https://www.sciencedaily.com/releases/2025/03/250327142001.htm Skip to main content ScienceDaily --------------------------------------------------------------------- Your source for the latest research news Follow: Facebook X/Twitter Subscribe: RSS Feeds Newsletter New! Sign up for our free email newsletter. Science News from research organizations --------------------------------------------------------------------- How calcium may have unlocked the origins of life's molecular asymmetry Research hints at calcium's potential role in enforcing a specific molecular handedness among primitive polyesters and early biomolecules Date: March 27, 2025 Source: Institute of Science Tokyo Summary: Scientists have uncovered a surprising role for calcium in shaping the building blocks of life. Their study reveals that calcium ions help determine the molecular 'handedness' (chirality) of tartaric acid polymers -- an essential feature of biological molecules like DNA and proteins. This discovery sheds light on how life's uniform molecular structures may have first emerged on early Earth. In a twist on traditional theories, the researchers suggest that simple polyesters, in addition to peptides or nucleic acids, could have adopted this crucial trait on early Earth, offering a fresh perspective on life's chemical origins. Share: Facebook Twitter Pinterest LinkedIN Email FULL STORY --------------------------------------------------------------------- A new study led by researchers at the Earth-Life Science Institute (ELSI) at Institute of Science Tokyo has uncovered a surprising role for calcium in shaping life's earliest molecular structures. Their findings suggest that calcium ions can selectively influence how primitive polymers form, shedding light on a long-standing mystery: how life's molecules came to prefer a single "handedness" (chirality). Like our left and right hands, many molecules exist in two mirror-image forms. Yet life on Earth has a striking preference: DNA's sugars are right-handed, while proteins are built from left-handed amino acids. This phenomenon, called homochirality, is essential for life as we know it -- but how it first emerged remains a major puzzle in origins of life research. The team investigated tartaric acid (TA), a simple molecule with two chiral centers, to explore how early Earth's environment might have influenced the formation of homochiral polymers. They discovered that calcium dramatically alters how TA molecules link together. Without calcium, pure left- or right-handed TA readily polymerises into polyesters, but mixtures containing equal amounts of both forms fail to form polymers readily. However, in the presence of calcium, this pattern reverses -- calcium slows down the polymerisation of pure TA while enabling mixed solutions to polymerise. "This suggests that calcium availability could have created environments on early Earth where homochiral polymers were favoured or disfavoured," says Chen Chen, Special Postdoctoral Researcher at RIKEN Center for Sustainable Resource Science (CSRS), who co-led the study. The researchers propose that calcium drives this effect through two mechanisms: first, by binding with TA to form calcium tartrate crystals, which selectively remove equal amounts of both left- and right-handed molecules from the solution; and second, by altering the polymerisation chemistry of the remaining TA molecules. This process could have amplified small imbalances in chirality, ultimately leading to the uniform handedness seen in modern biomolecules. What makes this study especially intriguing is its suggestion that polyesters -- simple polymers formed from molecules like tartaric acid -- could have been among life's earliest homochiral molecules, even before RNA, DNA, or proteins. "The origin of life is often discussed in terms of biomolecules like nucleic acids and amino acids," ELSI's Specially Appointed Associate Professor Tony Z. Jia, who co-led the study, explains. "However, our work introduces an alternative perspective: that 'non-biomolecules' like polyesters may have played a critical role in the earliest steps toward life." The findings also highlight how different environments on early Earth could have influenced which types of polymers formed. Calcium-poor settings, such as some lakes or ponds, may have promoted homochiral polymers, while calcium-rich environments might have favoured mixed-chirality polymers. Beyond chemistry, this research bridges multiple scientific fields -- biophysics, geology, and materials science -- to explore how simple molecules interacted in dynamic prebiotic environments. The study is also the result of years of interdisciplinary collaboration, bringing together researchers from seven countries across Asia, Europe, Australia, and North America. "We faced significant challenges in integrating all of the complex chemical, biophysical, and physical analyses in a clear and logical way," says project co-leader Ruiqin Yi of the Guangzhou Institute of Geochemistry, Chinese Academy of Sciences. "But thanks to the hard work and dedication of our team, we've uncovered a compelling new piece of the origins of life puzzle." This research not only deepens our understanding of life's beginnings on Earth but also suggests that similar processes could be at play on other planets, helping scientists search for life beyond our world. NOTE: Since the submission of the paper, the name of the university has changed from Tokyo Institute of Technology to Institute of Science Tokyo. Co-author Chen Chen acquired most of the data during his period as a researcher at ELSI. * RELATED TOPICS + Plants & Animals o Genetics o Biology o Molecular Biology + Earth & Climate o Acid Rain o Earth Science o Geology + Fossils & Ruins o Origin of Life o Charles Darwin o Human Evolution * RELATED TERMS + DNA + Molecular biology + Calcium + Amino acid + Macromolecule + Trait (biology) + RNA + Protein --------------------------------------------------------------------- Story Source: Materials provided by Institute of Science Tokyo. Note: Content may be edited for style and length. --------------------------------------------------------------------- Journal Reference: 1. Chen Chen, Ruiqin Yi, Motoko Igisu, Rehana Afrin, Mahendran Sithamparam, Kuhan Chandru, Yuichiro Ueno, Linhao Sun, Tommaso Laurenzi, Ivano Eberini, Tommaso P. Fraccia, Anna Wang, H. James Cleaves, Tony Z. Jia. Primitive homochiral polyester formation driven by tartaric acid and calcium availability. Proceedings of the National Academy of Sciences, 2025; 122 (12) DOI: 10.1073/ pnas.2419554122 --------------------------------------------------------------------- Cite This Page: * MLA * APA * Chicago Institute of Science Tokyo. "How calcium may have unlocked the origins of life's molecular asymmetry." ScienceDaily. ScienceDaily, 27 March 2025. . Institute of Science Tokyo. (2025, March 27). How calcium may have unlocked the origins of life's molecular asymmetry. ScienceDaily. Retrieved April 16, 2025 from www.sciencedaily.com/releases/2025/03/ 250327142001.htm Institute of Science Tokyo. "How calcium may have unlocked the origins of life's molecular asymmetry." ScienceDaily. www.sciencedaily.com/releases/2025/03/250327142001.htm (accessed April 16, 2025). 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