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[Title & authors         ]
Melanoma Res
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. 2023 Apr 1;33(2):126-135.
doi: 10.1097/CMR.0000000000000870. Epub 2022 Dec 28.

Regular use of vitamin D supplement is associated with fewer melanoma
cases compared to non-use: a cross-sectional study in 498 adult
subjects at risk of skin cancers

Emilia Kanasuo^  1 , Hanna Siiskonen, Salla Haimakainen, Jenni
Komulainen, Ilkka T Harvima
Affiliations Expand

Affiliation

  * ^1 Department of Dermatology, University of Eastern Finland and
    Kuopio University Hospital, Kuopio, Finland.

  * PMID: 36580363
  * DOI: 10.1097/CMR.0000000000000870

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Regular use of vitamin D supplement is associated with fewer melanoma
cases compared to non-use: a cross-sectional study in 498 adult
subjects at risk of skin cancers

Emilia Kanasuo et al. Melanoma Res. 2023.
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Melanoma Res
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. 2023 Apr 1;33(2):126-135.
doi: 10.1097/CMR.0000000000000870. Epub 2022 Dec 28.

Authors

Emilia Kanasuo^  1 , Hanna Siiskonen, Salla Haimakainen, Jenni
Komulainen, Ilkka T Harvima

Affiliation

  * ^1 Department of Dermatology, University of Eastern Finland and
    Kuopio University Hospital, Kuopio, Finland.

  * PMID: 36580363
  * DOI: 10.1097/CMR.0000000000000870

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Abstract

There are conflicting results on the role of vitamin D system in
cutaneous carcinogenesis. Therefore, it was investigated whether the
use of oral vitamin D supplements associates with photoaging, actinic
keratoses, pigment cell nevi, and skin cancers. In this
cross-sectional study, 498 adults (aged 21-79 years, 253 males, 245
females, 96 with immunosuppression) subjects at risk of any type of
skin cancer were examined, and possible confounding factors were
evaluated. The subjects were divided into three groups based on their
self-reported use of oral vitamin D supplements: non-use, occasional
use, or regular use. The serum level of 25-hydroxyvitamin-D3 was
analyzed in 260 subjects. In 402 immunocompetent subjects, vitamin D
use did not associate with photoaging, actinic keratoses, nevi,
basal, and squamous cell carcinoma. In contrast, there were lower
percentages of subjects with a history of past or present melanoma
(32/177, 18.1% versus 32/99, 32.3%, P = 0.021) or any type of skin
cancer (110/177, 62.1% versus 74/99, 74.7%, P = 0.027) among regular
users compared to non-users. In the logistic regression analysis, the
odds ratio for melanoma was 0.447 ( P = 0.016, 95% confidence
interval, 0.231-0.862) among regular users. Furthermore, the
investigator-estimated risk class of skin cancers was significantly
lower among regular users. Serum 25-hydroxyvitamin-D3 did not show
marked associations with skin-related parameters. The results on 96
immunosuppressed subjects were somewhat similar, although the number
of subjects was low. In conclusion, regular use of vitamin D
associates with fewer melanoma cases, when compared to non-use, but
the causality between them is obscure.

Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.

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References

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        of worldwide incidence of nonmelanoma skin cancer. Br J
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     1. Schadendorf D, van Akkooi ACJ, Berking C, Griewank KG,
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     1. Murphy GM. Ultraviolet radiation and immunosuppression. Br J
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     1. Ulrich C, Kanitakis J, Stockfleth E, Euvrard S. Skin cancer
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