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[Title & authors         ]
Comparative Study
Anesthesiology
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. 1975 Jun;42(6):658-61.
doi: 10.1097/00000542-197506000-00003.

The anesthetic effect of air at atmospheric pressure

P M Winter, D L Bruce, M J Bach, G W Jay, E I Eger 2nd

  * PMID: 1130736
  * DOI: 10.1097/00000542-197506000-00003

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Comparative Study

The anesthetic effect of air at atmospheric pressure

P M Winter et al. Anesthesiology. 1975 Jun.
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Anesthesiology
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. 1975 Jun;42(6):658-61.
doi: 10.1097/00000542-197506000-00003.

Authors

P M Winter, D L Bruce, M J Bach, G W Jay, E I Eger 2nd

  * PMID: 1130736
  * DOI: 10.1097/00000542-197506000-00003

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Abstract

Nitrogen has recognized narcotic potential at hyperbaric pressures.
No narcotic effect of helium has been demonstrated at any pressure.
We evaluated the effect of nitrogen in air at one atmosphere on human
performance by comparing it with helium-oxygen using a
four-alternative divided-attention task that requires rapid response
to auditory and visual signal changes. There was a 9.3 per cent
decrease in response time when subjects breathed helium-oxygen, a
signigicant change (P less than 0.001). This change could not be
ascribed to practice since the order of presentation of gases did not
have a significant effect. It concluded that the nitrogen in ambient
air slightly but measurable impairs human performance compared with a
non-anesthetic gas such as helium.

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Cited by

  * Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl
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    Brosnan RJ, Ramos K, Aguiar AJA, Cenani A, Knych HK. Brosnan RJ,
    et al. Pharmacology. 2022;107(3-4):167-178. doi: 10.1159/
    000520762. Epub 2022 Jan 31. Pharmacology. 2022. PMID: 35100605 
    Free PMC article.
  * Electron spin changes during general anesthesia in Drosophila.
    Turin L, Skoulakis EM, Horsfield AP. Turin L, et al. Proc Natl
    Acad Sci U S A. 2014 Aug 26;111(34):E3524-33. doi: 10.1073/
    pnas.1404387111. Epub 2014 Aug 11. Proc Natl Acad Sci U S A.
    2014. PMID: 25114249 Free PMC article.
  * General anesthetics: a comparative review of pharmacodynamics.
    Milam SB. Milam SB. Anesth Prog. 1984 May-Jun;31(3):116-23. 
    Anesth Prog. 1984. PMID: 6591844 Free PMC article.

Publication types

  * Comparative Study
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  * Research Support, U.S. Gov't, P.H.S.
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MeSH terms

  * Air
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  * Anesthetics*
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  * Atmospheric Pressure*
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  * Female
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  * Helium / pharmacology
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  * Humans
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  * Male
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  * Nitrogen / pharmacology*
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  * Oxygen / pharmacology
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  * Reaction Time / drug effects
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  * Anesthetics
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  * Helium
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  * Nitrogen
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  * Oxygen
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