[HN Gopher] Better drainage of brain debris improves Alzheimer's...
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       Better drainage of brain debris improves Alzheimer's disease
       therapies
        
       Author : JPLeRouzic
       Score  : 36 points
       Date   : 2021-04-28 20:09 UTC (2 hours ago)
        
 (HTM) web link (padiracinnovation.org)
 (TXT) w3m dump (padiracinnovation.org)
        
       | api wrote:
       | This is fascinating... could Alzheimers be a result of a
       | lymphatic analogue of arteriosclerosis or artery blockage?
       | 
       | If so then maybe similar treatments might work.
        
       | Zababa wrote:
       | In mice. Still, it's nice that it's working (in mice).
        
         | jonplackett wrote:
         | I think I'm gonna get a pet mouse.
         | 
         | We really have a lot of excellent therapies to keep mice
         | healthy.
        
       | 1e-9 wrote:
       | Perhaps this is why physical exercise appears to reduce the risk
       | of Alzheimer's disease[1]. Our lymphatic system relies on muscle
       | contractions to move lymph. So, increasing exercise results in
       | increased lymph flow, which might then clear more amyloid-beta
       | from our brain.
       | 
       | [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113559/
        
         | plutonorm wrote:
         | I was actually wondering today if hot/cold cycling the head
         | could increase lymphatic drainage and increase cerebrospinal
         | fluid cycling.
         | 
         | Cold shower, hot shower, cold shower etc on the head... Will I
         | become mega mind?
        
         | voisin wrote:
         | Fascinating! As someone not familiar with how the lymph system
         | operates, do you care to explain how muscle contractions
         | outside the brain cause the lymph system in the brain to expel
         | waste? I understood the blood-brain barrier sort of insulated
         | the brain from a lot of this kind of thing.
        
           | throwaway5752 wrote:
           | Lymph is fascinating. It is your _other_ circulatory system.
           | 
           | Capillaries are are so narrow they can only allow a single
           | erythrocyte through at the same time. The pressure from your
           | heart causes fluid leakage from the thin vessels. Lymph
           | ducts/nodes help get this fluid back into your blood. Since
           | the heart doesn't pump lymph, that helps move it through your
           | body is actually your musculoskeletal system. That is to a
           | certain degree true from your venous / return flow in your
           | "normal" circulatory system, too. It's why your feet can
           | swell if you're sitting down too much. I'd speculate that
           | lymphatic flow efficiency has local and systemic elements
           | that contribute to it (and so your leg muscles moving lymph
           | help your overall lymphatic system health).
        
             | plutonorm wrote:
             | This didn't answer the question, like at all!
        
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       (page generated 2021-04-28 23:00 UTC)