[HN Gopher] Advice for young scientists and curious people in ge...
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       Advice for young scientists and curious people in general
        
       Author : yarapavan
       Score  : 166 points
       Date   : 2021-05-19 07:44 UTC (15 hours ago)
        
 (HTM) web link (fs.blog)
 (TXT) w3m dump (fs.blog)
        
       | tudorw wrote:
       | I'd love to hear from a mature scientist familiar with this
       | advice from the outset of their career tell us how the reality
       | lined up, things like '"A scientist will normally have
       | contractual obligations to his employer and has always a special
       | and unconditionally binding obligation to the truth."' seem a
       | little idealistic in a contemporary setting?
        
         | vagrantJin wrote:
         | I'd say science is itself an ideal, like the law, but with
         | application of rigour. The moment you stop seeking trutg, it's
         | no longer science but akin to alchemy or astrology.
         | 
         | But then we get to the slippery slope of lying outright vs
         | "cooking the math" to suit your hypothesis. It's still not
         | clear where the line is drawn.
        
         | DrAwdeOccarim wrote:
         | It's very apt. The only issue I take is the point to work on
         | something important rather than something interesting. Sure,
         | you can find interest at sufficient depth in nearly any topic
         | if you're a good scientist, but you'll miss out on the truly
         | groundbreaking stuff--the long tail stuff.
         | 
         | For example (obvs YMWV), when I started graduate school in the
         | mid-aughts, my interest was piqued by a little studied RNA
         | modification called pseudouridine. I actually had another prof
         | in the department ask why I didn't want to work on something
         | "important". Turns out it was pretty important for improving
         | human health and reducing disease in unforeseen ways. If I
         | hadn't followed my gut interest that said "hmm?" when I first
         | learned about it, I would have missed out on something grand.
         | 
         | Maybe what I would add is the pursuit of a PhD, IMHO, is a
         | privilege. It's a time to drift and wander around a topic of
         | interest; not a time to bust your ass. It's a time for pious
         | interrogation of the universe. You should not be gunning for
         | money or fame or success, but rather focused on making
         | connections with other scientists to come up with answers to
         | interesting questions about how things work.
         | 
         | So who can spend so many of their prime years possibly not
         | accomplishing anything of value? Someone who is privileged. I
         | am all, all, all for opening up doors to everyone, but the risk
         | is that "getting a PhD" turns into the pursuit in and of
         | itself. We are seeing this now more with people assuming the
         | higher degree is simply the next step after a masters or
         | bachelors degree. It wasn't designed for that.
         | 
         | But with all this being said, I love how humanity evolves and
         | I'm down for enabling anyone who hustles to get ahead. If this
         | is what society thinks a PhD should become, then let's try it
         | out. But people need to make sure they realize the way things
         | used to play out after the degree are no longer the rule but
         | more of the exception.
        
           | ProjectArcturis wrote:
           | Just curious, how did that work out for you, career-wise? How
           | would it have worked out if pseudiuridine didn't turn out to
           | be important?
        
         | ramraj07 wrote:
         | The only thing that's hard to reconcile for me is advice to
         | "work on something important". That's like asking someone to
         | just get better from depression. If we can all truly agree on
         | what's important and what's not that's half the problem solved
         | right there.
         | 
         | Other issue is that if a problem is important then a lot of
         | folks are already on it. Is it worth everyone's time for one
         | more person to come and compete for the same goal? This only
         | makes sense if you know that you can bring a new perspective to
         | that topic (which unfortunately every scientist believes they
         | do).
        
       | wombat23 wrote:
       | Nice reminder of some general principles. I wonder how well it
       | applies to young scientists given today's academic career
       | prospects, though.
       | 
       | > If you want to make progress in any area, you need to be
       | willing to give up your best ideas from time to time. [...]
       | Medawar notes that he twice spent two whole years trying to
       | corroborate groundless hypotheses.
       | 
       | Unfortunately, being willing to scrap your idea is only one part
       | of the equation. Securing funding after 2 "failed" post-docs is
       | an entirely different matter.
        
         | DrAwdeOccarim wrote:
         | Ouch. Your point is tough to stomach, but there is another side
         | to it they don't teach you in school: tenure-track research
         | isn't the only path. In fact, tenure-track research may
         | actually be the worst path for the vast, vast majority of PhD
         | graduates.
        
           | thatcherc wrote:
           | What are the other options here? Sounds like you've got some
           | good perspective!
        
           | ramraj07 wrote:
           | Exactly. It's foolish to follow this path. There's a ton of
           | VC money out there, if you need millions or billions to see
           | your idea through. If not just make your own money. Honestly
           | feels less stressful and hypocritical than the academic Ponzi
           | scheme.
        
             | veddox wrote:
             | Few academic disciplines lend themselves to monetarisation
             | via startups. Indeed, many academic disciplines don't lend
             | themselves to _any_ kind of monetarisation, except academic
             | funding.
        
             | linguae wrote:
             | However, building a business is a different problem from
             | doing research. When one accepts VC funding, the funding
             | comes with the expectation that it will lead to a high-
             | growth business. This is fine when you have an idea that
             | has the potential to "take off" from a business standpoint.
             | 
             | However, there are many research problems where there is no
             | obvious or immediate business application. The aim of such
             | research is different from the aim of investors. This
             | requires a different funding source, one that is willing to
             | embrace the risks that come with research and is willing to
             | do work solely for the advancement of science, with
             | productization being a nice side effect rather than an
             | expectation.
             | 
             | Of course, obtaining such funding is not easy. Part of what
             | makes modern academia such a rat race is because of how
             | competitive it is to procure research funding from funding
             | agencies such as the NSF (disclaimer: this is a US point of
             | view; I'm not very familiar with the situation abroad). My
             | advisor works hard applying for grants, and sometimes they
             | get rejected. I'd love a Genius Grant ($125,000 a year for
             | five years with no strings attached) to work on whatever
             | research I want without any pressures from the funding
             | agency or from managers, but there are only so few awarded
             | per year.
             | 
             | There is also the matter of research freedom in the sense
             | of being free from the pressures of short term thinking and
             | "publish or perish" mentality. I am reminded of Alan Kay's
             | observations (http://worrydream.com/2017-12-30-alan/) about
             | short-term research. I'm also reminded of what the
             | discoverer of the electron, J.J. Thompson, once said in a
             | 1916 speech that resonates with me whenever I think about
             | research:
             | 
             | "If you pay a man a salary for doing research, he and you
             | will want to have something to point to at the end of the
             | year to show that the money has not been wasted. In
             | promising work of the highest class, however, results do
             | not come in this regular fashion, in fact years may pass
             | without any tangible result being obtained, and the
             | position of the paid worker would be very embarrassing and
             | he would naturally take to work on a lower, or at any rate
             | a different plane where he could be sure of getting year by
             | year tangible results which would justify his salary. The
             | position is this: You want one kind of research, but, if
             | you pay a man to do it, it will drive him to research of a
             | different kind. The only thing to do is to pay him for
             | doing something else and give him enough leisure to do
             | research for the love of it."
             | 
             | For me, my dream is to start and grow a non-research
             | lifestyle business that pays the bills, so that way I can
             | spend the rest of my time on research, which is what I'm
             | passionate about.
        
               | ramraj07 wrote:
               | I am in the same path, make the money and fund my own
               | research. All other models have been perverted by
               | existing long enough that the culture around them is very
               | antithetic to the true motivation of the endeavor.
               | 
               | The only systems not amenable to this model is perhaps
               | high energy physics or things of that sort but I'm sure
               | some resourceful mind will come up with ideas!
        
         | hundreddaysoff wrote:
         | Exactly. Most academics really can't win. It's how the system
         | is designed.
         | 
         | This is why I sold out after my MD/PhD and became just a
         | regular physician. Maybe in a few decades I'll have enough in
         | savings to fulfill my dream of becoming a mad scientist...
        
           | wombatpm wrote:
           | Sprague Dawley rats are so expensive though. You might just
           | want to get informed-ish consent from your patients.
        
             | [deleted]
        
         | danieltillett wrote:
         | This is why you should not ever dedicate yourself to a single
         | project no matter how much you believe in it. You should at a
         | minimum have one back up project that will generate publishable
         | results no matter what happens.
        
           | chiefalchemist wrote:
           | You should always have some "R&D" regardless of what you do,
           | what you're working on, etc.
           | 
           | Focus is great. But it has a tendency to create blinders,
           | feed confirmation bias, etc.
        
       | tasogare wrote:
       | This page is full of junk statements. Picking some extracts and
       | adding some commentary made by someone without experience in the
       | field isn't helpful.
       | 
       | > Science proceeds because researchers do all they can to
       | disprove their hypotheses rather than prove them right.
       | 
       | Obviously written by someone who has never step a foot in a lab.
       | 
       | > When there's an urgent need, we learn faster and avoid
       | unnecessary learning.
       | 
       | There is no such thing as unnecessary learning as the benefits of
       | something learn can pay in an unexpected way later on. Which is
       | how some great discoveries were made. I agree that reading too
       | much is a form of procrastination, but advocating ignorance is no
       | good either.
        
         | thejackgoode wrote:
         | > This page is full of junk statements. Picking some extracts
         | and adding some commentary made by someone without experience
         | in the field isn't helpful.
         | 
         | IMHO FS is a "modern gospel" echo chamber with little to no new
         | ideas. Why people link it here so often is a mystery to me
        
           | borroka wrote:
           | FS: "It sounds good, but it does not work."
        
       | pitspotter wrote:
       | _> To be creative, scientists need libraries and laboratories and
       | the company of other scientists; certainly a quiet and untroubled
       | life is a help_
       | 
       | This is contradicted by Richard Hamming in his lecture on
       | creativity. He points out a famous, tranquil, well-equipped
       | environment, viz. the Institute for Advanced Study, where only
       | very few breakthroughs have been made:
       | 
       | https://www.youtube.com/watch?v=FlTybZvds0U
        
       | thisismyswamp wrote:
       | I like the general tone of this advice towards action over
       | consumption. I have found that to be a good way to approach my
       | interest in deep learning research.
        
       | ProjectArcturis wrote:
       | If this were written today, most of the advice would be tips and
       | tricks for getting your papers into high-profile journals and
       | writing grants. Which in turn boils down to having a good
       | pedigree from your PhD and postdoc advisors.
        
       | williesleg wrote:
       | Globalist advice is to shit up and conform.
        
       | neopba wrote:
       | Very interesting. I also advise the check out the famous Advice
       | for a Young Investigator by S.R. y Cajal
        
       | boringg wrote:
       | Am I the only one who is getting kind of ill from the amount of
       | blogs out there (farnam street is just an example) that have a
       | business about selling ideas/advice to people?
       | 
       | Maybe I've been listening to too many podcasts and I'm jaded but
       | when people selling the ideas and their entire business model is
       | constantly pushing out new ideas and interviewing thought leaders
       | at some point quality content drops off and the pressure to
       | publish probably makes the content suspect. Not sure I'm
       | describing this right but just something I've been noticing
       | lately.
        
         | ncfausti wrote:
         | I think this is just the nature of the "buffet of information"
         | we currently enjoy. As in a restaurant, if you keep eating, no
         | matter how good the food might be, you'll get sick of it
         | eventually.
         | 
         | You don't have to read them all. At some point (after much
         | learning and preparation of course) we all have to decide to be
         | our own guide; to trust our own intuition and primary research
         | to know what's best for us.
         | 
         | Each of us have incredibly unique backgrounds, experiences,
         | goals, and values. Until we start to take action on the things
         | that we really want to achieve, articles like these will
         | eventually come to sound like the same tired platitudes. Check
         | out Emerson's essay Self-Reliance if this resonates with you.
         | (And yes I recognize the irony :) of my comment.)
        
         | ducharmdev wrote:
         | As problematic as academia is, that's kinda the idea behind
         | tenure - to make the pursuit of research independent of
         | economic incentives. Obviously this is not the case in practice
         | with grants, the allure of industry jobs, low pay, etc., but I
         | wonder if something similar could be achieved in a more
         | contemporary context with platforms like Patreon.
        
           | nickff wrote:
           | Well, you seem to be tacitly assuming that those individuals
           | have more interesting thoughts to contribute, but the market
           | is somehow corrupting them, or misguiding them. It's also
           | possible that each person only has so much to give, and is
           | thereafter a spent force; tenure/patreon/other wouldn't
           | change that.
        
         | planet-and-halo wrote:
         | You sure aren't. One of my buddies worked with an older woman
         | who owned a bunch of self-help-y type business books, they were
         | talking one day and she said, "You know, I noticed we all owned
         | a bunch of these and it wasn't changing the way anyone worked."
         | I thought that was pretty salient. The demand for ideas seems
         | to be much more based on the satisfaction of novelty and being
         | "in the know" and much less on actually utilizing any of it.
         | These publishers try to feed that demand continuously, which is
         | just kind of a ridiculous quirk of the human brain, and like
         | any other irrational demand it has no inherent limit. So like
         | you said they start scraping the bottom of the barrel.
        
           | stocknoob wrote:
           | The benefit of self-help can be like escapist fiction, except
           | the protagonist isn't Luke Skywalker or Frodo but you,
           | yourself.
        
           | snapcore wrote:
           | It seems to me, self-help is mostly just people spouting
           | ideas with little scientific backing anyway. People get
           | caught up in famous person X wrote this book. It seems like
           | sometimes the person is actually knowledgeable like Jordan
           | Peterson given their credentials for instance, but then they
           | just draw conclusions that don't follow, make logical leaps,
           | write platitudes, state common sense, etc.
           | 
           | Also it requires a lot of conscious effort to change the
           | patterns that make up yourself. The first step is to learn
           | that skill. It seems like that is where everyone mostly
           | fails.
           | 
           | Ironically, I could write a self-help book/blog using these
           | observations and present myself as an authority, but I
           | realize these are just my opinions.
        
             | Aerroon wrote:
             | It's likely that self-help books do help some people, but
             | only some. The disconnect people have is probably a result
             | of different self-help books being suitable for different
             | people in a way that we have a hard time defining. Eg
             | imagine a self-help book catered towards introverts.
             | Extroverts might not find it all that helpful, but be
             | unable to realize why, yet their (introvert) friend swears
             | that it was enormously helpful. Some (small) group of
             | people feel that the book was helpful to them. They got
             | that kick from it that started their engine. Another group
             | might get it from another book.
             | 
             | Combine this with people liking new things and I think it
             | explains a significant part of the self-help book industry.
             | And why do people write them? Money, but also the same
             | reason we write comments here. It somehow _feels_ good to
             | share your opinion, regardless whether you say you 're an
             | authority or are just sharing an opinion you're not
             | completely sure of.
        
           | tenkabuto wrote:
           | Yeah, I had similar feelings about the self-help/personal
           | development/business "literature" space, and it drove me
           | towards learning more about philosophy. A big thing that
           | frustrated me was a lack of critical thinking, especially
           | attempts to understand or reconcile why seemingly
           | contradicting principles each seem reasonable and effective
           | in similar situations. (Given seemingly the same situation,
           | book A says X is the correct approach to take, but book B
           | says (seemingly) not-X is the correct approach.)
           | 
           | I think there should be a sort of academic-esque literature
           | (in the sense of journals and critique) that analyzes these
           | things.
        
         | swyx wrote:
         | exactly - the kind of people who these posts admire don't
         | actually read these posts. I called this the Metacreator
         | Ceiling https://www.swyx.io/meta-creator-ceiling/
        
           | andbberger wrote:
           | I couldn't be bothered to read your post so I took it upon
           | myself to write a blog post I like to call "Self-awareness
           | and the meta-meta-creator ceiling"
        
       | jxramos wrote:
       | A related set of advice from a Nobel laureate:
       | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198756/
        
       | giantg2 wrote:
       | My advice is either make as much money as possible, or find a job
       | you enjoy even if you're poor.
       | 
       | Most of this feel good talk from companies (or schools) are
       | either lies or promises they can't deliver on. Be skeptical.
        
       | ggm wrote:
       | Having been guilty of "can we try another algorithm" which is
       | only one remove from p-jacking, I think we need to encourage more
       | negative results publication. We need to incentivise and reward
       | it.
       | 
       | There should be a way to get tenure on it, at least partially.
        
         | roenxi wrote:
         | It is too easy to churn out negative results though. If someone
         | were to hit this at an incentives level, I think it might be
         | fruitful to require that anyone getting tenure has to have had
         | a major study replicated by an independent researcher. That'd
         | have complicated ramifications and probably encourage a very
         | insular community.
        
           | abnry wrote:
           | That would improve incentives for those trying to get tenure,
           | but what are the incentives for the replicators? That seems
           | to be the biggest problem. It costs money, time, and with the
           | current incentive structure, reputation.
        
         | mhh__ wrote:
         | I think some lower pressure medium for publication could work.
         | Publishing every attempt that didn't work would be tedious, but
         | a database of attempts, implementation, and results would allow
         | others to not walk into the same bog
        
         | inter_netuser wrote:
         | 10x bonus for every disproven dogma.
        
           | veddox wrote:
           | "Dogmas" are pretty much never disproven. (Technically,
           | outside of mathematics, they _can 't_ be.)
           | 
           | Science is a long process of lots of people looking at lots
           | of data and coming up with different explanations to make
           | sense of it all. Some of these explanations make more sense
           | than others, but it's pretty much guaranteed that even the
           | experts won't be able to agree on which ones. As new data and
           | new generations of researchers emerge, the explanations
           | evolve, consolidate, and sometimes are discarded again. In
           | short: science is a mess of opinions, gradually moving along.
           | 
           | If you want to get a feel for what that looks like in
           | practice, have a look at this blog post about diverging
           | opinions in ecology:
           | https://dynamicecology.wordpress.com/2018/04/30/poll-
           | results... (Most of the hypotheses he explores are current
           | "textbook knowledge"!)
        
             | wombatpm wrote:
             | A new scientific truth does not triumph by convincing its
             | opponents and making them see the light, but rather because
             | its opponents eventually die and a new generation grows up
             | that is familiar with it. . . . An important scientific
             | innovation rarely makes its way by gradually winning over
             | and converting its opponents: it rarely happens that Saul
             | becomes Paul. What does happen is that its opponents
             | gradually die out, and that the growing generation is
             | familiarized with the ideas from the beginning: another
             | instance of the fact that the future lies with the youth.
             | 
             | -- Max Planck, Scientific autobiography, 1950, p. 33, 97
        
         | fabian2k wrote:
         | The problem is that good negative results are also a lot of
         | effort to achieve. You need to figure out if you have a real
         | negative result, and not just some error or mistake in your
         | experiments. And spending that additional effort when the
         | result by itself is not interesting might not be justified.
        
       | vixen99 wrote:
       | My favourite: "I cannot give any scientist of any age better
       | advice than this: the intensity of the conviction that a
       | hypothesis is true has no bearing of whether it is true or not."
        
       | mensetmanusman wrote:
       | I was surprised to see the Irish famine alluded to. It is still a
       | common misconception that the Irish were too dependent on the
       | potato:
       | 
       | https://mises.org/library/what-caused-irish-potato-famine
        
       | jleyank wrote:
       | People in general: Understand basic statistics and risk
       | estimates. Know how to balance a checkbook. Have an open mind and
       | be careful when dealing with "experts". Such people are not the
       | same as "knowledgeable people"...
       | 
       | Young scientists: I assume this means PhD in a scientific or
       | biomedical field. Those with the latter could go into medical
       | work, which requires empathy and an ability to handle stress.
       | Either of these could go into academic work, which requires luck,
       | a publication record and the ability to secure funding.
       | 
       | For those interested in "working", (reasonably) strong computer
       | chops are becoming a necessity. One either works with
       | professional developers, handles the output from such or become
       | professional developers themselves. Appreciating the data that is
       | created, its limitations and how to participate in and run a
       | project (people skills, too) are critical. There's a number of
       | scientific developers reaching retirement, and the codes they
       | maintain and expand need new people or we need new alternatives.
       | 
       | Finally, if you're a rock star interested in
       | scientific/biomedical works, get enough background to understand
       | the jargon and nomenclature of these fields. Trust me, dealing
       | with chemists without knowing proper nomenclature makes them
       | think you're an idiot. Yeah, there are translators in the middle
       | but better to not need one. Remember Egan's Rule - the number of
       | failures before the project ignores you is 1.
        
       | chiefalchemist wrote:
       | As a semi side note, in Adam Grant's latest book "Think Again" he
       | often uses the phrase:
       | 
       | "Think like a scientist."
       | 
       | https://www.thriftbooks.com/w/think-again--the-power-of-know...
        
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       (page generated 2021-05-19 23:02 UTC)