https://www.biorxiv.org/content/10.1101/2024.10.11.617955v1 Skip to main content bioRxiv * Home * About * Submit * ALERTS / RSS Search for this keyword [ ] [Search] Advanced Search New Results Human brain changes after first psilocybin use Taylor Lyons, Meg Spriggs, Leevi Kerkela, Fernando Rosas, Leor Roseman, Chris Timmermann, Lena Oestreich, Broc Pagni, Rick Zeifman, Adam Hampshire, Will Trender, Hannah Douglas, Manesh Girn, Kate Godfrey, Hannes Kettner, Faissal Sharif, Luigi Espasiano, Adam Gazzaley, Matt Wall, David Erritzoe, David Nutt, Robin Carhart-Harris doi: https://doi.org/10.1101/2024.10.11.617955 Taylor Lyons 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Meg Spriggs 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Leevi Kerkela 2 UCL; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Fernando Rosas 3 University of Sussex; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Leor Roseman 4 Exeter University; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Chris Timmermann 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Lena Oestreich 5 University of Queensland; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Broc Pagni 6 NYU; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Rick Zeifman 6 NYU; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Adam Hampshire 7 KCL; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Will Trender 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Hannah Douglas 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Manesh Girn 8 UCSF; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Kate Godfrey 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Hannes Kettner 8 UCSF; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Faissal Sharif 9 University of Oxford * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Luigi Espasiano 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Adam Gazzaley 8 UCSF; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Matt Wall 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site David Erritzoe 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site David Nutt 1 Imperial College London; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Robin Carhart-Harris 8 UCSF; * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site * For correspondence: robin.carhart-harris@ucsf.edu * Abstract * Info/History * Metrics * Supplementary material * Preview PDF Loading Abstract Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is unknown. In a placebo-controlled, within-subjects, electroencephalography, and magnetic resonance imaging study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes were detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being were seen at one-month. Diffusion imaging done before and one-month after 25mg psilocybin revealed decreased axial diffusivity bilaterally in prefrontal-subcortical tracts that correlated with decreased brain network modularity over the same time period. Decreased modularity also correlated with improved well-being. Increased cortical signal entropy at 1- and 2-hours post-dosing predicted improved psychological well-being at one-month. Next-day psychological insight mediated the entropy to well-being relationship. All effects were exclusive to 25mg psilocybin; no effects occurred with a 1mg placebo dose. Competing Interest Statement RC-H is a scientific advisor to Entheos Labs, Journey Collab, Otsuka, and Mindstate and has received fees or share from these companies. DJN is Chief Research Officer for Awakn Life Sciences and, within the past 2 years, has been a scientific advisor to COMPASS Pathways, Neural therapeutics, Algernon pharmaceuticals and Alvarius. RJZ and BAP are postdoctoral fellows in the NYU Langone Psychedelic Medicine Research Training program funded by MindMed. MBW's primary employer is Invicro LLC., a contract research organization which provides services to the pharmaceutical and biotechnology industries. DE has, within the last 2 years, received fees for scientific advisory work from the following (novel psychedelic) companies: Mydecine, Field Trip Health, SmallPharma Ltd, Aya Biosciences, Clerkenwell Health, and Mindstate Design Lab, and has received an honorarium fee from each of Compass Pathways and Lundbeck for a talk about psychedelic science. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. View the discussion thread. Back to top PreviousNext Posted October 14, 2024. Download PDF Supplementary Material Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * [ ] Your Name * [ ] Send To * [ ] [ ] [ ] [ ] [ ] Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Human brain changes after first psilocybin use Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. 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