[HN Gopher] A backdoor lets the immune system monitor the brain
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A backdoor lets the immune system monitor the brain
Author : theafh
Score : 132 points
Date : 2021-04-28 14:33 UTC (8 hours ago)
(HTM) web link (www.quantamagazine.org)
(TXT) w3m dump (www.quantamagazine.org)
| Wassimo wrote:
| Hopefully this will lead to better treatment of brain tumors and
| other diseases.
| doggodaddo78 wrote:
| Brain region to immune system: _I am root._
|
| Immune system: _Yes you are, my bad._
|
| or _I 'm going to call bullshit on that. Put your arms up and
| prepare for phagocytosis._
| judge2020 wrote:
| Now if only the immune system was open source and not some
| binary blob we can only interfaced with by giving it fake
| targets.
| tux3 wrote:
| The GPL makes this "binary" vs "source" distinction by
| talking about the "preferred form for making changes". Well,
| the binary blob of DNA happens to be also be the source!
|
| Feel free to publish your genome under an open source license
| =)
| bronzeage wrote:
| It is open source. You can go ahead and download the human
| genome. You just can't run it because of a lack of efficient
| simulation, and unlike human-created code the code is both
| obfuscated and lacks clear separation of intents.
| smegger001 wrote:
| yeah its a code base millions of years old consisting of
| spaghetti code with no comments written in a turring tarpit
| of a language that compiles directly to hardware with
| ridiculous compile times
| bserge wrote:
| Yeah, every time someone says I need to believe in God, I
| tell them that I want to believe, if only to get there
| and punch them in the face for creating such bullshit :D
| grouphugs wrote:
| headline: more harmful nazi technology
|
| what a surprise, anyone notice a very strong and deliberate
| pattern here?
| Diggsey wrote:
| I like that it is a literal "back door" in that there's an
| opening in the barrier at the back of the brain.
| steelframe wrote:
| As somebody who has a somewhat strange form of Multiple Sclerosis
| wherein almost all of the damage is in my so-called "water
| channel" nerves located in my optic nerves and around my brain
| stem, the observation that pathogens get "swept" into the area of
| my CNS where most of my lesions occur is very interesting. I've
| been tested multiple times for neuromyelitis optica, but that's
| come back negative each time, so it's still officially diagnosed
| as MS. It's just that my white matter has been completely
| untouched for the 23 years I've had symptoms, which is really
| unusual.
|
| Interferon beta worked really well for me, and now Ocrelizumab is
| doing even better.
|
| I'm convinced that what we call "Multiple Sclerosis" today is
| actually a collection of distinct conditions with largely
| orthogonal causes, and just about the best we can do in absence
| of a more thorough understanding of the issues is nuke all the
| adolescent B-lymphocytes (which is what Ocrelizumab does).
| rusty-rust wrote:
| When last did you perform the tests for NMO? In the last decade
| quite a few new tests have been developed.
|
| There are two antibody tests you can perform to determine if
| you have NMOSD; Anti-Mog and Aquaporin-4
| faeyanpiraat wrote:
| Do you happen to know an online MS community with folks similar
| to the HN crowd?
| treeman79 wrote:
| Reddit and Facebook tend to have good communities.
| therein wrote:
| Here is an interesting fact for anyone who might be reading.
|
| All the medications with the -mab suffix are monoclonal
| antibodies.
|
| For instance the "monoclonal antibody cocktail" Trump received
| was casirivimab and imdevimab, made by Regeneron.
| steelframe wrote:
| Another fun fact: BioNTech, the company that co-developed the
| mRNA COVID vaccine, applied similar techniques to develop an
| experimental MS vaccine.
|
| https://theweek.com/speedreads/960371/vaccine-maker-
| biontech...
|
| Of course if I could have a Bitcoin for every time
| "autoimmune encephalomyelitis" has been cured in a mouse
| model I would be set for life!
| treeman79 wrote:
| Ever been tested for Sjogrens? An autoimmune disorder that
| attacks fluid producing systems.
| wombatmobile wrote:
| > The new findings help clarify one detail of Shirai's 1921 mouse
| study that never sat well with the naive notion of immune
| privilege. Shirai found that tumors survived and grew when
| implanted in some locations in mice's brains. But when Shirai
| placed tumors right next to the ventricles -- now known to be the
| locations where the brain produces the fluid that sweeps antigens
| off to the immune cells -- the tumors didn't survive.
|
| So, the key experiment to reveal this fact was performed one
| hundred years ago, but overlooked.
| alanchen wrote:
| Don't run unsafe code with root. That's common sense lol
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