https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1 Skip to main content bioRxiv * Home * About * Submit * ALERTS / RSS Search for this keyword [ ] [Search] Advanced Search New Results Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2-related Pangolin Coronavirus GX_P2V(short_3UTR) Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Weiwei Chen, Erguang Li, Yigang Tong, View ORCID Profile Lihua Song doi: https://doi.org/10.1101/2024.01.03.574008 Lai Wei 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Shuiqing Liu 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Shanshan Lu 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Shengdong Luo 2Research Center for Clinical Medicine, The Fifth Medical Center of PLA General Hospital, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Xiaoping An 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Huahao Fan 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Weiwei Chen 2Research Center for Clinical Medicine, The Fifth Medical Center of PLA General Hospital, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Erguang Li 3State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Yigang Tong 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site Lihua Song 1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China * Find this author on Google Scholar * Find this author on PubMed * Search for this author on this site * ORCID record for Lihua Song * For correspondence: songlihua@gmail.com * Abstract * Full Text * Info/History * Metrics * Supplementary material * Preview PDF Loading Abstract SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses. Competing Interest Statement The authors have declared no competing interest. Footnotes * |* email: erguang{at}nju.edu.cn; tong.yigang{at}gmail.com; Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. View the discussion thread. Back to top PreviousNext Posted January 04, 2024. Download PDF Supplementary Material Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * [ ] Your Name * [ ] Send To * [ ] [ ] [ ] [ ] [ ] Enter multiple addresses on separate lines or separate them with commas. 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[Send Message] Share Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2-related Pangolin Coronavirus GX_P2V(short_3UTR) Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Weiwei Chen, Erguang Li, Yigang Tong, Lihua Song bioRxiv 2024.01.03.574008; doi: https://doi.org/10.1101/ 2024.01.03.574008 Share This Article: [https://www.biorxiv.org/content/10.1101/2024.01.03] Copy Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo Citation Tools Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2-related Pangolin Coronavirus GX_P2V(short_3UTR) Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Weiwei Chen, Erguang Li, Yigang Tong, Lihua Song bioRxiv 2024.01.03.574008; doi: https://doi.org/10.1101/ 2024.01.03.574008 Citation Manager Formats * BibTeX * Bookends * EasyBib * EndNote (tagged) * EndNote 8 (xml) * Medlars * Mendeley * Papers * RefWorks Tagged * Ref Manager * RIS * Zotero * Tweet Widget * Facebook Like * Google Plus One Subject Area * Microbiology Subject Areas All Articles * Animal Behavior and Cognition (4955) * Biochemistry (11083) * Bioengineering (8239) * Bioinformatics (27843) * Biophysics (14284) * Cancer Biology (11404) * Cell Biology (16464) * Clinical Trials (138) * Developmental Biology (8957) * Ecology (13566) * Epidemiology (2067) * Evolutionary Biology (17639) * Genetics (11836) * Genomics (16167) * Immunology (11266) * Microbiology (26629) * Molecular Biology (10915) * Neuroscience (57818) * Paleontology (426) * Pathology (1772) * Pharmacology and Toxicology (3062) * Physiology (4654) * Plant Biology (9871) * Scientific Communication and Education (1631) * Synthetic Biology (2755) * Systems Biology (7100) * Zoology (1550)