[HN Gopher] Hydroxychloroquine-mediated inhibition of SARS-CoV-2...
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       Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry
       attenuated by TMPRSS2
        
       Author : drocer88
       Score  : 7 points
       Date   : 2021-01-22 21:52 UTC (1 hours ago)
        
 (HTM) web link (journals.plos.org)
 (TXT) w3m dump (journals.plos.org)
        
       | AndrewBissell wrote:
       | > _We further show that SARS-CoV-2 is more reliant than SARS
       | coronavirus (SARS-CoV-1) on the TMPRSS2 pathway, and that this
       | difference is due to a furin cleavage site present in the SARS-
       | CoV-2 S protein._
       | 
       | That's interesting, it's a furin cleavage site that the _New
       | York_ "Lab leak hypothesis" article pointed to as suspicious and
       | possibly man-made, though I'm not sure if it's exactly the same.
        
       | 11thEarlOfMar wrote:
       | "human clinical trials of hydroxychloroquine failed to establish
       | its usefulness as treatment for COVID-19."
       | 
       | But no mention of whether any of the trials included both Zinc
       | and Azithromyzin, which are frequently cited as necessary co-
       | medications.
        
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       (page generated 2021-01-22 23:02 UTC)