https://www.researchsquare.com/article/rs-3976380/v1 Research Square [ ] Browse Preprints COVID-19 Preprints Protocols Videos Journals Tools & Services Overview Curie Professional Editing Research Promotion Your Cart About Preprint Platform In Review Editorial Policies Research Quality Evaluation Our Team Advisory Board Blog Help Center Sign In Submit a Preprint Cite Share Download PDF Article Decreased CO[2] saturation during circular breathwork supports emergence of altered states of consciousness Martha Havenith, Max Leidenberger, Jelena Brasanac, Mafalda Corvacho, and 11 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/10.21203/rs.3.rs-3976380/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Nature Portfolio Version 1 posted You are reading this latest preprint version Abstract Altered states of consciousness (ASCs), induced e.g. by psychedelics, show great potential to treat widespread mental health disorders like depression and PTSD. However, access to such treatments is restricted by legal, medical, and financial barriers. Here, we explore the potential of circular breathwork to serve as an accessible, non-pharmacological alternative to engage similar therapeutic processes. Scientific studies investigating the mental health effects of breathwork are only just emerging and the underlying physiological and psychological mechanisms are largely unknown. In this study, we address these questions by tracking physiological and experiential dynamics throughout a breathwork session, comparing two popular forms of breathwork: Holotropic Breathwork^(r) and Consciously-Connected breathwork. We show that a reduction in end-tidal CO2 pressure due to deliberate hyperventilation is instrumental in catalyzing ASCs during breathwork. ASCs evoked by breathwork were comparable to those produced by psychedelics, and their depth predicted psychological and physiological follow-on effects, including improved well-being and a reduction of depressive symptoms. Moreover, different breathwork formats produced highly similar physiological, experiential and psychological outcomes. These results outline physiological boundary conditions for ASCs to arise in a non-pharmacological context, shedding light on the functional mechanisms of breathwork as well as its potential as a psychotherapeutic tool. Biological sciences/Neuroscience/Cognitive neuroscience/Consciousness Social science/Psychology/Human behaviour Biological sciences/Psychology/Human behaviour Full Text Additional Declarations There is NO Competing Interest. Supplementary Files * 202402BreathworkCO2SuppMaterials.pdf Cite Share Download PDF Status: Under Review Nature Portfolio Version 1 posted You are reading this latest preprint version Research Square Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we're committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Twitter logoFacebook logoYouTube logoVimeo logoInstagram logoLinkedIn logo Also discoverable on ResearcherApp logo Platform About Our Team In Review Editorial Policies Advisory Board Contact Us Help Center Resources Author Services Research Quality Evaluation Blog Accessibility API Access RSS feed Cookie Settings Company About Us Careers Partner With Us Responsibility Press (c) Research Square 2024 | ISSN 2693-5015 (online) Privacy PolicyTerms of ServiceDo Not Sell My Personal Information