of 5-9
           | servings of fresh fruits and vegetables a day, it was
           | replaced with a paltry 2-3 servings (changed to 5-7 servings
           | a couple of years later because an anti-cancer campaign by
           | another government agency, the National Cancer Institute,
           | forced the USDA to adopt the higher standard). Our
           | recommendation of 3-4 daily servings of whole-grain breads
           | and cereals was changed to a whopping 6-11 servings forming
           | the base of the Food Pyramid as a concession to the processed
           | wheat and corn industries. Moreover, my nutritionist group
           | had placed baked goods made with white flour -- including
           | crackers, sweets and other low-nutrient foods laden with
           | sugars and fats -- at the peak of the pyramid, recommending
           | that they be eaten sparingly. To our alarm, in the "revised"
           | Food Guide, they were now made part of the Pyramid's base.
           | And, in yet one more assault on dietary logic, changes were
           | made to the wording of the dietary guidelines from "eat less"
           | to "avoid too much," giving a nod to the processed-food
           | industry interests by not limiting highly profitable "fun
           | foods" (junk foods by any other name) that might affect the
           | bottom line of food companies."
        
       | zwieback wrote:
       | Looks like there were rats being fed with a "recommended rat
       | diet" and other rats being fed burgers, fries and a soft drink,
       | e.g. the typical fast food meal.
        
       | aszantu wrote:
       | Makes sense in hindsight. When i cut it all out, all kinds of
       | joint and back pain went away
        
         | spaetzleesser wrote:
         | Same for me. I also recently started eating mainly pasta or
         | potatoes with some boiled or sauteed vegetables. Rarely any
         | bread or other processed foods. Comparing to most other people
         | I already had a very good diet before but now I am dropping
         | some more pounds and my joints feel much better.
         | 
         | Seems we are really poisoning us with the typical diet of most
         | people.
        
       | kortex wrote:
       | * in rats
       | 
       | Rats are pretty good models for humans, but they are a leaky
       | abstraction like all models. Obviously no one is arguing junk
       | food is _good_ for you, but rats have rather different dietary
       | and metabolic needs than humans. Both Homo sapiens and Rattus
       | norvegicus are garbage disposals of the animal kingdom, but
       | believe it or not humans are actually a little better equipped to
       | handle extreme diets vs rats. Feeding lab rats ultra-high fat
       | diets is pretty much guaranteed to result in obesity, insulin
       | resistance, and all the problems that come with it, but Inuits
       | and other groups have survived thousands of years with exactly
       | such a diet for large parts of the year.
       | 
       | Also, rats are wicked smart and even the "human" conditions for
       | lab rats are likely insufficiently stimulating physically and
       | mentally.
        
       | londons_explore wrote:
       | Lots of dietary science seems to study "processed food", but none
       | seems to break down the effects they find to the specific food
       | ingredients or processing steps.
       | 
       | For example, a hot dog is ultra processed by most definitions.
       | But if you feed mice the raw ingredients that go into a hot dog,
       | but not yet ground up into a hot dog, do they have the same
       | health effects?
       | 
       | How about when you start adding and removing ingredients?
       | 
       | I suspect a _specific_ processing step or ingredient causes many
       | of these developmental issues, yet no study seems to attempt to
       | find it
        
       | lambdaba wrote:
       | > Only in the US does UPF comprise 57.9% of energy intake, of
       | which 89.7% is derived from added sugars.
       | 
       | It should be no mystery that refined sugar is devastating to
       | bones.
        
         | SketchySeaBeast wrote:
         | > It should be no mystery that refined sugar is devastating to
         | bones.
         | 
         | Why? What particular qualities does sugar have that directly
         | affects bone?
         | 
         | I took a look and found one study[1] that indicated Fructose
         | doesn't affect bone growth. This study[2] indicates that
         | Fructose strengthens bones. This meta-analysis [3] says that
         | there can't be any conclusions drawn due to not enough
         | evidence.
         | 
         | [1] https://pubmed.ncbi.nlm.nih.gov/27832314/ [2]
         | https://pubmed.ncbi.nlm.nih.gov/24267046/ [3]
         | https://academic.oup.com/nutritionreviews/article/66/6/301/1...
        
           | lambdaba wrote:
           | It's depleting magnesium, induces inflammation, reduces
           | vitamin D.
           | 
           | > The overconsumption of dietary sugar has the potential to
           | increase the risk of osteoporosis by: a) increasing the
           | urinary excretion of both calcium and magnesium, b) reducing
           | the intestinal absorption of calcium by lowering the levels
           | of active vitamin D, and c) impairing bone formation by
           | reducing osteoblast proliferation and increasing osteoclast
           | activation as well as lactic acid production.
           | 
           | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140170/
        
         | Filligree wrote:
         | This definition of "refined sugar" includes starch, I guess?
        
           | lambdaba wrote:
           | Starch breaks down into glucose, while sucrose is glucose +
           | fructose. Refined fructose is uniquely harmful.
        
             | Filligree wrote:
             | I'm aware. But the numbers given imply that Americans get
             | fifty percent of their energy from sugar, which fails the
             | sniff test -- it's completely unbelievable.
        
               | spaetzleesser wrote:
               | Sugar gives me joint pain and headaches so I have started
               | to read food labels very closely. The amount of sugar in
               | a lot of foods is completely insane. Especially a lot of
               | "healthy" foods have a ton of it, for example protein
               | bars, granola bars and a lot of breakfast food. A lot of
               | salad dressing are high in sugar, so are pasta sauces,
               | fruit juices and so on. Most bread has added sugar and
               | pastry has way too much sugar compared to Germany.
               | 
               | Almost everything is sweetened to an extreme level.
        
               | freeflight wrote:
               | _> it's completely unbelievable_
               | 
               | Is it tho? High-fructose corn-syrup is ever-present in
               | most convenient foods in the US down to such basics like
               | bread and the hilariously oversized sodas, while obesity
               | and diabetes rates have reached epidemic proportions [0]
               | 
               | [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887150/
        
               | lambdaba wrote:
               | Yes, might be an issue with more restrictive definitions
               | of added sugar. The number I found is 70-80g/day, which
               | is a lot but if you count things like fruit juices which
               | only have "natural" sugars...
               | 
               | Made me think about:
               | 
               | > Oatly has voluntarily agreed to stop marketing its
               | oatmilks as containing 'n added sugars' in ad campaigns
               | followir a complaint by Campbell Soup drawing attention
               | to its oatmilk production process, which breaks down oat
               | starch into simple sugars.
        
       | hatsunearu wrote:
       | *in mice
        
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