https://www.nature.com/articles/d41586-024-02731-9 Skip to main content Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Advertisement Nature * View all journals * Search * Log in * Explore content * About the journal * Publish with us * Subscribe * Sign up for alerts * RSS feed 1. nature 2. research briefing 3. article * RESEARCH BRIEFINGS * 23 August 2024 Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen -- a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mechanism that underlies this unexpected role of lactate in cancer. * Twitter * Facebook * Email Access through your institution Buy or subscribe This is a summary of: Chen, H. et al. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature 631, 663-669 (2024). Access options Access through your institution Access through your institution Change institution Buy or subscribe Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Rent or buy this article Prices vary by article type from$1.95 to$39.95 Learn more Prices may be subject to local taxes which are calculated during checkout Additional access options: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support doi: https://doi.org/10.1038/d41586-024-02731-9 References 1. Koppenol, W. H., Bounds, P. L. & Dang, C. V. Nature Rev. Cancer 11, 325-337 (2011). Article PubMed Google Scholar 2. Barnes, E. M. E. et al. Br. J. Cancer 122, 1298-1308 (2020). Article PubMed Google Scholar 3. Dong, Q. et al. Cell Commun. Signal. 18, 167 (2020). Article PubMed Google Scholar 4. Lan, L. et al. Nature 607, 163-168 (2022). 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