https://news.cuanschutz.edu/news-stories/study-suggests-fructose-could-drive-alzheimers-disease CU Anschutz Logo CU Anschutz Logo Search for: [ ] SubmitSubmit * Webmail * UCD Access * Canvas * Quick Links + Webmail + UCD Access + Canvas + Tools & Resources o Events Calendar o Newsroom o Strauss Health Sciences Library o Department A-Z Directory o Campus Directory o Leadership o Faculty & Staff Resources o Supporter & Alumni Resources o Student Resources o Campus Map o University Policies o Give Now + CU Campuses o CU Anschutz Medical Campus o CU Boulder o CU Colorado Springs o CU Denver o CU System o CU Online + CU Anschutz Medical Campus o School of Dental Medicine o Graduate School o School of Medicine o College of Nursing o Skaggs School of Pharmacy and Pharmaceutical Sciences o Colorado School of Public Health CU Anschutz Medical Campus * Education Student Resources * Research * Innovation * Patient Care * News Latest Stories In The News Press Releases CU Anschutz 360 Podcast * About Contact Us Leadership Visit the CU Anschutz Medical Campus CU Anschutz Map * Health Resources [AdobeStock] Home News Study Suggests Fructose Could Drive Alzheimer's Disease back to News Study Suggests Fructose Could Drive Alzheimer's Disease An evolutionary foraging instinct that relied on the sugar fructose may now be fueling the formation of Alzheimer's disease, CU Anschutz researchers say minute read Written by David Kelly on February 13, 2023 What You Need To Know Our ancient ancestors relied on fructose in the brain to help them successfully forage for food. Now researchers suggest it may be driving Alzheimer's disease. An ancient human foraging instinct, fueled by fructose production in the brain, may hold clues to the development and possible treatment of Alzheimer's disease (AD), according to researchers at the University of Colorado Anschutz Medical Campus. The study, published today in The American Journal of Clinical Nutrition, offers a new way of looking at a disease characterized by abnormal accumulations of proteins in the brain that slowly erode memory and cognition. "We make the case that Alzheimer's disease is driven by diet," said the study's lead author Richard Johnson, MD, professor at the University of Colorado School of Medicine specializing in renal disease and hypertension. The study co-authors include Maria Nagel, MD, research professor of neurology at the CU School of Medicine. Johnson and his team suggest that AD is a harmful adaptation of an evolutionary survival pathway used in animals and our distant ancestors during times of scarcity. "A basic tenet of life is to assure enough food, water and oxygen for survival," the study said. "Much attention has focused on the acute survival responses to hypoxia and starvation. However, nature has developed a clever way to protect animals before the crisis actually occurs." Fructose: foraging survival response trigger When threatened with the possibility of starvation, early humans developed a survival response that sent them foraging for food. Yet foraging is effective only if metabolism is inhibited in various parts of the brain. Foraging requires focus, rapid assessment, impulsivity, exploratory behavior and risk taking. It is enhanced by blocking whatever gets in the way, like recent memories and attention to time. Fructose, a kind of sugar, helps damp down these centers, allowing more focus on food gathering. In fact, the researchers found the entire foraging response was set in motion by the metabolism of fructose whether it was eaten or produced in the body. Metabolizing fructose and its byproduct, intracellular uric acid, was critical to the survival of both humans and animals. The researchers noted that fructose reduces blood flow to the brain's cerebral cortex involved in self-control, as well as the hippocampus and thalamus. Meanwhile, blood flow increased around the visual cortex associated with food reward. All of this stimulated the foraging response. "We believe that initially the fructose-dependent reduction in cerebral metabolism in these regions was reversible and meant to be beneficial," Johnson said. "But chronic and persistent reduction in cerebral metabolism driven by recurrent fructose metabolism leads to progressive brain atrophy and neuron loss with all of the features of AD." 'Survival switch' stuck in 'on' position Johnson suspects the survival response, what he calls the "survival switch," that helped ancient humans get through periods of scarcity is now stuck in the "on" position in a time of relative abundance. This leads to the overeating of high fat, sugary and salty food prompting excess fructose production. Fructose produced in the brain could possibly lead to inflammation and ultimately Alzheimer's disease, the study said. Animals given fructose show memory lapses, a loss in the ability to navigate a maze and inflammation of the neurons. "A study found that if you keep laboratory rats on fructose long enough, they get tau and amyloid beta proteins in the brain, the same proteins seen in Alzheimer's disease," Johnson said. "You can find high fructose levels in the brains of people with Alzheimer's as well." Johnson suspects that the tendency of some AD patients to wander off might be a vestige of the ancient foraging response. The study said more research is needed on the role of fructose and uric acid metabolism in AD. "We suggest that both dietary and pharmacologic trials to reduce fructose exposure or block fructose metabolism should be performed to determine if there is potential benefit in the prevention, management or treatment of this disease," Johnson said. The study's co-authors include Dean R. Tolan, Dale Bredesen, Laura G. Sanchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A. Lanaspa and David Pearlmutter. Topics: Diabetes, Geriatrics, Alzheimer's Share on facebook Share on linkedin Share on twitter Share on email Featured Experts Staff Mention Richard Johnson, MD Staff Mention Maria Nagel, MD Related Stories * Research Patient Care Diabetes Study Examines Power of Group Sessions in Managing Diabetes ----------------------------------------------------------------- Author Chris Casey | Publish Date February 15, 2023 * Diabetes Geriatrics Alzheimer's Study Suggests Fructose Could Drive Alzheimer's Disease ----------------------------------------------------------------- Author David Kelly | Publish Date February 13, 2023 * Patient Care Diabetes Obesity Elon Musk Rockets Weight-Loss Drug Into Public Eye ----------------------------------------------------------------- Author Chris Casey | Publish Date October 19, 2022 University of Colorado Anschutz Medical Campus CU Anschutz Fitzsimons Building 13001 East 17th Place Aurora, CO 80045 info@cuanschutz.edu 303-724-9290 Facebook Twitter Instagram LinkedIn Partnerships UCHealth University of Colorado Hospital Children's Hospital Colorado University of Colorado Medicine Resources Employment Ethics and Compliance Freedom of Expression Submit Content Subscribe Sustainability FindHelpNow Tools Faculty/Staff Directory A-Z Index Find a Doctor Academic Calendar Events Calendar Media Newsroom Media Contacts Filming Requests RSS Feed This is Breakthrough * Contact Us * Website Feedback * CU System * Privacy Policy * Terms of Use * Accessibility * Accreditation * Employment * Give Now --------------------------------------------------------------------- (c) 2022 The Regents of the University of Colorado, a body corporate. 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