https://www.sciencedirect.com/science/article/pii/S1550413125002232

JavaScript is disabled on your browser. Please enable JavaScript to
use all the features on this page. [1749423657] Skip to main content
Skip to article
Elsevier logo

  * Journals & Books

  * Help
  * Search

My account
Sign in

  * View PDF

Search ScienceDirect[                    ]
Cell Metabolism

Cell Metabolism

Available online 16 May 2025
In Press, Corrected ProofWhat's this?
Journal home page for Cell Metabolism

Article
Acetylated cellulose suppresses body mass gain through gut commensals
consuming host-accessible carbohydrates

Author links open overlay panelTadashi Takeuchi ^1, Eiji Miyauchi ^1 
^2, Yumiko Nakanishi ^1, Yusuke Ito ^1 ^3, Tamotsu Kato ^1, Katsuki 
Yaguchi ^1 ^4, Masami Kawasumi ^1, Naoko Tachibana ^1, Ayumi Ito ^1, 
Shu Shimamoto ^5, Akinobu Matsuyama ^5, Nobuo Sasaki ^2, Ikuo Kimura 
^6 ^7, Hiroshi Ohno ^1 ^3 ^8 ^9
Show more
Add to Mendeley
Share
Cite
https://doi.org/10.1016/j.cmet.2025.04.013Get rights and content
Under a Creative Commons license
Open access

Highlights

  * *
    Acetylated cellulose (AceCel) reduces body mass gain in wild-type
    and ob/ob mice
  * *
    AceCel limits host carbohydrate oxidation and promotes fatty acid
    utilization
  * *
    AceCel reduces gut simple sugars and body mass gain in a
    microbiota-dependent manner
  * *
    Acetate facilitates carbohydrate fermentation by a gut
    Bacteroides species

Summary

Effective approaches to preventing and treating obesity are urgently
needed. Although current strategies primarily focus on direct
modulation of host metabolism, another promising approach may involve
limiting nutrient availability through regulation of the gut
microbiota, which links diet and host physiology. Here, we report
that acetylated cellulose (AceCel), which markedly alters gut
bacterial composition and function, reduces body mass gain in both
wild-type and obese mice. AceCel limits carbohydrate oxidation and
promotes fatty acid oxidation in the host liver in a
microbiota-dependent manner. We further show that acetate enhances
carbohydrate fermentation by the gut commensal Bacteroides
thetaiotaomicron, depleting host-accessible simple sugars in the gut
of AceCel-fed mice. These findings highlight the potential of AceCel
as a prebiotic that regulates carbohydrate metabolism in both
bacteria and host, offering promise as a therapeutic strategy for
obesity.

Graphical abstract

[1-s2]

 1. Download: Download high-res image (189KB)
 2. Download: Download full-size image

Keywords

gut microbiota
bacterial metabolism
short-chain fatty acid
obesity
prebiotics
Recommended articles

Cited by (0)

^9
    Lead contact

(c) 2025 The Authors. Published by Elsevier Inc.

Recommended articles

No articles found.
Elsevier logo with wordmark

  * About ScienceDirect
  * Remote access
  * Advertise
  * Contact and support
  * Terms and conditions
  * Privacy policy

Cookies are used by this site. Cookie Settings

All content on this site: Copyright (c) 2025 Elsevier B.V., its
licensors, and contributors. All rights are reserved, including those
for text and data mining, AI training, and similar technologies. For
all open access content, the relevant licensing terms apply.

RELX group home page