https://www.nytimes.com/2024/04/22/technology/generative-ai-gene-editing-crispr.html

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Artificial Intelligence

  * Harvesting Data for A.I.
  * A.I. Data Race, Explained
  * What Is 'Synthetic Data'?
  * Key Figures in the Field
  * A.I. Faces Quiz

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[11AI-CRISP]
The physical structure of OpenCRISPR-1, a gene editor created by A.I.
technology from Profluent.Credit...Video by Profluent Bio

Generative A.I. Arrives in the Gene Editing World of CRISPR

Much as ChatGPT generates poetry, a new A.I. system devises
blueprints for microscopic mechanisms that can edit your DNA.

The physical structure of OpenCRISPR-1, a gene editor created by A.I.
technology from Profluent.Credit...Video by Profluent Bio

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Cade Metz

By Cade Metz

Has reported on the intersection of A.I. and health care for a
decade.

  * April 22, 2024

Generative A.I. technologies can write poetry and computer programs
or create images of teddy bears and videos of cartoon characters that
look like something from a Hollywood movie.

Now, new A.I. technology is generating blueprints for microscopic
biological mechanisms that can edit your DNA, pointing to a future
when scientists can battle illness and diseases with even greater
precision and speed than they can today.

Described in a research paper published on Monday by a Berkeley,
Calif., startup called Profluent, the technology is based on the same
methods that drive ChatGPT, the online chatbot that launched the A.I.
boom after its release in 2022. The company is expected to present
the paper next month at the annual meeting of the American Society of
Gene and Cell Therapy.

Much as ChatGPT learns to generate language by analyzing Wikipedia
articles, books and chat logs, Profluent's technology creates new
gene editors after analyzing enormous amounts of biological data,
including microscopic mechanisms that scientists already use to edit
human DNA.

These gene editors are based on Nobel Prize-winning methods involving
biological mechanisms called CRISPR. Technology based on CRISPR is
already changing how scientists study and fight illness and disease,
providing a way of altering genes that cause hereditary conditions,
such as sickle cell anemia and blindness.

ImageA group of casually dressed people pose on a cement walkway.
Credit...Rachel Bujalski for The New York Times

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